Journal of Pharmacology and Experimental Therapeutics: 332 (1)

January 01, 2010; Volume 332,Issue 1

EDITOR'S NOTE

You have access
Editor's Note
Michael F. Jarvis,

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 1-2;

HIGHLIGHTED PAPER

You have access
Mechanisms for Synergistic Cardiotoxicity of Anti-Cancer Therapeutics
Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 3;

BEHAVIORAL PHARMACOLOGY

You have access
Reducing Abuse Liability of GABA_A/Benzodiazepine Ligands via Selective Partial Agonist Efficacy at α₁ and α_2/3 Subtypes
Nancy A. Ator, John R. Atack, Richard J. Hargreaves, H. Donald Burns and Gerard R. Dawson

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 4-16; DOI: https://doi.org/10.1124/jpet.109.158303
You have access
WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: A Novel Dopamine D₂ Receptor Partial Agonist/Serotonin Reuptake Inhibitor with Preclinical Antipsychotic-Like and Antidepressant-Like Activity
Julie A. Brennan, Radka Graf, Steven M. Grauer, Rachel L. Navarra, Claudine M. Pulicicchio, Zoë A. Hughes, Qian Lin, Caitlin Wantuch, Sharon Rosenzweig-Lipson, Farhana Pruthi, Margaret Lai, Deborah Smith, Wouter Goutier, Martina van de Neut, Albert J. Robichaud, David Rotella, Rolf W. Feenstra, Chris Kruse, Pierre Broqua, Chad E. Beyer, Andrew C. McCreary, Mark H. Pausch and Karen L. Marquis

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 190-201; DOI: https://doi.org/10.1124/jpet.109.157388
You have access
Dopamine D3 Receptors Mediate the Discriminative Stimulus Effects of Quinpirole in Free-Feeding Rats
Michelle G. Baladi, Amy H. Newman and Charles P. France

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 308-315; DOI: https://doi.org/10.1124/jpet.109.158394

CARDIOVASCULAR

You have access
Sublethal Doses of an Anti-erbB2 Antibody Leads to Death by Apoptosis in Cardiomyocytes Sensitized by Low Prosenescent Doses of Epirubicin: The Protective Role of Dexrazoxane
Paolo Spallarossa, Paola Altieri, Paolo Pronzato, Concetta Aloi, Giorgio Ghigliotti, Antonio Barsotti and Claudio Brunelli

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 87-96; DOI: https://doi.org/10.1124/jpet.109.159525
You have access
Angiotensin II-Induced Migration of Vascular Smooth Muscle Cells Is Mediated by p38 Mitogen-Activated Protein Kinase-Activated c-Src through Spleen Tyrosine Kinase and Epidermal Growth Factor Receptor Transactivation
Benon E. Mugabe, Fariborz A. Yaghini, Chi Young Song, Cuneyt K. Buharalioglu, Christopher M. Waters and Kafait U. Malik

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 116-124; DOI: https://doi.org/10.1124/jpet.109.157552
You have access
Endogenous Nitric Oxide Contributes to Bradykinin-Stimulated Glucose Uptake but Attenuates Vascular Tissue-Type Plasminogen Activator Release
Mias Pretorius and Nancy J. Brown

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 291-297; DOI: https://doi.org/10.1124/jpet.109.160168

CELLULAR AND MOLECULAR

You have access
20-Hydroxy-5,8,11,14-eicosatetraenoic Acid Mediates Endothelial Dysfunction via IκB Kinase-Dependent Endothelial Nitric-Oxide Synthase Uncoupling
Jennifer Cheng, Cheng-Chia Wu, Katherine H. Gotlinger, Frank Zhang, John R. Falck, Dubasi Narsimhaswamy and Michal Laniado Schwartzman

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 57-65; DOI: https://doi.org/10.1124/jpet.109.159863
You have access
A Conserved Motif in the Membrane Proximal C-Terminal Tail of Human Muscarinic M₁ Acetylcholine Receptors Affects Plasma Membrane Expression
Gregory W. Sawyer, Frederick J. Ehlert and Crystal A. Shults

