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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

November 01, 2011; Volume 339,Issue 2

Highlighted Papers

  • You have access
    Regulation of Fatty Acid-Induced Lipotoxicity by Autophagy and Apoptosis
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 323;
  • You have access
    Combined σ Receptor Antagonism and Dopamine Transporter Inhibition Regulate Cocaine Self-Administration
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 323;
  • You have access
    Mephedrone: New Designer Stimulant and Potential for Abuse
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 323;
  • You have access
    c-Met Hinge-Region Mimics as Potential Anticancer Agents
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 323;

2011 Torald Sollmann Award Lecture

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    Drug Discontinuation Effects Are Part of the Pharmacology of a Drug
    Marcus M. Reidenberg
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 324-328; DOI: https://doi.org/10.1124/jpet.111.183285

Behavioral Pharmacology

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    Decreases in Cocaine Self-Administration with Dual Inhibition of the Dopamine Transporter and σ Receptors
    Takato Hiranita, Paul L. Soto, Stephen J. Kohut, Theresa Kopajtic, Jianjing Cao, Amy H. Newman, Gianluigi Tanda and Jonathan L. Katz
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 662-677; DOI: https://doi.org/10.1124/jpet.111.185025
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    Effects of Varenicline on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rhesus Monkeys
    Robert W. Gould, Paul W. Czoty, Susan H. Nader and Michael A. Nader
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 678-686; DOI: https://doi.org/10.1124/jpet.111.185538
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    Differential Effects of Nociceptin/Orphanin FQ (NOP) Receptor Agonists in Acute versus Chronic Pain: Studies with Bifunctional NOP/μ Receptor Agonists in the Sciatic Nerve Ligation Chronic Pain Model in Mice
    Taline V. Khroyan, Willma E. Polgar, Juan Orduna, Jose Montenegro, Faming Jiang, Nurulain T. Zaveri and Lawrence Toll
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 687-693; DOI: https://doi.org/10.1124/jpet.111.184663

Cardiovascular

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    Amelioration of Doxorubicin-Induced Cardiotoxicity by an Anticancer-Antioxidant Dual-Function Compound, HO-3867
    Alex Dayton, Karuppaiyah Selvendiran, Sarath Meduru, Mahmood Khan, M. Lakshmi Kuppusamy, Shan Naidu, Tamás Kálai, Kálmán Hideg and Periannan Kuppusamy
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 350-357; DOI: https://doi.org/10.1124/jpet.111.183681
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    Beneficial Effects of Combination of Valsartan and Amlodipine on Salt-Induced Brain Injury in Hypertensive Rats
    Yi-Fei Dong, Keiichiro Kataoka, Yoshiko Tokutomi, Hisato Nako, Taishi Nakamura, Kensuke Toyama, Daisuke Sueta, Nobutaka Koibuchi, Eiichiro Yamamoto, Hisao Ogawa and Shokei Kim-Mitsuyama
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 358-366; DOI: https://doi.org/10.1124/jpet.111.182576
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    Role of Neuronal Nitric-Oxide Synthase in Estrogen-Induced Relaxation in Rat Resistance Arteries
    Olga Lekontseva, Subhadeep Chakrabarti, Yanyan Jiang, Christopher C. Cheung and Sandra T. Davidge
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 367-375; DOI: https://doi.org/10.1124/jpet.111.183798
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    The Soluble Guanylate Cyclase Stimulator BAY 41-2272 Inhibits Vascular Smooth Muscle Growth through the cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase Pathways
    Chintamani N. Joshi, Danielle N. Martin, Jonathan C. Fox, Natalia N. Mendelev, Trisha A. Brown and David A. Tulis
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 394-402; DOI: https://doi.org/10.1124/jpet.111.183400
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    Dissecting the Activation of Thienopyridines by Cytochromes P450 Using a Pharmacodynamic Assay In Vitro
    Lynn M. Abell and Eddie C.-K. Liu
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 589-596; DOI: https://doi.org/10.1124/jpet.111.184895
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    Hydrogen Sulfide Regulates Na+/H+ Exchanger Activity via Stimulation of Phosphoinositide 3-Kinase/Akt and Protein Kinase G Pathways
    Li-Fang Hu, Yu Li, Kay Li Neo, Qian Chen Yong, Shiau Wei Lee, Benny Kwong Huat Tan and Jin-Song Bian
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 726-735; DOI: https://doi.org/10.1124/jpet.111.184754

