Journal of Pharmacology and Experimental Therapeutics: 328 (3)

March 01, 2009; Volume 328,Issue 3

HIGHLIGHTED PAPER

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VEGF Contributes to Ulcerative Colitis Pathogenesis
Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 681;

BEHAVIORAL PHARMACOLOGY

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Discriminative Stimulus Effects of 1-(2,5-Dimethoxy-4-Methylphenyl)-2-Aminopropane in Rhesus Monkeys: Antagonism and Apparent pA₂ Analyses
Jun-Xu Li, Kenner C. Rice and Charles P. France

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 976-981; DOI: https://doi.org/10.1124/jpet.108.145458
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Discriminative Stimulus and Subject-Rated Effects of Methamphetamine, d-Amphetamine, Methylphenidate, and Triazolam in Methamphetamine-Trained Humans
Rajkumar J. Sevak, William W. Stoops, Lon R. Hays and Craig R. Rush

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 1007-1018; DOI: https://doi.org/10.1124/jpet.108.147124

CARDIOVASCULAR

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INO-4885 [5,10,15,20-Tetra[N-(benzyl-4′-carboxylate)-2-pyridinium]-21H,23H-porphine Iron(III) Chloride], a Peroxynitrite Decomposition Catalyst, Protects the Heart against Reperfusion Injury in Mice
Xiang-Ying Jiao, Erhe Gao, Yuexin Yuan, Yajing Wang, Wayne Bond Lau, Walter Koch, Xin-Liang Ma and Ling Tao

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 777-784; DOI: https://doi.org/10.1124/jpet.108.144352
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Angiotensin-(1-7) with Thioether Bridge: An Angiotensin-Converting Enzyme-Resistant, Potent Angiotensin-(1-7) Analog
Leon D. Kluskens, S. Adriaan Nelemans, Rick Rink, Louwe de Vries, Anita Meter-Arkema, Yong Wang, Thomas Walther, Anneke Kuipers, Gert N. Moll and Marijke Haas

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 849-854; DOI: https://doi.org/10.1124/jpet.108.146431
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The Impact of α₁-Adrenoceptors Up-Regulation Accompanied by the Impairment of β-Adrenergic Vasodilatation in Hypertension
Eduardo Oliver, Daniel Martí, Fermí Montó, Nicla Flacco, Lucrecia Moreno, Domingo Barettino, M. Dolores Ivorra and Pilar D'Ocon

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 982-990; DOI: https://doi.org/10.1124/jpet.108.146043
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Late, but Not Early, Inhibition of Soluble Guanylate Cyclase Decreases Mortality in a Rat Sepsis Model
Daniel Fernandes, Regina Sordi, Letícia Kramer Pacheco, Geisson Marcos Nardi, Bettina Tomio Heckert, Christina Gaspar Villela, Amanda Revoredo Lobo, Christina Barja-Fidalgo and Jamil Assreuy

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 991-999; DOI: https://doi.org/10.1124/jpet.108.142034

CELLULAR AND MOLECULAR

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Characterization of Serotonin Receptors in Pregnant Human Myometrium
Yolande Cordeaux, Dharmintra Pasupathy, Joanne Bacon, D. Stephen Charnock-Jones and Gordon C. S. Smith

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 682-691; DOI: https://doi.org/10.1124/jpet.108.143040
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Preclinical Efficacy and Safety of 1-Deoxygalactonojirimycin in Mice for Fabry Disease
Satoshi Ishii, Hui-Hwa Chang, Hidekatsu Yoshioka, Tatsuo Shimada, Kazuaki Mannen, Yasunori Higuchi, Atsumi Taguchi and Jian-Qiang Fan

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 723-731; DOI: https://doi.org/10.1124/jpet.108.149054
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Cathepsins B and L Differentially Regulate Amyloid Precursor Protein Processing
Donna M. Klein, Kevin M. Felsenstein and Douglas E. Brenneman

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 813-821; DOI: https://doi.org/10.1124/jpet.108.147082

