Journal of Pharmacology and Experimental Therapeutics: 333 (1)

April 01, 2010; Volume 333,Issue 1

HIGHLIGHTED PAPERS

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Rho Kinase Signaling and Regulation of Erectile Function
Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 1;
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Lysosomal pH and Predicting Chemotherapy-Induced Toxicity
Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 1;
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Minimizing Adverse Side Effects of Anti-Inflammatory Glucocorticoids
Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 1;
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Treating Migraine with Calcitonin Gene-Related Peptide Antagonists
Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 1;

ENDOCRINE AND DIABETES

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The Application of Target Information and Preclinical Pharmacokinetic/Pharmacodynamic Modeling in Predicting Clinical Doses of a Dickkopf-1 Antibody for Osteoporosis
Alison M. Betts, Tracey H. Clark, Jianxin Yang, Judith L. Treadway, Mei Li, Michael A. Giovanelli, Yasmina Abdiche, Donna M. Stone and Vishwas M. Paralkar

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 2-13; DOI: https://doi.org/10.1124/jpet.109.164129
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Amelioration of Glucose Intolerance by the Synthetic Androstene HE3286: Link to Inflammatory Pathways
Tianlun Wang, Sonia Villegas, Yujin Huang, Steve K. White, Clarence Ahlem, Min Lu, Jerrold M. Olefsky, Chris Reading, James M. Frincke, David Alleva and Jaime Flores-Riveros

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 70-80; DOI: https://doi.org/10.1124/jpet.109.161182
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Nuclear Factor Erythroid 2-Related Factor 2 Deletion Impairs Glucose Tolerance and Exacerbates Hyperglycemia in Type 1 Diabetic Mice
Lauren M. Aleksunes, Scott A. Reisman, Ronnie L. Yeager, Michael J. Goedken and Curtis D. Klaassen

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 140-151; DOI: https://doi.org/10.1124/jpet.109.162271

NEUROPHARMACOLOGY

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Anesthetic-Induced Neurodegeneration Mediated via Inositol 1,4,5-Trisphosphate Receptors
Yifan Zhao, Ge Liang, Qianru Chen, Donald J. Joseph, Qingcheng Meng, Roderic G. Eckenhoff, Maryellen F. Eckenhoff and Huafeng Wei

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 14-22; DOI: https://doi.org/10.1124/jpet.109.161562
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A Novel Cognitive Enhancer, ZSET1446/ST101, Promotes Hippocampal Neurogenesis and Ameliorates Depressive Behavior in Olfactory Bulbectomized Mice
Norifumi Shioda, Yui Yamamoto, Feng Han, Shigeki Moriguchi, Yoshimasa Yamaguchi, Masataka Hino and Kohji Fukunaga

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 43-50; DOI: https://doi.org/10.1124/jpet.109.163535
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Oral Treatment with a γ-Secretase Inhibitor Improves Long-Term Potentiation in a Mouse Model of Alzheimer's Disease
Matthew Townsend, Yujie Qu, Audrey Gray, Zhenhua Wu, Tiffany Seto, Mike Hutton, Mark S. Shearman and Richard E. Middleton

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 110-119; DOI: https://doi.org/10.1124/jpet.109.163691
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Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist
Christopher A. Salvatore, Eric L. Moore, Amy Calamari, Jacquelynn J. Cook, Maria S. Michener, Stacey O'Malley, Patricia J. Miller, Cyrille Sur, David L. Williams, Zhizhen Zeng, Andrew Danziger, Joseph J. Lynch, Christopher P. Regan, John F. Fay, Yui S. Tang, Chi-Chung Li, Nicole T. Pudvah, Rebecca B. White, Ian M. Bell, Steven N. Gallicchio, Samuel L. Graham, Harold G. Selnick, Joseph P. Vacca and Stefanie A. Kane

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 152-160; DOI: https://doi.org/10.1124/jpet.109.163816
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Subcellular Localization of μ-Opioid Receptor G_s Signaling
Sumita Chakrabarti, Andrew Chang and Alan R. Gintzler

