Research ArticleGASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
Potent and Specific Inhibition of mMate1-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine
Sumito Ito, Hiroyuki Kusuhara, Yushun Kuroiwa, Chunyong Wu, Yoshinori Moriyama, Katsuhisa Inoue, Tsunenori Kondo, Hiroaki Yuasa, Hideki Nakayama, Shigeru Horita and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 341-350; DOI: https://doi.org/10.1124/jpet.109.163642
Sumito Ito
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
Hiroyuki Kusuhara
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
Yushun Kuroiwa
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
Chunyong Wu
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
Yoshinori Moriyama
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
Katsuhisa Inoue
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
Tsunenori Kondo
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
Hiroaki Yuasa
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
Hideki Nakayama
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
Shigeru Horita
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
Yuichi Sugiyama
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)

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Research ArticleGASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
Potent and Specific Inhibition of mMate1-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine
Sumito Ito, Hiroyuki Kusuhara, Yushun Kuroiwa, Chunyong Wu, Yoshinori Moriyama, Katsuhisa Inoue, Tsunenori Kondo, Hiroaki Yuasa, Hideki Nakayama, Shigeru Horita and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics April 1, 2010, 333 (1) 341-350; DOI: https://doi.org/10.1124/jpet.109.163642
Research ArticleGASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
Potent and Specific Inhibition of mMate1-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine
Sumito Ito, Hiroyuki Kusuhara, Yushun Kuroiwa, Chunyong Wu, Yoshinori Moriyama, Katsuhisa Inoue, Tsunenori Kondo, Hiroaki Yuasa, Hideki Nakayama, Shigeru Horita and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics April 1, 2010, 333 (1) 341-350; DOI: https://doi.org/10.1124/jpet.109.163642
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