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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

January 01, 2010; Volume 332,Issue 1

EDITOR'S NOTE

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    Editor's Note
    Michael F. Jarvis,
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 1-2;

HIGHLIGHTED PAPER

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    Mechanisms for Synergistic Cardiotoxicity of Anti-Cancer Therapeutics
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 3;

BEHAVIORAL PHARMACOLOGY

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    Reducing Abuse Liability of GABAA/Benzodiazepine Ligands via Selective Partial Agonist Efficacy at α1 and α2/3 Subtypes
    Nancy A. Ator, John R. Atack, Richard J. Hargreaves, H. Donald Burns and Gerard R. Dawson
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 4-16; DOI: https://doi.org/10.1124/jpet.109.158303
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    WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: A Novel Dopamine D2 Receptor Partial Agonist/Serotonin Reuptake Inhibitor with Preclinical Antipsychotic-Like and Antidepressant-Like Activity
    Julie A. Brennan, Radka Graf, Steven M. Grauer, Rachel L. Navarra, Claudine M. Pulicicchio, Zoë A. Hughes, Qian Lin, Caitlin Wantuch, Sharon Rosenzweig-Lipson, Farhana Pruthi, Margaret Lai, Deborah Smith, Wouter Goutier, Martina van de Neut, Albert J. Robichaud, David Rotella, Rolf W. Feenstra, Chris Kruse, Pierre Broqua, Chad E. Beyer, Andrew C. McCreary, Mark H. Pausch and Karen L. Marquis
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 190-201; DOI: https://doi.org/10.1124/jpet.109.157388
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    Dopamine D3 Receptors Mediate the Discriminative Stimulus Effects of Quinpirole in Free-Feeding Rats
    Michelle G. Baladi, Amy H. Newman and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 308-315; DOI: https://doi.org/10.1124/jpet.109.158394

CARDIOVASCULAR

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    Sublethal Doses of an Anti-erbB2 Antibody Leads to Death by Apoptosis in Cardiomyocytes Sensitized by Low Prosenescent Doses of Epirubicin: The Protective Role of Dexrazoxane
    Paolo Spallarossa, Paola Altieri, Paolo Pronzato, Concetta Aloi, Giorgio Ghigliotti, Antonio Barsotti and Claudio Brunelli
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 87-96; DOI: https://doi.org/10.1124/jpet.109.159525
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    Angiotensin II-Induced Migration of Vascular Smooth Muscle Cells Is Mediated by p38 Mitogen-Activated Protein Kinase-Activated c-Src through Spleen Tyrosine Kinase and Epidermal Growth Factor Receptor Transactivation
    Benon E. Mugabe, Fariborz A. Yaghini, Chi Young Song, Cuneyt K. Buharalioglu, Christopher M. Waters and Kafait U. Malik
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 116-124; DOI: https://doi.org/10.1124/jpet.109.157552
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    Endogenous Nitric Oxide Contributes to Bradykinin-Stimulated Glucose Uptake but Attenuates Vascular Tissue-Type Plasminogen Activator Release
    Mias Pretorius and Nancy J. Brown
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 291-297; DOI: https://doi.org/10.1124/jpet.109.160168

