Journal of Pharmacology and Experimental Therapeutics: 338 (3)

September 01, 2011; Volume 338,Issue 3

Highlighted Papers

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Simultaneous Targeting of Both Thymidine Kinase and Thymidylate Synthase
Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 731;
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Role of Oxidative Stress in the Action of Anticancer Agents—Phospho-Nonsteroidal Anti-Inflammatory Drugs
Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 731;
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Nonsteroidal Anti-Inflammatory Drug Gastric Lesions Enhanced by Selective Serotonin-Reuptake Inhibitor
Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 731;
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SIRT1 Activation (Resveratrol) and Treatment of Duchenne Muscular Dystrophy
Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 731;

Behavioral Pharmacology

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Lorcaserin, a 5-HT_2C Agonist, Decreases Nicotine Self-Administration in Female Rats
Edward D. Levin, Joshua E. Johnson, Susan Slade, Corinne Wells, Marty Cauley, Ann Petro and Jed E. Rose

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 890-896; DOI: https://doi.org/10.1124/jpet.111.183525
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Nicotine Reduces l-DOPA-Induced Dyskinesias by Acting at β2* Nicotinic Receptors
Luping Z. Huang, Sharon R. Grady and Maryka Quik

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 932-941; DOI: https://doi.org/10.1124/jpet.111.182949

Cardiovascular

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Role of Calcium-Activated Potassium Channels in the Genesis of 3,4-Diaminopyridine-Induced Periodic Contractions in Isolated Canine Coronary Artery Smooth Muscles
Yasumi Uchida, Yuko Maezawa, Yoshiro Maezawa, Yasuto Uchida and Fumitaka Nakamura

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 974-983; DOI: https://doi.org/10.1124/jpet.111.180687

Cellular and Molecular

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Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy
Yusuke S. Hori, Atsushi Kuno, Ryusuke Hosoda, Masaya Tanno, Tetsuji Miura, Kazuaki Shimamoto and Yoshiyuki Horio

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 784-794; DOI: https://doi.org/10.1124/jpet.111.183210
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Reciprocal Potentiation of the Antitumoral Activities of FK866, an Inhibitor of Nicotinamide Phosphoribosyltransferase, and Etoposide or Cisplatin in Neuroblastoma Cells
Cristina Travelli, Valentina Drago, Elena Maldi, Nina Kaludercic, Ubaldina Galli, Renzo Boldorini, Fabio Di Lisa, Gian Cesare Tron, Pier Luigi Canonico and Armando A. Genazzani

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 829-840; DOI: https://doi.org/10.1124/jpet.111.184630
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Retinoic Acid Isomers Up-Regulate ATP Binding Cassette A1 and G1 and Cholesterol Efflux in Rat Astrocytes: Implications for Their Therapeutic and Teratogenic Effects
Jing Chen, Lucio G. Costa and Marina Guizzetti

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 870-878; DOI: https://doi.org/10.1124/jpet.111.182196
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The Soluble Guanylyl Cyclase Activator YC-1 Increases Intracellular cGMP and cAMP via Independent Mechanisms in INS-1E Cells
Lavoisier S. Ramos-Espiritu, Kenneth C. Hess, Jochen Buck and Lonny R. Levin

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 925-931; DOI: https://doi.org/10.1124/jpet.111.184135

Chemotherapy, Antibiotics, and Gene Therapy

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Combining Small Interfering RNAs Targeting Thymidylate Synthase and Thymidine Kinase 1 or 2 Sensitizes Human Tumor Cells to 5-Fluorodeoxyuridine and Pemetrexed
C. Di Cresce, R. Figueredo, P. J. Ferguson, M. D. Vincent and J. Koropatnick

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 952-963; DOI: https://doi.org/10.1124/jpet.111.183178

Drug Discovery and Translational Medicine

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Oxidative Stress Mediates through Apoptosis the Anticancer Effect of Phospho-Nonsteroidal Anti-Inflammatory Drugs: Implications for the Role of Oxidative Stress in the Action of Anticancer Agents
Yu Sun, Liqun Huang, Gerardo G. Mackenzie and Basil Rigas

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 775-783; DOI: https://doi.org/10.1124/jpet.111.183533
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Characterization of a Sphingosine 1-Phosphate Receptor Antagonist Prodrug
Perry C. Kennedy, Ran Zhu, Tao Huang, Jose L. Tomsig, Thomas P. Mathews, Marion David, Olivier Peyruchaud, Timothy L. Macdonald and Kevin R. Lynch

