Journal of Pharmacology and Experimental Therapeutics: 332 (2)

February 01, 2010; Volume 332,Issue 2

HIGHLIGHTED PAPER

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CYP2C9*1B Promoter Polymorphisms Affect Phenytoin Auto-Induction of Clearance and Maintenance Dose
Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 335;

PERSPECTIVES IN PHARMACOLOGY

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Antitumorigenic Effects of Cannabinoids beyond Apoptosis
Nadine Freimuth, Robert Ramer and Burkhard Hinz

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 336-344; DOI: https://doi.org/10.1124/jpet.109.157735

BEHAVIORAL PHARMACOLOGY

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Reinforcing Effects of σ-Receptor Agonists in Rats Trained to Self-Administer Cocaine
Takato Hiranita, Paul L. Soto, Gianluigi Tanda and Jonathan L. Katz

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 515-524; DOI: https://doi.org/10.1124/jpet.109.159236
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Pharmacologic Antagonism of the Oral Aversive Taste-Directed Response to Capsaicin in a Mouse Brief Access Taste Aversion Assay
Daniel J. Long, Heather R. Devantier, Francis X. Brennan, Robert W. Bryant, F. Raymond Salemme and R. Kyle Palmer

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 525-530; DOI: https://doi.org/10.1124/jpet.109.155416
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Attenuation of Phencyclidine-Induced Object Recognition Deficits by the Combination of Atypical Antipsychotic Drugs and Pimavanserin (ACP 103), a 5-Hydroxytryptamine_2A Receptor Inverse Agonist
S. Snigdha, M. Horiguchi, M. Huang, Z. Li, M. Shahid, J. C. Neill and H. Y. Meltzer

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 622-631; DOI: https://doi.org/10.1124/jpet.109.156349
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Acute Effects of Cocaine on Movement-Related Firing of Dorsolateral Striatal Neurons Depend on Predrug Firing Rate and Dose
Anthony P. Pawlak, Chris C. Tang, Cathy Pederson, Martin B. Wolske and Mark O. West

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 667-683; DOI: https://doi.org/10.1124/jpet.109.158253

CARDIOVASCULAR

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TVP1022 Protects Neonatal Rat Ventricular Myocytes against Doxorubicin-Induced Functional Derangements
Alexandra Berdichevski, Gideon Meiry, Felix Milman, Irena Reiter, Oshra Sedan, Sivan Eliyahu, Heather S. Duffy, Moussa B. Youdim and Ofer Binah

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 413-420; DOI: https://doi.org/10.1124/jpet.109.161158
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Inhibition of Dystrophin Breakdown and Endothelial Nitric-Oxide Synthase Uncoupling Accounts for Cytoprotection by 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydrochloride 3.5 Hydrate (DY-9760e) in Left Ventricular Hypertrophied Mice
Feng Han, Ying-Mei Lu, Hideyuki Hasegawa, Hiroshi Kanai, Erika Hachimura, Yasufumi Shirasaki and Kohji Fukunaga

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 421-428; DOI: https://doi.org/10.1124/jpet.109.161646
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Liposome-Encapsulated Hemoglobin Ameliorates Ischemic Stroke in Nonhuman Primates: An Acute Study
Akira T. Kawaguchi, Munetaka Haida, Mariko Yamano, Dai Fukumoto, Yoshitaka Ogata and Hideo Tsukada

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 429-436; DOI: https://doi.org/10.1124/jpet.109.160051
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Impaired Vasoconstriction and Nitric Oxide-Mediated Relaxation in Pulmonary Arteries of Hypoxia- and Monocrotaline-Induced Pulmonary Hypertensive Rats
Virak Mam, Alain F. Tanbe, Sally H. Vitali, Elena Arons, Helen A. Christou and Raouf A. Khalil