CELLULAR AND MOLECULAR

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    20-Hydroxy-5,8,11,14-eicosatetraenoic Acid Mediates Endothelial Dysfunction via IκB Kinase-Dependent Endothelial Nitric-Oxide Synthase Uncoupling
    Jennifer Cheng, Cheng-Chia Wu, Katherine H. Gotlinger, Frank Zhang, John R. Falck, Dubasi Narsimhaswamy and Michal Laniado Schwartzman
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 57-65; DOI: https://doi.org/10.1124/jpet.109.159863
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    A Conserved Motif in the Membrane Proximal C-Terminal Tail of Human Muscarinic M1 Acetylcholine Receptors Affects Plasma Membrane Expression
    Gregory W. Sawyer, Frederick J. Ehlert and Crystal A. Shults
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 76-86; DOI: https://doi.org/10.1124/jpet.109.160986
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    Early Intervention of Tyrosine Nitration Prevents Vaso-Obliteration and Neovascularization in Ischemic Retinopathy
    Mohammed A. Abdelsaid, Bindu A. Pillai, Suraporn Matragoon, Roshini Prakash, Mohamed Al-Shabrawey and Azza B. El-Remessy
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 125-134; DOI: https://doi.org/10.1124/jpet.109.157941
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    Nicotinamide Glycolates Antagonize CXCR2 Activity through an Intracellular Mechanism
    Dean Y. Maeda, Mark T. Quinn, Igor A. Schepetkin, Liliya N. Kirpotina and John A. Zebala
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 145-152; DOI: https://doi.org/10.1124/jpet.109.159020
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    NF546 [4,4′-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-α,α′-diphosphonic Acid) Tetrasodium Salt] Is a Non-Nucleotide P2Y11 Agonist and Stimulates Release of Interleukin-8 from Human Monocyte-Derived Dendritic Cells
    Sabine Meis, Alexandra Hamacher, Darunee Hongwiset, Claudia Marzian, Michael Wiese, Niels Eckstein, Hans-Dieter Royer, Didier Communi, Jean-Marie Boeynaems, Ralf Hausmann, Günther Schmalzing and Matthias U. Kassack
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 238-247; DOI: https://doi.org/10.1124/jpet.109.157750

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Topotecan Triggers Apoptosis in p53-Deficient Cells by Forcing Degradation of XIAP and Survivin Thereby Activating Caspase-3-Mediated Bid Cleavage
    Maja T. Tomicic, Markus Christmann and Bernd Kaina
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 316-325; DOI: https://doi.org/10.1124/jpet.109.159962

ENDOCRINE AND DIABETES

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    Glyceollin I, a Novel Antiestrogenic Phytoalexin Isolated from Activated Soy
    M. Carla Zimmermann, Syreeta L. Tilghman, Stephen M. Boué, Virgilio A. Salvo, Steven Elliott, K. Y. Williams, Elena V. Skripnikova, Hasina Ashe, Florastina Payton-Stewart, Lyndsay Vanhoy-Rhodes, Juan Pablo Fonseca, Cynthia Corbitt, Bridgette M. Collins-Burow, Melanie H. Howell, Michelle Lacey, Betty Y. Shih, Carol Carter-Wientjes, Thomas E. Cleveland, John A. McLachlan, Thomas E. Wiese, Barbara S. Beckman and Matthew E. Burow
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 35-45; DOI: https://doi.org/10.1124/jpet.109.160382

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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    Inhibition of Phosphoinositide 3-Kinase Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mice
    Xiao-dong Peng, Xiao-hua Wu, Li-juan Chen, Zhen-ling Wang, Xiao-hong Hu, Li-fang Song, Chun-mei He, You-fu Luo, Zhi-zhi Chen, Ke Jin, Hong-gang Lin, Xiao-lei Li, Yong-sheng Wang and Yu-quan Wei
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 46-56; DOI: https://doi.org/10.1124/jpet.109.153494

