Journal of Pharmacology and Experimental Therapeutics: 337 (3)

June 01, 2011; Volume 337,Issue 3

Highlighted Papers

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Novel Potassium-Competitive Acid Blocker Versus Proton Pump Inhibitors
Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 571;
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Cancer Prevention and Use of “Classical” Non-Steroidal Anti-Inflammatory Agents?
Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 571;
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Rationale for Extended Duration of Long Acting β Agonists
Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 571;
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Controlling Chronic Tacrolimus-Induced Hypertension through Inhibition of Protein Kinase C β_II
Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 571;

Behavioral Pharmacology

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Behavioral and Cellular Modulation of l-DOPA-Induced Dyskinesia by β-Adrenoceptor Blockade in the 6-Hydroxydopamine-Lesioned Rat
David Lindenbach, Corinne Y. Ostock, Karen L. Eskow Jaunarajs, Kristin B. Dupre, Christopher J. Barnum, Nirmal Bhide and Christopher Bishop

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 755-765; DOI: https://doi.org/10.1124/jpet.111.179416
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Anticonflict and Reinforcing Effects of Triazolam + Pregnanolone Combinations in Rhesus Monkeys
Bradford D. Fischer and James K. Rowlett

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 805-811; DOI: https://doi.org/10.1124/jpet.111.180422
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The Role of Central Gastrin-Releasing Peptide and Neuromedin B Receptors in the Modulation of Scratching Behavior in Rats
Pin-Yen Su and Mei-Chuan Ko

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 822-829; DOI: https://doi.org/10.1124/jpet.111.178970

Cardiovascular

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Dose-Dependent Modulatory Effects of Insulin on Glucose-Induced Endothelial Senescence In Vitro and In Vivo: A Relationship between Telomeres and Nitric Oxide
Hisako Matsui-Hirai, Toshio Hayashi, Seiji Yamamoto, Koichiro Ina, Morihiko Maeda, Hitoshi Kotani, Akihisa Iguchi, Louis J. Ignarro and Yuichi Hattori

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 591-599; DOI: https://doi.org/10.1124/jpet.110.177584
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Doxycycline Ameliorates the Susceptibility to Aortic Lesions in a Mouse Model for the Vascular Type of Ehlers-Danlos Syndrome
Wilfried Briest, Timothy K. Cooper, Hyun-Jin Tae, Melissa Krawczyk, Nazli B. McDonnell and Mark I. Talan

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 621-627; DOI: https://doi.org/10.1124/jpet.110.177782
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Protein Kinase Cβ_II-Mediated Phosphorylation of Endothelial Nitric Oxide Synthase Threonine 495 Mediates the Endothelial Dysfunction Induced by FK506 (Tacrolimus)
Valorie L. Chiasson, Matthew A. Quinn, Kristina J. Young and Brett M. Mitchell

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 718-723; DOI: https://doi.org/10.1124/jpet.110.178095
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Pharmacological Characterization of FE 202158, a Novel, Potent, Selective, and Short-Acting Peptidic Vasopressin V_1a Receptor Full Agonist for the Treatment of Vasodilatory Hypotension
Régent Laporte, Arash Kohan, Joshua Heitzmann, Halina Wiśniewska, Jeannine Toy, Erin La, Hiroe Tariga, Sudarkodi Alagarsamy, Brian Ly, John Dykert, Steve Qi, Kazimierz Wiśniewski, Robert Galyean, Glenn Croston, Claudio D. Schteingart and Pierre J.-M. Rivière

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 786-796; DOI: https://doi.org/10.1124/jpet.111.178848

Cellular and Molecular

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Age Dependency of Inhibition of α7 Nicotinic Receptors and Tonically Active N-Methyl-d-aspartate Receptors by Endogenously Produced Kynurenic Acid in the Brain
Manickavasagom Alkondon, Edna F. R. Pereira, Howard M. Eisenberg, Yasushi Kajii, Robert Schwarcz and Edson X. Albuquerque

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 572-582; DOI: https://doi.org/10.1124/jpet.110.177386
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Functional and Biochemical Rationales for the 24-Hour-Long Duration of Action of Olodaterol
Paola Casarosa, Ines Kollak, Tobias Kiechle, Angela Ostermann, Andreas Schnapp, Ralf Kiesling, Michael Pieper, Peter Sieger and Florian Gantner

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 600-609; DOI: https://doi.org/10.1124/jpet.111.179259
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Efficacy of Ganitumab (AMG 479), Alone and in Combination with Rapamycin, in Ewing's and Osteogenic Sarcoma Models
Pedro J. Beltran, Young-Ah Chung, Gordon Moody, Petia Mitchell, Elaina Cajulis, Steven Vonderfecht, Richard Kendall, Robert Radinsky and Frank J. Calzone

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 644-654; DOI: https://doi.org/10.1124/jpet.110.178400
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Characterization of Vabicaserin (SCA-136), a Selective 5-Hydroxytryptamine 2C Receptor Agonist
John Dunlop, Stephanie W. Watts, James E. Barrett, Joseph Coupet, Boyd Harrison, Hossein Mazandarani, Stanley Nawoschik, Menelas N. Pangalos, Siva Ramamoorthy, Lee Schechter, Deborah Smith, Gary Stack, Jean Zhang, Guoming Zhang and Sharon Rosenzweig-Lipson

