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Research ArticleMETABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Distribution of Gefitinib to the Brain Is Limited by P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2)-Mediated Active Efflux

Sagar Agarwal, Ramola Sane, Jose L. Gallardo, John R. Ohlfest and William F. Elmquist
Journal of Pharmacology and Experimental Therapeutics July 2010, 334 (1) 147-155; DOI: https://doi.org/10.1124/jpet.110.167601
Sagar Agarwal
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Ramola Sane
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Jose L. Gallardo
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John R. Ohlfest
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William F. Elmquist
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Article Information

vol. 334 no. 1 147-155
DOI 
https://doi.org/10.1124/jpet.110.167601
PubMed 
20421331

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received February 23, 2010
  • Accepted April 23, 2010
  • Published online June 17, 2010.

Article Versions

  • Earlier version (April 26, 2010 - 07:18).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sagar Agarwal,
  2. Ramola Sane,
  3. Jose L. Gallardo,
  4. John R. Ohlfest and
  5. William F. Elmquist
  1. Department of Pharmaceutics (S.A., R.S., W.F.E.), Department of Pediatrics (J.L.G., J.R.O.), Department of Neurosurgery (J.R.O.), University of Minnesota, Minneapolis, Minnesota; and Brain Barriers Research Center, University of Minnesota, Minnesota (W.F.E., J.R.O.)
  1. Address correspondence to:
    William F. Elmquist, Department of Pharmaceutics, University of Minnesota, 9-177 Weaver Densford Hall, 308 Harvard Street SE, Minneapolis, MN 55455. E-mail: elmqu011{at}umn.edu
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Journal of Pharmacology and Experimental Therapeutics: 384 (2)
Journal of Pharmacology and Experimental Therapeutics
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Research ArticleMETABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Distribution of Gefitinib to the Brain Is Limited by P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2)-Mediated Active Efflux

Sagar Agarwal, Ramola Sane, Jose L. Gallardo, John R. Ohlfest and William F. Elmquist
Journal of Pharmacology and Experimental Therapeutics July 1, 2010, 334 (1) 147-155; DOI: https://doi.org/10.1124/jpet.110.167601

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Research ArticleMETABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Distribution of Gefitinib to the Brain Is Limited by P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2)-Mediated Active Efflux

Sagar Agarwal, Ramola Sane, Jose L. Gallardo, John R. Ohlfest and William F. Elmquist
Journal of Pharmacology and Experimental Therapeutics July 1, 2010, 334 (1) 147-155; DOI: https://doi.org/10.1124/jpet.110.167601
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