Journal of Pharmacology and Experimental Therapeutics: 340 (1)

January 01, 2012; Volume 340,Issue 1

Highlighted Papers

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Histamine 3 Receptor and Angiotensin II Receptor Balance Regulates Cardiac Arrythmias
Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 1;
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Targeting the Arthritic Joint with Small Interfering RNA-Encapsulated Liposomes
Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 1;
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Role of Neuronal Nitric-Oxide Synthase in Acetaminophen-Induced Hepatotoxicity
Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 1;
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Glycogen Synthase Kinase 3β/β-Catenin Signaling but Not Hypoxia-Inducible Factor-1α Contributes to Defective Renal Wound Healing during Hypoxia
Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 1;

Behavioral Pharmacology

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JWH-018 and JWH-073: Δ⁹-Tetrahydrocannabinol-Like Discriminative Stimulus Effects in Monkeys
Brett C. Ginsburg, David R. Schulze, Lenka Hruba and Lance R. McMahon

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 37-45; DOI: https://doi.org/10.1124/jpet.111.187757
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Synergistic Self-Administration of Ethanol and Cocaine Directly into the Posterior Ventral Tegmental Area: Involvement of Serotonin-3 Receptors
Zheng-Ming Ding, Scott M. Oster, Sheketha R. Hauser, Jamie E. Toalston, Richard L. Bell, William J. McBride and Zachary A. Rodd

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 202-209; DOI: https://doi.org/10.1124/jpet.111.187245

Cardiovascular

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Differential Modulation of Brainstem Phosphatidylinositol 3-Kinase/Akt and Extracellular Signal-Regulated Kinase 1/2 Signaling Underlies WIN55,212-2 Centrally Mediated Pressor Response in Conscious Rats
Badr Mostafa Ibrahim and Abdel A. Abdel-Rahman

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 11-18; DOI: https://doi.org/10.1124/jpet.111.186858
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Atrial-Selective Sodium Channel Block Strategy to Suppress Atrial Fibrillation: Ranolazine versus Propafenone
Alexander Burashnikov, Luiz Belardinelli and Charles Antzelevitch

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 161-168; DOI: https://doi.org/10.1124/jpet.111.186395
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Histamine 3 Receptor Activation Reduces the Expression of Neuronal Angiotensin II Type 1 Receptors in the Heart
Narumi Hashikawa-Hobara, Noel Yan-Ki Chan and Roberto Levi

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 185-191; DOI: https://doi.org/10.1124/jpet.111.187765

Cellular and Molecular

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Adenylate Cyclase/cAMP/Protein Kinase A Signaling Pathway Inhibits Endothelin Type A Receptor-Operated Ca²⁺ Entry Mediated via Transient Receptor Potential Canonical 6 Channels
Takahiro Horinouchi, Tsunaki Higa, Hiroyuki Aoyagi, Tadashi Nishiya, Koji Terada and Soichi Miwa

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 143-151; DOI: https://doi.org/10.1124/jpet.111.187500

Drug Discovery and Translational Medicine

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The Fate of Bacterial Cocaine Esterase (CocE): An In Vivo Study of CocE-Mediated Cocaine Hydrolysis, CocE Pharmacokinetics, and CocE Elimination
Remy L. Brim, Kathleen R. Noon, Gregory T. Collins, Aron Stein, Joseph Nichols, Diwa Narasimhan, Mei-Chuan Ko, James H. Woods and Roger K. Sunahara

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 83-95; DOI: https://doi.org/10.1124/jpet.111.186049
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Small Molecule Positive Allosteric Modulation of TRPV1 Activation by Vanilloids and Acidic pH
Krisztian Kaszas, Jason M. Keller, Claudio Coddou, Santosh K. Mishra, Mark A. Hoon, Stanko Stojilkovic, Kenneth A. Jacobson and Michael J. Iadarola

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 152-160; DOI: https://doi.org/10.1124/jpet.111.183053
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Protection from Myocardial Ischemia/Reperfusion Injury by a Positive Allosteric Modulator of the A₃ Adenosine Receptor
Lili Du, Zhan-Guo Gao, Kasem Nithipatikom, Adriaan P. IJzerman, Jacobus P. D. van Veldhoven, Kenneth A. Jacobson, Garrett J. Gross and John A. Auchampach

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 210-217; DOI: https://doi.org/10.1124/jpet.111.187559

Endocrine and Diabetes

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Beneficial Effects of PKF275-055, a Novel, Selective, Orally Bioavailable, Long-Acting Dipeptidyl Peptidase IV Inhibitor in Streptozotocin-Induced Diabetic Peripheral Neuropathy
R. Bianchi, I. Cervellini, C. Porretta-Serapiglia, N. Oggioni, B. Burkey, P. Ghezzi, G. Cavaletti and G. Lauria

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 64-72; DOI: https://doi.org/10.1124/jpet.111.181529

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Heme Oxygenase-1 Alleviates Mouse Hepatic Failure through Suppression of Adaptive Immune Responses
Qiaoli Gu, Qiong Wu, Min Jin, Yichuan Xiao, Jingwei Xu, Chaoming Mao, Fang Zhao, Yi Zhang and Yanyun Zhang

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 2-10; DOI: https://doi.org/10.1124/jpet.111.186551
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Hemokinin-1 Stimulates Prostaglandin E₂ Production in Human Colon through Activation of Cyclooxygenase-2 and Inhibition of 15-Hydroxyprostaglandin Dehydrogenase
Liying Dai, D. Shevy Perera, Denis W. King, Bridget R. Southwell, Elizabeth Burcher and Lu Liu

