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Research ArticleNeuropharmacology

CTEP: A Novel, Potent, Long-Acting, and Orally Bioavailable Metabotropic Glutamate Receptor 5 Inhibitor

Lothar Lindemann, Georg Jaeschke, Aubin Michalon, Eric Vieira, Michael Honer, Will Spooren, Richard Porter, Thomas Hartung, Sabine Kolczewski, Bernd Büttelmann, Christophe Flament, Catherine Diener, Christophe Fischer, Silvia Gatti, Eric P. Prinssen, Neil Parrott, Gerhard Hoffmann and Joseph G. Wettstein
Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 474-486; DOI: https://doi.org/10.1124/jpet.111.185660

Article Information

vol. 339 no. 2 474-486
DOI 
https://doi.org/10.1124/jpet.111.185660
PubMed 
21849627
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received July 4, 2011
  • Accepted August 15, 2011
  • Published online October 19, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Lothar Lindemann,
  2. Georg Jaeschke,
  3. Aubin Michalon,
  4. Eric Vieira,
  5. Michael Honer,
  6. Will Spooren,
  7. Richard Porter,
  8. Thomas Hartung,
  9. Sabine Kolczewski,
  10. Bernd Büttelmann,
  11. Christophe Flament,
  12. Catherine Diener,
  13. Christophe Fischer,
  14. Silvia Gatti,
  15. Eric P. Prinssen,
  16. Neil Parrott,
  17. Gerhard Hoffmann and
  18. Joseph G. Wettstein
  1. Pharmaceuticals Division, Discovery Neuroscience (L.L., A.M., M.H., W.S., R.P., C.D., C.Fi., S.G., E.P.P., J.G.W.), Discovery Chemistry (G.J., E.V., T.H., S.K., B.B.), Nonclinical Safety (C.Fl., N.P., G.H.), and Academic Alliances (R.P.), F. Hoffmann-La Roche Ltd., Basel, Switzerland
  1. Address correspondence to:
    Dr. Lothar Lindemann, F. Hoffmann-La Roche Ltd. Pharmaceuticals Division, Discovery Neuroscience, Grenzacherstrasse 124, 4070 Basel, Switzerland. E-mail: lothar.lindemann{at}roche.com
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Research ArticleNeuropharmacology

CTEP: A Novel Potent mGlu5 Inhibitor

Lothar Lindemann, Georg Jaeschke, Aubin Michalon, Eric Vieira, Michael Honer, Will Spooren, Richard Porter, Thomas Hartung, Sabine Kolczewski, Bernd Büttelmann, Christophe Flament, Catherine Diener, Christophe Fischer, Silvia Gatti, Eric P. Prinssen, Neil Parrott, Gerhard Hoffmann and Joseph G. Wettstein
Journal of Pharmacology and Experimental Therapeutics November 1, 2011, 339 (2) 474-486; DOI: https://doi.org/10.1124/jpet.111.185660
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