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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

January 01, 2012; Volume 340,Issue 1

Highlighted Papers

  • You have access
    Histamine 3 Receptor and Angiotensin II Receptor Balance Regulates Cardiac Arrythmias
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 1;
  • You have access
    Targeting the Arthritic Joint with Small Interfering RNA-Encapsulated Liposomes
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 1;
  • You have access
    Role of Neuronal Nitric-Oxide Synthase in Acetaminophen-Induced Hepatotoxicity
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 1;
  • You have access
    Glycogen Synthase Kinase 3β/β-Catenin Signaling but Not Hypoxia-Inducible Factor-1α Contributes to Defective Renal Wound Healing during Hypoxia
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 1;

Behavioral Pharmacology

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    JWH-018 and JWH-073: Δ9-Tetrahydrocannabinol-Like Discriminative Stimulus Effects in Monkeys
    Brett C. Ginsburg, David R. Schulze, Lenka Hruba and Lance R. McMahon
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 37-45; DOI: https://doi.org/10.1124/jpet.111.187757
  • You have access
    Synergistic Self-Administration of Ethanol and Cocaine Directly into the Posterior Ventral Tegmental Area: Involvement of Serotonin-3 Receptors
    Zheng-Ming Ding, Scott M. Oster, Sheketha R. Hauser, Jamie E. Toalston, Richard L. Bell, William J. McBride and Zachary A. Rodd
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 202-209; DOI: https://doi.org/10.1124/jpet.111.187245

Cardiovascular

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    Differential Modulation of Brainstem Phosphatidylinositol 3-Kinase/Akt and Extracellular Signal-Regulated Kinase 1/2 Signaling Underlies WIN55,212-2 Centrally Mediated Pressor Response in Conscious Rats
    Badr Mostafa Ibrahim and Abdel A. Abdel-Rahman
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 11-18; DOI: https://doi.org/10.1124/jpet.111.186858
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    Atrial-Selective Sodium Channel Block Strategy to Suppress Atrial Fibrillation: Ranolazine versus Propafenone
    Alexander Burashnikov, Luiz Belardinelli and Charles Antzelevitch
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 161-168; DOI: https://doi.org/10.1124/jpet.111.186395
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    Histamine 3 Receptor Activation Reduces the Expression of Neuronal Angiotensin II Type 1 Receptors in the Heart
    Narumi Hashikawa-Hobara, Noel Yan-Ki Chan and Roberto Levi
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 185-191; DOI: https://doi.org/10.1124/jpet.111.187765

Cellular and Molecular

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    Adenylate Cyclase/cAMP/Protein Kinase A Signaling Pathway Inhibits Endothelin Type A Receptor-Operated Ca2+ Entry Mediated via Transient Receptor Potential Canonical 6 Channels
    Takahiro Horinouchi, Tsunaki Higa, Hiroyuki Aoyagi, Tadashi Nishiya, Koji Terada and Soichi Miwa
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 143-151; DOI: https://doi.org/10.1124/jpet.111.187500

Drug Discovery and Translational Medicine

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    The Fate of Bacterial Cocaine Esterase (CocE): An In Vivo Study of CocE-Mediated Cocaine Hydrolysis, CocE Pharmacokinetics, and CocE Elimination
    Remy L. Brim, Kathleen R. Noon, Gregory T. Collins, Aron Stein, Joseph Nichols, Diwa Narasimhan, Mei-Chuan Ko, James H. Woods and Roger K. Sunahara
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 83-95; DOI: https://doi.org/10.1124/jpet.111.186049
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    Small Molecule Positive Allosteric Modulation of TRPV1 Activation by Vanilloids and Acidic pH
    Krisztian Kaszas, Jason M. Keller, Claudio Coddou, Santosh K. Mishra, Mark A. Hoon, Stanko Stojilkovic, Kenneth A. Jacobson and Michael J. Iadarola
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 152-160; DOI: https://doi.org/10.1124/jpet.111.183053
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    Protection from Myocardial Ischemia/Reperfusion Injury by a Positive Allosteric Modulator of the A3 Adenosine Receptor
    Lili Du, Zhan-Guo Gao, Kasem Nithipatikom, Adriaan P. IJzerman, Jacobus P. D. van Veldhoven, Kenneth A. Jacobson, Garrett J. Gross and John A. Auchampach
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 210-217; DOI: https://doi.org/10.1124/jpet.111.187559

Endocrine and Diabetes

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    Beneficial Effects of PKF275-055, a Novel, Selective, Orally Bioavailable, Long-Acting Dipeptidyl Peptidase IV Inhibitor in Streptozotocin-Induced Diabetic Peripheral Neuropathy
    R. Bianchi, I. Cervellini, C. Porretta-Serapiglia, N. Oggioni, B. Burkey, P. Ghezzi, G. Cavaletti and G. Lauria
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 64-72; DOI: https://doi.org/10.1124/jpet.111.181529