Cellular and Molecular

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    Bromoenol Lactone Inhibits Voltage-Gated Ca2+ and Transient Receptor Potential Canonical Channels
    Saikat Chakraborty, Zachary C. Berwick, Paula J. Bartlett, Sanjay Kumar, Andrew P. Thomas, Michael Sturek, Johnathan D. Tune and Alexander G. Obukhov
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 329-340; DOI: https://doi.org/10.1124/jpet.111.183673
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    Activated G Protein αs Subunits Increase the Ethanol Sensitivity of Human Glycine Receptors
    Gonzalo E. Yévenes, Gustavo Moraga-Cid, Ximena Romo and Luis G. Aguayo
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 386-393; DOI: https://doi.org/10.1124/jpet.111.184408
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    Epoxyeicosatrienoic Acids Attenuate Reactive Oxygen Species Level, Mitochondrial Dysfunction, Caspase Activation, and Apoptosis in Carcinoma Cells Treated with Arsenic Trioxide
    Liu Liu, Chen Chen, Wei Gong, Yuanjing Li, Matthew L. Edin, Darryl C. Zeldin and Dao Wen Wang
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 451-463; DOI: https://doi.org/10.1124/jpet.111.180505
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    Differential Roles of Unsaturated and Saturated Fatty Acids on Autophagy and Apoptosis in Hepatocytes
    Shuang Mei, Hong-Min Ni, Sharon Manley, Abigail Bockus, Karen M. Kassel, James P. Luyendyk, Bryan L. Copple and Wen-Xing Ding
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 487-498; DOI: https://doi.org/10.1124/jpet.111.184341
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    Isoform-Selective Activation of Human Constitutive Androstane Receptor by Ginkgo biloba Extract: Functional Analysis of the SV23, SV24, and SV25 Splice Variants
    Aik Jiang Lau, Guixiang Yang and Thomas K. H. Chang
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 704-715; DOI: https://doi.org/10.1124/jpet.111.186130

Chemotherapy, Antibiotics, and Gene Therapy

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    ATP Analog Enhances the Actions of a Heat Shock Protein 90 Inhibitor in Multiple Myeloma Cells
    Fabiola Cervantes-Gomez, Ramadevi Nimmanapalli and Varsha Gandhi
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 545-554; DOI: https://doi.org/10.1124/jpet.111.184903

Drug Discovery and Translational Medicine

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    Anacardic Acid (6-Pentadecylsalicylic Acid) Inhibits Tumor Angiogenesis by Targeting Src/FAK/Rho GTPases Signaling Pathway
    Yuanyuan Wu, Lijun He, Li Zhang, Jing Chen, Zhengfang Yi, Jian Zhang, Mingyao Liu and Xiufeng Pang
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 403-411; DOI: https://doi.org/10.1124/jpet.111.181891
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    Multimodal Biomarker Investigation on Efficacy and Mechanism of Action for the Mammalian Target of Rapamycin Inhibitor, Temsirolimus, in a Preclinical Mammary Carcinoma OncoMouse Model: A Translational Medicine Study in Support for Early Clinical Development
    Xinkang Wang, Yutian Zhan, Lei Zhao, John Alvarez, Inder Chaudhary, Bin-Bing Zhou, Robert T. Abraham and Giora Z. Feuerstein
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 421-429; DOI: https://doi.org/10.1124/jpet.111.185249
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    Mimics of the Dimerization Domain of Hepatocyte Growth Factor Exhibit Anti-Met and Anticancer Activity
    Leen H. Kawas, Brent J. Yamamoto, John W. Wright and Joseph W. Harding
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 509-518; DOI: https://doi.org/10.1124/jpet.111.185694
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    Development of a High-Affinity Inhibitor of the Prostaglandin Transporter
    Yuling Chi, Jaeki Min, Jean-Francois Jasmin, Michael P. Lisanti, Young-Tae Chang and Victor L. Schuster
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 633-641; DOI: https://doi.org/10.1124/jpet.111.181354
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    The Translational Efficacy of a Nonsteroidal Progesterone Receptor Antagonist, 4-[3-Cyclopropyl-1-(mesylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy,-2,6-dimethylbenzonitrile (PF-02413873), on Endometrial Growth in Macaque and Human
    David C. Howe, Natalie M. Mount, Kirsty Bess, Amy Brown, Peter Bungay, Karl R. Gibson, Tony Hawcock, Jacques Richard, Gareth Jones, Rosalind Walley, Alison McLeod, Coralie Apfeldorfer, Simeon Ramsey, Sarah Tweedy and Nick Pullen
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 642-653; DOI: https://doi.org/10.1124/jpet.111.183848

