Journal of Pharmacology and Experimental Therapeutics: 339 (2)

November 01, 2011; Volume 339,Issue 2

Highlighted Papers

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Regulation of Fatty Acid-Induced Lipotoxicity by Autophagy and Apoptosis
Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 323;
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Combined σ Receptor Antagonism and Dopamine Transporter Inhibition Regulate Cocaine Self-Administration
Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 323;
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Mephedrone: New Designer Stimulant and Potential for Abuse
Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 323;
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c-Met Hinge-Region Mimics as Potential Anticancer Agents
Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 323;

2011 Torald Sollmann Award Lecture

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Drug Discontinuation Effects Are Part of the Pharmacology of a Drug
Marcus M. Reidenberg

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 324-328; DOI: https://doi.org/10.1124/jpet.111.183285

Behavioral Pharmacology

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Decreases in Cocaine Self-Administration with Dual Inhibition of the Dopamine Transporter and σ Receptors
Takato Hiranita, Paul L. Soto, Stephen J. Kohut, Theresa Kopajtic, Jianjing Cao, Amy H. Newman, Gianluigi Tanda and Jonathan L. Katz

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 662-677; DOI: https://doi.org/10.1124/jpet.111.185025
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Effects of Varenicline on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rhesus Monkeys
Robert W. Gould, Paul W. Czoty, Susan H. Nader and Michael A. Nader

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 678-686; DOI: https://doi.org/10.1124/jpet.111.185538
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Differential Effects of Nociceptin/Orphanin FQ (NOP) Receptor Agonists in Acute versus Chronic Pain: Studies with Bifunctional NOP/μ Receptor Agonists in the Sciatic Nerve Ligation Chronic Pain Model in Mice
Taline V. Khroyan, Willma E. Polgar, Juan Orduna, Jose Montenegro, Faming Jiang, Nurulain T. Zaveri and Lawrence Toll

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 687-693; DOI: https://doi.org/10.1124/jpet.111.184663

Cardiovascular

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Amelioration of Doxorubicin-Induced Cardiotoxicity by an Anticancer-Antioxidant Dual-Function Compound, HO-3867
Alex Dayton, Karuppaiyah Selvendiran, Sarath Meduru, Mahmood Khan, M. Lakshmi Kuppusamy, Shan Naidu, Tamás Kálai, Kálmán Hideg and Periannan Kuppusamy

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 350-357; DOI: https://doi.org/10.1124/jpet.111.183681
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Beneficial Effects of Combination of Valsartan and Amlodipine on Salt-Induced Brain Injury in Hypertensive Rats
Yi-Fei Dong, Keiichiro Kataoka, Yoshiko Tokutomi, Hisato Nako, Taishi Nakamura, Kensuke Toyama, Daisuke Sueta, Nobutaka Koibuchi, Eiichiro Yamamoto, Hisao Ogawa and Shokei Kim-Mitsuyama

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 358-366; DOI: https://doi.org/10.1124/jpet.111.182576
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Role of Neuronal Nitric-Oxide Synthase in Estrogen-Induced Relaxation in Rat Resistance Arteries
Olga Lekontseva, Subhadeep Chakrabarti, Yanyan Jiang, Christopher C. Cheung and Sandra T. Davidge

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 367-375; DOI: https://doi.org/10.1124/jpet.111.183798
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The Soluble Guanylate Cyclase Stimulator BAY 41-2272 Inhibits Vascular Smooth Muscle Growth through the cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase Pathways
Chintamani N. Joshi, Danielle N. Martin, Jonathan C. Fox, Natalia N. Mendelev, Trisha A. Brown and David A. Tulis

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 394-402; DOI: https://doi.org/10.1124/jpet.111.183400
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Dissecting the Activation of Thienopyridines by Cytochromes P450 Using a Pharmacodynamic Assay In Vitro
Lynn M. Abell and Eddie C.-K. Liu

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 589-596; DOI: https://doi.org/10.1124/jpet.111.184895
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Hydrogen Sulfide Regulates Na⁺/H⁺ Exchanger Activity via Stimulation of Phosphoinositide 3-Kinase/Akt and Protein Kinase G Pathways
Li-Fang Hu, Yu Li, Kay Li Neo, Qian Chen Yong, Shiau Wei Lee, Benny Kwong Huat Tan and Jin-Song Bian

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 726-735; DOI: https://doi.org/10.1124/jpet.111.184754

