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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

October 01, 2011; Volume 339,Issue 1

Highlighted Papers

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    Hemeoxygenase Regulation of Hypertension in Spontaneous Hypertensive Rats
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 1;
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    Activation of GPR40/FFA1 Improves Hyperglycemia in Type 2 Diabetes
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 1;
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    Pharmacological Properties Modulated by Tissue Integrity and Tissue Type
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 1;
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    Selectively Targeting HDACs in Monocytes and Macrophages
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 1;

Perspectives in Pharmacology

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    Anatomically Selective Serotonergic Type 1A and Serotonergic Type 2A Therapies for Parkinson's Disease: An Approach to Reducing Dyskinesia without Exacerbating Parkinsonism?
    Philippe Huot, Susan H. Fox, Adrian Newman-Tancredi and Jonathan M. Brotchie
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 2-8; DOI: https://doi.org/10.1124/jpet.111.184093

Behavioral Pharmacology

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    Facilitation of Hippocampal Synaptogenesis and Spatial Memory by C-Terminal Truncated Nle1-Angiotensin IV Analogs
    Caroline C. Benoist, John W. Wright, Mingyan Zhu, Suzanne M. Appleyard, Gary A. Wayman and Joseph W. Harding
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 35-44; DOI: https://doi.org/10.1124/jpet.111.182220
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    Blockade of Endocannabinoid Hydrolytic Enzymes Attenuates Precipitated Opioid Withdrawal Symptoms in Mice
    Divya Ramesh, Gracious R. Ross, Joel E. Schlosburg, Robert A. Owens, Rehab A. Abdullah, Steven G. Kinsey, Jonathan Z. Long, Daniel K. Nomura, Laura J. Sim-Selley, Benjamin F. Cravatt, Hamid I. Akbarali and Aron H. Lichtman
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 173-185; DOI: https://doi.org/10.1124/jpet.111.181370
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    Patterns of Nicotinic Receptor Antagonism: Nicotine Discrimination Studies
    Emily M. Jutkiewicz, Emily A. Brooks, Adam D. Kynaston, Kenner C. Rice and James H. Woods
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 194-202; DOI: https://doi.org/10.1124/jpet.111.182170

Cardiovascular

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    A Clopidogrel-Insensitive Inducible Pool of P2Y12 Receptors Contributes to Thrombus Formation: Inhibition by Elinogrel, a Direct-Acting, Reversible P2Y12 Antagonist
    Helena Haberstock-Debic, Patrick Andre, Scott Mills, David R. Phillips and Pamela B. Conley
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 54-61; DOI: https://doi.org/10.1124/jpet.111.184143
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    Chymase Inhibition Reduces Infarction and Matrix Metalloproteinase-9 Activation and Attenuates Inflammation and Fibrosis after Acute Myocardial Ischemia/Reperfusion
    Shizu Oyamada, Cesario Bianchi, Shinji Takai, Louis M. Chu and Frank W. Sellke
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 143-151; DOI: https://doi.org/10.1124/jpet.111.179697
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    Glucocorticoids Improve Renal Responsiveness to Atrial Natriuretic Peptide by Up-Regulating Natriuretic Peptide Receptor-A Expression in the Renal Inner Medullary Collecting Duct in Decompensated Heart Failure
    Chao Liu, Ying Chen, Yunxiao Kang, Zhihua Ni, Heming Xiu, Jing Guan and Kunshen Liu
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 203-209; DOI: https://doi.org/10.1124/jpet.111.184796
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    Enhanced Hemeoxygenase Activity in the Rostral Ventrolateral Medulla Mediates Exaggerated Hemin-Evoked Hypotension in the Spontaneously Hypertensive Rat
    Noha N. Nassar, Guichu Li, Aurel L. Strat and Abdel A. Abdel-Rahman
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 267-274; DOI: https://doi.org/10.1124/jpet.111.183368
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    Inhibition of Smooth Muscle Myosin as a Novel Therapeutic Target for Hypertension
    Xin Zhao, David Ho, Patricio Abarzúa, Sunil K. Dhar, Xi Wang, Zhiheng Jia, Malar Pannirselvam, David J. Morgans, Fady I. Malik and Stephen F. Vatner
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 307-312; DOI: https://doi.org/10.1124/jpet.111.182402