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 193-200; DOI: https://doi.org/10.1124/jpet.109.165142
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Transport across the Blood-Brain Barrier of Pluronic Leptin
Tulin O. Price, Susan A. Farr, Xiang Yi, Serguei Vinogradov, Elena Batrakova, William A. Banks and Alexander V. Kabanov

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 253-263; DOI: https://doi.org/10.1124/jpet.109.158147
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How Does Calcium-Dependent Intracellular Regulation of Voltage-Dependent Sodium Current Increase the Sensitivity to the Oxadiazine Insecticide Indoxacarb Metabolite Decarbomethoxylated JW062 (DCJW) in Insect Pacemaker Neurons?
Céline Lavialle-Defaix, Bénédicte Moignot, Christian Legros and Bruno Lapied

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 264-272; DOI: https://doi.org/10.1124/jpet.109.163519
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Muscarinic Receptor Stimulation of d-Aspartate Uptake into Human SH-SY5Y Neuroblastoma Cells Is Attenuated by Hypoosmolarity
Daniel J. Foster, Anne M. Heacock and Stephen K. Fisher

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 297-309; DOI: https://doi.org/10.1124/jpet.109.164277
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Cariprazine (RGH-188), a Dopamine D₃ Receptor-Preferring, D₃/D₂ Dopamine Receptor Antagonist–Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile
Béla Kiss, Attila Horváth, Zsolt Némethy, Éva Schmidt, István Laszlovszky, Gyula Bugovics, Károly Fazekas, Katalin Hornok, Szabolcs Orosz, István Gyertyán, Éva Ágai-Csongor, György Domány, Károly Tihanyi, Nika Adham and Zsolt Szombathelyi

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 328-340; DOI: https://doi.org/10.1124/jpet.109.160432

CELLULAR AND MOLECULAR

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A Novel Geranylgeranyl Transferase Inhibitor in Combination with Lovastatin Inhibits Proliferation and Induces Autophagy in STS-26T MPNST Cells
Komal M. Sane, Michelle Mynderse, Daniel T. LaLonde, Ivory S. Dean, Jonathan W. Wojtkowiak, Farid Fouad, Richard F. Borch, John J. Reiners, Richard A. Gibbs and Raymond R. Mattingly

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 23-33; DOI: https://doi.org/10.1124/jpet.109.160192
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Molecular Basis for Agonism in the BB₃ Receptor: An Epitope Located on the Interface of Transmembrane-III, -VI, and -VII
F. Gbahou, B. Holst and T. W. Schwartz

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 51-59; DOI: https://doi.org/10.1124/jpet.109.162131
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Cystic Fibrosis Transmembrane Regulator Inhibitors CFTR_inh-172 and GlyH-101 Target Mitochondrial Functions, Independently of Chloride Channel Inhibition
Mairead Kelly, Stephanie Trudel, Franck Brouillard, Frederick Bouillaud, Julien Colas, Thao Nguyen-Khoa, Mario Ollero, Aleksander Edelman and Janine Fritsch

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 60-69; DOI: https://doi.org/10.1124/jpet.109.162032
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The Angiotensin IV Analog Nle-Tyr-Leu-ψ-(CH₂-NH₂)^3-4-His-Pro-Phe (Norleual) Can Act as a Hepatocyte Growth Factor/c-Met Inhibitor
B. J. Yamamoto, P. D. Elias, J. A. Masino, B. D. Hudson, A. T. McCoy, Z. J. Anderson, M. D. Varnum, M. F. Sardinia, J. W. Wright and J. W. Harding

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 161-173; DOI: https://doi.org/10.1124/jpet.109.161711
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ADP-Ribosylation Factors Modulate the Cell Surface Transport of G Protein-Coupled Receptors
Chunmin Dong, Xiaoping Zhang, Fuguo Zhou, Huijuan Dou, Matthew T. Duvernay, Ping Zhang and Guangyu Wu

