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Research ArticleMetabolism, Transport, and Pharmacogenomics

Polymorphic Variants of Cytochrome P450 2B6 (CYP2B6.4–CYP2B6.9) Exhibit Altered Rates of Metabolism for Bupropion and Efavirenz: A Charge-Reversal Mutation in the K139E Variant (CYP2B6.8) Impairs Formation of a Functional Cytochrome P450-Reductase Complex

Haoming Zhang, Chitra Sridar, Cesar Kenaan, Hemali Amunugama, David P. Ballou and Paul F. Hollenberg
Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 803-809; DOI: https://doi.org/10.1124/jpet.111.183111

Article Information

vol. 338 no. 3 803-809
DOI 
https://doi.org/10.1124/jpet.111.183111
PubMed 
21659470
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 19, 2011
  • Accepted June 8, 2011
  • Published online August 22, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Haoming Zhang,
  2. Chitra Sridar,
  3. Cesar Kenaan,
  4. Hemali Amunugama,
  5. David P. Ballou and
  6. Paul F. Hollenberg
  1. Departments of Pharmacology (H.Z., C.S., C.K., H.A., P.F.H.) and Biological Chemistry (D.P.B.), University of Michigan, Ann Arbor, Michigan
  1. Address correspondence to:
    Dr. Paul F. Hollenberg, Department of Pharmacology, University of Michigan, 1150 West Medical Center Drive, 2301 MSRB III, Ann Arbor, MI 48109-5632. E-mail: phollen{at}umich.edu.
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Research ArticleMetabolism, Transport, and Pharmacogenomics

Polymorphic Variants of Cytochrome P450 2B6 (CYP2B6.4–CYP2B6.9) Exhibit Altered Rates of Metabolism for Bupropion and Efavirenz: A Charge-Reversal Mutation in the K139E Variant (CYP2B6.8) Impairs Formation of a Functional Cytochrome P450-Reductase Complex

Haoming Zhang, Chitra Sridar, Cesar Kenaan, Hemali Amunugama, David P. Ballou and Paul F. Hollenberg
Journal of Pharmacology and Experimental Therapeutics September 1, 2011, 338 (3) 803-809; DOI: https://doi.org/10.1124/jpet.111.183111
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