Cellular and Molecular

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    Role of Vimentin in the Inhibitory Effects of Low-Molecular-Weight Heparin on PC-3M Cell Adhesion to, and Migration through, Endothelium
    Yan Pan, Tianluo Lei, Bao Teng, Jihong Liu, Jianzhao Zhang, Yu An, Yuan Xiao, Jing Han, Xueyang Pan, Junhua Wang, Heming Yu, Hong Ren and Xuejun Li
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 82-92; DOI: https://doi.org/10.1124/jpet.111.182055
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    Influence of Tissue Integrity on Pharmacological Phenotypes of Muscarinic Acetylcholine Receptors in the Rat Cerebral Cortex
    Abu Syed Md Anisuzzaman, Atsushi Nishimune, Hatsumi Yoshiki, Junsuke Uwada and Ikunobu Muramatsu
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 186-193; DOI: https://doi.org/10.1124/jpet.111.182857
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    Caffeic Acid 3,4-Dihydroxy-Phenethyl Ester Induces Cancer Cell Senescence by Suppressing Twist Expression
    Anliang Dong, Yuanzhang Fang, Li Zhang, Juan Xie, Xian Wu, Lipeng Zhang, Xiaoyuan Lian, Yihua Chen, Jian Luo and Mingyao Liu
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 238-247; DOI: https://doi.org/10.1124/jpet.111.181081
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    Nonsteroidal Anti-Inflammatory Drug Flufenamic Acid Is a Potent Activator of AMP-Activated Protein Kinase
    Yuan Chi, Kai Li, Qiaojing Yan, Schuichi Koizumi, Liye Shi, Shuhei Takahashi, Ying Zhu, Hiroyuki Matsue, Masayuki Takeda, Masanori Kitamura and Jian Yao
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 257-266; DOI: https://doi.org/10.1124/jpet.111.183020

Drug Discovery and Translational Medicine

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    Regulation of Ingestive Behaviors in the Rat by GSK1521498, a Novel μ-Opioid Receptor-Selective Inverse Agonist
    Diane M. Ignar, Aaron S. Goetz, Kimberly Nichols Noble, Luz Helena Carballo, Andrea E. Stroup, Julie C. Fisher, Joyce A. Boucheron, Tracy A. Brainard, Andrew L. Larkin, Andrea H. Epperly, Todd W. Shearer, Scott D. Sorensen, Jason D. Speake and Jonathan D. Hommel
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 24-34; DOI: https://doi.org/10.1124/jpet.111.180943
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    Pharmacologic Inhibition of Ghrelin Receptor Signaling Is Insulin Sparing and Promotes Insulin Sensitivity
    Kenneth A. Longo, Elizabeth K. Govek, Anna Nolan, Thomas McDonagh, Soratree Charoenthongtrakul, Derek J. Giuliana, Kristen Morgan, Jeffrey Hixon, Chaoseng Zhou, Bruce Kelder, John J. Kopchick, Jeffrey O. Saunders, Manuel A. Navia, Rory Curtis, Peter S. DiStefano and Brad J. Geddes
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 115-124; DOI: https://doi.org/10.1124/jpet.111.183764
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    Drug Targeting to Monocytes and Macrophages Using Esterase-Sensitive Chemical Motifs
    Lindsey A. Needham, Alan H. Davidson, Lindsay J. Bawden, Andrew Belfield, Elisabeth A. Bone, Deborah H. Brotherton, Sam Bryant, Michael H. Charlton, Vanessa L. Clark, Stephen J. Davies, Alastair Donald, Francesca A. Day, David Krige, Valérie Legris, Joanne McDermott, Yvonne McGovern, Jo Owen, Sanjay R. Patel, Stéphane Pintat, Richard J. Testar, Graham M. A. Wells, David Moffat and Alan H. Drummond
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 132-142; DOI: https://doi.org/10.1124/jpet.111.183640
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    Novel N-1,2-Dihydroxypropyl Analogs of Lobelane Inhibit Vesicular Monoamine Transporter-2 Function and Methamphetamine-Evoked Dopamine Release
    David B. Horton, Kiran B. Siripurapu, Guangrong Zheng, Peter A. Crooks and Linda P. Dwoskin
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 286-297; DOI: https://doi.org/10.1124/jpet.111.184770
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    AZD9668: Pharmacological Characterization of a Novel Oral Inhibitor of Neutrophil Elastase
    T. Stevens, K. Ekholm, M. Gränse, M. Lindahl, V. Kozma, C. Jungar, T. Ottosson, H. Falk-Håkansson, A. Churg, J. L. Wright, H. Lal and A. Sanfridson
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 313-320; DOI: https://doi.org/10.1124/jpet.111.182139

Endocrine and Diabetes

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    TAK-875, an Orally Available G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist, Enhances Glucose-Dependent Insulin Secretion and Improves Both Postprandial and Fasting Hyperglycemia in Type 2 Diabetic Rats
    Yoshiyuki Tsujihata, Ryo Ito, Masami Suzuki, Ayako Harada, Nobuyuki Negoro, Tsuneo Yasuma, Yu Momose and Koji Takeuchi
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 228-237; DOI: https://doi.org/10.1124/jpet.111.183772