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 673-680; DOI: https://doi.org/10.1124/jpet.111.179572
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Nitrite-Mediated Modulation of HL-60 Cell Cycle and Proliferation: Involvement of Cyclin-Dependent Kinase 2 Activation
Sachin Kumar, Manoj Kumar Barthwal and Madhu Dikshit

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 812-821; DOI: https://doi.org/10.1124/jpet.110.177444
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Heteromerization of the μ- and δ-Opioid Receptors Produces Ligand-Biased Antagonism and Alters μ-Receptor Trafficking
Laura Milan-Lobo and Jennifer L. Whistler

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 868-875; DOI: https://doi.org/10.1124/jpet.111.179093

Chemotherapy, Antibiotics, and Gene Therapy

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Tipifarnib-Induced Apoptosis in Acute Myeloid Leukemia and Multiple Myeloma Cells Depends on Ca²⁺ Influx through Plasma Membrane Ca²⁺ Channels
Niranjan Yanamandra, Robert W. Buzzeo, Mark Gabriel, Lori A. Hazlehurst, Yelenis Mari, Darrin M. Beaupre and Javier Cuevas

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 636-643; DOI: https://doi.org/10.1124/jpet.110.172809
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Mitochondria Determine the Efficacy of Anticancer Agents that Interact with DNA but Not the Cytoskeleton
Kenjirou Hara, Emiko Kasahara, Nozomi Takahashi, Masami Konishi, June Inoue, Mika Jikumaru, Shuji Kubo, Haruki Okamura, Eisuke Sato and Masayasu Inoue

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 838-845; DOI: https://doi.org/10.1124/jpet.111.179473

Drug Discovery and Translational Medicine

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Agonist-Induced Internalization of CC Chemokine Receptor 5 as a Mechanism to Inhibit HIV Replication
Thierry Ferain, Hamid Hoveyda, Frédéric Ooms, Dominique Schols, Jérôme Bernard and Graeme Fraser

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 655-662; DOI: https://doi.org/10.1124/jpet.111.179622
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Discovery of a Calcimimetic with Differential Effects on Parathyroid Hormone and Calcitonin Secretion
Charles Henley, Yuhua Yang, James Davis, Jenny Ying Lin Lu, Sean Morony, Wei Fan, Monica Florio, Banghua Sun, Edward Shatzen, James K. Pretorius, William G. Richards, David J. St. Jean, Christopher Fotsch and Jeff D. Reagan

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 681-691; DOI: https://doi.org/10.1124/jpet.110.178681

Endocrine and Diabetes

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Mechanistic Modeling of the Effects of Glucocorticoids and Circadian Rhythms on Adipokine Expression
Siddharth Sukumaran, William J. Jusko, Debra C. DuBois and Richard R. Almon

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 734-746; DOI: https://doi.org/10.1124/jpet.111.179960
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Inhibitory Effects of Antivascular Endothelial Growth Factor Strategies in Experimental Dopamine-Resistant Prolactinomas
Guillermina María Luque, Maria Ines Perez-Millán, Ana Maria Ornstein, Carolina Cristina and Damasia Becu-Villalobos

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 766-774; DOI: https://doi.org/10.1124/jpet.110.177790

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Role of Intrarenal Angiotensin System Activation, Oxidative Stress, Inflammation, and Impaired Nuclear Factor-Erythroid-2-Related Factor 2 Activity in the Progression of Focal Glomerulosclerosis
Hyun Ju Kim, Tadashi Sato, Bernardo Rodríguez-Iturbe and Nosratola D. Vaziri

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 583-590; DOI: https://doi.org/10.1124/jpet.110.175828
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Impact of a Glycogen Phosphorylase Inhibitor and Metformin on Basal and Glucagon-Stimulated Hepatic Glucose Flux in Conscious Dogs
Tracy P. Torres, Noriyasu Sasaki, E. Patrick Donahue, Brooks Lacy, Richard L. Printz, Alan D. Cherrington, Judith L. Treadway and Masakazu Shiota

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 610-620; DOI: https://doi.org/10.1124/jpet.110.177899
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Reduction of Fibrogenesis by Selective Delivery of a Rho Kinase Inhibitor to Hepatic Stellate Cells in Mice
M. M. van Beuge, J. Prakash, M. Lacombe, R. Gosens, E. Post, C. Reker-Smit, L. Beljaars and K. Poelstra

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 628-635; DOI: https://doi.org/10.1124/jpet.111.179143
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A Small-Molecule Inhibitor of Enterocytic Microsomal Triglyceride Transfer Protein, SLx-4090: Biochemical, Pharmacodynamic, Pharmacokinetic, and Safety Profile
Enoch Kim, Stewart Campbell, Olivier Schueller, Eric Wong, Bridget Cole, Jay Kuo, James Ellis, John Ferkany and Paul Sweetnam

