Journal of Pharmacology and Experimental Therapeutics: 328 (1)

January 01, 2009; Volume 328,Issue 1

EDITOR'S NOTE

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Rick G. Schnellmann

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 1;

HIGHLIGHTED PAPERS

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Pentraxins as Modulators of Cocaine-Induced Synaptic Modulation
Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 2;
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The Mechanism Behind Lecithinized Superoxide Dismutase Therapy
Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 2;
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A Role for the Farnesoid X Receptor in Nonalcoholic Steatohepatitis
Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 2;

PERSPECTIVES IN PHARMACOLOGY

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The Role of ATP Binding Cassette Transporters in Tissue Defense and Organ Regeneration
Miriam Huls, Frans G. M. Russel and Rosalinde Masereeuw

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 3-9; DOI: https://doi.org/10.1124/jpet.107.132225

BEHAVIORAL PHARMACOLOGY

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Effects of Atypical κ-Opioid Receptor Agonists on Intrathecal Morphine-Induced Itch and Analgesia in Primates
Mei-Chuan Ko and Stephen M. Husbands

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 193-200; DOI: https://doi.org/10.1124/jpet.108.143925
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M₅ Muscarinic Receptor Knockout Mice Show Reduced Morphine-Induced Locomotion but Increased Locomotion after Cholinergic Antagonism in the Ventral Tegmental Area
Stephan Steidl and John S. Yeomans

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 263-275; DOI: https://doi.org/10.1124/jpet.108.144824
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α₁-Adrenoceptors Mediate Dihydroxyphenylalanine-Induced Activity in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Lesioned Macaques
N. P. Visanji, S. H. Fox, T. H. Johnston, M. J. Millan and J. M. Brotchie

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 276-283; DOI: https://doi.org/10.1124/jpet.108.144097
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Divergent Effects of Anandamide Transporter Inhibitors with Different Target Selectivity on Social Play Behavior in Adolescent Rats
Viviana Trezza and Louk J. M. J. Vanderschuren

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 343-350; DOI: https://doi.org/10.1124/jpet.108.141069

CARDIOVASCULAR

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A Novel and Orally Active Poly(ADP-Ribose) Polymerase Inhibitor, KR-33889 [2-[Methoxycarbonyl(4-methoxyphenyl) methylsulfanyl]-1H-benzimidazole-4-carboxylic Acid Amide], Attenuates Injury in in Vitro Model of Cell Death and in Vivo Model of Cardiac Ischemia
Kwang-Seok Oh, Sunkyung Lee, Kyu Yang Yi, Ho Won Seo, Hyun-Na Koo and Byung Ho Lee

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 10-18; DOI: https://doi.org/10.1124/jpet.108.143719
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Hypertension Increases Contractile Responses to Hydrogen Peroxide in Resistance Arteries through Increased Thromboxane A₂, Ca²⁺, and Superoxide Anion Levels
Ana Belén García-Redondo, Ana María Briones, Amada Elia Beltrán, María Jesús Alonso, Ulf Simonsen and Mercedes Salaices

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 19-27; DOI: https://doi.org/10.1124/jpet.108.144295
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Brainstem Adenosine A₁ Receptor Signaling Masks Phosphorylated Extracellular Signal-Regulated Kinase 1/2-Dependent Hypotensive Action of Clonidine in Conscious Normotensive Rats
Noha Nassar and Abdel A. Abdel-Rahman

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 83-89; DOI: https://doi.org/10.1124/jpet.108.143883
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Opposite Effects of Two Resveratrol (trans-3,5,4′-Trihydroxystilbene) Tetramers, Vitisin A and Hopeaphenol, on Apoptosis of Myocytes Isolated from Adult Rat Heart
Kazuhiko Seya, Kouta Kanemaru, Chiharu Sugimoto, Megumi Suzuki, Teruko Takeo, Shigeru Motomura, Haruo Kitahara, Masatake Niwa, Yoshiteru Oshima and Ken-Ichi Furukawa

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 90-98; DOI: https://doi.org/10.1124/jpet.108.143172
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Chronic Cocaine-Induced Cardiac Oxidative Stress and Mitogen-Activated Protein Kinase Activation: The Role of Nox2 Oxidase
Lampson Fan, David Sawbridge, Vinoj George, Lei Teng, Alexis Bailey, Ian Kitchen and Jian-Mei Li