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Heme Oxygenase-1 Alleviates Mouse Hepatic Failure through Suppression of Adaptive Immune Responses
    Qiaoli Gu, Qiong Wu, Min Jin, Yichuan Xiao, Jingwei Xu, Chaoming Mao, Fang Zhao, Yi Zhang and Yanyun Zhang
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 2-10; DOI: https://doi.org/10.1124/jpet.111.186551
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    Hemokinin-1 Stimulates Prostaglandin E2 Production in Human Colon through Activation of Cyclooxygenase-2 and Inhibition of 15-Hydroxyprostaglandin Dehydrogenase
    Liying Dai, D. Shevy Perera, Denis W. King, Bridget R. Southwell, Elizabeth Burcher and Lu Liu
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 27-36; DOI: https://doi.org/10.1124/jpet.111.186155
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    Pharmacological Activation of Small Conductance Calcium-Activated Potassium Channels with Naphtho[1,2-d]thiazol-2-ylamine Decreases Guinea Pig Detrusor Smooth Muscle Excitability and Contractility
    Shankar P. Parajuli, Rupal P. Soder, Kiril L. Hristov and Georgi V. Petkov
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 114-123; DOI: https://doi.org/10.1124/jpet.111.186213
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    Impaired Wound Healing in Hypoxic Renal Tubular Cells: Roles of Hypoxia-Inducible Factor-1 and Glycogen Synthase Kinase 3β/β-Catenin Signaling
    Jianping Peng, Ganesan Ramesh, Lin Sun and Zheng Dong
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 176-184; DOI: https://doi.org/10.1124/jpet.111.187427

Inflammation, Immunopharmacology, and Asthma

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    Arthritic Joint-Targeting Small Interfering RNA-Encapsulated Liposome: Implication for Treatment Strategy for Rheumatoid Arthritis
    Yukiko Komano, Nobuhiro Yagi, Ikumi Onoue, Kayoko Kaneko, Nobuyuki Miyasaka and Toshihiro Nanki
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 109-113; DOI: https://doi.org/10.1124/jpet.111.185884

Metabolism, Transport, and Pharmacogenomics

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    Analysis of R- and S-Hydroxywarfarin Glucuronidation Catalyzed by Human Liver Microsomes and Recombinant UDP-Glucuronosyltransferases
    Stacie M. Bratton, Carrie M. Mosher, Farid Khallouki, Moshe Finel, Michael H. Court, Jeffery H. Moran and Anna Radominska-Pandya
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 46-55; DOI: https://doi.org/10.1124/jpet.111.184721
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    Expression of ATP-Binding Cassette Membrane Transporters in Rodent and Human Sertoli Cells: Relevance to the Permeability of Antiretroviral Therapy at the Blood-Testis Barrier
    Kevin R. Robillard, Md. Tozammel Hoque and Reina Bendayan
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 96-108; DOI: https://doi.org/10.1124/jpet.111.186916

Neuropharmacology

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    GABAB Receptor-Positive Modulators: Brain Region-Dependent Effects
    Julie G. Hensler, Tushar Advani, Teresa F. Burke, Kejun Cheng, Kenner C. Rice and Wouter Koek
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 19-26; DOI: https://doi.org/10.1124/jpet.111.186577
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    Pleiotropic Opioid Regulation of Spinal Endomorphin 2 Release and Its Adaptations to Opioid Withdrawal Are Sexually Dimorphic
    Sumita Chakrabarti, Nai-Jiang Liu, James E. Zadina, Tarak Sharma and Alan R. Gintzler
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 56-63; DOI: https://doi.org/10.1124/jpet.111.186874
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    Effects of Repeated 3,4-Methylenedioxymethamphetamine Administration on Neurotransmitter Efflux and Sensory-Evoked Discharge in the Ventral Posterior Medial Thalamus
    M. A. Starr, M. E. Page and B. D. Waterhouse
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 73-82; DOI: https://doi.org/10.1124/jpet.111.185728
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    CEP-26401 (Irdabisant), a Potent and Selective Histamine H3 Receptor Antagonist/Inverse Agonist with Cognition-Enhancing and Wake-Promoting Activities
    Rita Raddatz, Robert L. Hudkins, Joanne R. Mathiasen, John A. Gruner, Dorothy G. Flood, Lisa D. Aimone, Siyuan Le, Hervé Schaffhauser, Emir Duzic, Maciej Gasior, Donna Bozyczko-Coyne, Michael J. Marino, Mark A. Ator, Edward R. Bacon, John P. Mallamo and Michael Williams
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 124-133; DOI: https://doi.org/10.1124/jpet.111.186585
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    Ethanol Inhibition of Constitutively Open N-Methyl-d-Aspartate Receptors
    Minfu Xu, C. Thetford Smothers, James Trudell and John J. Woodward
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 218-226; DOI: https://doi.org/10.1124/jpet.111.187179

Toxicology

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    Acetaminophen-Induced Hepatotoxicity and Protein Nitration in Neuronal Nitric-Oxide Synthase Knockout Mice
    Rakhee Agarwal, Leah Hennings, Tonya M. Rafferty, Lynda G. Letzig, Sandra McCullough, Laura P. James, Lee Ann MacMillan-Crow and Jack A. Hinson
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 134-142; DOI: https://doi.org/10.1124/jpet.111.184192
  • You have access
    Angiotensin II Type 1 Receptor Antagonist Attenuates Lung Fibrosis in Hyperoxia-Exposed Newborn Rats
    Hsiu-Chu Chou, Yaw-Dong Lang, Leng-Fang Wang, Tzu-Ying Wu, Yu-Fang Hsieh and Chung-Ming Chen
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 169-175; DOI: https://doi.org/10.1124/jpet.111.186288
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    Role of Mitochondrial Oxidants in an In Vitro Model of Sepsis-Induced Renal Injury
    Elina Pathak, Lee Ann MacMillan-Crow and Philip R. Mayeux
    Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 192-201; DOI: https://doi.org/10.1124/jpet.111.183756
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Journal of Pharmacology and Experimental Therapeutics: 340 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 340, Issue 1
1 Jan 2012
  • Table of Contents
  • Table of Contents (PDF)
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  • Highlighted Papers
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  • Inflammation, Immunopharmacology, and Asthma
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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