Journal of Pharmacology and Experimental Therapeutics: 328 (2)

February 01, 2009; Volume 328,Issue 2

HIGHLIGHTED PAPERS

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The Role of the Farnesoid X Receptor in Intestinal Carcinogenesis
Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 363;
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Anti-Inflammatory Cardioprotection via Formyl-Peptide Receptor-Like 1
Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 363;

PERSPECTIVES IN PHARMACOLOGY

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Desensitization of Nicotinic Acetylcholine Receptors as a Strategy for Drug Development
Jerry J. Buccafusco, J. Warren Beach and Alvin V. Terry

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 364-370; DOI: https://doi.org/10.1124/jpet.108.145292

BEHAVIORAL PHARMACOLOGY

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Unconditioned Behavioral Effects of the Powerful κ-Opioid Hallucinogen Salvinorin A in Nonhuman Primates: Fast Onset and Entry into Cerebrospinal Fluid
Eduardo R. Butelman, Thomas E. Prisinzano, Haiteng Deng, Szymon Rus and Mary Jeanne Kreek

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 588-597; DOI: https://doi.org/10.1124/jpet.108.145342

CARDIOVASCULAR

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Parstatin, the Cleaved Peptide on Proteinase-Activated Receptor 1 Activation, Is a Potent Inhibitor of Angiogenesis
Panagiota Zania, Despina Gourni, Alfred C. Aplin, Roberto F. Nicosia, Christodoulos S. Flordellis, Michael E. Maragoudakis and Nikos E. Tsopanoglou

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 378-389; DOI: https://doi.org/10.1124/jpet.108.145664
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Role of Protein Kinase Cζ and Calcium Entry in KCl-Induced Vascular Smooth Muscle Calcium Sensitization and Feedback Control of Cellular Calcium Levels
Paul H. Ratz and Amy S. Miner

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 399-408; DOI: https://doi.org/10.1124/jpet.108.142422
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Everolimus Inhibits Monocyte/Macrophage Migration in Vitro and Their Accumulation in Carotid Lesions of Cholesterol-Fed Rabbits
Roberta Baetta, Agnese Granata, Monica Canavesi, Nicola Ferri, Lorenzo Arnaboldi, Stefano Bellosta, Pascal Pfister and Alberto Corsini

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 419-425; DOI: https://doi.org/10.1124/jpet.108.144147
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A Novel Peptide Agonist of Formyl-Peptide Receptor-Like 1 (ALX) Displays Anti-Inflammatory and Cardioprotective Effects
Iris Hecht, Jiang Rong, André L. F. Sampaio, Chen Hermesh, Caleb Rutledge, Ronen Shemesh, Amir Toporik, Merav Beiman, Liat Dassa, Hagit Niv, Gady Cojocaru, Arie Zauberman, Galit Rotman, Mauro Perretti, Jakob Vinten-Johansen and Yossi Cohen

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 426-434; DOI: https://doi.org/10.1124/jpet.108.145821
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Angiotensin II-Induced Hypertension Is Associated with a Selective Inhibition of Endothelium-Derived Hyperpolarizing Factor-Mediated Responses in the Rat Mesenteric Artery
Stéphanie Dal-Ros, Christian Bronner, Christa Schott, Modou O. Kane, Marta Chataigneau, Valerie B. Schini-Kerth and Thierry Chataigneau

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 478-486; DOI: https://doi.org/10.1124/jpet.108.145326
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Chymase-Dependent Conversion of Big Endothelin-1 in the Mouse in Vivo
Elie Simard, Denan Jin, Shinji Takai, Mizuo Miyazaki, Isabelle Brochu and Pedro D'Orléans-Juste

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 540-548; DOI: https://doi.org/10.1124/jpet.108.142992
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Calcitonin Gene-Related Peptide Receptor Antagonism Does Not Affect the Severity of Myocardial Ischemia during Atrial Pacing in Dogs with Coronary Artery Stenosis
Christopher P. Regan, Gary L. Stump, Stefanie A. Kane and Joseph J. Lynch

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 571-578; DOI: https://doi.org/10.1124/jpet.108.144220
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Increased Endothelial Nitric-Oxide Synthase Expression Reduces Hypertension and Hyperinsulinemia in Fructose-Treated Rats
Chun Xia Zhao, Xizhen Xu, Yinghua Cui, Peihua Wang, Xin Wei, Shilin Yang, Matthew L. Edin, Darryl C. Zeldin and Dao Wen Wang

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 610-620; DOI: https://doi.org/10.1124/jpet.108.143396
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Molecular Pharmacology of Human Ca_v3.2 T-Type Ca²⁺ Channels: Block by Antihypertensives, Antiarrhythmics, and Their Analogs
Edward Perez-Reyes, Amy L. Van Deusen and Iuliia Vitko

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 621-627; DOI: https://doi.org/10.1124/jpet.108.145672

CELLULAR AND MOLECULAR

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Pharmacological Characterization of Pannexin-1 Currents Expressed in Mammalian Cells
Weihong Ma, Hui Hui, Pablo Pelegrin and Annmarie Surprenant

