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Research ArticleNEUROPHARMACOLOGY

Neuronal Pentraxins Modulate Cocaine-Induced Neuroadaptations

Alejandra M. Pacchioni, Joseph Vallone, Paul F. Worley and Peter W. Kalivas
Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 183-192; DOI: https://doi.org/10.1124/jpet.108.143115
Alejandra M. Pacchioni
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Joseph Vallone
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Paul F. Worley
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Peter W. Kalivas
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Abstract

Neuronal pentraxins (NPs) function in the extracellular matrix to bind α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Three NPs have been described, neuronal activity-regulated pentraxin (Narp), which is regulated as an immediate early gene, NP1, and neuronal pentraxin receptor (NPR). Narp and NP1 enhance synaptogenesis and glutamate signaling by clustering AMPA receptors, whereas NPR contributes to removing AMPA receptors during group I metabotropic glutamate receptor-dependent long-term depression. Here, we examine mice with genetic deletions [knockout (KO)] of each NP to assess their contributions to cocaine-induced neuroplasticity. Consistent with a shared AMPA receptor clustering function for Narp and NP1, deletion of either NP caused similar behavioral alterations. Thus, although both Narp and NP1 deletion promoted cocaine-induced place preference, NPR deletion was without effect. In addition, although Narp and NP1 KO showed reduced time in the center of a novel environment, NPR KO mice spent more time in the center. Finally, although Narp and NP1 KO mice showed blunted locomotion after AMPA microinjection into the accumbens 3 weeks after discontinuing repeated cocaine injections, the AMPA response was augmented in NPR KO. Likewise, endogenous glutamate release elicited less motor activity in Narp KO mice. Consistent with reduced AMPA responsiveness after chronic cocaine in Narp KO mice, glutamate receptor 1 was reduced in the PSD fraction of Narp KO mice withdrawn from cocaine. These data indicate that NPs differentially contribute to cocaine-induced plasticity in a manner that parallels their actions in synaptic plasticity.

Footnotes

  • This study was supported by United States Public Health Service [Grants DA03906 and DA015851].

  • Article, publication date, and citation information can be found at http://jpet.aspetjournals.org.

  • doi:10.1124/jpet.108.143115.

  • ABBREVIATIONS: NP, neuronal pentraxin; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR, AMPA receptor; Narp, neuronal activity-regulated pentraxin; NPR, neuronal pentraxin receptor; mGluR, group I metabotropic glutamate receptor; GluR, glutamate receptor subunit; KO, knockout; WT, wild type; DHPG, (S)-3,5-dihydroxyphenylglycine; PSD, postsynaptic density fraction; ANOVA, analysis of variance.

  • ↵ Embedded Image The online version of this article (available at http://jpet.aspetjournals.org) contains supplemental material.

    • Received July 5, 2008.
    • Accepted October 6, 2008.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 377 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 377, Issue 2
1 May 2021
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Research ArticleNEUROPHARMACOLOGY

Neuronal Pentraxins Modulate Cocaine-Induced Neuroadaptations

Alejandra M. Pacchioni, Joseph Vallone, Paul F. Worley and Peter W. Kalivas
Journal of Pharmacology and Experimental Therapeutics January 1, 2009, 328 (1) 183-192; DOI: https://doi.org/10.1124/jpet.108.143115

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Research ArticleNEUROPHARMACOLOGY

Neuronal Pentraxins Modulate Cocaine-Induced Neuroadaptations

Alejandra M. Pacchioni, Joseph Vallone, Paul F. Worley and Peter W. Kalivas
Journal of Pharmacology and Experimental Therapeutics January 1, 2009, 328 (1) 183-192; DOI: https://doi.org/10.1124/jpet.108.143115
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