Cellular and Molecular

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Bromoenol Lactone Inhibits Voltage-Gated Ca²⁺ and Transient Receptor Potential Canonical Channels
Saikat Chakraborty, Zachary C. Berwick, Paula J. Bartlett, Sanjay Kumar, Andrew P. Thomas, Michael Sturek, Johnathan D. Tune and Alexander G. Obukhov

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 329-340; DOI: https://doi.org/10.1124/jpet.111.183673
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Activated G Protein α_s Subunits Increase the Ethanol Sensitivity of Human Glycine Receptors
Gonzalo E. Yévenes, Gustavo Moraga-Cid, Ximena Romo and Luis G. Aguayo

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 386-393; DOI: https://doi.org/10.1124/jpet.111.184408
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Epoxyeicosatrienoic Acids Attenuate Reactive Oxygen Species Level, Mitochondrial Dysfunction, Caspase Activation, and Apoptosis in Carcinoma Cells Treated with Arsenic Trioxide
Liu Liu, Chen Chen, Wei Gong, Yuanjing Li, Matthew L. Edin, Darryl C. Zeldin and Dao Wen Wang

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 451-463; DOI: https://doi.org/10.1124/jpet.111.180505
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Differential Roles of Unsaturated and Saturated Fatty Acids on Autophagy and Apoptosis in Hepatocytes
Shuang Mei, Hong-Min Ni, Sharon Manley, Abigail Bockus, Karen M. Kassel, James P. Luyendyk, Bryan L. Copple and Wen-Xing Ding

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 487-498; DOI: https://doi.org/10.1124/jpet.111.184341
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Isoform-Selective Activation of Human Constitutive Androstane Receptor by Ginkgo biloba Extract: Functional Analysis of the SV23, SV24, and SV25 Splice Variants
Aik Jiang Lau, Guixiang Yang and Thomas K. H. Chang

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 704-715; DOI: https://doi.org/10.1124/jpet.111.186130

Chemotherapy, Antibiotics, and Gene Therapy

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ATP Analog Enhances the Actions of a Heat Shock Protein 90 Inhibitor in Multiple Myeloma Cells
Fabiola Cervantes-Gomez, Ramadevi Nimmanapalli and Varsha Gandhi

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 545-554; DOI: https://doi.org/10.1124/jpet.111.184903

Drug Discovery and Translational Medicine

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Anacardic Acid (6-Pentadecylsalicylic Acid) Inhibits Tumor Angiogenesis by Targeting Src/FAK/Rho GTPases Signaling Pathway
Yuanyuan Wu, Lijun He, Li Zhang, Jing Chen, Zhengfang Yi, Jian Zhang, Mingyao Liu and Xiufeng Pang

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 403-411; DOI: https://doi.org/10.1124/jpet.111.181891
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Multimodal Biomarker Investigation on Efficacy and Mechanism of Action for the Mammalian Target of Rapamycin Inhibitor, Temsirolimus, in a Preclinical Mammary Carcinoma OncoMouse Model: A Translational Medicine Study in Support for Early Clinical Development
Xinkang Wang, Yutian Zhan, Lei Zhao, John Alvarez, Inder Chaudhary, Bin-Bing Zhou, Robert T. Abraham and Giora Z. Feuerstein

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 421-429; DOI: https://doi.org/10.1124/jpet.111.185249
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Mimics of the Dimerization Domain of Hepatocyte Growth Factor Exhibit Anti-Met and Anticancer Activity
Leen H. Kawas, Brent J. Yamamoto, John W. Wright and Joseph W. Harding

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 509-518; DOI: https://doi.org/10.1124/jpet.111.185694
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Development of a High-Affinity Inhibitor of the Prostaglandin Transporter
Yuling Chi, Jaeki Min, Jean-Francois Jasmin, Michael P. Lisanti, Young-Tae Chang and Victor L. Schuster

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 633-641; DOI: https://doi.org/10.1124/jpet.111.181354
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The Translational Efficacy of a Nonsteroidal Progesterone Receptor Antagonist, 4-[3-Cyclopropyl-1-(mesylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy,-2,6-dimethylbenzonitrile (PF-02413873), on Endometrial Growth in Macaque and Human
David C. Howe, Natalie M. Mount, Kirsty Bess, Amy Brown, Peter Bungay, Karl R. Gibson, Tony Hawcock, Jacques Richard, Gareth Jones, Rosalind Walley, Alison McLeod, Coralie Apfeldorfer, Simeon Ramsey, Sarah Tweedy and Nick Pullen