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 455-462; DOI: https://doi.org/10.1124/jpet.109.160119
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Cardamonin Is a Bifunctional Vasodilator that Inhibits Ca_v1.2 Current and Stimulates K_Ca1.1 Current in Rat Tail Artery Myocytes
Fabio Fusi, Maurizio Cavalli, Dulcie Mulholland, Neil Crouch, Phil Coombes, Gill Dawson, Sergio Bova, Giampietro Sgaragli and Simona Saponara

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 531-540; DOI: https://doi.org/10.1124/jpet.109.161265
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Endothelium-Dependent Vasodilator Effects of Peroxisome Proliferator-Activated Receptor β Agonists via the Phosphatidyl-Inositol-3 Kinase-Akt Pathway
Rosario Jiménez, Manuel Sánchez, María José Zarzuelo, Miguel Romero, Ana María Quintela, Rocío López-Sepúlveda, Pilar Galindo, Manuel Gómez-Guzmán, Jose Manuel Haro, Antonio Zarzuelo, Francisco Pérez-Vizcaíno and Juan Duarte

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 554-561; DOI: https://doi.org/10.1124/jpet.109.159806

CELLULAR AND MOLECULAR

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Identification and Analysis of Two Splice Variants of Human G2A Generated by Alternative Splicing
Ai Ogawa, Hideru Obinata, Tomoyasu Hattori, Mikiko Kishi, Kazuaki Tatei, Osamu Ishikawa and Takashi Izumi

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 469-478; DOI: https://doi.org/10.1124/jpet.109.158758
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5-Hydroxytryptamine Receptor Stimulation of Mitochondrial Biogenesis
Kyle A. Rasbach, Jason A. Funk, Tamilselvan Jayavelu, Peter T. Green and Rick G. Schnellmann

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 632-639; DOI: https://doi.org/10.1124/jpet.109.159947
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The D₅ Dopamine Receptor Mediates Large-Conductance, Calcium- and Voltage-Activated Potassium Channel Activation in Human Coronary Artery Smooth Muscle Cells
Aruna Natarajan, Guichun Han, Shi-you Chen, Peiying Yu, Richard White and Pedro Jose

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 640-649; DOI: https://doi.org/10.1124/jpet.109.159871
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Putative Transmembrane Domain 12 of the Human Organic Anion Transporter hOAT1 Determines Transporter Stability and Maturation Efficiency
Mei Hong, Shanshan Li, Fanfan Zhou, Paul E. Thomas and Guofeng You

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 650-658; DOI: https://doi.org/10.1124/jpet.109.160515

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Differential Pharmacodynamic Effects of Paclitaxel Formulations in an Intracranial Rat Brain Tumor Model
Rong Zhou, Richard V. Mazurchuk, Judith H. Tamburlin, John M. Harrold, Donald E. Mager and Robert M. Straubinger

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 479-488; DOI: https://doi.org/10.1124/jpet.109.160044
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Dysopsonin Activity of Serum DNA-Binding Proteins Favorable for Gene Delivery
Feng Liu, Amber Frick, Xing Yuan and Leaf Huang

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 500-504; DOI: https://doi.org/10.1124/jpet.109.159541

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Influence of Cyclooxygenase Inhibitors on the Function of the Prostaglandin Transporter Organic Anion-Transporting Polypeptide 2A1 Expressed in Human Gastroduodenal Mucosa
Kathrin Mandery, Krystyna Bujok, Ingrid Schmidt, Thomas Wex, Gerhard Treiber, Peter Malfertheiner, Tilman T. Rau, Kerstin U. Amann, Kay Brune, Martin F. Fromm and Hartmut Glaeser

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 345-351; DOI: https://doi.org/10.1124/jpet.109.154518
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Mechanistic Insight from In Silico Pharmacokinetic Experiments: Roles of P-glycoprotein, Cyp3A4 Enzymes, and Microenvironments
Tai Ning Lam and C. Anthony Hunt