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 409-418; DOI: https://doi.org/10.1124/jpet.108.146365
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Inhibition of Lipopolysaccharide-Stimulated Chronic Obstructive Pulmonary Disease Macrophage Inflammatory Gene Expression by Dexamethasone and the p38 Mitogen-Activated Protein Kinase Inhibitor N-cyano-N′-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504)
Lauren M. Kent, Lucy J. C. Smyth, Jonathan Plumb, Chris L. Clayton, Steve M. Fox, David W. Ray, Stuart N. Farrow and Dave Singh

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 458-468; DOI: https://doi.org/10.1124/jpet.108.142950

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Carbendazim Inhibits Cancer Cell Proliferation by Suppressing Microtubule Dynamics
Mythili Yenjerla, Corey Cox, Leslie Wilson and Mary Ann Jordan

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 390-398; DOI: https://doi.org/10.1124/jpet.108.143537
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New Ifosfamide Analogs Designed for Lower Associated Neurotoxicity and Nephrotoxicity with Modified Alkylating Kinetics Leading to Enhanced in Vitro Anticancer Activity
Thomas Storme, Alain Deroussent, Lionel Mercier, Elise Prost, Micheline Re, Fabienne Munier, Thierry Martens, Philippe Bourget, Gilles Vassal, Jacques Royer and Angelo Paci

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 598-609; DOI: https://doi.org/10.1124/jpet.108.144170

ENDOCRINE AND DIABETES

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Regulation of Plasma Fructose and Mortality in Mice by the Aldose Reductase Inhibitor Lidorestat
Hye-Lim Noh, Yunying Hu, Tae-Sik Park, Thomas DiCioccio, Andrew J. Nichols, Kazue Okajima, Shunichi Homma and Ira J. Goldberg

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 496-503; DOI: https://doi.org/10.1124/jpet.108.136283
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Chronic Treatment with the Dipeptidyl Peptidase-4 Inhibitor BI 1356 [(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione] Increases Basal Glucagon-Like Peptide-1 and Improves Glycemic Control in Diabetic Rodent Models
Leo Thomas, Moh Tadayyon and Michael Mark

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 556-563; DOI: https://doi.org/10.1124/jpet.108.143966
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Mechanism-Based Modeling of Nutritional and Leptin Influences on Growth in Normal and Type 2 Diabetic Rats
Cornelia B. Landersdorfer, Debra C. DuBois, Richard R. Almon and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 644-651; DOI: https://doi.org/10.1124/jpet.108.144766
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Pharmacokinetics and Pharmacodynamics of LGD-3303 [9-Chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-f]quinolin-7(6H)-one], an Orally Available Nonsteroidal-Selective Androgen Receptor Modulator
Eric G. Vajda, Francisco J. López, Peter Rix, Robert Hill, Yanling Chen, Kyoung-Jin Lee, Z. O'Brien, William Y. Chang, Martin D. Meglasson and Yong-Hee Lee

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 663-670; DOI: https://doi.org/10.1124/jpet.108.146811

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development
Rengasamy R.M. Maran, Ann Thomas, Megan Roth, Zhonghua Sheng, Noriko Esterly, David Pinson, Xin Gao, Yawei Zhang, Vadivel Ganapathy, Frank J. Gonzalez and Grace L. Guo

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 469-477; DOI: https://doi.org/10.1124/jpet.108.145409
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Nociceptin/Orphanin FQ Peptide Receptor Agonist Ac-RYYRWKKKKKKK-NH₂ (ZP120) Induces Antinatriuresis in Rats by Stimulation of Amiloride-Sensitive Sodium Reabsorption
Ulla S. K. van Deurs, Niels Hadrup, Jørgen Søberg Petersen, Sten Christensen and Thomas E. N. Jonassen

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 533-539; DOI: https://doi.org/10.1124/jpet.108.144774
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Vitamin D₃ Modulates the Expression of Bile Acid Regulatory Genes and Represses Inflammation in Bile Duct-Ligated Mice
Michitaka Ogura, Shigeru Nishida, Michiyasu Ishizawa, Kenichi Sakurai, Makoto Shimizu, Sadanori Matsuo, Sadao Amano, Shigeyuki Uno and Makoto Makishima

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 564-570; DOI: https://doi.org/10.1124/jpet.108.145987
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Peroxisome Proliferator-Activated Receptor-α Contributes to the Resolution of Inflammation after Renal Ischemia/Reperfusion Injury
Nimesh S. A. Patel, Rosanna di Paola, Emanuela Mazzon, Domenico Britti, Christoph Thiemermann and Salvatore Cuzzocrea

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 635-643; DOI: https://doi.org/10.1124/jpet.108.146191
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N-(2-Hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a Novel, Potent, and Selective Acid Pump Antagonist for the Treatment of Gastroesophageal Reflux Disease
Hiroki Mori, Hiroko Tonai-Kachi, Yasuo Ochi, Yasuhito Taniguchi, Hiroyuki Ohshiro, Nobuyuki Takahashi, Takeshi Aihara, Akiko Hirao, Teruhisa Kato, Minoru Sakakibara and Yoichi Kurebayashi

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 671-679; DOI: https://doi.org/10.1124/jpet.108.146415

