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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

March 01, 2009; Volume 328,Issue 3

HIGHLIGHTED PAPER

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    VEGF Contributes to Ulcerative Colitis Pathogenesis
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 681;

BEHAVIORAL PHARMACOLOGY

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    Discriminative Stimulus Effects of 1-(2,5-Dimethoxy-4-Methylphenyl)-2-Aminopropane in Rhesus Monkeys: Antagonism and Apparent pA2 Analyses
    Jun-Xu Li, Kenner C. Rice and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 976-981; DOI: https://doi.org/10.1124/jpet.108.145458
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    Discriminative Stimulus and Subject-Rated Effects of Methamphetamine, d-Amphetamine, Methylphenidate, and Triazolam in Methamphetamine-Trained Humans
    Rajkumar J. Sevak, William W. Stoops, Lon R. Hays and Craig R. Rush
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 1007-1018; DOI: https://doi.org/10.1124/jpet.108.147124

CARDIOVASCULAR

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    INO-4885 [5,10,15,20-Tetra[N-(benzyl-4′-carboxylate)-2-pyridinium]-21H,23H-porphine Iron(III) Chloride], a Peroxynitrite Decomposition Catalyst, Protects the Heart against Reperfusion Injury in Mice
    Xiang-Ying Jiao, Erhe Gao, Yuexin Yuan, Yajing Wang, Wayne Bond Lau, Walter Koch, Xin-Liang Ma and Ling Tao
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 777-784; DOI: https://doi.org/10.1124/jpet.108.144352
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    Angiotensin-(1-7) with Thioether Bridge: An Angiotensin-Converting Enzyme-Resistant, Potent Angiotensin-(1-7) Analog
    Leon D. Kluskens, S. Adriaan Nelemans, Rick Rink, Louwe de Vries, Anita Meter-Arkema, Yong Wang, Thomas Walther, Anneke Kuipers, Gert N. Moll and Marijke Haas
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 849-854; DOI: https://doi.org/10.1124/jpet.108.146431
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    The Impact of α1-Adrenoceptors Up-Regulation Accompanied by the Impairment of β-Adrenergic Vasodilatation in Hypertension
    Eduardo Oliver, Daniel Martí, Fermí Montó, Nicla Flacco, Lucrecia Moreno, Domingo Barettino, M. Dolores Ivorra and Pilar D'Ocon
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 982-990; DOI: https://doi.org/10.1124/jpet.108.146043
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    Late, but Not Early, Inhibition of Soluble Guanylate Cyclase Decreases Mortality in a Rat Sepsis Model
    Daniel Fernandes, Regina Sordi, Letícia Kramer Pacheco, Geisson Marcos Nardi, Bettina Tomio Heckert, Christina Gaspar Villela, Amanda Revoredo Lobo, Christina Barja-Fidalgo and Jamil Assreuy
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 991-999; DOI: https://doi.org/10.1124/jpet.108.142034

CELLULAR AND MOLECULAR

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    Characterization of Serotonin Receptors in Pregnant Human Myometrium
    Yolande Cordeaux, Dharmintra Pasupathy, Joanne Bacon, D. Stephen Charnock-Jones and Gordon C. S. Smith
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 682-691; DOI: https://doi.org/10.1124/jpet.108.143040
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    Preclinical Efficacy and Safety of 1-Deoxygalactonojirimycin in Mice for Fabry Disease
    Satoshi Ishii, Hui-Hwa Chang, Hidekatsu Yoshioka, Tatsuo Shimada, Kazuaki Mannen, Yasunori Higuchi, Atsumi Taguchi and Jian-Qiang Fan
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 723-731; DOI: https://doi.org/10.1124/jpet.108.149054
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    Cathepsins B and L Differentially Regulate Amyloid Precursor Protein Processing
    Donna M. Klein, Kevin M. Felsenstein and Douglas E. Brenneman
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 813-821; DOI: https://doi.org/10.1124/jpet.108.147082