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 642-653; DOI: https://doi.org/10.1124/jpet.111.183848

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Characterization of a Novel Potassium-Competitive Acid Blocker of the Gastric H,K-ATPase, 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Monofumarate (TAK-438)
Jai Moo Shin, Nobuhiro Inatomi, Keith Munson, David Strugatsky, Elmira Tokhtaeva, Olga Vagin and George Sachs

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 412-420; DOI: https://doi.org/10.1124/jpet.111.185314
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Molecular Mechanisms of Basic Fibroblast Growth Factor Effect on Healing of Ulcerative Colitis in Rats
Brankica Paunovic, Xiaoming Deng, Tetyana Khomenko, Amrita Ahluwalia, Ganna Tolstanova, Andrzej Tarnawski, Sandor Szabo and Zsuzsanna Sandor

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 430-437; DOI: https://doi.org/10.1124/jpet.111.183665
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Umami Receptor Activation Increases Duodenal Bicarbonate Secretion via Glucagon-Like Peptide-2 Release in Rats
Joon-Ho Wang, Takuya Inoue, Masaaki Higashiyama, Paul H. Guth, Eli Engel, Jonathan D. Kaunitz and Yasutada Akiba

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 464-473; DOI: https://doi.org/10.1124/jpet.111.184788
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RETRACTION: Indole-3-Carbinol Enhances the Resolution of Rat Liver Fibrosis and Stimulates Hepatic Stellate Cell Apoptosis by Blocking the Inhibitor of κB Kinase α/Inhibitor of κB-α/Nuclear Factor-κB Pathway
Jie Ping, Ai-mei Gao, Hai-quan Qin, Xiao-ning Wei, Jing Bai, Lian Liu, Xiao-hai Li, Rui-wen Li, Ying Ao and Hui Wang

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 694-703; DOI: https://doi.org/10.1124/jpet.111.179820

Inflammation, Immunopharmacology, and Asthma

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Competitive Enzymatic Interactions Determine the Relative Amounts of Prostaglandins E₂ and D₂
Rui Yu, Lei Xiao, Guiqing Zhao, John W. Christman and Richard B. van Breemen

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 716-725; DOI: https://doi.org/10.1124/jpet.111.185405

Metabolism, Transport, and Pharmacogenomics

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Molecular Analysis and Structure-Activity Relationship Modeling of the Substrate/Inhibitor Interaction Site of Plasma Membrane Monoamine Transporter
Horace T. B. Ho, Yongmei Pan, Zhiyi Cui, Haichuan Duan, Peter W. Swaan and Joanne Wang

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 376-385; DOI: https://doi.org/10.1124/jpet.111.184036
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Blood-Brain Barrier (BBB) Pharmacoproteomics: Reconstruction of In Vivo Brain Distribution of 11 P-Glycoprotein Substrates Based on the BBB Transporter Protein Concentration, In Vitro Intrinsic Transport Activity, and Unbound Fraction in Plasma and Brain in Mice
Yasuo Uchida, Sumio Ohtsuki, Junichi Kamiie and Tetsuya Terasaki

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 579-588; DOI: https://doi.org/10.1124/jpet.111.184200
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Regulation of Estrogen Sulfotransferase Expression by Confluence of MCF10A Breast Epithelial Cells: Role of the Aryl Hydrocarbon Receptor
Jiaqi Fu, Hailin Fang, Michelle Paulsen, Mats Ljungman, Thomas A. Kocarek and Melissa Runge-Morris

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 597-606; DOI: https://doi.org/10.1124/jpet.111.185173
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Isolation of Modulators of the Liver-Specific Organic Anion-Transporting Polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae)
Megan Roth, Juan J. Araya, Barbara N. Timmermann and Bruno Hagenbuch

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 624-632; DOI: https://doi.org/10.1124/jpet.111.184564
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Immunochemical Detection of Cytochrome P450 Enzymes in Liver Microsomes of 27 Cynomolgus Monkeys
Shotaro Uehara, Norie Murayama, Yasuharu Nakanishi, Darryl C. Zeldin, Hiroshi Yamazaki and Yasuhiro Uno

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 654-661; DOI: https://doi.org/10.1124/jpet.111.185009

Neuropharmacology

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Sex Difference in κ-Opioid Receptor (KOPR)-Mediated Behaviors, Brain Region KOPR Level and KOPR-Mediated Guanosine 5′-O-(3-[³⁵S]Thiotriphosphate) Binding in the Guinea Pig
Yu-Jun Wang, Khampaseuth Rasakham, Peng Huang, Darina Chudnovskaya, Alan Cowan and Lee-Yuan Liu-Chen