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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    Hepatobiliary Disposition of Troglitazone and Metabolites in Rat and Human Sandwich-Cultured Hepatocytes: Use of Monte Carlo Simulations to Assess the Impact of Changes in Biliary Excretion on Troglitazone Sulfate Accumulation
    Jin Kyung Lee, Tracy L. Marion, Koji Abe, Changwon Lim, Gary M. Pollock and Kim L. R. Brouwer
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 26-34; DOI: https://doi.org/10.1124/jpet.109.156653
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    A Single Amino Acid Controls the Functional Switch of Human Constitutive Androstane Receptor (CAR) 1 to the Xenobiotic-Sensitive Splicing Variant CAR3
    Tao Chen, Leslie M. Tompkins, Linhao Li, Haishan Li, Gregory Kim, Yuxin Zheng and Hongbing Wang
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 106-115; DOI: https://doi.org/10.1124/jpet.109.159210
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    Species Difference in the Effect of Grapefruit Juice on Intestinal Absorption of Talinolol between Human and Rat
    Yoshiyuki Shirasaka, Erika Kuraoka, Hildegard Spahn-Langguth, Takeo Nakanishi, Peter Langguth and Ikumi Tamai
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 181-189; DOI: https://doi.org/10.1124/jpet.109.159756
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    Nicotine Metabolism in African Americans and European Americans: Variation in Glucuronidation by Ethnicity and UGT2B10 Haplotype
    Jeannette Zinggeler Berg, Jesse Mason, Angela J. Boettcher, Dorothy K. Hatsukami and Sharon E. Murphy
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 202-209; DOI: https://doi.org/10.1124/jpet.109.159855
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    Transport of the Photodynamic Therapy Agent 5-Aminolevulinic Acid by Distinct H+-Coupled Nutrient Carriers Coexpressed in the Small Intestine
    Catriona M. H. Anderson, Mark Jevons, Muthusamy Thangaraju, Noel Edwards, Nichola J. Conlon, Steven Woods, Vadivel Ganapathy and David T. Thwaites
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 220-228; DOI: https://doi.org/10.1124/jpet.109.159822
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    Erythropoietic Response to Endogenous Erythropoietin in Premature Very Low Birth Weight Infants
    Kevin J. Freise, John A. Widness and Peter Veng-Pedersen
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 229-237; DOI: https://doi.org/10.1124/jpet.109.159905
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    Pharmacological Characterization of Human Incretin Receptor Missense Variants
    Jean-Philippe Fortin, Jonathan C. Schroeder, Yuantee Zhu, Martin Beinborn and Alan S. Kopin
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 274-280; DOI: https://doi.org/10.1124/jpet.109.160531
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    The Ethanol Metabolite Acetaldehyde Increases Paracellular Drug Permeability In Vitro and Oral Bioavailability In Vivo
    Scott J. Fisher, Peter W. Swaan and Natalie D. Eddington
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 326-333; DOI: https://doi.org/10.1124/jpet.109.158642