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Microtubule Binding and Disruption and Induction of Premature Senescence by Disorazole C1
    Marni Brisson Tierno, Carolyn A. Kitchens, Bethany Petrik, Thomas H. Graham, Peter Wipf, Fengfeng L. Xu, William S. Saunders, Brianne S. Raccor, Raghavan Balachandran, Billy W. Day, Jane R. Stout, Claire E. Walczak, Alexander P. Ducruet, Celeste E. Reese and John S. Lazo
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 715-722; DOI: https://doi.org/10.1124/jpet.108.147330
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    The Chemotherapeutic Agents XK469 (2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid) and SH80 (2-{4-[(7-Bromo-2-quinolinyl)oxy]phenoxy}propionic acid) Inhibit Cytokinesis and Promote Polyploidy and Induce Senescence
    John J. Reiners, Miriam Kleinman, Aby Joiakim and Patricia A. Mathieu
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 796-806; DOI: https://doi.org/10.1124/jpet.108.144808
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    Involvement of Extracellular Signal-Regulated Kinase Activation in Human Osteosarcoma Cell Resistance to the Histone Deacetylase Inhibitor FK228 [(1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone]
    Hiroshi Matsubara, Motonobu Watanabe, Tsuyoshi Imai, Yoshihiro Yui, Yasuhiro Mizushima, Yoshimi Hiraumi, Yuri Kamitsuji, Ken-ichiro Watanabe, Koichi Nishijo, Junya Toguchida, Tatsutoshi Nakahata and Souichi Adachi
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 839-848; DOI: https://doi.org/10.1124/jpet.108.147462
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    Double-Stranded RNA-Dependent Protein Kinase-Dependent Apoptosis Induction by a Novel Small Compound
    Wenxian Hu, Wayne Hofstetter, Xiaoli Wei, Wei Guo, Yanbin Zhou, Abujiang Pataer, Hong Li, Bingliang Fang and Stephen G. Swisher
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 866-872; DOI: https://doi.org/10.1124/jpet.108.141754

ENDOCRINE AND DIABETES

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    Glucose-Dependent Enhancement of Diabetic Bladder Contraction Is Associated with a Rho Kinase-Regulated Protein Kinase C Pathway
    Koji Nobe, Taigi Yamazaki, Naoki Tsumita, Terumasa Hashimoto and Kazuo Honda
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 940-950; DOI: https://doi.org/10.1124/jpet.108.144907
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    Inhaled Insulin Is Associated with Prolonged Enhancement of Glucose Disposal in Muscle and Liver in the Canine
    Dale S. Edgerton, Alan D. Cherrington, Doss W. Neal, Melanie Scott, Margaret Lautz, Nancy Brown, Jeff Petro, Charles H. Hobbs, Chet Leach, Angelo Del Parigi and Thomas R. Strack
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 970-975; DOI: https://doi.org/10.1124/jpet.108.146985

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death
    Hao Pan, Partha Mukhopadhyay, Mohanraj Rajesh, Vivek Patel, Bani Mukhopadhyay, Bin Gao, György Haskó and Pál Pacher
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 708-714; DOI: https://doi.org/10.1124/jpet.108.147181
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    Neutralizing Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Reduces Severity of Experimental Ulcerative Colitis in Rats: Direct Evidence for the Pathogenic Role of VEGF
    Ganna Tolstanova, Tetyana Khomenko, Xiaoming Deng, Longchuan Chen, Andrzej Tarnawski, Amrita Ahluwalia, Sandor Szabo and Zsuzsanna Sandor
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 749-757; DOI: https://doi.org/10.1124/jpet.108.145128
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    Improved Antiulcer and Anticancer Properties of a trans-Resveratrol Analog in Mice
    Prasun Guha, Anindya Dey, Biswanath Sarkar, Manish V. Dhyani, Subrata Chattopadhyay and Sandip K. Bandyopadhyay
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 829-838; DOI: https://doi.org/10.1124/jpet.108.145334
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    Identification and Quantification of 2′,3′-cAMP Release by the Kidney
    Jin Ren, Zaichuan Mi, Nicolas A. Stewart and Edwin K. Jackson
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 855-865; DOI: https://doi.org/10.1124/jpet.108.146712
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    Comparison of Receptor Binding Characteristics of Commonly Used Muscarinic Antagonists in Human Bladder Detrusor and Mucosa
    Kylie J. Mansfield, Jonathan J. Chandran, Kenneth J. Vaux, Richard J. Millard, Arthur Christopoulos, Frederick J. Mitchelson and Elizabeth Burcher
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 893-899; DOI: https://doi.org/10.1124/jpet.108.145508

