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Research ArticlePerspectives In Pharmacology

Functional Selectivity and Biased Receptor Signaling

Terry Kenakin
Journal of Pharmacology and Experimental Therapeutics February 2011, 336 (2) 296-302; DOI: https://doi.org/10.1124/jpet.110.173948
Terry Kenakin
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Article Information

vol. 336 no. 2 296-302
DOI 
https://doi.org/10.1124/jpet.110.173948
PubMed 
21030484

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received September 20, 2010
  • Accepted October 27, 2010
  • Published online January 18, 2011.

Article Versions

  • Earlier version (October 28, 2010 - 06:51).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Terry Kenakin
  1. Platform Technology Sciences, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina
  1. Address correspondence to:
    Terry Kenakin, Platform Technology Sciences, GlaxoSmithKline Research and Development, Research Triangle Park, NC 27709. E-mail: terry.p.kenakin{at}gsk.com
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Journal of Pharmacology and Experimental Therapeutics: 376 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 376, Issue 3
1 Mar 2021
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Research ArticlePerspectives In Pharmacology

Functional Selectivity and Biased Receptor Signaling

Terry Kenakin
Journal of Pharmacology and Experimental Therapeutics February 1, 2011, 336 (2) 296-302; DOI: https://doi.org/10.1124/jpet.110.173948

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Research ArticlePerspectives In Pharmacology

Functional Selectivity and Biased Receptor Signaling

Terry Kenakin
Journal of Pharmacology and Experimental Therapeutics February 1, 2011, 336 (2) 296-302; DOI: https://doi.org/10.1124/jpet.110.173948
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  • Article
    • Abstract
    • Introduction
    • Stephenson's Efficacy and Cells as Rheostats
    • Pluridimensional Efficacy
    • Receptors as Microprocessors
    • The Impact of Functional Selectivity on Pharmacology and Drug Discovery
    • The Impact of Functional Selectivity on Drug Therapeutics
    • Conclusions
    • Authorship Contributions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
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