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 27-36; DOI: https://doi.org/10.1124/jpet.111.186155
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Pharmacological Activation of Small Conductance Calcium-Activated Potassium Channels with Naphtho[1,2-d]thiazol-2-ylamine Decreases Guinea Pig Detrusor Smooth Muscle Excitability and Contractility
Shankar P. Parajuli, Rupal P. Soder, Kiril L. Hristov and Georgi V. Petkov

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 114-123; DOI: https://doi.org/10.1124/jpet.111.186213
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Impaired Wound Healing in Hypoxic Renal Tubular Cells: Roles of Hypoxia-Inducible Factor-1 and Glycogen Synthase Kinase 3β/β-Catenin Signaling
Jianping Peng, Ganesan Ramesh, Lin Sun and Zheng Dong

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 176-184; DOI: https://doi.org/10.1124/jpet.111.187427

Inflammation, Immunopharmacology, and Asthma

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Arthritic Joint-Targeting Small Interfering RNA-Encapsulated Liposome: Implication for Treatment Strategy for Rheumatoid Arthritis
Yukiko Komano, Nobuhiro Yagi, Ikumi Onoue, Kayoko Kaneko, Nobuyuki Miyasaka and Toshihiro Nanki

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 109-113; DOI: https://doi.org/10.1124/jpet.111.185884

Metabolism, Transport, and Pharmacogenomics

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Analysis of R- and S-Hydroxywarfarin Glucuronidation Catalyzed by Human Liver Microsomes and Recombinant UDP-Glucuronosyltransferases
Stacie M. Bratton, Carrie M. Mosher, Farid Khallouki, Moshe Finel, Michael H. Court, Jeffery H. Moran and Anna Radominska-Pandya

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 46-55; DOI: https://doi.org/10.1124/jpet.111.184721
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Expression of ATP-Binding Cassette Membrane Transporters in Rodent and Human Sertoli Cells: Relevance to the Permeability of Antiretroviral Therapy at the Blood-Testis Barrier
Kevin R. Robillard, Md. Tozammel Hoque and Reina Bendayan

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 96-108; DOI: https://doi.org/10.1124/jpet.111.186916

Neuropharmacology

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GABA_B Receptor-Positive Modulators: Brain Region-Dependent Effects
Julie G. Hensler, Tushar Advani, Teresa F. Burke, Kejun Cheng, Kenner C. Rice and Wouter Koek

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 19-26; DOI: https://doi.org/10.1124/jpet.111.186577
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Pleiotropic Opioid Regulation of Spinal Endomorphin 2 Release and Its Adaptations to Opioid Withdrawal Are Sexually Dimorphic
Sumita Chakrabarti, Nai-Jiang Liu, James E. Zadina, Tarak Sharma and Alan R. Gintzler

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 56-63; DOI: https://doi.org/10.1124/jpet.111.186874
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Effects of Repeated 3,4-Methylenedioxymethamphetamine Administration on Neurotransmitter Efflux and Sensory-Evoked Discharge in the Ventral Posterior Medial Thalamus
M. A. Starr, M. E. Page and B. D. Waterhouse

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 73-82; DOI: https://doi.org/10.1124/jpet.111.185728
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CEP-26401 (Irdabisant), a Potent and Selective Histamine H₃ Receptor Antagonist/Inverse Agonist with Cognition-Enhancing and Wake-Promoting Activities
Rita Raddatz, Robert L. Hudkins, Joanne R. Mathiasen, John A. Gruner, Dorothy G. Flood, Lisa D. Aimone, Siyuan Le, Hervé Schaffhauser, Emir Duzic, Maciej Gasior, Donna Bozyczko-Coyne, Michael J. Marino, Mark A. Ator, Edward R. Bacon, John P. Mallamo and Michael Williams

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 124-133; DOI: https://doi.org/10.1124/jpet.111.186585
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Ethanol Inhibition of Constitutively Open N-Methyl-d-Aspartate Receptors
Minfu Xu, C. Thetford Smothers, James Trudell and John J. Woodward

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 218-226; DOI: https://doi.org/10.1124/jpet.111.187179

Toxicology

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Acetaminophen-Induced Hepatotoxicity and Protein Nitration in Neuronal Nitric-Oxide Synthase Knockout Mice
Rakhee Agarwal, Leah Hennings, Tonya M. Rafferty, Lynda G. Letzig, Sandra McCullough, Laura P. James, Lee Ann MacMillan-Crow and Jack A. Hinson

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 134-142; DOI: https://doi.org/10.1124/jpet.111.184192
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Angiotensin II Type 1 Receptor Antagonist Attenuates Lung Fibrosis in Hyperoxia-Exposed Newborn Rats
Hsiu-Chu Chou, Yaw-Dong Lang, Leng-Fang Wang, Tzu-Ying Wu, Yu-Fang Hsieh and Chung-Ming Chen

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 169-175; DOI: https://doi.org/10.1124/jpet.111.186288
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Role of Mitochondrial Oxidants in an In Vitro Model of Sepsis-Induced Renal Injury
Elina Pathak, Lee Ann MacMillan-Crow and Philip R. Mayeux

Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 192-201; DOI: https://doi.org/10.1124/jpet.111.183756

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Table of Contents

Highlighted Papers

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

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