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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    Aerosolized Phosphoinositide 3-Kinase γ/δ Inhibitor TG100-115 [3-[2,4-Diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a Therapeutic Candidate for Asthma and Chronic Obstructive Pulmonary Disease
    John Doukas, Lisa Eide, Karin Stebbins, Adrienne Racanelli-Layton, Luis Dellamary, Michael Martin, Elena Dneprovskaia, Glenn Noronha, Richard Soll, Wolfgang Wrasidlo, Lisette M. Acevedo and David A. Cheresh
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 758-765; DOI: https://doi.org/10.1124/jpet.108.144311
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    Accumulation of Fingolimod (FTY720) in Lymphoid Tissues Contributes to Prolonged Efficacy
    Sven-Christian Sensken, Constantin Bode and Markus H. Gräler
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 963-969; DOI: https://doi.org/10.1124/jpet.108.148163

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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    Identification and Characterization of Proximal Promoter Polymorphisms in the Human Concentrative Nucleoside Transporter 2 (SLC28A2)
    Sook Wah Yee, James E. Shima, Stephanie Hesselson, Loan Nguyen, Sarah De Val, Rachel J. LaFond, Michiko Kawamoto, Susan J. Johns, Doug Stryke, Pui-Yan Kwok, Thomas E. Ferrin, Brian L. Black, David Gurwitz, Nadav Ahituv and Kathleen M. Giacomini
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 699-707; DOI: https://doi.org/10.1124/jpet.108.147207
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    Kinetics of Cellular Retention during Caco-2 Permeation Experiments: Role of Lysosomal Sequestration and Impact on Permeability Estimates
    Aki T. Heikkinen, Jukka Mönkkönen and Timo Korjamo
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 882-892; DOI: https://doi.org/10.1124/jpet.108.145797