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 76-86; DOI: https://doi.org/10.1124/jpet.109.160986
You have access
Early Intervention of Tyrosine Nitration Prevents Vaso-Obliteration and Neovascularization in Ischemic Retinopathy
Mohammed A. Abdelsaid, Bindu A. Pillai, Suraporn Matragoon, Roshini Prakash, Mohamed Al-Shabrawey and Azza B. El-Remessy

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 125-134; DOI: https://doi.org/10.1124/jpet.109.157941
You have access
Nicotinamide Glycolates Antagonize CXCR2 Activity through an Intracellular Mechanism
Dean Y. Maeda, Mark T. Quinn, Igor A. Schepetkin, Liliya N. Kirpotina and John A. Zebala

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 145-152; DOI: https://doi.org/10.1124/jpet.109.159020
You have access
NF546 [4,4′-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-α,α′-diphosphonic Acid) Tetrasodium Salt] Is a Non-Nucleotide P2Y₁₁ Agonist and Stimulates Release of Interleukin-8 from Human Monocyte-Derived Dendritic Cells
Sabine Meis, Alexandra Hamacher, Darunee Hongwiset, Claudia Marzian, Michael Wiese, Niels Eckstein, Hans-Dieter Royer, Didier Communi, Jean-Marie Boeynaems, Ralf Hausmann, Günther Schmalzing and Matthias U. Kassack

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 238-247; DOI: https://doi.org/10.1124/jpet.109.157750

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

You have access
Topotecan Triggers Apoptosis in p53-Deficient Cells by Forcing Degradation of XIAP and Survivin Thereby Activating Caspase-3-Mediated Bid Cleavage
Maja T. Tomicic, Markus Christmann and Bernd Kaina

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 316-325; DOI: https://doi.org/10.1124/jpet.109.159962

ENDOCRINE AND DIABETES

You have access
Glyceollin I, a Novel Antiestrogenic Phytoalexin Isolated from Activated Soy
M. Carla Zimmermann, Syreeta L. Tilghman, Stephen M. Boué, Virgilio A. Salvo, Steven Elliott, K. Y. Williams, Elena V. Skripnikova, Hasina Ashe, Florastina Payton-Stewart, Lyndsay Vanhoy-Rhodes, Juan Pablo Fonseca, Cynthia Corbitt, Bridgette M. Collins-Burow, Melanie H. Howell, Michelle Lacey, Betty Y. Shih, Carol Carter-Wientjes, Thomas E. Cleveland, John A. McLachlan, Thomas E. Wiese, Barbara S. Beckman and Matthew E. Burow

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 35-45; DOI: https://doi.org/10.1124/jpet.109.160382

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

You have access
Inhibition of Phosphoinositide 3-Kinase Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mice
Xiao-dong Peng, Xiao-hua Wu, Li-juan Chen, Zhen-ling Wang, Xiao-hong Hu, Li-fang Song, Chun-mei He, You-fu Luo, Zhi-zhi Chen, Ke Jin, Hong-gang Lin, Xiao-lei Li, Yong-sheng Wang and Yu-quan Wei

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 46-56; DOI: https://doi.org/10.1124/jpet.109.153494

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

You have access
Hepatobiliary Disposition of Troglitazone and Metabolites in Rat and Human Sandwich-Cultured Hepatocytes: Use of Monte Carlo Simulations to Assess the Impact of Changes in Biliary Excretion on Troglitazone Sulfate Accumulation
Jin Kyung Lee, Tracy L. Marion, Koji Abe, Changwon Lim, Gary M. Pollock and Kim L. R. Brouwer

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 26-34; DOI: https://doi.org/10.1124/jpet.109.156653
You have access
A Single Amino Acid Controls the Functional Switch of Human Constitutive Androstane Receptor (CAR) 1 to the Xenobiotic-Sensitive Splicing Variant CAR3
Tao Chen, Leslie M. Tompkins, Linhao Li, Haishan Li, Gregory Kim, Yuxin Zheng and Hongbing Wang

