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Research ArticleCellular and Molecular

Identification and Characterization of INCB9471, an Allosteric Noncompetitive Small-Molecule Antagonist of C-C Chemokine Receptor 5 with Potent Inhibitory Activity against Monocyte Migration and HIV-1 Infection

Niu Shin, Kim Solomon, Naiming Zhou, Kathy He Wang, Vasudha Garlapati, Beth Thomas, Yanlong Li, Maryanne Covington, Frederic Baribaud, Susan Erickson-Viitanen, Phil Czerniak, Nancy Contel, Phillip Liu, Timothy Burn, Gregory Hollis, Swamy Yeleswaram, Kris Vaddi, Chu-Biao Xue, Brian Metcalf, Steve Friedman, Peggy Scherle and Robert Newton
Journal of Pharmacology and Experimental Therapeutics July 2011, 338 (1) 228-239; DOI: https://doi.org/10.1124/jpet.111.179531
Niu Shin
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Kim Solomon
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Naiming Zhou
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Kathy He Wang
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Vasudha Garlapati
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Beth Thomas
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Yanlong Li
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Maryanne Covington
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Frederic Baribaud
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Susan Erickson-Viitanen
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Phil Czerniak
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Nancy Contel
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Phillip Liu
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Timothy Burn
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Gregory Hollis
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Swamy Yeleswaram
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Kris Vaddi
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Chu-Biao Xue
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Steve Friedman
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Peggy Scherle
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Article Information

vol. 338 no. 1 228-239
DOI 
https://doi.org/10.1124/jpet.111.179531
PubMed 
21459966

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received January 20, 2011
  • Accepted March 24, 2011
  • Published online June 22, 2011.

Article Versions

  • Earlier version (April 1, 2011 - 04:10).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Niu Shin,
  2. Kim Solomon,
  3. Naiming Zhou,
  4. Kathy He Wang,
  5. Vasudha Garlapati,
  6. Beth Thomas,
  7. Yanlong Li,
  8. Maryanne Covington,
  9. Frederic Baribaud,
  10. Susan Erickson-Viitanen,
  11. Phil Czerniak,
  12. Nancy Contel,
  13. Phillip Liu,
  14. Timothy Burn,
  15. Gregory Hollis,
  16. Swamy Yeleswaram,
  17. Kris Vaddi,
  18. Chu-Biao Xue,
  19. Brian Metcalf,
  20. Steve Friedman,
  21. Peggy Scherle and
  22. Robert Newton
  1. Incyte Corporation, Wilmington, Delaware
  1. Address correspondence to:
    Robert Newton, Department of In Vitro Biology, Incyte Corporation, Experimental Station-E400, Rt 141 and Henry Clay Road, Wilmington, DE 19880. E-mail: bnewton{at}incyte.com
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Journal of Pharmacology and Experimental Therapeutics: 338 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 338, Issue 1
1 Jul 2011
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Research ArticleCellular and Molecular

Identification and Characterization of INCB9471, an Allosteric Noncompetitive Small-Molecule Antagonist of C-C Chemokine Receptor 5 with Potent Inhibitory Activity against Monocyte Migration and HIV-1 Infection

Niu Shin, Kim Solomon, Naiming Zhou, Kathy He Wang, Vasudha Garlapati, Beth Thomas, Yanlong Li, Maryanne Covington, Frederic Baribaud, Susan Erickson-Viitanen, Phil Czerniak, Nancy Contel, Phillip Liu, Timothy Burn, Gregory Hollis, Swamy Yeleswaram, Kris Vaddi, Chu-Biao Xue, Brian Metcalf, Steve Friedman, Peggy Scherle and Robert Newton
Journal of Pharmacology and Experimental Therapeutics July 1, 2011, 338 (1) 228-239; DOI: https://doi.org/10.1124/jpet.111.179531

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Research ArticleCellular and Molecular

Identification and Characterization of INCB9471, an Allosteric Noncompetitive Small-Molecule Antagonist of C-C Chemokine Receptor 5 with Potent Inhibitory Activity against Monocyte Migration and HIV-1 Infection

Niu Shin, Kim Solomon, Naiming Zhou, Kathy He Wang, Vasudha Garlapati, Beth Thomas, Yanlong Li, Maryanne Covington, Frederic Baribaud, Susan Erickson-Viitanen, Phil Czerniak, Nancy Contel, Phillip Liu, Timothy Burn, Gregory Hollis, Swamy Yeleswaram, Kris Vaddi, Chu-Biao Xue, Brian Metcalf, Steve Friedman, Peggy Scherle and Robert Newton
Journal of Pharmacology and Experimental Therapeutics July 1, 2011, 338 (1) 228-239; DOI: https://doi.org/10.1124/jpet.111.179531
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