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 879-889; DOI: https://doi.org/10.1124/jpet.111.181552
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Neuroprotective Efficacy from a Lipophilic Redox-Modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: Rodent Models of Ischemic Stroke and Subarachnoid Hemorrhage
Huaxin Sheng, Ivan Spasojevic, Hubert M. Tse, Jin Yong Jung, Jun Hong, Zhiquan Zhang, Jon D. Piganelli, Ines Batinic-Haberle and David S. Warner

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 906-916; DOI: https://doi.org/10.1124/jpet.110.176701
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Pharmacokinetic-Pharmacodynamic Modeling of Biomarker Response and Tumor Growth Inhibition to an Orally Available Heat Shock Protein 90 Inhibitor in a Human Tumor Xenograft Mouse Model
Shinji Yamazaki, Leslie Nguyen, Sylvia Vekich, Zhongzhou Shen, Min-Jean Yin, Pramod P. Mehta, Pei-Pei Kung and Paolo Vicini

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 964-973; DOI: https://doi.org/10.1124/jpet.111.181339
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In Vivo Pharmacology and Toxicology Evaluation of Polyethylene Glycol-Conjugated Interferon β-1a
Xiao Hu, Kenneth Olivier, Evelyne Polack, Mary Crossman, Katie Zokowski, Robert S. Gronke, Suezanne Parker, Zhaoyang Li, Ivan Nestorov, Darren P. Baker, Janet Clarke and Meena Subramanyam

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 984-996; DOI: https://doi.org/10.1124/jpet.111.180661

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Administration of Naked Plasmid Encoding Hepatic Stimulator Substance by Hydrodynamic Tail Vein Injection Protects Mice from Hepatic Failure by Suppressing the Mitochondrial Permeability Transition
Shenglan Li, Zuoqing Tang, Hao Yu, Wen Li, Ying Jiang, Yutong Wang and Wei An

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 750-757; DOI: https://doi.org/10.1124/jpet.111.181305
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Delayed Administration of Suramin Attenuates the Progression of Renal Fibrosis in Obstructive Nephropathy
Na Liu, Evelyn Tolbert, Murugavel Ponnusamy, Haidong Yan and Shougang Zhuang

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 758-766; DOI: https://doi.org/10.1124/jpet.111.181727
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RETRACTION: Mechanisms Underlying the Renoprotective Effect of GABA against Ischemia/Reperfusion-Induced Renal Injury in Rats
Shuhei Kobuchi, Ryosuke Tanaka, Takuya Shintani, Rie Suzuki, Hidenobu Tsutsui, Mamoru Ohkita, Kazuhide Ayajiki and Yasuo Matsumura

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 767-774; DOI: https://doi.org/10.1124/jpet.111.180174
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Inhibition of Monoacylglycerol Lipase Attenuates Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Hemorrhages in Mice
Steven G. Kinsey, Daniel K. Nomura, Scott T. O'Neal, Jonathan Z. Long, Anu Mahadevan, Benjamin F. Cravatt, John R. Grider and Aron H. Lichtman

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 795-802; DOI: https://doi.org/10.1124/jpet.110.175778
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Therapeutic Effect of Lecithinized Superoxide Dismutase on Pulmonary Emphysema
Ken-Ichiro Tanaka, Yuta Tanaka, Yuri Miyazaki, Takushi Namba, Keizo Sato, Kazutetsu Aoshiba, Arata Azuma and Tohru Mizushima

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 810-818; DOI: https://doi.org/10.1124/jpet.111.179051
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Aggravation by Paroxetine, a Selective Serotonin Reuptake Inhibitor, of Antral Lesions Generated by Nonsteroidal Anti-Inflammatory Drugs in Rats
Koji Takeuchi, Akiko Tanaka, Kazuo Nukui, Azusa Kojo, Melinda Gyenge and Kikuko Amagase

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 850-859; DOI: https://doi.org/10.1124/jpet.111.183293
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Tetrahydroberberine, an Isoquinoline Alkaloid Isolated from Corydalis Tuber, Enhances Gastrointestinal Motor Function
Tae Ho Lee, Ki Hyun Kim, Sung Ok Lee, Kang Ro Lee, Miwon Son and Mirim Jin

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 917-924; DOI: https://doi.org/10.1124/jpet.111.182048

Inflammation, Immunopharmacology, and Asthma

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Synergistic Effects of p38 Mitogen-Activated Protein Kinase Inhibition with a Corticosteroid in Alveolar Macrophages from Patients with Chronic Obstructive Pulmonary Disease
J. Armstrong, C. Harbron, S. Lea, G. Booth, P. Cadden, K. A. Wreggett and D. Singh

