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Research ArticleMETABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Radiodefluorination of 3-Fluoro-5-(2-(2-[18F](fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a Radioligand for Imaging Brain Metabotropic Glutamate Subtype-5 Receptors with Positron Emission Tomography, Occurs by Glutathionylation in Rat Brain

H. Umesha Shetty, Sami S. Zoghbi, Fabrice G. Siméon, Jeih-San Liow, Amira K. Brown, Pavitra Kannan, Robert B. Innis and Victor W. Pike
Journal of Pharmacology and Experimental Therapeutics December 2008, 327 (3) 727-735; DOI: https://doi.org/10.1124/jpet.108.143347

Article Information

vol. 327 no. 3 727-735
DOI 
https://doi.org/10.1124/jpet.108.143347
PubMed 
18806125
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received July 9, 2008
  • Accepted September 18, 2008
  • Published online November 12, 2008.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. H. Umesha Shetty,
  2. Sami S. Zoghbi,
  3. Fabrice G. Siméon,
  4. Jeih-San Liow,
  5. Amira K. Brown,
  6. Pavitra Kannan,
  7. Robert B. Innis and
  8. Victor W. Pike
  1. Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
  1. Address correspondence to:
    Dr. H. Umesha Shetty, PET Radiopharmaceutical Sciences, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bldg. 10, Rm B3 C351, 10 Center Dr., MSC 1003, Bethesda, MD 20892-1003. E-mail: shettyu{at}mail.nih.gov
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Research ArticleMETABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Radiodefluorination of 3-Fluoro-5-(2-(2-[18F](fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a Radioligand for Imaging Brain Metabotropic Glutamate Subtype-5 Receptors with Positron Emission Tomography, Occurs by Glutathionylation in Rat Brain

H. Umesha Shetty, Sami S. Zoghbi, Fabrice G. Siméon, Jeih-San Liow, Amira K. Brown, Pavitra Kannan, Robert B. Innis and Victor W. Pike
Journal of Pharmacology and Experimental Therapeutics December 1, 2008, 327 (3) 727-735; DOI: https://doi.org/10.1124/jpet.108.143347
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