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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Anti-Ccl2 Spiegelmer Permits 75% Dose Reduction of Cyclophosphamide to Control Diffuse Proliferative Lupus Nephritis and Pneumonitis in MRL-Fas(lpr) Mice
Onkar Kulkarni, Dirk Eulberg, Norma Selve, Stefan Zöllner, Ramanjaneyulu Allam, Rahul D. Pawar, Stephanie Pfeiffer, Stephan Segerer, Sven Klussmann and Hans-Joachim Anders

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 371-377; DOI: https://doi.org/10.1124/jpet.108.142711

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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Functional Characterization of Multidrug and Toxin Extrusion Protein 1 as a Facilitative Transporter for Fluoroquinolones
Kin-ya Ohta, Yuichiro Imamura, Noriko Okudaira, Ryou Atsumi, Katsuhisa Inoue and Hiroaki Yuasa

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 628-634; DOI: https://doi.org/10.1124/jpet.108.142257

Metabolism, Transport, and Pharmacogenomics

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Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans
Takao Watanabe, Hiroyuki Kusuhara, Kazuya Maeda, Yoshihisa Shitara and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 652-662; DOI: https://doi.org/10.1124/jpet.108.146647

NEUROPHARMACOLOGY

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The Neuroprotective Effects of Benzylideneacetophenone Derivatives on Excitotoxicity and Inflammation via Phosphorylated Janus Tyrosine Kinase 2/Phosphorylated Signal Transducer and Activator of Transcription 3 and Mitogen-Activated Protein K Pathways
Soyong Jang, Jae-Chul Jung, Dong Hyun Kim, Jong Hoon Ryu, Yongnam Lee, Mankil Jung and Seikwan Oh

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 435-447; DOI: https://doi.org/10.1124/jpet.108.144014
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Novel, Potent, and Selective GABA_C Antagonists Inhibit Myopia Development and Facilitate Learning and Memory
Mary Chebib, Tina Hinton, Katrina L. Schmid, Darren Brinkworth, Haohua Qian, Susana Matos, Hye-Lim Kim, Heba Abdel-Halim, Rohan J. Kumar, Graham A. R. Johnston and Jane R. Hanrahan

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 448-457; DOI: https://doi.org/10.1124/jpet.108.146464
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A Functional Role for Sodium-Dependent Glucose Transport across the Blood-Brain Barrier during Oxygen Glucose Deprivation
Sharanya Vemula, Karen E. Roder, Tianzhi Yang, G. Jayarama Bhat, Thomas J. Thekkumkara and Thomas J. Abbruscato

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 487-495; DOI: https://doi.org/10.1124/jpet.108.146589
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Effect of Novel Negative Allosteric Modulators of Neuronal Nicotinic Receptors on Cells Expressing Native and Recombinant Nicotinic Receptors: Implications for Drug Discovery
Tatiana F. González-Cestari, Brandon J. Henderson, Ryan E. Pavlovicz, Susan B. McKay, Raed A. El-Hajj, Aravinda B. Pulipaka, Crina M. Orac, Damon D. Reed, R. Thomas Boyd, Michael X. Zhu, Chenglong Li, Stephen C. Bergmeier and Dennis B. McKay

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 504-515; DOI: https://doi.org/10.1124/jpet.108.144576
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Differential Pharmacologies of Mecamylamine Enantiomers: Positive Allosteric Modulation and Noncompetitive Inhibition
Nikolai B. Fedorov, Lisa C. Benson, John Graef, Patrick M. Lippiello and Merouane Bencherif

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 525-532; DOI: https://doi.org/10.1124/jpet.108.146910
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In Vitro and in Vivo Pharmacological Characterization of the Neuropeptide S Receptor Antagonist [d-Cys(tBu)⁵]Neuropeptide S
Valeria Camarda, Anna Rizzi, Chiara Ruzza, Silvia Zucchini, Giuliano Marzola, Erika Marzola, Remo Guerrini, Severo Salvadori, Rainer K. Reinscheid, Domenico Regoli and Girolamo Calò

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 549-555; DOI: https://doi.org/10.1124/jpet.108.143867
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Deletion of the Glutamate Receptor 5 Subunit of Kainate Receptors Affects the Development of Morphine Tolerance
Johanna J. Bogulavsky, Ann M. Gregus, Paul T.-H. Kim, Alberto C. S. Costa, Anjali M. Rajadhyaksha and Charles E. Inturrisi

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 579-587; DOI: https://doi.org/10.1124/jpet.108.144121

TOXICOLOGY

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Acute Toxicity of Organophosphorus Compounds in Guinea Pigs Is Sex- and Age-Dependent and Cannot Be Solely Accounted for by Acetylcholinesterase Inhibition
William P. Fawcett, Yasco Aracava, Michael Adler, Edna F. R. Pereira and Edson X. Albuquerque

Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 516-524; DOI: https://doi.org/10.1124/jpet.108.146639

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Table of Contents

HIGHLIGHTED PAPERS

PERSPECTIVES IN PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND DIABETES

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Metabolism, Transport, and Pharmacogenomics

NEUROPHARMACOLOGY

TOXICOLOGY

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