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 775-785; DOI: https://doi.org/10.1124/jpet.110.177527
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A Study Comparing the Antisecretory Effect of TAK-438, a Novel Potassium-Competitive Acid Blocker, with Lansoprazole in Animals
Yasunobu Hori, Jun Matsukawa, Toshiyuki Takeuchi, Haruyuki Nishida, Masahiro Kajino and Nobuhiro Inatomi

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 797-804; DOI: https://doi.org/10.1124/jpet.111.179556

Inflammation, Immunopharmacology, and Asthma

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Sphingosine-1-Phosphate Modulates Vascular Permeability and Cell Recruitment in Acute Inflammation In Vivo
Fiorentina Roviezzo, Vincenzo Brancaleone, Luana De Gruttola, Valentina Vellecco, Mariarosaria Bucci, Bruno D'Agostino, Dianne Cooper, Raffaella Sorrentino, Mauro Perretti and Giuseppe Cirino

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 830-837; DOI: https://doi.org/10.1124/jpet.111.179168

Metabolism, Transport, and Pharmacogenomics

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Glucuronidation of Anticancer Prodrug PR-104A: Species Differences, Identification of Human UDP-Glucuronosyltransferases, and Implications for Therapy
Yongchuan Gu, Malcolm D. Tingle and William R. Wilson

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 692-702; DOI: https://doi.org/10.1124/jpet.111.180703
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P-Glycoprotein (ABCB1) Transports the Primary Active Tamoxifen Metabolites Endoxifen and 4-Hydroxytamoxifen and Restricts Their Brain Penetration
Dilek Iusuf, Sebastiaan F. Teunissen, Els Wagenaar, Hilde Rosing, Jos H. Beijnen and Alfred H. Schinkel

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 710-717; DOI: https://doi.org/10.1124/jpet.110.178301
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1α,25-Dihydroxyvitamin D₃ Up-Regulates P-Glycoprotein via the Vitamin D Receptor and Not Farnesoid X Receptor in Both fxr(−/−) and fxr(+/+) Mice and Increased Renal and Brain Efflux of Digoxin in Mice In Vivo
Edwin C. Y. Chow, Matthew R. Durk, Carolyn L. Cummins and K. Sandy Pang

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 846-859; DOI: https://doi.org/10.1124/jpet.111.179101
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Phospho-Ibuprofen (MDC-917) Is a Novel Agent against Colon Cancer: Efficacy, Metabolism, and Pharmacokinetics in Mouse Models
Gang Xie, Yu Sun, Ting Nie, Gerardo G. Mackenzie, Liqun Huang, Levy Kopelovich, Despina Komninou and Basil Rigas

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 876-886; DOI: https://doi.org/10.1124/jpet.111.180224

Neuropharmacology

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Treatment with Z-Ligustilide, a Component of Angelica sinensis, Reduces Brain Injury after a Subarachnoid Hemorrhage in Rats
Di Chen, Jiping Tang, Nikan H. Khatibi, Mei Zhu, Yingbo Li, Chengyuan Wang, Rong Jiang, Liu Tu and Shali Wang

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 663-672; DOI: https://doi.org/10.1124/jpet.110.177055
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Design of Novel Melatonin Analogs for the Reduction of Intraocular Pressure in Normotensive Rabbits
Pilar Alarma-Estrany, Ana Guzman-Aranguez, Fernando Huete, Assumpta Peral, Robert Plourde, Teresa Pelaez, Benjamin Yerxa and Jesús Pintor

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 703-709; DOI: https://doi.org/10.1124/jpet.110.178319
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Previous Exposure to Δ⁹-Tetrahydrocannibinol Enhances Locomotor Responding to but Not Self-Administration of Amphetamine
James J. Cortright, Daniel S. Lorrain, Jeff A. Beeler, Wei-Jen Tang and Paul Vezina

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 724-733; DOI: https://doi.org/10.1124/jpet.111.180208
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Kaempferol Attenuates 4-Hydroxynonenal-Induced Apoptosis in PC12 Cells by Directly Inhibiting NADPH Oxidase
Young Jin Jang, Jiyoung Kim, Jaesung Shim, Jaekyoon Kim, Sanguine Byun, Min-Ho Oak, Ki Won Lee and Hyong Joo Lee

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 747-754; DOI: https://doi.org/10.1124/jpet.110.176925
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Toward Selective Drug Development for the Human 5-Hydroxytryptamine 1E Receptor: A Comparison of 5-Hydroxytryptamine 1E and 1F Receptor Structure-Affinity Relationships
Michael T. Klein, Małgorzata Dukat, Richard A. Glennon and Milt Teitler

Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 860-867; DOI: https://doi.org/10.1124/jpet.111.179606

Erratum

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Correction to “Inhibition of Anandamide Hydrolysis by Cyclohexyl Carbamic Acid 3′-Carbamoyl-3-yl Ester (URB597) Reverses Abuse-Related Behavioral and Neurochemical Effects of Nicotine in Rats”
Journal of Pharmacology and Experimental Therapeutics June 2011, 337 (3) 887;

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Table of Contents

Highlighted Papers

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Erratum

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