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Glycyrrhizin Prevents Liver Injury by Inhibition of High-Mobility Group Box 1 Production by Kupffer Cells after Ischemia-Reperfusion in Rats
    Masahito Ogiku, Hiroshi Kono, Michio Hara, Masato Tsuchiya and Hideki Fujii
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 93-98; DOI: https://doi.org/10.1124/jpet.111.182592
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    Omeprazole Attenuates Hyperoxic Lung Injury in Mice via Aryl Hydrocarbon Receptor Activation and Is Associated with Increased Expression of Cytochrome P4501A Enzymes
    Binoy Shivanna, Weiwu Jiang, Lihua Wang, Xanthi I. Couroucli and Bhagavatula Moorthy
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 106-114; DOI: https://doi.org/10.1124/jpet.111.182980
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    Signaling in H2O2-Induced Increase in Cell Proliferation in Barrett's Esophageal Adenocarcinoma Cells
    Xiaoxu Zhou, Dan Li, Murray B. Resnick, Jose Behar, Jack Wands and Weibiao Cao
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 218-227; DOI: https://doi.org/10.1124/jpet.111.182352
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    Thromboxane Prostanoid Receptor Activation Amplifies Airway Stretch-Activated Contractions Assessed in Perfused Intact Bovine Bronchial Segments
    Jeremy Mark Hernandez and Luke Jeffrey Janssen
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 248-256; DOI: https://doi.org/10.1124/jpet.111.182246
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    Copper Deficiency Exacerbates Bile Duct Ligation-Induced Liver Injury and Fibrosis in Rats
    Ming Song, Zhanxiang Zhou, Theresa Chen, Jingwen Zhang and Craig J. McClain
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 298-306; DOI: https://doi.org/10.1124/jpet.111.184325

Inflammation, Immunopharmacology, and Asthma

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    Inhibition of Neutrophil Apoptosis via Sphingolipid Signaling in Acute Lung Injury
    Wei-Chieh Lin, Chiou-Feng Lin, Chia-Ling Chen, Chang-Wen Chen and Yee-Shin Lin
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 45-53; DOI: https://doi.org/10.1124/jpet.111.181560
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    Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro
    Hyun-A Oh, Hyung-Min Kim and Hyun-Ja Jeong
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 72-81; DOI: https://doi.org/10.1124/jpet.111.184275

Metabolism, Transport, and Pharmacogenomics

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    Genetic Variants in Cytosolic 5′-Nucleotidase II Are Associated with Its Expression and Cytarabine Sensitivity in HapMap Cell Lines and in Patients with Acute Myeloid Leukemia
    Amit K. Mitra, Kristine R. Crews, Stanley Pounds, Xueyuan Cao, Tanya Feldberg, Yogita Ghodke, Varsha Gandhi, William Plunkett, M. Eileen Dolan, Christine Hartford, Susana Raimondi, Dario Campana, James Downing, Jeffrey E. Rubnitz, Raul C. Ribeiro and Jatinder K. Lamba
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 9-23; DOI: https://doi.org/10.1124/jpet.111.182873

Neuropharmacology

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    Antagonist Functional Selectivity: 5-HT2A Serotonin Receptor Antagonists Differentially Regulate 5-HT2A Receptor Protein Level In Vivo
    Prem N. Yadav, Wesley K. Kroeze, Martilias S. Farrell and Bryan L. Roth
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 99-105; DOI: https://doi.org/10.1124/jpet.111.183780
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    Varenicline Is a Potent Agonist of the Human 5-Hydroxytryptamine3 Receptor
    S. C. R. Lummis, A. J. Thompson, M. Bencherif and H. A. Lester
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 125-131; DOI: https://doi.org/10.1124/jpet.111.185306
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    Afobazole Modulates Neuronal Response to Ischemia and Acidosis via Activation of σ-1 Receptors
    Javier Cuevas, Adam Behensky, Wei Deng and Christopher Katnik
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 152-160; DOI: https://doi.org/10.1124/jpet.111.182774
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    Afobazole Modulates Microglial Function via Activation of Both σ-1 and σ-2 Receptors
    Javier Cuevas, Alex Rodriguez, Adam Behensky and Chris Katnik
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 161-172; DOI: https://doi.org/10.1124/jpet.111.182816
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    Patterns of Brain Glucose Metabolism Induced by Phosphodiesterase 10A Inhibitors in the Mouse: A Potential Translational Biomarker
    Stefanie Dedeurwaerdere, Cindy Wintmolders, Greet Vanhoof and Xavier Langlois
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 210-217; DOI: https://doi.org/10.1124/jpet.111.182766
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    Serotonin Transporter Occupancy in Rats Exposed to Serotonin Reuptake Inhibitors In Utero or via Breast Milk
    Catherine F. Capello, Chase H. Bourke, James C. Ritchie, Zachary N. Stowe, D. Jeffrey Newport, Amanda Nemeroff and Michael J. Owens
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 275-285; DOI: https://doi.org/10.1124/jpet.111.183855

Toxicology

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    Generation and Characterization of a Cyp2f2-Null Mouse and Studies on the Role of CYP2F2 in Naphthalene-Induced Toxicity in the Lung and Nasal Olfactory Mucosa
    Lei Li, Yuan Wei, Laura Van Winkle, Qing-Yu Zhang, Xin Zhou, Jinping Hu, Fang Xie, Kerri Kluetzman and Xinxin Ding
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 62-71; DOI: https://doi.org/10.1124/jpet.111.184671

Erratum

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    Correction to “Novel Peptide Antagonists of Adrenomedullin and Calcitonin Gene-Related Peptide Receptors: Identification, Pharmacological Characterization, and Interactions with Position 74 in Receptor Activity-Modifying Protein 1/3”
    Journal of Pharmacology and Experimental Therapeutics October 2011, 339 (1) 321;
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Journal of Pharmacology and Experimental Therapeutics: 339 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 339, Issue 1
1 Oct 2011
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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