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Research ArticleMetabolism, Transport, and Pharmacogenomics

Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans

Takao Watanabe, Hiroyuki Kusuhara, Kazuya Maeda, Yoshihisa Shitara and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 652-662; DOI: https://doi.org/10.1124/jpet.108.146647

Article Information

vol. 328 no. 2 652-662
DOI 
https://doi.org/10.1124/jpet.108.146647
PubMed 
19001154
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received September 25, 2008
  • Accepted November 7, 2008
  • Published online January 21, 2009.

Article Versions

Copyright & Usage 
Copyright © 2009 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Takao Watanabe,
  2. Hiroyuki Kusuhara,
  3. Kazuya Maeda,
  4. Yoshihisa Shitara and
  5. Yuichi Sugiyama
  1. Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (T.W., H.K., K.M., Y.Su.); and Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Sh.)
  1. Address correspondence to:
    Dr. Yuichi Sugiyama, Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyoku-Tokyo 113-0033, Japan. E-mail: sugiyama{at}mol.f.u-tokyo.ac.jp
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Research ArticleMetabolism, Transport, and Pharmacogenomics

Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans

Takao Watanabe, Hiroyuki Kusuhara, Kazuya Maeda, Yoshihisa Shitara and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics February 1, 2009, 328 (2) 652-662; DOI: https://doi.org/10.1124/jpet.108.146647
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