Journal of Pharmacology and Experimental Therapeutics: 331 (2)

November 01, 2009; Volume 331,Issue 2

HIGHLIGHTED PAPER

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Inflammation Gender Differences in Heart Disease Patients
Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 339;

PERSPECTIVES IN PHARMACOLOGY

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Allosteric Modulators of G Protein-Coupled Receptors: Future Therapeutics for Complex Physiological Disorders
Liyun Wang, Bronwen Martin, Randall Brenneman, Louis M. Luttrell and Stuart Maudsley

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 340-348; DOI: https://doi.org/10.1124/jpet.109.156380

BEHAVIORAL PHARMACOLOGY

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Extracellular Signal-Regulated Kinase 1/2 Activation Counteracts Morphine Tolerance in the Periaqueductal Gray of the Rat
Tara A. Macey, Erin N. Bobeck, Deborah M. Hegarty, Sue A. Aicher, Susan L. Ingram and Michael M. Morgan

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 412-418; DOI: https://doi.org/10.1124/jpet.109.152157
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Cocaine Esterase Prevents Cocaine-Induced Toxicity and the Ongoing Intravenous Self-Administration of Cocaine in Rats
Gregory T. Collins, Remy L. Brim, Diwahar Narasimhan, Mei-Chuan Ko, Roger K. Sunahara, Chang-Guo Zhan and James H. Woods

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 445-455; DOI: https://doi.org/10.1124/jpet.108.150029
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Discriminative Stimulus Effects of 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane (DOM), Ketanserin, and (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in Rats
Jun-Xu Li, Alison Unzeitig, Martin A. Javors, Kenner C. Rice, Wouter Koek and Charles P. France

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 671-679; DOI: https://doi.org/10.1124/jpet.109.157560
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Anxiolytic Effects of Phosphodiesterase-2 Inhibitors Associated with Increased cGMP Signaling
Anbrin Masood, Ying Huang, Hassan Hajjhussein, Lan Xiao, Hao Li, Wei Wang, Adel Hamza, Chang-Guo Zhan and James M. O'Donnell

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 690-699; DOI: https://doi.org/10.1124/jpet.109.156729
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Discriminative Stimulus Effects of Psychostimulants and Hallucinogens in S(+)-3,4-Methylenedioxymethamphetamine (MDMA) and R(−)-MDMA Trained Mice
K. S. Murnane, N. Murai, L. L. Howell and W. E. Fantegrossi

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 717-723; DOI: https://doi.org/10.1124/jpet.109.156174

CARDIOVASCULAR

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Ranolazine Antagonizes the Effects of Increased Late Sodium Current on Intracellular Calcium Cycling in Rat Isolated Intact Heart
J. Andrew Wasserstrom, Rohan Sharma, Matthew J. O'Toole, Jiabo Zheng, James E. Kelly, John Shryock, Luiz Belardinelli and Gary L. Aistrup

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 382-391; DOI: https://doi.org/10.1124/jpet.109.156471
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Targeted Detoxification of Selected Reactive Oxygen Species in the Vascular Endothelium
Vladimir V. Shuvaev, Melpo Christofidou-Solomidou, Faiz Bhora, Karine Laude, Hua Cai, Sergei Dikalov, Evguenia Arguiri, Charalambos C. Solomides, Steven M. Albelda, David G. Harrison and Vladimir R. Muzykantov

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 404-411; DOI: https://doi.org/10.1124/jpet.109.156877
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Natural Variation within the Neuronal Nicotinic Acetylcholine Receptor Cluster on Human Chromosome 15q24: Influence on Heritable Autonomic Traits in Twin Pairs
Brinda K. Rana, Jennifer Wessel, Vafa Mahboubi, Fangwen Rao, Jeannine Haeller, Jiaur R. Gayen, Eleazar Eskin, Anne M. Valle, Madhusudan Das, Sushil K. Mahata, Laurent Taupenot, Mats Stridsberg, Todd T. Talley, Michael G. Ziegler, Douglas W. Smith, Nicholas J. Schork, Daniel T. O'Connor and Palmer Taylor