NEUROPHARMACOLOGY

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    Ethanol Withdrawal Provokes Opening of the Mitochondrial Membrane Permeability Transition Pore in an Estrogen-Preventable Manner
    Marianna E. Jung, Andrew M. Wilson, Xiaohua Ju, Yi Wen, Daniel B. Metzger and James W. Simpkins
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 692-698; DOI: https://doi.org/10.1124/jpet.108.146829
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    Old and New Pharmacology: Positive Allosteric Modulation of the α7 Nicotinic Acetylcholine Receptor by the 5-Hydroxytryptamine2B/C Receptor Antagonist SB-206553 (3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b′]di pyrrole-1(2H)-carboxamide)
    John Dunlop, Tim Lock, Brian Jow, Fabrizio Sitzia, Steven Grauer, Flora Jow, Angela Kramer, Mark R. Bowlby, Andrew Randall, Dianne Kowal, Adam Gilbert, Thomas A. Comery, James LaRocque, Veronica Soloveva, Jon Brown and Renza Roncarati
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 766-776; DOI: https://doi.org/10.1124/jpet.108.146514
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    Inhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical Stimulation
    Sarah Threlfell, Stephen Sammut, Frank S. Menniti, Christopher J. Schmidt and Anthony R. West
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 785-795; DOI: https://doi.org/10.1124/jpet.108.146332
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    Cocaine Alters Vesicular Dopamine Sequestration and Potassium-Stimulated Dopamine Release: The Role of D2 Receptor Activation
    Sarah J. Farnsworth, Trent J. Volz, Glen R. Hanson and Annette E. Fleckenstein
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 807-812; DOI: https://doi.org/10.1124/jpet.108.146159
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    Cannabinoid Agonists Stimulate [3H]GABA Release in the Globus Pallidus of the Rat When Gi Protein-Receptor Coupling Is Restricted: Role of Dopamine D2 Receptors
    Brenda Gonzalez, Francisco Paz, Leonor Florán, Jorge Aceves, David Erlij and Benjamín Florán
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 822-828; DOI: https://doi.org/10.1124/jpet.108.145425
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    The Effect of a Chimeric Human/Murine Anti-Cocaine Monoclonal Antibody on Cocaine Self-Administration in Rats
    Andrew B. Norman, Mantana K. Norman, William R. Buesing, Michael R. Tabet, Vladimir L. Tsibulsky and William J. Ball
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 873-881; DOI: https://doi.org/10.1124/jpet.108.146407
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    The Novel Neuropeptide Y Y5 Receptor Antagonist Lu AA33810 [N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] Exerts Anxiolytic- and Antidepressant-Like Effects in Rat Models of Stress Sensitivity
    Mary W. Walker, Toni D. Wolinsky, Vrej Jubian, Gamini Chandrasena, Huailing Zhong, Xinyan Huang, Silke Miller, Laxminarayan G. Hegde, Douglas A. Marsteller, Mohammad R. Marzabadi, Mariusz Papp, David H. Overstreet, Christophe P. G. Gerald and Douglas A. Craig
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 900-911; DOI: https://doi.org/10.1124/jpet.108.144634
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    Protein Kinase Cβ Is a Critical Regulator of Dopamine Transporter Trafficking and Regulates the Behavioral Response to Amphetamine in Mice
    Rong Chen, Cheryse A. Furman, Minjia Zhang, Myung N. Kim, Robert W. Gereau, Michael Leitges and Margaret E. Gnegy
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 912-920; DOI: https://doi.org/10.1124/jpet.108.147959
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    The Behavioral and Neurochemical Effects of a Novel d-Amino Acid Oxidase Inhibitor Compound 8 [4H-Thieno [3,2-b]pyrrole-5-carboxylic Acid] and d-Serine
    Sean M. Smith, Jason M. Uslaner, Lihang Yao, Chadwick M. Mullins, Nathan O. Surles, Sarah L. Huszar, Caitlyn H. McNaughton, Danette M. Pascarella, Monika Kandebo, Richard M. Hinchliffe, Tim Sparey, Nicholas J. Brandon, Brian Jones, Shankar Venkatraman, Mary Beth Young, Nancy Sachs, Marlene A. Jacobson and Peter H. Hutson
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 921-930; DOI: https://doi.org/10.1124/jpet.108.147884
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    Nicotinic Receptor Activation Increases [3H]Dopamine Uptake and Cell Surface Expression of Dopamine Transporters in Rat Prefrontal Cortex
    Jun Zhu, Subbu Apparsundaram and Linda P. Dwoskin
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 931-939; DOI: https://doi.org/10.1124/jpet.108.147025
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    Antipsychotic-Like Effect of Retigabine [N-(2-Amino-4-(fluorobenzylamino)-phenyl)carbamic Acid Ester], a KCNQ Potassium Channel Opener, via Modulation of Mesolimbic Dopaminergic Neurotransmission
    Florence Sotty, Trine Damgaard, Liliana P. Montezinho, Arne Mørk, Christina K. Olsen, Christoffer Bundgaard and Henriette Husum
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 951-962; DOI: https://doi.org/10.1124/jpet.108.146944
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    The Modulation of Synaptic GABAA Receptors in the Thalamus by Eszopiclone and Zolpidem
    Fan Jia, Peter A. Goldstein and Neil L. Harrison
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 1000-1006; DOI: https://doi.org/10.1124/jpet.108.146084

TOXICOLOGY

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    A Role for Mitochondrial Oxidative Stress in Sulfur Mustard Analog 2-Chloroethyl Ethyl Sulfide-Induced Lung Cell Injury and Antioxidant Protection
    Neal S. Gould, Carl W. White and Brian J. Day
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 732-739; DOI: https://doi.org/10.1124/jpet.108.145037
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    Cardiac-Targeted Expression of Soluble Fas Attenuates Doxorubicin-Induced Cardiotoxicity in Mice
    Jianli Niu, Asim Azfer, Kangkai Wang, Xihai Wang and Pappachan E. Kolattukudy
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 740-748; DOI: https://doi.org/10.1124/jpet.108.146423

Erratum

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    Correction to “Radiodefluorination of 3-Fluoro-5-(2-(2-[18F](fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a Radioligand for Imaging Brain Metabotropic Glutamate Subtype-5 Receptors with Positron Emission Tomography, Occurs by Glutathionylation in Rat Brain”
    Journal of Pharmacology and Experimental Therapeutics March 2009, 328 (3) 1019;
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Journal of Pharmacology and Experimental Therapeutics: 328 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 328, Issue 3
1 Mar 2009
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  • INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA
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