Abstract
1. Morphine sulphate in high concentrations when added to the pace-maker causes increased tonus and "pendular movements" of the exposed ureter.
2. In moderate concentrations when added to the pace-maker morphine causes increased tonus and peristaltic activity if peristalsis exists and antiperistalsis if antiperistalsis is present.
3. If morphine sulphate is added to the solution bathing the dependent segment of ureter a reverse movement is quickly established, peristalsis is converted into antiperistalsis and vice versa.
4. Papaverine hydrochloride depresses both peristalsis and antiperistalsis in the ureter.
5. Papaverine hydrochloride added to the solution bathing the pace-maker quickly stops the spontaneous activity of that segment and in irritable ureters reverses the form of activity thus if peristalsis was present antiperistalsis is produced and vice versa.
6. Papaverine hydrochloride decreases the rate and height of contraction.
7. It requires about one-hundredth the quantity of papaverine hydrochloride to cause depression as it does of morphine sulphate to cause an equal stimulation of the ureters.
Footnotes
- Received January 30, 1928.
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II. THE EFFECT OF MORPHINE AND PAPAVERINE UPON THE PERISTALTIC AND ANTIPERISTALTIC CONTRACTIONS OF THE URETER