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 419-428; DOI: https://doi.org/10.1124/jpet.109.157271
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Participation of Oxidative Stress on Rat Middle Cerebral Artery Changes Induced by Focal Cerebral Ischemia: Beneficial Effects of 3,4-Dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6)
Francesc Jiménez-Altayó, Laura Caracuel, Fernando J. Pérez-Asensio, Sonia Martínez-Revelles, Ángel Messeguer, Anna M. Planas and Elisabet Vila

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 429-436; DOI: https://doi.org/10.1124/jpet.109.157131
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Enhanced Peroxisome Proliferator-Activated Receptor-γ Expression in Monocyte/Macrophages from Coronary Artery Disease Patients and Possible Gender Differences
Angela Amoruso, Claudio Bardelli, Luigia G. Fresu, Alessandra Palma, Matteo Vidali, Valeria Ferrero, Flavio Ribichini, Corrado Vassanelli and Sandra Brunelleschi

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 531-538; DOI: https://doi.org/10.1124/jpet.109.154419

CELLULAR AND MOLECULAR

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Novel Peptide Antagonists of Adrenomedullin and Calcitonin Gene-Related Peptide Receptors: Identification, Pharmacological Characterization, and Interactions with Position 74 in Receptor Activity-Modifying Protein 1/3
Samuel D. Robinson, Jacqueline F. Aitken, Richard J. Bailey, David R. Poyner and Debbie L. Hay

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 513-521; DOI: https://doi.org/10.1124/jpet.109.156448
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Tamoxifen Inhibits Inward Rectifier K⁺ 2.x Family of Inward Rectifier Channels by Interfering with Phosphatidylinositol 4,5-Bisphosphate-Channel Interactions
Daniela Ponce-Balbuena, Angélica López-Izquierdo, Tania Ferrer, Aldo A. Rodríguez-Menchaca, Iván A. Aréchiga-Figueroa and José A. Sánchez-Chapula

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 563-573; DOI: https://doi.org/10.1124/jpet.109.156075
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Interaction of New, Very Potent Non-Nucleotide Antagonists with Arg256 of the Human Platelet P2Y₁₂ Receptor
Kristina Hoffmann, Younis Baqi, María Sol Morena, Markus Glänzel, Christa E. Müller and Ivar von Kügelgen

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 648-655; DOI: https://doi.org/10.1124/jpet.109.156687
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Thioflavin S (NSC71948) Interferes with Bcl-2-Associated Athanogene (BAG-1)-Mediated Protein-Protein Interactions
Adam Sharp, Simon J. Crabb, Peter W. M. Johnson, Angela Hague, Ramsey Cutress, Paul A. Townsend, A. Ganesan and Graham Packham

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 680-689; DOI: https://doi.org/10.1124/jpet.109.153601
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Early Effects of Lasonolide A on Pancreatic Cancer Cells
Richard A. Isbrucker, Esther A. Guzmán, Tara P. Pitts and Amy E. Wright

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 733-739; DOI: https://doi.org/10.1124/jpet.109.155531
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Characterization of Aclidinium Bromide, a Novel Inhaled Muscarinic Antagonist, with Long Duration of Action and a Favorable Pharmacological Profile
Amadeu Gavaldà, Montserrat Miralpeix, Israel Ramos, Raquel Otal, Cristina Carreño, Marisa Viñals, Teresa Doménech, Carla Carcasona, Blanca Reyes, Dolors Vilella, Jordi Gras, Julio Cortijo, Esteban Morcillo, Jesús Llenas, Hamish Ryder and Jorge Beleta

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 740-751; DOI: https://doi.org/10.1124/jpet.109.151639

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Characterization of Novel Diaryl Oxazole-Based Compounds as Potential Agents to Treat Pancreatic Cancer
Arthur Y. Shaw, Meredith C. Henderson, Gary Flynn, Betty Samulitis, Haiyong Han, Steve P. Stratton, H.-H. Sherry Chow, Laurence H. Hurley and Robert T. Dorr

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 636-647; DOI: https://doi.org/10.1124/jpet.109.156406

