Table of Contents

NEUROPHARMACOLOGY

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  A Positive Modulator of K_Ca2 and K_Ca3 Channels, 4,5-Dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), Inhibits Bladder Afferent Firing in Vitro and Bladder Overactivity in Vivo

  C. Hougaard, M. O. Fraser, C. Chien, A. Bookout, M. Katofiasc, B. S. Jensen, F. Rode, J. Bitsch-Nørhave, L. Teuber, K. B. Thor, D. Strøbæk, E. C. Burgard and L. C. B. Rønn

  Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 28-39; DOI: https://doi.org/10.1124/jpet.108.143123
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  Ligand Selectivity of D₂ Dopamine Receptors Is Modulated by Changes in Local Dynamics Produced by Sodium Binding

  Spencer S. Ericksen, David F. Cummings, Harel Weinstein and John A. Schetz

  Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 40-54; DOI: https://doi.org/10.1124/jpet.108.141531
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  A Single in Vivo Application of Cholinesterase Inhibitors Has Neuron Type-Specific Effects on Nicotinic Receptor Activity in Guinea Pig Hippocampus

  Manickavasagom Alkondon, Yasco Aracava, Edna F. R. Pereira and Edson X. Albuquerque

  Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 69-82; DOI: https://doi.org/10.1124/jpet.108.146068
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  First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

  Sethu Sankaranarayanan, Marie A. Holahan, Dennis Colussi, Ming-Chih Crouthamel, Viswanath Devanarayan, Joan Ellis, Amy Espeseth, Adam T. Gates, Samuel L. Graham, Allison R. Gregro, Daria Hazuda, Jerome H. Hochman, Katharine Holloway, Lixia Jin, Jason Kahana, Ming-tain Lai, Janet Lineberger, Georgia McGaughey, Keith P. Moore, Philippe Nantermet, Beth Pietrak, Eric A. Price, Hemaka Rajapakse, Shaun Stauffer, Melissa A. Steinbeiser, Guy Seabrook, Harold G. Selnick, Xiao-Ping Shi, Matthew G. Stanton, John Swestock, Katherine Tugusheva, Keala X. Tyler, Joseph P. Vacca, Jacky Wong, Guoxin Wu, Min Xu, Jacquelynn J. Cook and Adam J. Simon

  Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 131-140; DOI: https://doi.org/10.1124/jpet.108.143628
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  Characterization of a Cannabinoid CB₂ Receptor-Selective Agonist, A-836339 [2,2,3,3-Tetramethyl-cyclopropanecarboxylic Acid [3-(2-Methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], Using in Vitro Pharmacological Assays, in Vivo Pain Models, and Pharmacological Magnetic Resonance Imaging

  Betty B. Yao, Gin Hsieh, Anthony V. Daza, Yihong Fan, George K. Grayson, Tiffany Runyan Garrison, Odile El Kouhen, Bradley A. Hooker, Madhavi Pai, Erica J. Wensink, Anita K. Salyers, Prasant Chandran, Chang Z. Zhu, Chengmin Zhong, Keith Ryther, Megan E. Gallagher, Chih-Liang Chin, Ann E. Tovcimak, Vincent P. Hradil, Gerard B. Fox, Michael J. Dart, Prisca Honore and Michael D. Meyer

  Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 141-151; DOI: https://doi.org/10.1124/jpet.108.145011
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  The Role of Melanin-Concentrating Hormone-1 Receptors in the Voiding Reflex in Rats

  Laxminarayan G. Hegde, Xiao Li Ping, Nina Jochnowitz and Douglas A. Craig

  Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 165-173; DOI: https://doi.org/10.1124/jpet.108.143495
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  Neuronal Pentraxins Modulate Cocaine-Induced Neuroadaptations

  Alejandra M. Pacchioni, Joseph Vallone, Paul F. Worley and Peter W. Kalivas

  Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 183-192; DOI: https://doi.org/10.1124/jpet.108.143115
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  Modulation of Sodium Channel Inactivation Gating by a Novel Lactam: Implications for Seizure Suppression in Chronic Limbic Epilepsy

  Paulianda J. Jones, Ellen C. Merrick, Timothy W. Batts, Nicholas J. Hargus, Yuesheng Wang, James P. Stables, Edward H. Bertram, Milton L. Brown and Manoj K. Patel

  Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 201-212; DOI: https://doi.org/10.1124/jpet.108.144709
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  μ-Opioid Receptors Selectively Regulate Basal Inhibitory Transmission in the Central Amygdala: Lack of Ethanol Interactions

  Maeng-Hee Kang-Park, Brigitte L. Kieffer, Amanda J. Roberts, Marisa Roberto, Samuel G. Madamba, George Robert Siggins and Scott D. Moore

  Journal of Pharmacology and Experimental Therapeutics January 2009, 328 (1) 284-293; DOI: https://doi.org/10.1124/jpet.108.140749