Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticlePERSPECTIVES IN PHARMACOLOGY

Antitumorigenic Effects of Cannabinoids beyond Apoptosis

Nadine Freimuth, Robert Ramer and Burkhard Hinz
Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 336-344; DOI: https://doi.org/10.1124/jpet.109.157735
Nadine Freimuth
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert Ramer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Burkhard Hinz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

According to the World Health Organization, the cases of death caused by cancer will have been doubled until the year 2030. By 2010, cancer is expected to be the number one cause of death. Therefore, it is necessary to explore novel approaches for the treatment of cancer. Over past years, the antitumorigenic effects of cannabinoids have emerged as an exciting field in cancer research. Apart from their proapoptotic and antiproliferative action, recent research has shown that cannabinoids may likewise affect tumor cell angiogenesis, migration, invasion, adhesion, and metastasization. This review will summarize the data concerning the influence of cannabinoids on these locomotive processes beyond modulation of cancer cell apoptosis and proliferation. The findings discussed here provide a new perspective on the antitumorigenic potential of cannabinoids.

Footnotes

  • Article, publication date, and citation information can be found at http://jpet.aspetjournals.org.

    doi:10.1124/jpet.109.157735

  • ABBREVIATIONS:

    Akt
    protein kinase B
    AEA
    anandamide
    Ang-1/2
    angiopoietin 1/2
    2-AG
    2-arachidonylglycerol
    CBD
    cannabidiol
    CB1
    cannabinoid receptor 1
    CB2
    cannabinoid receptor 2
    ECM
    extracellular matrix
    EGF
    epidermal growth factor
    EGFR
    epidermal growth factor receptor
    DEA
    docosatetraenylethanolamide
    ERK 1/2
    extracellular-signal regulated kinase 1/2
    FAK
    focal adhesion kinase
    FRNK
    FAK-related nonkinase
    HIF-1α
    hypoxia-inducible factor 1α
    HUVEC
    human umbilical vascular endothelial cells
    Id-1/3
    inhibitor of differentiation 1/3
    IgSF CAMs
    cell adhesion molecules of the immunoglobulin superfamily
    IL-1
    interleukin-1
    MMP
    matrix metalloproteinase
    MMP-2/9
    matrix metalloproteinase 2/9
    MA
    methanandamide
    Met-F-AEA
    met-fluoro-anandamide
    NSCLC
    non–small cell lung cancer
    PlGF
    placental growth factor
    RHOA
    Ras homolog gene family member A
    RHOA-ROCK
    RhoA/Rho-associated coiled coil-containing kinase
    ROS
    reactive oxygen species
    Src
    proto-oncogenic tyrosine kinase
    THC
    Δ9-tetrahydrocannabinol
    Tie-1
    tyrosine kinase with immunoglobulin-like and EGF-like domains 1
    TIMP-1
    tissue inhibitor of metalloproteinases 1
    TRPV1
    transient receptor potential vanilloid 1
    VEGF
    vascular endothelial growth factor
    VEGFR
    vascular endothelial growth factor receptor.

    • Received July 15, 2009.
    • Accepted November 2, 2009.
  • Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics
View Full Text

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics: 384 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 384, Issue 2
1 Feb 2023
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Antitumorigenic Effects of Cannabinoids beyond Apoptosis
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticlePERSPECTIVES IN PHARMACOLOGY

Antitumorigenic Effects of Cannabinoids beyond Apoptosis

Nadine Freimuth, Robert Ramer and Burkhard Hinz
Journal of Pharmacology and Experimental Therapeutics February 1, 2010, 332 (2) 336-344; DOI: https://doi.org/10.1124/jpet.109.157735

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticlePERSPECTIVES IN PHARMACOLOGY

Antitumorigenic Effects of Cannabinoids beyond Apoptosis

Nadine Freimuth, Robert Ramer and Burkhard Hinz
Journal of Pharmacology and Experimental Therapeutics February 1, 2010, 332 (2) 336-344; DOI: https://doi.org/10.1124/jpet.109.157735
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Acute and Delayed Clinical Manifestations of OP Toxicity
  • Miltefosine as Mediator of the Immune Response
  • Histamine Receptor Knockout Mice
Show more Perspectives in Pharmacology

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics