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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

February 01, 2009; Volume 328,Issue 2

HIGHLIGHTED PAPERS

  • You have access
    The Role of the Farnesoid X Receptor in Intestinal Carcinogenesis
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 363;
  • You have access
    Anti-Inflammatory Cardioprotection via Formyl-Peptide Receptor-Like 1
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 363;

PERSPECTIVES IN PHARMACOLOGY

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    Desensitization of Nicotinic Acetylcholine Receptors as a Strategy for Drug Development
    Jerry J. Buccafusco, J. Warren Beach and Alvin V. Terry
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 364-370; DOI: https://doi.org/10.1124/jpet.108.145292

BEHAVIORAL PHARMACOLOGY

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    Unconditioned Behavioral Effects of the Powerful κ-Opioid Hallucinogen Salvinorin A in Nonhuman Primates: Fast Onset and Entry into Cerebrospinal Fluid
    Eduardo R. Butelman, Thomas E. Prisinzano, Haiteng Deng, Szymon Rus and Mary Jeanne Kreek
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 588-597; DOI: https://doi.org/10.1124/jpet.108.145342

CARDIOVASCULAR

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    Parstatin, the Cleaved Peptide on Proteinase-Activated Receptor 1 Activation, Is a Potent Inhibitor of Angiogenesis
    Panagiota Zania, Despina Gourni, Alfred C. Aplin, Roberto F. Nicosia, Christodoulos S. Flordellis, Michael E. Maragoudakis and Nikos E. Tsopanoglou
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 378-389; DOI: https://doi.org/10.1124/jpet.108.145664
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    Role of Protein Kinase Cζ and Calcium Entry in KCl-Induced Vascular Smooth Muscle Calcium Sensitization and Feedback Control of Cellular Calcium Levels
    Paul H. Ratz and Amy S. Miner
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 399-408; DOI: https://doi.org/10.1124/jpet.108.142422
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    Everolimus Inhibits Monocyte/Macrophage Migration in Vitro and Their Accumulation in Carotid Lesions of Cholesterol-Fed Rabbits
    Roberta Baetta, Agnese Granata, Monica Canavesi, Nicola Ferri, Lorenzo Arnaboldi, Stefano Bellosta, Pascal Pfister and Alberto Corsini
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 419-425; DOI: https://doi.org/10.1124/jpet.108.144147
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    A Novel Peptide Agonist of Formyl-Peptide Receptor-Like 1 (ALX) Displays Anti-Inflammatory and Cardioprotective Effects
    Iris Hecht, Jiang Rong, André L. F. Sampaio, Chen Hermesh, Caleb Rutledge, Ronen Shemesh, Amir Toporik, Merav Beiman, Liat Dassa, Hagit Niv, Gady Cojocaru, Arie Zauberman, Galit Rotman, Mauro Perretti, Jakob Vinten-Johansen and Yossi Cohen
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 426-434; DOI: https://doi.org/10.1124/jpet.108.145821
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    Angiotensin II-Induced Hypertension Is Associated with a Selective Inhibition of Endothelium-Derived Hyperpolarizing Factor-Mediated Responses in the Rat Mesenteric Artery
    Stéphanie Dal-Ros, Christian Bronner, Christa Schott, Modou O. Kane, Marta Chataigneau, Valerie B. Schini-Kerth and Thierry Chataigneau
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 478-486; DOI: https://doi.org/10.1124/jpet.108.145326
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    Chymase-Dependent Conversion of Big Endothelin-1 in the Mouse in Vivo
    Elie Simard, Denan Jin, Shinji Takai, Mizuo Miyazaki, Isabelle Brochu and Pedro D'Orléans-Juste
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 540-548; DOI: https://doi.org/10.1124/jpet.108.142992
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    Calcitonin Gene-Related Peptide Receptor Antagonism Does Not Affect the Severity of Myocardial Ischemia during Atrial Pacing in Dogs with Coronary Artery Stenosis
    Christopher P. Regan, Gary L. Stump, Stefanie A. Kane and Joseph J. Lynch
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 571-578; DOI: https://doi.org/10.1124/jpet.108.144220
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    Increased Endothelial Nitric-Oxide Synthase Expression Reduces Hypertension and Hyperinsulinemia in Fructose-Treated Rats
    Chun Xia Zhao, Xizhen Xu, Yinghua Cui, Peihua Wang, Xin Wei, Shilin Yang, Matthew L. Edin, Darryl C. Zeldin and Dao Wen Wang
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 610-620; DOI: https://doi.org/10.1124/jpet.108.143396
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    Molecular Pharmacology of Human Cav3.2 T-Type Ca2+ Channels: Block by Antihypertensives, Antiarrhythmics, and Their Analogs
    Edward Perez-Reyes, Amy L. Van Deusen and Iuliia Vitko
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 621-627; DOI: https://doi.org/10.1124/jpet.108.145672

CELLULAR AND MOLECULAR

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    Pharmacological Characterization of Pannexin-1 Currents Expressed in Mammalian Cells
    Weihong Ma, Hui Hui, Pablo Pelegrin and Annmarie Surprenant
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 409-418; DOI: https://doi.org/10.1124/jpet.108.146365
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    Inhibition of Lipopolysaccharide-Stimulated Chronic Obstructive Pulmonary Disease Macrophage Inflammatory Gene Expression by Dexamethasone and the p38 Mitogen-Activated Protein Kinase Inhibitor N-cyano-N′-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504)
    Lauren M. Kent, Lucy J. C. Smyth, Jonathan Plumb, Chris L. Clayton, Steve M. Fox, David W. Ray, Stuart N. Farrow and Dave Singh
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 458-468; DOI: https://doi.org/10.1124/jpet.108.142950

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Carbendazim Inhibits Cancer Cell Proliferation by Suppressing Microtubule Dynamics
    Mythili Yenjerla, Corey Cox, Leslie Wilson and Mary Ann Jordan
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 390-398; DOI: https://doi.org/10.1124/jpet.108.143537
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    New Ifosfamide Analogs Designed for Lower Associated Neurotoxicity and Nephrotoxicity with Modified Alkylating Kinetics Leading to Enhanced in Vitro Anticancer Activity
    Thomas Storme, Alain Deroussent, Lionel Mercier, Elise Prost, Micheline Re, Fabienne Munier, Thierry Martens, Philippe Bourget, Gilles Vassal, Jacques Royer and Angelo Paci
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 598-609; DOI: https://doi.org/10.1124/jpet.108.144170

ENDOCRINE AND DIABETES

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    Regulation of Plasma Fructose and Mortality in Mice by the Aldose Reductase Inhibitor Lidorestat
    Hye-Lim Noh, Yunying Hu, Tae-Sik Park, Thomas DiCioccio, Andrew J. Nichols, Kazue Okajima, Shunichi Homma and Ira J. Goldberg
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 496-503; DOI: https://doi.org/10.1124/jpet.108.136283
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    Chronic Treatment with the Dipeptidyl Peptidase-4 Inhibitor BI 1356 [(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione] Increases Basal Glucagon-Like Peptide-1 and Improves Glycemic Control in Diabetic Rodent Models
    Leo Thomas, Moh Tadayyon and Michael Mark
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 556-563; DOI: https://doi.org/10.1124/jpet.108.143966
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    Mechanism-Based Modeling of Nutritional and Leptin Influences on Growth in Normal and Type 2 Diabetic Rats
    Cornelia B. Landersdorfer, Debra C. DuBois, Richard R. Almon and William J. Jusko
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 644-651; DOI: https://doi.org/10.1124/jpet.108.144766
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    Pharmacokinetics and Pharmacodynamics of LGD-3303 [9-Chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-f]quinolin-7(6H)-one], an Orally Available Nonsteroidal-Selective Androgen Receptor Modulator
    Eric G. Vajda, Francisco J. López, Peter Rix, Robert Hill, Yanling Chen, Kyoung-Jin Lee, Z. O'Brien, William Y. Chang, Martin D. Meglasson and Yong-Hee Lee
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 663-670; DOI: https://doi.org/10.1124/jpet.108.146811

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

  • You have access
    Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development
    Rengasamy R.M. Maran, Ann Thomas, Megan Roth, Zhonghua Sheng, Noriko Esterly, David Pinson, Xin Gao, Yawei Zhang, Vadivel Ganapathy, Frank J. Gonzalez and Grace L. Guo
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 469-477; DOI: https://doi.org/10.1124/jpet.108.145409
  • You have access
    Nociceptin/Orphanin FQ Peptide Receptor Agonist Ac-RYYRWKKKKKKK-NH2 (ZP120) Induces Antinatriuresis in Rats by Stimulation of Amiloride-Sensitive Sodium Reabsorption
    Ulla S. K. van Deurs, Niels Hadrup, Jørgen Søberg Petersen, Sten Christensen and Thomas E. N. Jonassen
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 533-539; DOI: https://doi.org/10.1124/jpet.108.144774
  • You have access
    Vitamin D3 Modulates the Expression of Bile Acid Regulatory Genes and Represses Inflammation in Bile Duct-Ligated Mice
    Michitaka Ogura, Shigeru Nishida, Michiyasu Ishizawa, Kenichi Sakurai, Makoto Shimizu, Sadanori Matsuo, Sadao Amano, Shigeyuki Uno and Makoto Makishima
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 564-570; DOI: https://doi.org/10.1124/jpet.108.145987
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    Peroxisome Proliferator-Activated Receptor-α Contributes to the Resolution of Inflammation after Renal Ischemia/Reperfusion Injury
    Nimesh S. A. Patel, Rosanna di Paola, Emanuela Mazzon, Domenico Britti, Christoph Thiemermann and Salvatore Cuzzocrea
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 635-643; DOI: https://doi.org/10.1124/jpet.108.146191
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    N-(2-Hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a Novel, Potent, and Selective Acid Pump Antagonist for the Treatment of Gastroesophageal Reflux Disease
    Hiroki Mori, Hiroko Tonai-Kachi, Yasuo Ochi, Yasuhito Taniguchi, Hiroyuki Ohshiro, Nobuyuki Takahashi, Takeshi Aihara, Akiko Hirao, Teruhisa Kato, Minoru Sakakibara and Yoichi Kurebayashi
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 671-679; DOI: https://doi.org/10.1124/jpet.108.146415

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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    Anti-Ccl2 Spiegelmer Permits 75% Dose Reduction of Cyclophosphamide to Control Diffuse Proliferative Lupus Nephritis and Pneumonitis in MRL-Fas(lpr) Mice
    Onkar Kulkarni, Dirk Eulberg, Norma Selve, Stefan Zöllner, Ramanjaneyulu Allam, Rahul D. Pawar, Stephanie Pfeiffer, Stephan Segerer, Sven Klussmann and Hans-Joachim Anders
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 371-377; DOI: https://doi.org/10.1124/jpet.108.142711

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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    Functional Characterization of Multidrug and Toxin Extrusion Protein 1 as a Facilitative Transporter for Fluoroquinolones
    Kin-ya Ohta, Yuichiro Imamura, Noriko Okudaira, Ryou Atsumi, Katsuhisa Inoue and Hiroaki Yuasa
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 628-634; DOI: https://doi.org/10.1124/jpet.108.142257

Metabolism, Transport, and Pharmacogenomics

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    Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans
    Takao Watanabe, Hiroyuki Kusuhara, Kazuya Maeda, Yoshihisa Shitara and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 652-662; DOI: https://doi.org/10.1124/jpet.108.146647

NEUROPHARMACOLOGY

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    The Neuroprotective Effects of Benzylideneacetophenone Derivatives on Excitotoxicity and Inflammation via Phosphorylated Janus Tyrosine Kinase 2/Phosphorylated Signal Transducer and Activator of Transcription 3 and Mitogen-Activated Protein K Pathways
    Soyong Jang, Jae-Chul Jung, Dong Hyun Kim, Jong Hoon Ryu, Yongnam Lee, Mankil Jung and Seikwan Oh
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 435-447; DOI: https://doi.org/10.1124/jpet.108.144014
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    Novel, Potent, and Selective GABAC Antagonists Inhibit Myopia Development and Facilitate Learning and Memory
    Mary Chebib, Tina Hinton, Katrina L. Schmid, Darren Brinkworth, Haohua Qian, Susana Matos, Hye-Lim Kim, Heba Abdel-Halim, Rohan J. Kumar, Graham A. R. Johnston and Jane R. Hanrahan
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 448-457; DOI: https://doi.org/10.1124/jpet.108.146464
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    A Functional Role for Sodium-Dependent Glucose Transport across the Blood-Brain Barrier during Oxygen Glucose Deprivation
    Sharanya Vemula, Karen E. Roder, Tianzhi Yang, G. Jayarama Bhat, Thomas J. Thekkumkara and Thomas J. Abbruscato
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 487-495; DOI: https://doi.org/10.1124/jpet.108.146589
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    Effect of Novel Negative Allosteric Modulators of Neuronal Nicotinic Receptors on Cells Expressing Native and Recombinant Nicotinic Receptors: Implications for Drug Discovery
    Tatiana F. González-Cestari, Brandon J. Henderson, Ryan E. Pavlovicz, Susan B. McKay, Raed A. El-Hajj, Aravinda B. Pulipaka, Crina M. Orac, Damon D. Reed, R. Thomas Boyd, Michael X. Zhu, Chenglong Li, Stephen C. Bergmeier and Dennis B. McKay
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 504-515; DOI: https://doi.org/10.1124/jpet.108.144576
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    Differential Pharmacologies of Mecamylamine Enantiomers: Positive Allosteric Modulation and Noncompetitive Inhibition
    Nikolai B. Fedorov, Lisa C. Benson, John Graef, Patrick M. Lippiello and Merouane Bencherif
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 525-532; DOI: https://doi.org/10.1124/jpet.108.146910
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    In Vitro and in Vivo Pharmacological Characterization of the Neuropeptide S Receptor Antagonist [d-Cys(tBu)5]Neuropeptide S
    Valeria Camarda, Anna Rizzi, Chiara Ruzza, Silvia Zucchini, Giuliano Marzola, Erika Marzola, Remo Guerrini, Severo Salvadori, Rainer K. Reinscheid, Domenico Regoli and Girolamo Calò
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 549-555; DOI: https://doi.org/10.1124/jpet.108.143867
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    Deletion of the Glutamate Receptor 5 Subunit of Kainate Receptors Affects the Development of Morphine Tolerance
    Johanna J. Bogulavsky, Ann M. Gregus, Paul T.-H. Kim, Alberto C. S. Costa, Anjali M. Rajadhyaksha and Charles E. Inturrisi
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 579-587; DOI: https://doi.org/10.1124/jpet.108.144121

TOXICOLOGY

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    Acute Toxicity of Organophosphorus Compounds in Guinea Pigs Is Sex- and Age-Dependent and Cannot Be Solely Accounted for by Acetylcholinesterase Inhibition
    William P. Fawcett, Yasco Aracava, Michael Adler, Edna F. R. Pereira and Edson X. Albuquerque
    Journal of Pharmacology and Experimental Therapeutics February 2009, 328 (2) 516-524; DOI: https://doi.org/10.1124/jpet.108.146639
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Journal of Pharmacology and Experimental Therapeutics: 328 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 328, Issue 2
1 Feb 2009
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