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Microtubule Binding and Disruption and Induction of Premature Senescence by Disorazole C₁
Marni Brisson Tierno, Carolyn A. Kitchens, Bethany Petrik, Thomas H. Graham, Peter Wipf, Fengfeng L. Xu, William S. Saunders, Brianne S. Raccor, Raghavan Balachandran, Billy W. Day, Jane R. Stout, Claire E. Walczak, Alexander P. Ducruet, Celeste E. Reese and John S. Lazo

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 715-722; DOI: https://doi.org/10.1124/jpet.108.147330
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The Chemotherapeutic Agents XK469 (2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid) and SH80 (2-{4-[(7-Bromo-2-quinolinyl)oxy]phenoxy}propionic acid) Inhibit Cytokinesis and Promote Polyploidy and Induce Senescence
John J. Reiners, Miriam Kleinman, Aby Joiakim and Patricia A. Mathieu

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 796-806; DOI: https://doi.org/10.1124/jpet.108.144808
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Involvement of Extracellular Signal-Regulated Kinase Activation in Human Osteosarcoma Cell Resistance to the Histone Deacetylase Inhibitor FK228 [(1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone]
Hiroshi Matsubara, Motonobu Watanabe, Tsuyoshi Imai, Yoshihiro Yui, Yasuhiro Mizushima, Yoshimi Hiraumi, Yuri Kamitsuji, Ken-ichiro Watanabe, Koichi Nishijo, Junya Toguchida, Tatsutoshi Nakahata and Souichi Adachi

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 839-848; DOI: https://doi.org/10.1124/jpet.108.147462
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Double-Stranded RNA-Dependent Protein Kinase-Dependent Apoptosis Induction by a Novel Small Compound
Wenxian Hu, Wayne Hofstetter, Xiaoli Wei, Wei Guo, Yanbin Zhou, Abujiang Pataer, Hong Li, Bingliang Fang and Stephen G. Swisher

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 866-872; DOI: https://doi.org/10.1124/jpet.108.141754

ENDOCRINE AND DIABETES

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Glucose-Dependent Enhancement of Diabetic Bladder Contraction Is Associated with a Rho Kinase-Regulated Protein Kinase C Pathway
Koji Nobe, Taigi Yamazaki, Naoki Tsumita, Terumasa Hashimoto and Kazuo Honda

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 940-950; DOI: https://doi.org/10.1124/jpet.108.144907
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Inhaled Insulin Is Associated with Prolonged Enhancement of Glucose Disposal in Muscle and Liver in the Canine
Dale S. Edgerton, Alan D. Cherrington, Doss W. Neal, Melanie Scott, Margaret Lautz, Nancy Brown, Jeff Petro, Charles H. Hobbs, Chet Leach, Angelo Del Parigi and Thomas R. Strack

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 970-975; DOI: https://doi.org/10.1124/jpet.108.146985

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death
Hao Pan, Partha Mukhopadhyay, Mohanraj Rajesh, Vivek Patel, Bani Mukhopadhyay, Bin Gao, György Haskó and Pál Pacher

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 708-714; DOI: https://doi.org/10.1124/jpet.108.147181
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Neutralizing Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Reduces Severity of Experimental Ulcerative Colitis in Rats: Direct Evidence for the Pathogenic Role of VEGF
Ganna Tolstanova, Tetyana Khomenko, Xiaoming Deng, Longchuan Chen, Andrzej Tarnawski, Amrita Ahluwalia, Sandor Szabo and Zsuzsanna Sandor

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 749-757; DOI: https://doi.org/10.1124/jpet.108.145128
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Improved Antiulcer and Anticancer Properties of a trans-Resveratrol Analog in Mice
Prasun Guha, Anindya Dey, Biswanath Sarkar, Manish V. Dhyani, Subrata Chattopadhyay and Sandip K. Bandyopadhyay

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 829-838; DOI: https://doi.org/10.1124/jpet.108.145334
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Identification and Quantification of 2′,3′-cAMP Release by the Kidney
Jin Ren, Zaichuan Mi, Nicolas A. Stewart and Edwin K. Jackson

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 855-865; DOI: https://doi.org/10.1124/jpet.108.146712
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Comparison of Receptor Binding Characteristics of Commonly Used Muscarinic Antagonists in Human Bladder Detrusor and Mucosa
Kylie J. Mansfield, Jonathan J. Chandran, Kenneth J. Vaux, Richard J. Millard, Arthur Christopoulos, Frederick J. Mitchelson and Elizabeth Burcher