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 174-183; DOI: https://doi.org/10.1124/jpet.109.161489
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Up-Regulation of the RhoA/Rho-Kinase Signaling Pathway in Corpus Cavernosum from Endothelial Nitric-Oxide Synthase (NOS), but Not Neuronal NOS, Null Mice
Fernanda B. M. Priviero, Li-Ming Jin, Zhekang Ying, Cleber E. Teixeira and R. Clinton Webb

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 184-192; DOI: https://doi.org/10.1124/jpet.109.160606
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The Constitutive Activity of the Human Muscarinic M3 Receptor Unmasks Differences in the Pharmacology of Anticholinergics
Paola Casarosa, Tobias Kiechle, Peter Sieger, Michael Pieper and Florian Gantner

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 201-209; DOI: https://doi.org/10.1124/jpet.109.163188
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Twenty-Four-Hour Exposure to Altered Blood Flow Modifies Endothelial Ca²⁺-Activated K⁺ Channels in Rat Mesenteric Arteries
Rob H. P. Hilgers, Ger M. J. Janssen, Gregorio E. Fazzi and Jo G. R. De Mey

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 210-217; DOI: https://doi.org/10.1124/jpet.109.161448

CARDIOVASCULAR

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Cyclosporine Up-Regulates Krüppel-Like Factor-4 (KLF4) in Vascular Smooth Muscle Cells and Drives Phenotypic Modulation In Vivo
Sean M. Garvey, Daniel S. Sinden, Pamela D. Schoppee Bortz and Brian R. Wamhoff

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 34-42; DOI: https://doi.org/10.1124/jpet.109.163949
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Lack of Hemodynamic Effects After Extended Heme Synthesis Inhibition by Succinylacetone in Rats
Stephane L. Bourque, Carling D. Benjamin, Michael A. Adams and Kanji Nakatsu

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 290-296; DOI: https://doi.org/10.1124/jpet.109.162966

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Clarithromycin Inhibits Type A Seasonal Influenza Virus Infection in Human Airway Epithelial Cells
Mutsuo Yamaya, Kyoko Shinya, Yukimasa Hatachi, Hiroshi Kubo, Masanori Asada, Hiroyasu Yasuda, Hidekazu Nishimura and Ryoichi Nagatomi

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 81-90; DOI: https://doi.org/10.1124/jpet.109.162149
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Pathogenic Importance of Cysteinyl Leukotrienes in Development of Gastric Lesions Induced by Ischemia/Reperfusion in Mice
Yuka Nakamori, Yoshino Komatsu, Tohru Kotani, Shinji Kojima and Koji Takeuchi

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 91-98; DOI: https://doi.org/10.1124/jpet.109.162578
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Differential Effect of l-Cysteine in Isolated Whole-Bladder Preparations from Neonatal and Adult Rats
Hacer S. G. Büyüknacar, Cemil Göçmen, William C. de Groat, Eda K. Kumcu, Hsi-Yang Wu and Serpil Önder

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 228-235; DOI: https://doi.org/10.1124/jpet.109.161661
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Potent and Specific Inhibition of mMate1-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine
Sumito Ito, Hiroyuki Kusuhara, Yushun Kuroiwa, Chunyong Wu, Yoshinori Moriyama, Katsuhisa Inoue, Tsunenori Kondo, Hiroaki Yuasa, Hideki Nakayama, Shigeru Horita and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 341-350; DOI: https://doi.org/10.1124/jpet.109.163642

TOXICOLOGY

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Persistent Induction of Cytochrome P4501A1 in Human Hepatoma Cells by 3-Methylcholanthrene: Evidence for Sustained Transcriptional Activation of the CYP1A1 Promoter
Inayat S. Fazili, Weiwu Jiang, Lihua Wang, Edward A. Felix, Tanvir Khatlani, Xavier Coumoul, Robert Barouki and Bhagavatula Moorthy

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 99-109; DOI: https://doi.org/10.1124/jpet.109.162222

