Antiarthritis Effect of a Novel Bruton's Tyrosine Kinase (BTK) Inhibitor in Rat Collagen-Induced Arthritis and Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling: Relationships between Inhibition of BTK Phosphorylation and Efficacy

Lichuan Liu; Julie Di Paolo; Jim Barbosa; Hong Rong; Karin Reif; Harvey Wong

doi:10.1124/jpet.111.181545

Research ArticleInflammation, Immunopharmacology, and Asthma

Antiarthritis Effect of a Novel Bruton's Tyrosine Kinase (BTK) Inhibitor in Rat Collagen-Induced Arthritis and Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling: Relationships between Inhibition of BTK Phosphorylation and Efficacy

Lichuan Liu, Julie Di Paolo, Jim Barbosa, Hong Rong, Karin Reif and Harvey Wong

Journal of Pharmacology and Experimental Therapeutics July 2011, 338 (1) 154-163; DOI: https://doi.org/10.1124/jpet.111.181545

Lichuan Liu

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Julie Di Paolo

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Jim Barbosa

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Hong Rong

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Karin Reif

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Harvey Wong

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Journal of Pharmacology and Experimental Therapeutics

Vol. 338, Issue 1

1 Jul 2011

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Research ArticleInflammation, Immunopharmacology, and Asthma

Antiarthritis Effect of a Novel Bruton's Tyrosine Kinase (BTK) Inhibitor in Rat Collagen-Induced Arthritis and Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling: Relationships between Inhibition of BTK Phosphorylation and Efficacy

Lichuan Liu, Julie Di Paolo, Jim Barbosa, Hong Rong, Karin Reif and Harvey Wong

Journal of Pharmacology and Experimental Therapeutics July 1, 2011, 338 (1) 154-163; DOI: https://doi.org/10.1124/jpet.111.181545

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Research ArticleInflammation, Immunopharmacology, and Asthma

Antiarthritis Effect of a Novel Bruton's Tyrosine Kinase (BTK) Inhibitor in Rat Collagen-Induced Arthritis and Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling: Relationships between Inhibition of BTK Phosphorylation and Efficacy

Lichuan Liu, Julie Di Paolo, Jim Barbosa, Hong Rong, Karin Reif and Harvey Wong

Journal of Pharmacology and Experimental Therapeutics July 1, 2011, 338 (1) 154-163; DOI: https://doi.org/10.1124/jpet.111.181545

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Antiarthritis Effect of a Novel Bruton's Tyrosine Kinase (BTK) Inhibitor in Rat Collagen-Induced Arthritis and Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling: Relationships between Inhibition of BTK Phosphorylation and Efficacy

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Antiarthritis Effect of a Novel Bruton's Tyrosine Kinase (BTK) Inhibitor in Rat Collagen-Induced Arthritis and Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling: Relationships between Inhibition of BTK Phosphorylation and Efficacy

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Antiarthritis Effect of a Novel Bruton's Tyrosine Kinase (BTK) Inhibitor in Rat Collagen-Induced Arthritis and Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling: Relationships between Inhibition of BTK Phosphorylation and Efficacy

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