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Characterization of a Novel Potassium-Competitive Acid Blocker of the Gastric H,K-ATPase, 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Monofumarate (TAK-438)
    Jai Moo Shin, Nobuhiro Inatomi, Keith Munson, David Strugatsky, Elmira Tokhtaeva, Olga Vagin and George Sachs
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 412-420; DOI: https://doi.org/10.1124/jpet.111.185314
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    Molecular Mechanisms of Basic Fibroblast Growth Factor Effect on Healing of Ulcerative Colitis in Rats
    Brankica Paunovic, Xiaoming Deng, Tetyana Khomenko, Amrita Ahluwalia, Ganna Tolstanova, Andrzej Tarnawski, Sandor Szabo and Zsuzsanna Sandor
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 430-437; DOI: https://doi.org/10.1124/jpet.111.183665
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    Umami Receptor Activation Increases Duodenal Bicarbonate Secretion via Glucagon-Like Peptide-2 Release in Rats
    Joon-Ho Wang, Takuya Inoue, Masaaki Higashiyama, Paul H. Guth, Eli Engel, Jonathan D. Kaunitz and Yasutada Akiba
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 464-473; DOI: https://doi.org/10.1124/jpet.111.184788
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    RETRACTION: Indole-3-Carbinol Enhances the Resolution of Rat Liver Fibrosis and Stimulates Hepatic Stellate Cell Apoptosis by Blocking the Inhibitor of κB Kinase α/Inhibitor of κB-α/Nuclear Factor-κB Pathway
    Jie Ping, Ai-mei Gao, Hai-quan Qin, Xiao-ning Wei, Jing Bai, Lian Liu, Xiao-hai Li, Rui-wen Li, Ying Ao and Hui Wang
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 694-703; DOI: https://doi.org/10.1124/jpet.111.179820

Inflammation, Immunopharmacology, and Asthma

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    Competitive Enzymatic Interactions Determine the Relative Amounts of Prostaglandins E2 and D2
    Rui Yu, Lei Xiao, Guiqing Zhao, John W. Christman and Richard B. van Breemen
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 716-725; DOI: https://doi.org/10.1124/jpet.111.185405

Metabolism, Transport, and Pharmacogenomics

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    Molecular Analysis and Structure-Activity Relationship Modeling of the Substrate/Inhibitor Interaction Site of Plasma Membrane Monoamine Transporter
    Horace T. B. Ho, Yongmei Pan, Zhiyi Cui, Haichuan Duan, Peter W. Swaan and Joanne Wang
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 376-385; DOI: https://doi.org/10.1124/jpet.111.184036
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    Blood-Brain Barrier (BBB) Pharmacoproteomics: Reconstruction of In Vivo Brain Distribution of 11 P-Glycoprotein Substrates Based on the BBB Transporter Protein Concentration, In Vitro Intrinsic Transport Activity, and Unbound Fraction in Plasma and Brain in Mice
    Yasuo Uchida, Sumio Ohtsuki, Junichi Kamiie and Tetsuya Terasaki
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 579-588; DOI: https://doi.org/10.1124/jpet.111.184200
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    Regulation of Estrogen Sulfotransferase Expression by Confluence of MCF10A Breast Epithelial Cells: Role of the Aryl Hydrocarbon Receptor
    Jiaqi Fu, Hailin Fang, Michelle Paulsen, Mats Ljungman, Thomas A. Kocarek and Melissa Runge-Morris
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 597-606; DOI: https://doi.org/10.1124/jpet.111.185173
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    Isolation of Modulators of the Liver-Specific Organic Anion-Transporting Polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae)
    Megan Roth, Juan J. Araya, Barbara N. Timmermann and Bruno Hagenbuch
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 624-632; DOI: https://doi.org/10.1124/jpet.111.184564
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    Immunochemical Detection of Cytochrome P450 Enzymes in Liver Microsomes of 27 Cynomolgus Monkeys
    Shotaro Uehara, Norie Murayama, Yasuharu Nakanishi, Darryl C. Zeldin, Hiroshi Yamazaki and Yasuhiro Uno
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 654-661; DOI: https://doi.org/10.1124/jpet.111.185009