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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The Role of Lysosomes in Limiting Drug Toxicity in Mice
Rosemary A. Ndolo, M. Laird Forrest and Jeffrey P. Krise

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 120-128; DOI: https://doi.org/10.1124/jpet.109.160226
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Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2
Kevin J. French, Yan Zhuang, Lynn W. Maines, Peng Gao, Wenxue Wang, Vladimir Beljanski, John J. Upson, Cecelia L. Green, Staci N. Keller and Charles D. Smith

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 129-139; DOI: https://doi.org/10.1124/jpet.109.163444

BEHAVIORAL PHARMACOLOGY

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Estrogen Treatment Blocks 8-Hydroxy-2-dipropylaminotetralin- and Apomorphine-Induced Disruptions of Prepulse Inhibition: Involvement of Dopamine D₁ or D₂ or Serotonin 5-HT_1A, 5-HT_2A, or 5-HT₇ Receptors
Andrea Gogos, Perrin Kwek, Carolina Chavez and Maarten van den Buuse

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 218-227; DOI: https://doi.org/10.1124/jpet.109.162123
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Differential Effects of Serotonin 5-HT_1A Receptor Agonists on the Discriminative Stimulus Effects of the 5-HT_2A Receptor Agonist 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane in Rats and Rhesus Monkeys
Jun-Xu Li, Wouter Koek, Kenner C. Rice and Charles P. France

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 244-252; DOI: https://doi.org/10.1124/jpet.109.163451

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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Inhibition of Inflammatory Cytokine Production from Rheumatoid Synovial Fibroblasts by a Novel IκB Kinase Inhibitor
Atsushi Tsuchiya, Kenichi Imai, Kaori Asamitsu, Yuko Waguri-Nagaya, Takanobu Otsuka and Takashi Okamoto

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 236-243; DOI: https://doi.org/10.1124/jpet.109.158899
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Budesonide Prevents Cytokine-Induced Decrease of the Relaxant Responses to Formoterol and Terbutaline, but Not to Salmeterol, in Mouse Trachea
Mikael Adner, Bengt Larsson, Jesper Säfholm, Ian Naya and Anna Miller-Larsson

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 273-280; DOI: https://doi.org/10.1124/jpet.109.156224
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Differential In Vivo Effects on Target Pathways of a Novel Arylpyrazole Glucocorticoid Receptor Modulator Compared with Prednisolone
Donald J. Roohk, Krista A. Varady, Scott M. Turner, Claire L. Emson, Richard W. Gelling, Mahalakshmi Shankaran, Glen Lindwall, Lauren E. Shipp, Thomas S. Scanlan, Jen-Chywan Wang and Marc K. Hellerstein

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 281-289; DOI: https://doi.org/10.1124/jpet.109.162487
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Mitogen-Activated Protein Kinase Phosphatase-1 Negatively Regulates the Expression of Interleukin-6, Interleukin-8, and Cyclooxygenase-2 in A549 Human Lung Epithelial Cells
Tuija Turpeinen, Riina Nieminen, Eeva Moilanen and Riku Korhonen

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 310-318; DOI: https://doi.org/10.1124/jpet.109.157438
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Cannabinoid Inhibition of Macrophage Migration to the Trans-Activating (Tat) Protein of HIV-1 Is Linked to the CB₂ Cannabinoid Receptor
Erinn S. Raborn and Guy A. Cabral

Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 319-327; DOI: https://doi.org/10.1124/jpet.109.163055

Erratum

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Correction to “Modulation of α₂-Adrenoceptor Functions by Heterotrimeric Gα_i Protein Isoforms”
Journal of Pharmacology and Experimental Therapeutics April 2010, 333 (1) 351;

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Table of Contents

HIGHLIGHTED PAPERS

ENDOCRINE AND DIABETES

NEUROPHARMACOLOGY

CELLULAR AND MOLECULAR

CARDIOVASCULAR

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

TOXICOLOGY

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

BEHAVIORAL PHARMACOLOGY

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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