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 99-106; DOI: https://doi.org/10.1124/jpet.108.145201
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Distinct Roles of Estrogen Receptor-α and β in the Modulation of Vascular Inducible Nitric-Oxide Synthase in Diabetes
Andrea Cignarella, Chiara Bolego, Valeria Pelosi, Clara Meda, Andrée Krust, Christian Pinna, Rosa Maria Gaion, Elisabetta Vegeto and Adriana Maggi

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 174-182; DOI: https://doi.org/10.1124/jpet.108.143511
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Increased Oxidant Activity Mediates Vascular Dysfunction in Vibration Injury
Jennifer M. Hughes, Oliver Wirth, Kristine Krajnak, Roger Miller, Sheila Flavahan, Dan E. Berkowitz, Dan Welcome and Nicholas A. Flavahan

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 223-230; DOI: https://doi.org/10.1124/jpet.108.144618
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Epoxyeicosatrienoic Acids Function as Selective, Endogenous Antagonists of Native Thromboxane Receptors: Identification of a Novel Mechanism of Vasodilation
David J. Behm, Andrea Ogbonna, Charlene Wu, Cynthia L. Burns-Kurtis and Stephen A. Douglas

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 231-239; DOI: https://doi.org/10.1124/jpet.108.145102
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Partial A₁ Adenosine Receptor Agonist Regulates Cardiac Substrate Utilization in Insulin-Resistant Rats in Vivo
Jane Shearer, David L. Severson, Lin Su, Luiz Belardinelli and Arvinder K. Dhalla

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 306-311; DOI: https://doi.org/10.1124/jpet.108.143594
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The Endogenous Brain Constituent N-Arachidonoyl l-Serine Is an Activator of Large Conductance Ca²⁺-Activated K⁺ Channels
Grzegorz Godlewski, László Offertáler, Douglas Osei-Hyiaman, Fong Ming Mo, Judith Harvey-White, Jie Liu, Margaret I. Davis, Li Zhang, Raj K. Razdan, Garry Milman, Pal Pacher, Partha Mukhopadhyay, David M. Lovinger and George Kunos

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 351-361; DOI: https://doi.org/10.1124/jpet.108.144717

CELLULAR AND MOLECULAR

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Selectivity of Agonists for the Active State of M₁ to M₄ Muscarinic Receptor Subtypes
Katherine W. Figueroa, Michael T. Griffin and Frederick J. Ehlert

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 331-342; DOI: https://doi.org/10.1124/jpet.108.145219

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Improved Pharmacokinetics and Efficacy of a Highly Stable Nanoliposomal Vinorelbine
Daryl C. Drummond, Charles O. Noble, Zexiong Guo, Mark E. Hayes, John W. Park, Ching-Ju Ou, Yun-Long Tseng, Keelung Hong and Dmitri B. Kirpotin

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 321-330; DOI: https://doi.org/10.1124/jpet.108.141200

ENDOCRINE AND DIABETES

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Differential Effects of Diet-Induced Dyslipidemia and Hyperglycemia on Mesenteric Resistance Artery Structure and Function in Type 2 Diabetes
Kamakshi Sachidanandam, Jim R. Hutchinson, Mostafa M. Elgebaly, Erin M. Mezzetti, Mong-Heng Wang and Adviye Ergul

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 123-130; DOI: https://doi.org/10.1124/jpet.108.142612

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Suplatast Tosilate Prevents Bleomycin-Induced Pulmonary Fibrosis in Mice
Makoto Furonaka, Noboru Hattori, Takuya Tanimoto, Tadashi Senoo, Nobuhisa Ishikawa, Kazunori Fujitaka, Yoshinori Haruta, Akihito Yokoyama and Nobuoki Kohno

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 55-61; DOI: https://doi.org/10.1124/jpet.108.141721
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Sensitization by 5-Azacytidine toward Death Receptor-Induced Hepatic Apoptosis
Timo Weiland, Markus Weiller, Gerald Künstle and Albrecht Wendel

