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Research ArticleGASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Potent and Specific Inhibition of mMate1-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine

Sumito Ito, Hiroyuki Kusuhara, Yushun Kuroiwa, Chunyong Wu, Yoshinori Moriyama, Katsuhisa Inoue, Tsunenori Kondo, Hiroaki Yuasa, Hideki Nakayama, Shigeru Horita and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 341-350; DOI: https://doi.org/10.1124/jpet.109.163642
Sumito Ito
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
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Hiroyuki Kusuhara
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
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Yushun Kuroiwa
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
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Chunyong Wu
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
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Yoshinori Moriyama
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
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Katsuhisa Inoue
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
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Tsunenori Kondo
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
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Hiroaki Yuasa
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
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Hideki Nakayama
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
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Shigeru Horita
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
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Yuichi Sugiyama
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
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Article Information

vol. 333 no. 1 341-350
DOI 
https://doi.org/10.1124/jpet.109.163642
PubMed 
20065018

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received November 11, 2009
  • Accepted January 6, 2010
  • Published online March 19, 2010.

Article Versions

  • Earlier version (January 11, 2010 - 08:52).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sumito Ito,
  2. Hiroyuki Kusuhara,
  3. Yushun Kuroiwa,
  4. Chunyong Wu,
  5. Yoshinori Moriyama,
  6. Katsuhisa Inoue,
  7. Tsunenori Kondo,
  8. Hiroaki Yuasa,
  9. Hideki Nakayama,
  10. Shigeru Horita, and
  11. Yuichi Sugiyama
  1. Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (S.I., H.K., Y.K., C.W., Y.S.); Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan (Y.M.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (K.I., H.Y.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)
  1. Address correspondence to:
    Dr. Yuichi Sugiyama, Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. E-mail: sugiyama{at}mol.f.u-tokyo.ac.jp
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Research ArticleGASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Potent and Specific Inhibition of mMate1-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine

Sumito Ito, Hiroyuki Kusuhara, Yushun Kuroiwa, Chunyong Wu, Yoshinori Moriyama, Katsuhisa Inoue, Tsunenori Kondo, Hiroaki Yuasa, Hideki Nakayama, Shigeru Horita and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics April 1, 2010, 333 (1) 341-350; DOI: https://doi.org/10.1124/jpet.109.163642

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Research ArticleGASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Potent and Specific Inhibition of mMate1-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine

Sumito Ito, Hiroyuki Kusuhara, Yushun Kuroiwa, Chunyong Wu, Yoshinori Moriyama, Katsuhisa Inoue, Tsunenori Kondo, Hiroaki Yuasa, Hideki Nakayama, Shigeru Horita and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics April 1, 2010, 333 (1) 341-350; DOI: https://doi.org/10.1124/jpet.109.163642
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