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 438-450; DOI: https://doi.org/10.1124/jpet.111.183905
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CTEP: A Novel, Potent, Long-Acting, and Orally Bioavailable Metabotropic Glutamate Receptor 5 Inhibitor
Lothar Lindemann, Georg Jaeschke, Aubin Michalon, Eric Vieira, Michael Honer, Will Spooren, Richard Porter, Thomas Hartung, Sabine Kolczewski, Bernd Büttelmann, Christophe Flament, Catherine Diener, Christophe Fischer, Silvia Gatti, Eric P. Prinssen, Neil Parrott, Gerhard Hoffmann and Joseph G. Wettstein

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 474-486; DOI: https://doi.org/10.1124/jpet.111.185660
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Characterization of Neuroprotective Effects of Biphalin, an Opioid Receptor Agonist, in a Model of Focal Brain Ischemia
Li Yang, Kaushik Shah, Hezhen Wang, Vardan T. Karamyan and Thomas J. Abbruscato

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 499-508; DOI: https://doi.org/10.1124/jpet.111.184127
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Exposure Levels of Anti-LINGO-1 Li81 Antibody in the Central Nervous System and Dose-Efficacy Relationships in Rat Spinal Cord Remyelination Models after Systemic Administration
R. Blake Pepinsky, Zhaohui Shao, Benxiu Ji, Qin Wang, Gym Meng, Lee Walus, Xinhua Lee, Yinghui Hu, Christilyn Graff, Ellen Garber, Werner Meier and Sha Mi

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 519-529; DOI: https://doi.org/10.1124/jpet.111.183483
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4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse
Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 530-536; DOI: https://doi.org/10.1124/jpet.111.184119
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Antinociceptive and Antihyperalgesic Effects of Tapentadol in Animal Models of Inflammatory Pain
Klaus Schiene, Jean De Vry and Thomas M. Tzschentke

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 537-544; DOI: https://doi.org/10.1124/jpet.111.181263
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Pharmacological Characterization of 2-Methyl-N-((2′-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a High-Affinity Antagonist Selective for κ-Opioid Receptors
S. Grimwood, Y. Lu, A. W. Schmidt, M. A. Vanase-Frawley, A. Sawant-Basak, E. Miller, S. McLean, J. Freeman, S. Wong, J. P. McLaughlin and P. R. Verhoest

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 555-566; DOI: https://doi.org/10.1124/jpet.111.185108
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Preclinical Pharmacology and Pharmacokinetics of AZD3783, a Selective 5-Hydroxytryptamine 1B Receptor Antagonist
Minli Zhang, Diansong Zhou, Yi Wang, Donna L. Maier, Daniel V. Widzowski, Cynthia D. Sobotka-Briner, Becky J. Brockel, William M. Potts, Ashok B. Shenvi, Peter R. Bernstein and M. Edward Pierson

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 567-578; DOI: https://doi.org/10.1124/jpet.110.174433
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Neuroprotection with a Brain-Penetrating Biologic Tumor Necrosis Factor Inhibitor
Qing-Hui Zhou, Rachita Sumbria, Eric Ka-Wai Hui, Jeff Zhiqiang Lu, Ruben J. Boado and William M. Pardridge

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 618-623; DOI: https://doi.org/10.1124/jpet.111.185876

Toxicology

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Effects of Chlorpyrifos and Chlorpyrifos-Oxon on the Dynamics and Movement of Mitochondria in Rat Cortical Neurons
Mary-Louise Middlemore-Risher, Bao-Ling Adam, Nevin A. Lambert and Alvin V. Terry

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 341-349; DOI: https://doi.org/10.1124/jpet.111.184762
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Perinatal Exposure to Δ⁹-Tetrahydrocannabinol Triggers Profound Defects in T Cell Differentiation and Function in Fetal and Postnatal Stages of Life, Including Decreased Responsiveness to HIV Antigens
Catherine Lombard, Venkatesh L. Hegde, Mitzi Nagarkatti and Prakash S. Nagarkatti

Journal of Pharmacology and Experimental Therapeutics November 2011, 339 (2) 607-617; DOI: https://doi.org/10.1124/jpet.111.181206

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Table of Contents

Highlighted Papers

2011 Torald Sollmann Award Lecture

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

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