NEUROPHARMACOLOGY

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    Benzodiazepine Binding Site Occupancy by the Novel GABAA Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans
    John R. Atack, Dean F. Wong, Tim D. Fryer, Christine Ryan, Sandra Sanabria, Yun Zhou, Robert F. Dannals, Wai-si Eng, Raymond E. Gibson, H. Donald Burns, Jose M. Vega, Laura Vessy, Paul Scott-Stevens, John S. Beech, Jean-Claude Baron, Bindi Sohal, Michael L. Schrag, Franklin I. Aigbirhio, Ruth M. McKernan and Richard J. Hargreaves
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 17-25; DOI: https://doi.org/10.1124/jpet.109.157909
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    Predominance of Adenosine Excitatory over Inhibitory Effects on Transmission at the Neuromuscular Junction of Infant Rats
    Paula A. Pousinha, Alexandra M. Correia, Ana M. Sebastião and Joaquim A. Ribeiro
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 153-163; DOI: https://doi.org/10.1124/jpet.109.157255
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    Regional Differential Effects of the Novel Histamine H3 Receptor Antagonist 6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) on Histamine Release in the Central Nervous System of Freely Moving Rats
    Patrizia Giannoni, Andrew D. Medhurst, Maria Beatrice Passani, Maria Grazia Giovannini, Chiara Ballini, Laura Della Corte and Patrizio Blandina
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 164-172; DOI: https://doi.org/10.1124/jpet.109.158444
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    An α7 Nicotinic Acetylcholine Receptor-Selective Agonist Reduces Weight Gain and Metabolic Changes in a Mouse Model of Diabetes
    Mario B. Marrero, Rudolf Lucas, Christina Salet, Terry A. Hauser, Anatoly Mazurov, Patrick M. Lippiello and Merouane Bencherif
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 173-180; DOI: https://doi.org/10.1124/jpet.109.154633
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    Inhibition of Presynaptic Release-Facilitatory Kainate Autoreceptors by Extracellular Cyclic GMP
    Chiara Cervetto, Guido Maura and Manuela Marcoli
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 210-219; DOI: https://doi.org/10.1124/jpet.109.154955
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    Spinal d-Amino Acid Oxidase Contributes to Neuropathic Pain in Rats
    Wen-Juan Zhao, Zhen-Yu Gao, Hong Wei, Hui-Zhen Nie, Qian Zhao, Xiang-Jun Zhou and Yong-Xiang Wang
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 248-254; DOI: https://doi.org/10.1124/jpet.109.158816
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    Direct Agonist Activity of Tricyclic Antidepressants at Distinct Opioid Receptor Subtypes
    Pierluigi Onali, Simona Dedoni and Maria C. Olianas
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 255-265; DOI: https://doi.org/10.1124/jpet.109.159939
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    Sex-Specific Effects of Chronic Fluoxetine Treatment on Neuroplasticity and Pharmacokinetics in Mice
    Georgia E. Hodes, Tiffany E. Hill-Smith, Raymond F. Suckow, Thomas B. Cooper and Irwin Lucki
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 266-273; DOI: https://doi.org/10.1124/jpet.109.158717
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    Nelotanserin, a Novel Selective Human 5-Hydroxytryptamine2A Inverse Agonist for the Treatment of Insomnia
    Hussien A. Al-Shamma, Christen Anderson, Emil Chuang, Remy Luthringer, Andrew J. Grottick, Erin Hauser, Michael Morgan, William Shanahan, Bradley R. Teegarden, William J. Thomsen and Dominic Behan
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 281-290; DOI: https://doi.org/10.1124/jpet.109.160994
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    Corticotropin-Releasing Factor (CRF) Sensitization of Ethanol Withdrawal-Induced Anxiety-Like Behavior is Brain Site Specific and Mediated by CRF-1 Receptors: Relation to Stress-Induced Sensitization
    Mae M. Huang, David H. Overstreet, Darin J. Knapp, Robert Angel, Tiffany A. Wills, Montserrat Navarro, Jean Rivier, Wylie Vale and George R. Breese
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 298-307; DOI: https://doi.org/10.1124/jpet.109.159186

TOXICOLOGY

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    Critical Cysteine Residues of Kelch-Like ECH-Associated Protein 1 in Arsenic Sensing and Suppression of Nuclear Factor Erythroid 2-Related Factor 2
    Xiaoqing He and Qiang Ma
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 66-75; DOI: https://doi.org/10.1124/jpet.109.160465
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    Cyanide-Induced Apoptosis of Dopaminergic Cells Is Promoted by BNIP3 and Bax Modulation of Endoplasmic Reticulum-Mitochondrial Ca2+ Levels
    Lu Zhang, Li Li, Heather W. Leavesley, Xun Zhang, Joseph L. Borowitz and Gary E. Isom
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 97-105; DOI: https://doi.org/10.1124/jpet.109.159103
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    Antagonism of Aryl Hydrocarbon Receptor Signaling by 6,2′,4′-Trimethoxyflavone
    Iain A. Murray, Colin A. Flaveny, Brett C. DiNatale, Chris R. Chairo, Jennifer C. Schroeder, Ann Kusnadi and Gary H. Perdew
    Journal of Pharmacology and Experimental Therapeutics January 2010, 332 (1) 135-144; DOI: https://doi.org/10.1124/jpet.109.158261
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Journal of Pharmacology and Experimental Therapeutics: 332 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 332, Issue 1
1 Jan 2010
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