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 106-115; DOI: https://doi.org/10.1124/jpet.109.159210
You have access
Species Difference in the Effect of Grapefruit Juice on Intestinal Absorption of Talinolol between Human and Rat
Yoshiyuki Shirasaka, Erika Kuraoka, Hildegard Spahn-Langguth, Takeo Nakanishi, Peter Langguth and Ikumi Tamai

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 181-189; DOI: https://doi.org/10.1124/jpet.109.159756
You have access
Nicotine Metabolism in African Americans and European Americans: Variation in Glucuronidation by Ethnicity and UGT2B10 Haplotype
Jeannette Zinggeler Berg, Jesse Mason, Angela J. Boettcher, Dorothy K. Hatsukami and Sharon E. Murphy

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 202-209; DOI: https://doi.org/10.1124/jpet.109.159855
You have access
Transport of the Photodynamic Therapy Agent 5-Aminolevulinic Acid by Distinct H⁺-Coupled Nutrient Carriers Coexpressed in the Small Intestine
Catriona M. H. Anderson, Mark Jevons, Muthusamy Thangaraju, Noel Edwards, Nichola J. Conlon, Steven Woods, Vadivel Ganapathy and David T. Thwaites

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 220-228; DOI: https://doi.org/10.1124/jpet.109.159822
You have access
Erythropoietic Response to Endogenous Erythropoietin in Premature Very Low Birth Weight Infants
Kevin J. Freise, John A. Widness and Peter Veng-Pedersen

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 229-237; DOI: https://doi.org/10.1124/jpet.109.159905
You have access
Pharmacological Characterization of Human Incretin Receptor Missense Variants
Jean-Philippe Fortin, Jonathan C. Schroeder, Yuantee Zhu, Martin Beinborn and Alan S. Kopin

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 274-280; DOI: https://doi.org/10.1124/jpet.109.160531
You have access
The Ethanol Metabolite Acetaldehyde Increases Paracellular Drug Permeability In Vitro and Oral Bioavailability In Vivo
Scott J. Fisher, Peter W. Swaan and Natalie D. Eddington

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 326-333; DOI: https://doi.org/10.1124/jpet.109.158642

NEUROPHARMACOLOGY

You have access
Benzodiazepine Binding Site Occupancy by the Novel GABA_A Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans
John R. Atack, Dean F. Wong, Tim D. Fryer, Christine Ryan, Sandra Sanabria, Yun Zhou, Robert F. Dannals, Wai-si Eng, Raymond E. Gibson, H. Donald Burns, Jose M. Vega, Laura Vessy, Paul Scott-Stevens, John S. Beech, Jean-Claude Baron, Bindi Sohal, Michael L. Schrag, Franklin I. Aigbirhio, Ruth M. McKernan and Richard J. Hargreaves

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 17-25; DOI: https://doi.org/10.1124/jpet.109.157909
You have access
Predominance of Adenosine Excitatory over Inhibitory Effects on Transmission at the Neuromuscular Junction of Infant Rats
Paula A. Pousinha, Alexandra M. Correia, Ana M. Sebastião and Joaquim A. Ribeiro

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 153-163; DOI: https://doi.org/10.1124/jpet.109.157255
You have access
Regional Differential Effects of the Novel Histamine H₃ Receptor Antagonist 6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) on Histamine Release in the Central Nervous System of Freely Moving Rats
Patrizia Giannoni, Andrew D. Medhurst, Maria Beatrice Passani, Maria Grazia Giovannini, Chiara Ballini, Laura Della Corte and Patrizio Blandina