Neuropharmacology

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    Sex Difference in κ-Opioid Receptor (KOPR)-Mediated Behaviors, Brain Region KOPR Level and KOPR-Mediated Guanosine 5′-O-(3-[35S]Thiotriphosphate) Binding in the Guinea Pig
    Yu-Jun Wang, Khampaseuth Rasakham, Peng Huang, Darina Chudnovskaya, Alan Cowan and Lee-Yuan Liu-Chen
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 438-450; DOI: https://doi.org/10.1124/jpet.111.183905
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    CTEP: A Novel, Potent, Long-Acting, and Orally Bioavailable Metabotropic Glutamate Receptor 5 Inhibitor
    Lothar Lindemann, Georg Jaeschke, Aubin Michalon, Eric Vieira, Michael Honer, Will Spooren, Richard Porter, Thomas Hartung, Sabine Kolczewski, Bernd Büttelmann, Christophe Flament, Catherine Diener, Christophe Fischer, Silvia Gatti, Eric P. Prinssen, Neil Parrott, Gerhard Hoffmann and Joseph G. Wettstein
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 474-486; DOI: https://doi.org/10.1124/jpet.111.185660
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    Characterization of Neuroprotective Effects of Biphalin, an Opioid Receptor Agonist, in a Model of Focal Brain Ischemia
    Li Yang, Kaushik Shah, Hezhen Wang, Vardan T. Karamyan and Thomas J. Abbruscato
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 499-508; DOI: https://doi.org/10.1124/jpet.111.184127
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    Exposure Levels of Anti-LINGO-1 Li81 Antibody in the Central Nervous System and Dose-Efficacy Relationships in Rat Spinal Cord Remyelination Models after Systemic Administration
    R. Blake Pepinsky, Zhaohui Shao, Benxiu Ji, Qin Wang, Gym Meng, Lee Walus, Xinhua Lee, Yinghui Hu, Christilyn Graff, Ellen Garber, Werner Meier and Sha Mi
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 519-529; DOI: https://doi.org/10.1124/jpet.111.183483
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    4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse
    Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 530-536; DOI: https://doi.org/10.1124/jpet.111.184119
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    Antinociceptive and Antihyperalgesic Effects of Tapentadol in Animal Models of Inflammatory Pain
    Klaus Schiene, Jean De Vry and Thomas M. Tzschentke
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 537-544; DOI: https://doi.org/10.1124/jpet.111.181263
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    Pharmacological Characterization of 2-Methyl-N-((2′-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a High-Affinity Antagonist Selective for κ-Opioid Receptors
    S. Grimwood, Y. Lu, A. W. Schmidt, M. A. Vanase-Frawley, A. Sawant-Basak, E. Miller, S. McLean, J. Freeman, S. Wong, J. P. McLaughlin and P. R. Verhoest
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 555-566; DOI: https://doi.org/10.1124/jpet.111.185108
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    Preclinical Pharmacology and Pharmacokinetics of AZD3783, a Selective 5-Hydroxytryptamine 1B Receptor Antagonist
    Minli Zhang, Diansong Zhou, Yi Wang, Donna L. Maier, Daniel V. Widzowski, Cynthia D. Sobotka-Briner, Becky J. Brockel, William M. Potts, Ashok B. Shenvi, Peter R. Bernstein and M. Edward Pierson
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 567-578; DOI: https://doi.org/10.1124/jpet.110.174433
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    Neuroprotection with a Brain-Penetrating Biologic Tumor Necrosis Factor Inhibitor
    Qing-Hui Zhou, Rachita Sumbria, Eric Ka-Wai Hui, Jeff Zhiqiang Lu, Ruben J. Boado and William M. Pardridge
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 618-623; DOI: https://doi.org/10.1124/jpet.111.185876

Toxicology

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    Effects of Chlorpyrifos and Chlorpyrifos-Oxon on the Dynamics and Movement of Mitochondria in Rat Cortical Neurons
    Mary-Louise Middlemore-Risher, Bao-Ling Adam, Nevin A. Lambert and Alvin V. Terry
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 341-349; DOI: https://doi.org/10.1124/jpet.111.184762
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    Perinatal Exposure to Δ9-Tetrahydrocannabinol Triggers Profound Defects in T Cell Differentiation and Function in Fetal and Postnatal Stages of Life, Including Decreased Responsiveness to HIV Antigens
    Catherine Lombard, Venkatesh L. Hegde, Mitzi Nagarkatti and Prakash S. Nagarkatti
    Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 607-617; DOI: https://doi.org/10.1124/jpet.111.181206
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Journal of Pharmacology and Experimental Therapeutics: 339 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 339, Issue 2
1 Nov 2011
  • Table of Contents
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  • Highlighted Papers
  • 2011 Torald Sollmann Award Lecture
  • Behavioral Pharmacology
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  • Chemotherapy, Antibiotics, and Gene Therapy
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  • Gastrointestinal, Hepatic, Pulmonary, and Renal
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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