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 107-115; DOI: https://doi.org/10.1124/jpet.108.143560
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Farnesoid X Receptor Deficiency Induces Nonalcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Knockout Mice Fed a High-Fat Diet
Bo Kong, James P. Luyendyk, Ossama Tawfik and Grace L. Guo

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 116-122; DOI: https://doi.org/10.1124/jpet.108.144600
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Therapeutic Effect of Lecithinized Superoxide Dismutase against Colitis
Tomoaki Ishihara, Ken-Ichiro Tanaka, Yuichi Tasaka, Takushi Namba, Jun Suzuki, Tsutomu Ishihara, Susumu Okamoto, Toshifumi Hibi, Mitsuko Takenaga, Rie Igarashi, Keizo Sato, Yutaka Mizushima and Tohru Mizushima

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 152-164; DOI: https://doi.org/10.1124/jpet.108.144451
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Catecholamines Relax Detrusor through β₂-Adrenoceptors in Mouse and β₃-Adrenoceptors in Man
Melinda Wuest, Birgit Eichhorn, Marc O. Grimm, Manfred P. Wirth, Ursula Ravens and Alberto J. Kaumann

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 213-222; DOI: https://doi.org/10.1124/jpet.108.142562
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Risperidone Attenuates Local and Systemic Inflammatory Responses to Ameliorate Diet-Induced Severe Necrotic Pancreatitis in Mice: It May Provide a New Therapy for Acute Pancreatitis
Isamu Yamaguchi, Kentaro Hamada, Masanori Yoshida, Hiroyuki Isayama, Shuichi Kanazashi and Koji Takeuchi

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 256-262; DOI: https://doi.org/10.1124/jpet.108.141895
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Computational Strategies Unravel and Trace How Liver Disease Changes Hepatic Drug Disposition
Sunwoo Park, Glen E. P. Ropella, Sean H. J. Kim, Michael S. Roberts and C. Anthony Hunt

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 294-305; DOI: https://doi.org/10.1124/jpet.108.142497

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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CNTO736, a Novel Glucagon-Like Peptide-1 Receptor Agonist, Ameliorates Insulin Resistance and Inhibits Very Low-Density Lipoprotein Production in High-Fat-Fed Mice
Edwin T. Parlevliet, Janny P. Schröder-van der Elst, Eleonora P. M. Corssmit, Kristen Picha, Karyn O'Neil, Vedrana Stojanovic-Susulic, Tatiana Ort, Louis M. Havekes, Johannes A. Romijn and Hanno Pijl

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 240-248; DOI: https://doi.org/10.1124/jpet.108.144154
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Decreased Oral Absorption of Cyclosporine A after Liver Ischemia-Reperfusion Injury in Rats: The Contribution of CYP3A and P-Glycoprotein to the First-Pass Metabolism in Intestinal Epithelial Cells
Kenji Ikemura, Kimihiko Urano, Hiroko Matsuda, Hideki Mizutani, Takuya Iwamoto and Masahiro Okuda

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 249-255; DOI: https://doi.org/10.1124/jpet.108.145581
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Novel Vasoconstrictor Formulation to Enhance Intranasal Targeting of Neuropeptide Therapeutics to the Central Nervous System
Shyeilla V. Dhuria, Leah R. Hanson and William H. Frey

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 312-320; DOI: https://doi.org/10.1124/jpet.108.145565

NEUROPHARMACOLOGY

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A Positive Modulator of K_Ca2 and K_Ca3 Channels, 4,5-Dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), Inhibits Bladder Afferent Firing in Vitro and Bladder Overactivity in Vivo
C. Hougaard, M. O. Fraser, C. Chien, A. Bookout, M. Katofiasc, B. S. Jensen, F. Rode, J. Bitsch-Nørhave, L. Teuber, K. B. Thor, D. Strøbæk, E. C. Burgard and L. C. B. Rønn

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 28-39; DOI: https://doi.org/10.1124/jpet.108.143123
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Ligand Selectivity of D₂ Dopamine Receptors Is Modulated by Changes in Local Dynamics Produced by Sodium Binding
Spencer S. Ericksen, David F. Cummings, Harel Weinstein and John A. Schetz