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 732-740; DOI: https://doi.org/10.1124/jpet.111.180737
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Targeting Cannabinoid Receptors as a Novel Approach in the Treatment of Graft-versus-Host Disease: Evidence from an Experimental Murine Model
Rupal Pandey, Venkatesh L. Hegde, Mitzi Nagarkatti and Prakash S. Nagarkatti

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 819-828; DOI: https://doi.org/10.1124/jpet.111.182717
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Inflammatory Stimuli Inhibit Glucocorticoid-Dependent Transactivation in Human Pulmonary Epithelial Cells: Rescue by Long-Acting β₂-Adrenoceptor Agonists
Christopher F. Rider, Elizabeth M. King, Neil S. Holden, Mark A. Giembycz and Robert Newton

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 860-869; DOI: https://doi.org/10.1124/jpet.111.181016
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A Role for the Low-Affinity A_2B Adenosine Receptor in Regulating Superoxide Generation by Murine Neutrophils
Dharini van der Hoeven, Tina C. Wan, Elizabeth T. Gizewski, Laura M. Kreckler, Jason E. Maas, Jordan Van Orman, Katya Ravid and John A. Auchampach

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 1004-1012; DOI: https://doi.org/10.1124/jpet.111.181792
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Luteolin, a Novel Natural Inhibitor of Tumor Progression Locus 2 Serine/Threonine Kinase, Inhibits Tumor Necrosis Factor-α-Induced Cyclooxygenase-2 Expression in JB6 Mouse Epidermis Cells
Jong-Eun Kim, Joe Eun Son, Young Jin Jang, Dong Eun Lee, Nam Joo Kang, Sung Keun Jung, Yong-Seok Heo, Ki Won Lee and Hyong Joo Lee

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 1013-1022; DOI: https://doi.org/10.1124/jpet.111.179200

Metabolism, Transport, and Pharmacogenomics

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Polymorphic Variants of Cytochrome P450 2B6 (CYP2B6.4–CYP2B6.9) Exhibit Altered Rates of Metabolism for Bupropion and Efavirenz: A Charge-Reversal Mutation in the K139E Variant (CYP2B6.8) Impairs Formation of a Functional Cytochrome P450-Reductase Complex
Haoming Zhang, Chitra Sridar, Cesar Kenaan, Hemali Amunugama, David P. Ballou and Paul F. Hollenberg

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 803-809; DOI: https://doi.org/10.1124/jpet.111.183111

Neuropharmacology

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Therapeutic Effect of Nicotine in a Mouse Model of Intracerebral Hemorrhage
Masanori Hijioka, Hideaki Matsushita, Akinori Hisatsune, Yoichiro Isohama and Hiroshi Katsuki

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 741-749; DOI: https://doi.org/10.1124/jpet.111.182519
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Subchronic Administration and Combination Metabotropic Glutamate and GABA_B Receptor Drug Therapy in Fragile X Syndrome
Laura K. K. Pacey, Sujeenthar Tharmalingam and David R. Hampson

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 897-905; DOI: https://doi.org/10.1124/jpet.111.183327

Toxicology

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Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients
Xiaoli Meng, Rosalind E. Jenkins, Neil G. Berry, James L. Maggs, John Farrell, Catherine S. Lane, Andrew V. Stachulski, Neil S. French, Dean J. Naisbitt, Munir Pirmohamed and B. Kevin Park

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 841-849; DOI: https://doi.org/10.1124/jpet.111.183871
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2-(Naphthalene-1-yl)-6-pyrrolidinyl-4-quinazolinone Inhibits Skin Cancer M21 Cell Proliferation through Aberrant Expression of Microtubules and the Cell Cycle
Yang C. Wu, Mann J. Hour, Wing C. Leung, Chi Y. Wu, Wen Z. Liu, Yu H. Chang and Hong Z. Lee

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 942-951; DOI: https://doi.org/10.1124/jpet.110.176115
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The Repressor Element 1-Silencing Transcription Factor Is a Novel Molecular Target for the Neurotoxic Effect of the Polychlorinated Biphenyl Mixture Aroclor 1254 in Neuroblastoma SH-SY5Y Cells
Luigi Formisano, Natascia Guida, Stefania Cocco, Agnese Secondo, Rossana Sirabella, Luca Ulianich, Flora Paturzo, Gianfranco Di Renzo and Lorella M. T. Canzoniero

Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 997-1003; DOI: https://doi.org/10.1124/jpet.111.181289

Erratum

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Correction to “Donepezil Improves Cognitive Function in Mice by Increasing the Production of Insulin-Like Growth Factor-I in the Hippocampus”
Journal of Pharmacology and Experimental Therapeutics September 2011, 338 (3) 1023;

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Table of Contents

Highlighted Papers

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Erratum

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