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 893-899; DOI: https://doi.org/10.1124/jpet.108.145508

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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Aerosolized Phosphoinositide 3-Kinase γ/δ Inhibitor TG100-115 [3-[2,4-Diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a Therapeutic Candidate for Asthma and Chronic Obstructive Pulmonary Disease
John Doukas, Lisa Eide, Karin Stebbins, Adrienne Racanelli-Layton, Luis Dellamary, Michael Martin, Elena Dneprovskaia, Glenn Noronha, Richard Soll, Wolfgang Wrasidlo, Lisette M. Acevedo and David A. Cheresh

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 758-765; DOI: https://doi.org/10.1124/jpet.108.144311
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Accumulation of Fingolimod (FTY720) in Lymphoid Tissues Contributes to Prolonged Efficacy
Sven-Christian Sensken, Constantin Bode and Markus H. Gräler

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 963-969; DOI: https://doi.org/10.1124/jpet.108.148163

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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Identification and Characterization of Proximal Promoter Polymorphisms in the Human Concentrative Nucleoside Transporter 2 (SLC28A2)
Sook Wah Yee, James E. Shima, Stephanie Hesselson, Loan Nguyen, Sarah De Val, Rachel J. LaFond, Michiko Kawamoto, Susan J. Johns, Doug Stryke, Pui-Yan Kwok, Thomas E. Ferrin, Brian L. Black, David Gurwitz, Nadav Ahituv and Kathleen M. Giacomini

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 699-707; DOI: https://doi.org/10.1124/jpet.108.147207
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Kinetics of Cellular Retention during Caco-2 Permeation Experiments: Role of Lysosomal Sequestration and Impact on Permeability Estimates
Aki T. Heikkinen, Jukka Mönkkönen and Timo Korjamo

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 882-892; DOI: https://doi.org/10.1124/jpet.108.145797

NEUROPHARMACOLOGY

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Ethanol Withdrawal Provokes Opening of the Mitochondrial Membrane Permeability Transition Pore in an Estrogen-Preventable Manner
Marianna E. Jung, Andrew M. Wilson, Xiaohua Ju, Yi Wen, Daniel B. Metzger and James W. Simpkins

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 692-698; DOI: https://doi.org/10.1124/jpet.108.146829
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Old and New Pharmacology: Positive Allosteric Modulation of the α7 Nicotinic Acetylcholine Receptor by the 5-Hydroxytryptamine_2B/C Receptor Antagonist SB-206553 (3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b′]di pyrrole-1(2H)-carboxamide)
John Dunlop, Tim Lock, Brian Jow, Fabrizio Sitzia, Steven Grauer, Flora Jow, Angela Kramer, Mark R. Bowlby, Andrew Randall, Dianne Kowal, Adam Gilbert, Thomas A. Comery, James LaRocque, Veronica Soloveva, Jon Brown and Renza Roncarati

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 766-776; DOI: https://doi.org/10.1124/jpet.108.146514
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Inhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical Stimulation
Sarah Threlfell, Stephen Sammut, Frank S. Menniti, Christopher J. Schmidt and Anthony R. West

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 785-795; DOI: https://doi.org/10.1124/jpet.108.146332
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Cocaine Alters Vesicular Dopamine Sequestration and Potassium-Stimulated Dopamine Release: The Role of D2 Receptor Activation
Sarah J. Farnsworth, Trent J. Volz, Glen R. Hanson and Annette E. Fleckenstein

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 807-812; DOI: https://doi.org/10.1124/jpet.108.146159
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Cannabinoid Agonists Stimulate [³H]GABA Release in the Globus Pallidus of the Rat When G_i Protein-Receptor Coupling Is Restricted: Role of Dopamine D2 Receptors
Brenda Gonzalez, Francisco Paz, Leonor Florán, Jorge Aceves, David Erlij and Benjamín Florán

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 822-828; DOI: https://doi.org/10.1124/jpet.108.145425
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The Effect of a Chimeric Human/Murine Anti-Cocaine Monoclonal Antibody on Cocaine Self-Administration in Rats
Andrew B. Norman, Mantana K. Norman, William R. Buesing, Michael R. Tabet, Vladimir L. Tsibulsky and William J. Ball