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 164-172; DOI: https://doi.org/10.1124/jpet.109.158444
You have access
An α7 Nicotinic Acetylcholine Receptor-Selective Agonist Reduces Weight Gain and Metabolic Changes in a Mouse Model of Diabetes
Mario B. Marrero, Rudolf Lucas, Christina Salet, Terry A. Hauser, Anatoly Mazurov, Patrick M. Lippiello and Merouane Bencherif

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 173-180; DOI: https://doi.org/10.1124/jpet.109.154633
You have access
Inhibition of Presynaptic Release-Facilitatory Kainate Autoreceptors by Extracellular Cyclic GMP
Chiara Cervetto, Guido Maura and Manuela Marcoli

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 210-219; DOI: https://doi.org/10.1124/jpet.109.154955
You have access
Spinal d-Amino Acid Oxidase Contributes to Neuropathic Pain in Rats
Wen-Juan Zhao, Zhen-Yu Gao, Hong Wei, Hui-Zhen Nie, Qian Zhao, Xiang-Jun Zhou and Yong-Xiang Wang

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 248-254; DOI: https://doi.org/10.1124/jpet.109.158816
You have access
Direct Agonist Activity of Tricyclic Antidepressants at Distinct Opioid Receptor Subtypes
Pierluigi Onali, Simona Dedoni and Maria C. Olianas

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 255-265; DOI: https://doi.org/10.1124/jpet.109.159939
You have access
Sex-Specific Effects of Chronic Fluoxetine Treatment on Neuroplasticity and Pharmacokinetics in Mice
Georgia E. Hodes, Tiffany E. Hill-Smith, Raymond F. Suckow, Thomas B. Cooper and Irwin Lucki

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 266-273; DOI: https://doi.org/10.1124/jpet.109.158717
You have access
Nelotanserin, a Novel Selective Human 5-Hydroxytryptamine_2A Inverse Agonist for the Treatment of Insomnia
Hussien A. Al-Shamma, Christen Anderson, Emil Chuang, Remy Luthringer, Andrew J. Grottick, Erin Hauser, Michael Morgan, William Shanahan, Bradley R. Teegarden, William J. Thomsen and Dominic Behan

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 281-290; DOI: https://doi.org/10.1124/jpet.109.160994
You have access
Corticotropin-Releasing Factor (CRF) Sensitization of Ethanol Withdrawal-Induced Anxiety-Like Behavior is Brain Site Specific and Mediated by CRF-1 Receptors: Relation to Stress-Induced Sensitization
Mae M. Huang, David H. Overstreet, Darin J. Knapp, Robert Angel, Tiffany A. Wills, Montserrat Navarro, Jean Rivier, Wylie Vale and George R. Breese

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 298-307; DOI: https://doi.org/10.1124/jpet.109.159186

TOXICOLOGY

You have access
Critical Cysteine Residues of Kelch-Like ECH-Associated Protein 1 in Arsenic Sensing and Suppression of Nuclear Factor Erythroid 2-Related Factor 2
Xiaoqing He and Qiang Ma

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 66-75; DOI: https://doi.org/10.1124/jpet.109.160465
You have access
Cyanide-Induced Apoptosis of Dopaminergic Cells Is Promoted by BNIP3 and Bax Modulation of Endoplasmic Reticulum-Mitochondrial Ca²⁺ Levels
Lu Zhang, Li Li, Heather W. Leavesley, Xun Zhang, Joseph L. Borowitz and Gary E. Isom

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 97-105; DOI: https://doi.org/10.1124/jpet.109.159103
You have access
Antagonism of Aryl Hydrocarbon Receptor Signaling by 6,2′,4′-Trimethoxyflavone
Iain A. Murray, Colin A. Flaveny, Brett C. DiNatale, Chris R. Chairo, Jennifer C. Schroeder, Ann Kusnadi and Gary H. Perdew

Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 135-144; DOI: https://doi.org/10.1124/jpet.109.158261

Main menu

User menu

Search

Table of Contents

EDITOR'S NOTE

HIGHLIGHTED PAPER

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND DIABETES

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

In this issue

Jump to

Navigate

More Information

ASPET's Other Journals