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 398-412; DOI: https://doi.org/10.1124/jpet.109.160739
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Functional Characterization of Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3) in the Basolateral Efflux of Glucuronide Conjugates in the Mouse Small Intestine
Yoshiaki Kitamura, Hiroyuki Kusuhara and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 659-666; DOI: https://doi.org/10.1124/jpet.109.156943
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Significance of Chymase-Dependent Matrix Metalloproteinase-9 Activation on Indomethacin-Induced Small Intestinal Damages in Rats
Kazuki Kakimoto, Shinji Takai, Mitsuyuki Murano, Kumi Ishida, Yukiko Yoda, Takuya Inoue, Denan Jin, Eiji Umegaki and Kazuhide Higuchi

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 684-689; DOI: https://doi.org/10.1124/jpet.109.162933

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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Inhibition of Delayed-Type Hypersensitivity by Cucurbitacin R through the Curbing of Lymphocyte Proliferation and Cytokine Expression by Means of Nuclear Factor AT Translocation to the Nucleus
José M. Escandell, María-Carmen Recio, Rosa M. Giner, Salvador Máñez, Miguel Cerdá-Nicolás, Irmgard Merfort and José-Luis Ríos

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 352-363; DOI: https://doi.org/10.1124/jpet.109.159327
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Lipoxin A₄ Reduces Lipopolysaccharide-Induced Inflammation in Macrophages and Intestinal Epithelial Cells through Inhibition of Nuclear Factor-κB Activation
Izumi Kure, Shin Nishiumi, Yosuke Nishitani, Takeshi Tanoue, Tsukasa Ishida, Masashi Mizuno, Tsuyoshi Fujita, Hiromu Kutsumi, Makoto Arita, Takeshi Azuma and Masaru Yoshida

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 541-548; DOI: https://doi.org/10.1124/jpet.109.159046

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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Quantitative Prediction and Clinical Observation of a CYP3A Inhibitor-Based Drug-Drug Interactions with MLN3897, a Potent C-C Chemokine Receptor-1 Antagonist
Chuang Lu, Suresh K. Balani, Mark G. Qian, Shimoga R. Prakash, Patricia S. Ducray and Lisa L. von Moltke

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 562-568; DOI: https://doi.org/10.1124/jpet.109.161893
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Role of CYP2A5 in the Clearance of Nicotine and Cotinine: Insights from Studies on a Cyp2a5-null Mouse Model
Xin Zhou, Xiaoliang Zhuo, Fang Xie, Kerri Kluetzman, Yue-Zhong Shu, W. Griffith Humphreys and Xinxin Ding

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 578-587; DOI: https://doi.org/10.1124/jpet.109.162610
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CYP2C9*1B Promoter Polymorphisms, in Linkage with CYP2C19*2, Affect Phenytoin Autoinduction of Clearance and Maintenance Dose
Amarjit S. Chaudhry, Thomas J. Urban, Jatinder K. Lamba, Angela K. Birnbaum, Rory P. Remmel, Murali Subramanian, Stephen Strom, Joyce H. You, Dalia Kasperaviciute, Claudia B. Catarino, Rodney A. Radtke, Sanjay M. Sisodiya, David B. Goldstein and Erin G. Schuetz

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 599-611; DOI: https://doi.org/10.1124/jpet.109.161026

NEUROPHARMACOLOGY

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Neurotransmitters and Energy Metabolites in Amyloid-Bearing APP_SWE×PSEN1dE9 Mouse Brain
Joachim Hartmann, Cornelia Kiewert and Jochen Klein

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 364-370; DOI: https://doi.org/10.1124/jpet.109.161091
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Nicotine Exacerbates Brain Edema during In Vitro and In Vivo Focal Ischemic Conditions
Jennifer R. Paulson, Tianzhi Yang, Pradeep K. Selvaraj, Alexander Mdzinarishvili, Cornelis J. Van der Schyf, Jochen Klein, Ulrich Bickel and Thomas J. Abbruscato