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 873-881; DOI: https://doi.org/10.1124/jpet.108.146407
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The Novel Neuropeptide Y Y₅ Receptor Antagonist Lu AA33810 [N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] Exerts Anxiolytic- and Antidepressant-Like Effects in Rat Models of Stress Sensitivity
Mary W. Walker, Toni D. Wolinsky, Vrej Jubian, Gamini Chandrasena, Huailing Zhong, Xinyan Huang, Silke Miller, Laxminarayan G. Hegde, Douglas A. Marsteller, Mohammad R. Marzabadi, Mariusz Papp, David H. Overstreet, Christophe P. G. Gerald and Douglas A. Craig

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 900-911; DOI: https://doi.org/10.1124/jpet.108.144634
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Protein Kinase Cβ Is a Critical Regulator of Dopamine Transporter Trafficking and Regulates the Behavioral Response to Amphetamine in Mice
Rong Chen, Cheryse A. Furman, Minjia Zhang, Myung N. Kim, Robert W. Gereau, Michael Leitges and Margaret E. Gnegy

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 912-920; DOI: https://doi.org/10.1124/jpet.108.147959
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The Behavioral and Neurochemical Effects of a Novel d-Amino Acid Oxidase Inhibitor Compound 8 [4H-Thieno [3,2-b]pyrrole-5-carboxylic Acid] and d-Serine
Sean M. Smith, Jason M. Uslaner, Lihang Yao, Chadwick M. Mullins, Nathan O. Surles, Sarah L. Huszar, Caitlyn H. McNaughton, Danette M. Pascarella, Monika Kandebo, Richard M. Hinchliffe, Tim Sparey, Nicholas J. Brandon, Brian Jones, Shankar Venkatraman, Mary Beth Young, Nancy Sachs, Marlene A. Jacobson and Peter H. Hutson

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 921-930; DOI: https://doi.org/10.1124/jpet.108.147884
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Nicotinic Receptor Activation Increases [³H]Dopamine Uptake and Cell Surface Expression of Dopamine Transporters in Rat Prefrontal Cortex
Jun Zhu, Subbu Apparsundaram and Linda P. Dwoskin

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 931-939; DOI: https://doi.org/10.1124/jpet.108.147025
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Antipsychotic-Like Effect of Retigabine [N-(2-Amino-4-(fluorobenzylamino)-phenyl)carbamic Acid Ester], a KCNQ Potassium Channel Opener, via Modulation of Mesolimbic Dopaminergic Neurotransmission
Florence Sotty, Trine Damgaard, Liliana P. Montezinho, Arne Mørk, Christina K. Olsen, Christoffer Bundgaard and Henriette Husum

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 951-962; DOI: https://doi.org/10.1124/jpet.108.146944
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The Modulation of Synaptic GABA_A Receptors in the Thalamus by Eszopiclone and Zolpidem
Fan Jia, Peter A. Goldstein and Neil L. Harrison

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 1000-1006; DOI: https://doi.org/10.1124/jpet.108.146084

TOXICOLOGY

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A Role for Mitochondrial Oxidative Stress in Sulfur Mustard Analog 2-Chloroethyl Ethyl Sulfide-Induced Lung Cell Injury and Antioxidant Protection
Neal S. Gould, Carl W. White and Brian J. Day

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 732-739; DOI: https://doi.org/10.1124/jpet.108.145037
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Cardiac-Targeted Expression of Soluble Fas Attenuates Doxorubicin-Induced Cardiotoxicity in Mice
Jianli Niu, Asim Azfer, Kangkai Wang, Xihai Wang and Pappachan E. Kolattukudy

Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 740-748; DOI: https://doi.org/10.1124/jpet.108.146423

Erratum

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Correction to “Radiodefluorination of 3-Fluoro-5-(2-(2-[18F](fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a Radioligand for Imaging Brain Metabotropic Glutamate Subtype-5 Receptors with Positron Emission Tomography, Occurs by Glutathionylation in Rat Brain”
Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 1019;

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Table of Contents

HIGHLIGHTED PAPER

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND DIABETES

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

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