ENDOCRINE AND DIABETES

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Ca_v1.2 and Ca_v1.3 Are Differentially Coupled to Glucagon-Like Peptide-1 Potentiation of Glucose-Stimulated Insulin Secretion in the Pancreatic β-Cell Line INS-1
Sarah Melissa P. Jacobo, Marcy L. Guerra and Gregory H. Hockerman

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 724-732; DOI: https://doi.org/10.1124/jpet.109.158519

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Peroxisome Proliferator-Activated Receptor γ Activation Alleviates Postoperative Ileus in Mice by Inhibition of Egr-1 Expression and Its Downstream Target Genes
Ole De Backer, Ellen Elinck, Evelien Priem, Luc Leybaert and Romain A. Lefebvre

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 496-503; DOI: https://doi.org/10.1124/jpet.109.155135
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(R)-(3-Amino-2-fluoropropyl) Phosphinic Acid (AZD3355), a Novel GABA_B Receptor Agonist, Inhibits Transient Lower Esophageal Sphincter Relaxation through a Peripheral Mode of Action
Anders Lehmann, Madeleine Antonsson, Ann Aurell Holmberg, L. Ashley Blackshaw, Lena Brändén, Hans Bräuner-Osborne, Bolette Christiansen, John Dent, Thomas Elebring, Britt-Marie Jacobson, Jörgen Jensen, Jan P. Mattsson, Karolina Nilsson, Simo S. Oja, Amanda J. Page, Pirjo Saransaari and Sverker von Unge

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 504-512; DOI: https://doi.org/10.1124/jpet.109.153593

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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Periodic, Partial Inhibition of IκB Kinase β-Mediated Signaling Yields Therapeutic Benefit in Preclinical Models of Rheumatoid Arthritis
Kathleen M. Gillooly, Mark A. Pattoli, Tracy L. Taylor, Laishun Chen, Lihong Cheng, Kurt R. Gregor, Gena S. Whitney, Vojkan Susulic, Scott H. Watterson, James Kempson, William J. Pitts, Hollie Booth-Lute, Guchen Yang, Paul Davies, Daniel W. Kukral, Joann Strnad, Kim W. McIntyre, Celia J. Darienzo, Luisa Salter-Cid, Zheng Yang, David B. Wang-Iverson and James R. Burke

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 349-360; DOI: https://doi.org/10.1124/jpet.109.156018
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Apoptotic Signaling Activated by Modulation of the F₀F₁-ATPase: Implications for Selective Killing of Autoimmune Lymphocytes
Thomas B. Sundberg, Lara Swenson, Daniel R. Wahl, Anthony W. Opipari and Gary D. Glick

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 437-444; DOI: https://doi.org/10.1124/jpet.109.156422
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E6201 [(3S,4R,5Z,8S,9S,11E)-14-(Ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a Novel Kinase Inhibitor of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase (MEK)-1 and MEK Kinase-1: In Vitro Characterization of Its Anti-Inflammatory and Antihyperproliferative Activities
Masaki Goto, Jesse Chow, Kenzo Muramoto, Ken-ichi Chiba, Satoshi Yamamoto, Masanori Fujita, Hiroshi Obaishi, Kenji Tai, Yoshiharu Mizui, Isao Tanaka, Donna Young, Hua Yang, Yuan J. Wang, Hiroshi Shirota and Fabian Gusovsky

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 485-495; DOI: https://doi.org/10.1124/jpet.109.156554
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Pentoxifylline Prevents Loss of PP2A Phosphatase Activity and Recruitment of Histone Acetyltransferases to Proinflammatory Genes in Acute Pancreatitis
Juan Sandoval, Javier Escobar, Javier Pereda, Natalia Sacilotto, José Luis Rodriguez, Luis Sabater, Luis Aparisi, Luis Franco, Gerardo López-Rodas and Juan Sastre

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 609-617; DOI: https://doi.org/10.1124/jpet.109.157537
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Prostaglandin E₂ Inhibits Advanced Glycation End Product-Induced Adhesion Molecule Expression, Cytokine Production, and Lymphocyte Proliferation in Human Peripheral Blood Mononuclear Cells
Hideo Kohka Takahashi, Keyue Liu, Hidenori Wake, Shuji Mori, Jiyong Zhang, Rui Liu, Tadashi Yoshino and Masahiro Nishibori