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 40-54; DOI: https://doi.org/10.1124/jpet.108.141531
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A Single in Vivo Application of Cholinesterase Inhibitors Has Neuron Type-Specific Effects on Nicotinic Receptor Activity in Guinea Pig Hippocampus
Manickavasagom Alkondon, Yasco Aracava, Edna F. R. Pereira and Edson X. Albuquerque

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 69-82; DOI: https://doi.org/10.1124/jpet.108.146068
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First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates
Sethu Sankaranarayanan, Marie A. Holahan, Dennis Colussi, Ming-Chih Crouthamel, Viswanath Devanarayan, Joan Ellis, Amy Espeseth, Adam T. Gates, Samuel L. Graham, Allison R. Gregro, Daria Hazuda, Jerome H. Hochman, Katharine Holloway, Lixia Jin, Jason Kahana, Ming-tain Lai, Janet Lineberger, Georgia McGaughey, Keith P. Moore, Philippe Nantermet, Beth Pietrak, Eric A. Price, Hemaka Rajapakse, Shaun Stauffer, Melissa A. Steinbeiser, Guy Seabrook, Harold G. Selnick, Xiao-Ping Shi, Matthew G. Stanton, John Swestock, Katherine Tugusheva, Keala X. Tyler, Joseph P. Vacca, Jacky Wong, Guoxin Wu, Min Xu, Jacquelynn J. Cook and Adam J. Simon

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 131-140; DOI: https://doi.org/10.1124/jpet.108.143628
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Characterization of a Cannabinoid CB₂ Receptor-Selective Agonist, A-836339 [2,2,3,3-Tetramethyl-cyclopropanecarboxylic Acid [3-(2-Methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], Using in Vitro Pharmacological Assays, in Vivo Pain Models, and Pharmacological Magnetic Resonance Imaging
Betty B. Yao, Gin Hsieh, Anthony V. Daza, Yihong Fan, George K. Grayson, Tiffany Runyan Garrison, Odile El Kouhen, Bradley A. Hooker, Madhavi Pai, Erica J. Wensink, Anita K. Salyers, Prasant Chandran, Chang Z. Zhu, Chengmin Zhong, Keith Ryther, Megan E. Gallagher, Chih-Liang Chin, Ann E. Tovcimak, Vincent P. Hradil, Gerard B. Fox, Michael J. Dart, Prisca Honore and Michael D. Meyer

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 141-151; DOI: https://doi.org/10.1124/jpet.108.145011
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The Role of Melanin-Concentrating Hormone-1 Receptors in the Voiding Reflex in Rats
Laxminarayan G. Hegde, Xiao Li Ping, Nina Jochnowitz and Douglas A. Craig

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 165-173; DOI: https://doi.org/10.1124/jpet.108.143495
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Neuronal Pentraxins Modulate Cocaine-Induced Neuroadaptations
Alejandra M. Pacchioni, Joseph Vallone, Paul F. Worley and Peter W. Kalivas

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 183-192; DOI: https://doi.org/10.1124/jpet.108.143115
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Modulation of Sodium Channel Inactivation Gating by a Novel Lactam: Implications for Seizure Suppression in Chronic Limbic Epilepsy
Paulianda J. Jones, Ellen C. Merrick, Timothy W. Batts, Nicholas J. Hargus, Yuesheng Wang, James P. Stables, Edward H. Bertram, Milton L. Brown and Manoj K. Patel

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 201-212; DOI: https://doi.org/10.1124/jpet.108.144709
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μ-Opioid Receptors Selectively Regulate Basal Inhibitory Transmission in the Central Amygdala: Lack of Ethanol Interactions
Maeng-Hee Kang-Park, Brigitte L. Kieffer, Amanda J. Roberts, Marisa Roberto, Samuel G. Madamba, George Robert Siggins and Scott D. Moore

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 284-293; DOI: https://doi.org/10.1124/jpet.108.140749

TOXICOLOGY

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Tumor Necrosis Factorα Is a Proximal Mediator of Synergistic Hepatotoxicity from Trovafloxacin/Lipopolysaccharide Coexposure
Patrick J. Shaw, Patricia E. Ganey and Robert A. Roth

Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 62-68; DOI: https://doi.org/10.1124/jpet.108.143792

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Table of Contents

EDITOR'S NOTE

HIGHLIGHTED PAPERS

PERSPECTIVES IN PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND DIABETES

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

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