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 371-379; DOI: https://doi.org/10.1124/jpet.109.157776
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A Novel Calpain Inhibitor, ((1S)-1-((((1S)-1-Benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic Acid 5-Methoxy-3-oxapentyl Ester (SNJ-1945), Reduces Murine Retinal Cell Death In Vitro and In Vivo
Masamitsu Shimazawa, Shinsuke Suemori, Yuta Inokuchi, Nozomu Matsunaga, Yoshimi Nakajima, Takayuki Oka, Tetsuya Yamamoto and Hideaki Hara

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 380-387; DOI: https://doi.org/10.1124/jpet.109.156612
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Sigma-1 Receptors Regulate Bcl-2 Expression by Reactive Oxygen Species-Dependent Transcriptional Regulation of Nuclear Factor κB
Johann Meunier and Teruo Hayashi

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 388-397; DOI: https://doi.org/10.1124/jpet.109.160960
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Amoxapine Inhibits the Delayed Rectifier Outward K⁺ Current in Mouse Cortical Neurons via cAMP/Protein Kinase A Pathways
Yan-Lin He, Xiao-Qin Zhan, Guang Yang, Ji Sun and Yan-Ai Mei

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 437-445; DOI: https://doi.org/10.1124/jpet.109.159160
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Multipotent Neurotrophin Antagonist Targets Brain-Derived Neurotrophic Factor and Nerve Growth Factor
J. K. Eibl, S. A. Chapelsky and G. M. Ross

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 446-454; DOI: https://doi.org/10.1124/jpet.109.159079
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Brain-Derived Neurotrophic Factor Signaling Modulates Cocaine Induction of Reward-Associated Ultrasonic Vocalization in Rats
Stacey N. Williams and Ashiwel S. Undieh

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 463-468; DOI: https://doi.org/10.1124/jpet.109.158535
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The Aminoglycosides Modulate the Acid-Sensing Ionic Channel Currents in Dorsal Root Ganglion Neurons from the Rat
Aníbal Garza, Omar López-Ramírez, Rosario Vega and Enrique Soto

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 489-499; DOI: https://doi.org/10.1124/jpet.109.152884
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Imipramine, in Part through Tumor Necrosis Factor α Inhibition, Prevents Cognitive Decline and β-Amyloid Accumulation in a Mouse Model of Alzheimer's Disease
F. Chavant, J. Deguil, S. Pain, I. Ingrand, S. Milin, B. Fauconneau, M.-C. Pérault-Pochat and C. Lafay-Chebassier

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 505-514; DOI: https://doi.org/10.1124/jpet.109.162164
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Intrahypothalamic Injection of the HIV-1 Envelope Glycoprotein Induces Fever via Interaction with the Chemokine System
Khalid Benamar, Saad Addou, Menachem Yondorf, Ellen B. Geller, Toby K. Eisenstein and Martin W. Adler

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 549-553; DOI: https://doi.org/10.1124/jpet.109.160309
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Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo
Nicholas A. Jones, Andrew J. Hill, Imogen Smith, Sarah A. Bevan, Claire M. Williams, Benjamin J. Whalley and Gary J. Stephens

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 569-577; DOI: https://doi.org/10.1124/jpet.109.159145
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Physiological Concentrations of Choline Activate Native α7-Containing Nicotinic Acetylcholine Receptors in the Presence of PNU-120596 [1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea]
Alexander G. Gusev and Victor V. Uteshev

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 588-598; DOI: https://doi.org/10.1124/jpet.109.162099
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Lobelane Inhibits Methamphetamine-Evoked Dopamine Release via Inhibition of the Vesicular Monoamine Transporter-2
Justin R. Nickell, Sairam Krishnamurthy, Seth Norrholm, Gabriela Deaciuc, Kiran B. Siripurapu, Guangrong Zheng, Peter A. Crooks and Linda P. Dwoskin

Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 612-621; DOI: https://doi.org/10.1124/jpet.109.160275

Erratum

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Correction to “Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor”
Journal of Pharmacology and Experimental Therapeutics February 2010, 332 (2) 690;

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Table of Contents

HIGHLIGHTED PAPER

PERSPECTIVES IN PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

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