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 656-670; DOI: https://doi.org/10.1124/jpet.109.157594
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A Novel Indole-3-propanamide Exerts Its Immunosuppressive Activity by Inhibiting JAK3 in T Cells
Delphine Carbonnelle, Muriel Duflos, Pascal Marchand, Catherine Chauvet, Jean-Yves Petit and François Lang

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 710-716; DOI: https://doi.org/10.1124/jpet.109.155986

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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Mechanism-Based Inactivation of CYP2B1 and Its F-Helix Mutant by Two tert-Butyl Acetylenic Compounds: Covalent Modification of Prosthetic Heme Versus Apoprotein
Hsia-lien Lin, Haoming Zhang, Kathleen R. Noon and Paul F. Hollenberg

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 392-403; DOI: https://doi.org/10.1124/jpet.109.158782
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Pharmacokinetic-Pharmacodynamic and Response Sensitization Modeling of the Intraocular Pressure-Lowering Effect of the EP4 Agonist 5-{3-[(2S)-2-{(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenyl]butyl}-5-oxopyrrolidin-1-yl]propyl}thiophene-2-carboxylate (PF-04475270)
Kenneth T. Luu, Eric Y. Zhang, Ganesh Prasanna, Cathie Xiang, Scott Anderson, Jay Fortner and Paolo Vicini

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 627-635; DOI: https://doi.org/10.1124/jpet.109.157800
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Lymphatic Transport of Methylnortestosterone Undecanoate (MU) and the Bioavailability of Methylnortestosterone Are Highly Sensitive to the Mass of Coadministered Lipid after Oral Administration of MU
Karen L. White, Gary Nguyen, William N. Charman, Glenn A. Edwards, W. A. (Fried) Faassen and Christopher J. H. Porter

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 700-709; DOI: https://doi.org/10.1124/jpet.109.154542

NEUROPHARMACOLOGY

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Capsaicin Protects Mouse Neuromuscular Junctions from the Neuroparalytic Effects of Botulinum Neurotoxin A
Baskaran Thyagarajan, Natalia Krivitskaya, Joseph G. Potian, Kormakur Hognason, Carmen C. Garcia and Joseph J. McArdle

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 361-371; DOI: https://doi.org/10.1124/jpet.109.156901
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In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABA_A Receptor α5 Subtype-Selective Inverse Agonist
John R. Atack, Karen A. Maubach, Keith A. Wafford, Desmond O'Connor, A. David Rodrigues, David C. Evans, F. David Tattersall, Mark S. Chambers, Angus M. MacLeod, Wai-Si Eng, Christine Ryan, Eric Hostetler, Sandra M. Sanabria, Raymond E. Gibson, Stephen Krause, H. Donald Burns, Richard J. Hargreaves, Nancy G. B. Agrawal, Ruth M. McKernan, M. Gail Murphy, Kevin Gingrich, Gerard R. Dawson, Donald G. Musson and Kevin J. Petty

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 470-484; DOI: https://doi.org/10.1124/jpet.109.157636
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Neuroprotection by Tosyl-Polyamine Derivatives through the Inhibition of Ionotropic Glutamate Receptors
Takashi Masuko, Rie Namiki, Yuta Nemoto, Muneharu Miyake, Yasuo Kizawa, Toyofumi Suzuki, Keiko Kashiwagi, Kazuei Igarashi and Tadashi Kusama

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 522-530; DOI: https://doi.org/10.1124/jpet.109.152926
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Immunoneutralization of Agmatine Sensitizes Mice to μ-Opioid Receptor Tolerance
Carrie L. Wade, Lori L. Eskridge, H. Oanh X. Nguyen, Kelley F. Kitto, Laura S. Stone, George Wilcox and Carolyn A. Fairbanks

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 539-546; DOI: https://doi.org/10.1124/jpet.109.155424
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The Role of α6-Containing Nicotinic Acetylcholine Receptors in Nicotine Reward and Withdrawal
K. J. Jackson, J. M. McIntosh, D. H. Brunzell, S. S. Sanjakdar and M. I. Damaj

