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Research ArticleCELLULAR AND MOLECULAR

NF546 [4,4′-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-α,α′-diphosphonic Acid) Tetrasodium Salt] Is a Non-Nucleotide P2Y11 Agonist and Stimulates Release of Interleukin-8 from Human Monocyte-Derived Dendritic Cells

Sabine Meis, Alexandra Hamacher, Darunee Hongwiset, Claudia Marzian, Michael Wiese, Niels Eckstein, Hans-Dieter Royer, Didier Communi, Jean-Marie Boeynaems, Ralf Hausmann, Günther Schmalzing and Matthias U. Kassack
Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 238-247; DOI: https://doi.org/10.1124/jpet.109.157750
Sabine Meis
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Alexandra Hamacher
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Darunee Hongwiset
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Claudia Marzian
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Michael Wiese
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Niels Eckstein
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Hans-Dieter Royer
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Didier Communi
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Jean-Marie Boeynaems
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Ralf Hausmann
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Günther Schmalzing
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Matthias U. Kassack
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Article Information

vol. 332 no. 1 238-247
DOI 
https://doi.org/10.1124/jpet.109.157750
PubMed 
19815812

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received June 16, 2009
  • Accepted October 8, 2009
  • Published online December 17, 2009.

Article Versions

  • Earlier version (October 8, 2009 - 12:36).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sabine Meis,
  2. Alexandra Hamacher,
  3. Darunee Hongwiset,
  4. Claudia Marzian,
  5. Michael Wiese,
  6. Niels Eckstein,
  7. Hans-Dieter Royer,
  8. Didier Communi,
  9. Jean-Marie Boeynaems,
  10. Ralf Hausmann,
  11. Günther Schmalzing and
  12. Matthias U. Kassack
  1. Institute of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Biochemistry, Heinrich-Heine-University of Duesseldorf, Duesseldorf, Germany (S.M., A.H., D.H., M.U.K.); Institute of Pharmaceutical and Medicinal Chemistry, University of Bonn, Bonn, Germany (C.M., M.W.); Institute of Human Genetics, University of Duesseldorf, Duesseldorf, and Forschungszentrum Caesar, Bonn, Germany (N.E., H.-D.R.); Institute of Interdisciplinary Research, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire – Faculty of Medicine, Université Libre de Bruxelles, Campus Erasme, Brussels, Belgium (D.C., J.-M.B.); and Molecular Pharmacology, Rheinisch-Westfaelische Technische Hochschule Aachen University, Aachen, Germany (R.H., G.S.)
  1. Address correspondence to:
    Dr. Matthias U. Kassack,
    Institute of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Biochemistry, Heinrich-Heine-University of Duesseldorf, Universitaetsstr. 1, Building 26.23.01, d-40225 Duesseldorf, Germany.
    E-mail: matthias.kassack{at}uni-duesseldorf.de
  1. S.M. and A.H. have contributed equally to this work.

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Journal of Pharmacology and Experimental Therapeutics: 332 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 332, Issue 1
1 Jan 2010
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NF546 [4,4′-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-α,α′-diphosphonic Acid) Tetrasodium Salt] Is a Non-Nucleotide P2Y11 Agonist and Stimulates Release of Interleukin-8 from Human Monocyte-Der…
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Research ArticleCELLULAR AND MOLECULAR

NF546 [4,4′-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-α,α′-diphosphonic Acid) Tetrasodium Salt] Is a Non-Nucleotide P2Y11 Agonist and Stimulates Release of Interleukin-8 from Human Monocyte-Derived Dendritic Cells

Sabine Meis, Alexandra Hamacher, Darunee Hongwiset, Claudia Marzian, Michael Wiese, Niels Eckstein, Hans-Dieter Royer, Didier Communi, Jean-Marie Boeynaems, Ralf Hausmann, Günther Schmalzing and Matthias U. Kassack
Journal of Pharmacology and Experimental Therapeutics January 1, 2010, 332 (1) 238-247; DOI: https://doi.org/10.1124/jpet.109.157750

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Research ArticleCELLULAR AND MOLECULAR

NF546 [4,4′-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-α,α′-diphosphonic Acid) Tetrasodium Salt] Is a Non-Nucleotide P2Y11 Agonist and Stimulates Release of Interleukin-8 from Human Monocyte-Derived Dendritic Cells

Sabine Meis, Alexandra Hamacher, Darunee Hongwiset, Claudia Marzian, Michael Wiese, Niels Eckstein, Hans-Dieter Royer, Didier Communi, Jean-Marie Boeynaems, Ralf Hausmann, Günther Schmalzing and Matthias U. Kassack
Journal of Pharmacology and Experimental Therapeutics January 1, 2010, 332 (1) 238-247; DOI: https://doi.org/10.1124/jpet.109.157750
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