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 547-554; DOI: https://doi.org/10.1124/jpet.109.155457
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Extended Methamphetamine Self-Administration in Rats Results in a Selective Reduction of Dopamine Transporter Levels in the Prefrontal Cortex and Dorsal Striatum Not Accompanied by Marked Monoaminergic Depletion
Marek Schwendt, Angelica Rocha, Ronald E. See, Alejandra M. Pacchioni, Jacqueline F. McGinty and Peter W. Kalivas

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 555-562; DOI: https://doi.org/10.1124/jpet.109.155770
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Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia
Steven M. Grauer, Virginia L. Pulito, Rachel L. Navarra, Michele P. Kelly, Cody Kelley, Radka Graf, Barbara Langen, Sheree Logue, Julie Brennan, Lixin Jiang, Erik Charych, Ute Egerland, Feng Liu, Karen L. Marquis, Michael Malamas, Thorsten Hage, Thomas A. Comery and Nicholas J. Brandon

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 574-590; DOI: https://doi.org/10.1124/jpet.109.155994
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Blockade of 2-Arachidonoylglycerol Hydrolysis by Selective Monoacylglycerol Lipase Inhibitor 4-Nitrophenyl 4-(Dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances Retrograde Endocannabinoid Signaling
Bin Pan, Wei Wang, Jonathan Z. Long, Dalong Sun, Cecilia J. Hillard, Benjamin F. Cravatt and Qing-song Liu

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 591-597; DOI: https://doi.org/10.1124/jpet.109.158162
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Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein γ-Secretase for the Treatment of Alzheimer's Disease
Robert L. Martone, Hua Zhou, Kevin Atchison, Thomas Comery, Jane Z. Xu, Xinyi Huang, Xioahai Gong, Mei Jin, Anthony Kreft, Boyd Harrison, Scott C. Mayer, Suzan Aschmies, Cathleen Gonzales, Margaret M. Zaleska, David R. Riddell, Erik Wagner, Peimin Lu, Shaiu-Ching Sun, June Sonnenberg-Reines, Aram Oganesian, Karissa Adkins, Michael W. Leach, David W. Clarke, Donna Huryn, Magid Abou-Gharbia, Ronald Magolda, Jonathan Bard, Glen Frick, Sangeeta Raje, S. Bradley Forlow, Carrie Balliet, Michael E. Burczynski, Peter H. Reinhart, Hong I. Wan, Menelas N. Pangalos and J. Steven Jacobsen

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 598-608; DOI: https://doi.org/10.1124/jpet.109.152975
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N-Methyl-d-aspartate (NMDA) Receptor NR2 Subunit Selectivity of a Series of Novel Piperazine-2,3-dicarboxylate Derivatives: Preferential Blockade of Extrasynaptic NMDA Receptors in the Rat Hippocampal CA3-CA1 Synapse
Blaise Mathias Costa, Bihua Feng, Timur S. Tsintsadze, Richard M. Morley, Mark W. Irvine, Vera Tsintsadze, Natasha A. Lozovaya, David E. Jane and Daniel T. Monaghan

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 618-626; DOI: https://doi.org/10.1124/jpet.109.156752
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Comparison of the Effects of Central and Peripheral Dopamine Receptor Activation on Evoked Firing in the Trigeminocervical Complex
Annabelle R Charbit, Simon Akerman and Peter J Goadsby

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 752-763; DOI: https://doi.org/10.1124/jpet.109.151951

TOXICOLOGY

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“Danger” Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells
S. N. Lavergne, H. Wang, H. E. Callan, B. K. Park and D. J. Naisbitt

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 372-381; DOI: https://doi.org/10.1124/jpet.109.155374
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Increased Sensitivity of Glutathione S-Transferase P-Null Mice to Cyclophosphamide-Induced Urinary Bladder Toxicity
Daniel J. Conklin, Petra Haberzettl, Jean-Francois Lesgards, Russell A. Prough, Sanjay Srivastava and Aruni Bhatnagar

Journal of Pharmacology and Experimental Therapeutics November 2009, 331 (2) 456-469; DOI: https://doi.org/10.1124/jpet.109.156513

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Table of Contents

HIGHLIGHTED PAPER

PERSPECTIVES IN PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND DIABETES

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

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