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Research ArticleMETABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Increasing Systemic Exposure of Methotrexate by Active Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3)

Yoshiaki Kitamura, Masakazu Hirouchi, Hiroyuki Kusuhara, John D. Schuetz and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 465-473; DOI: https://doi.org/10.1124/jpet.108.140475
Yoshiaki Kitamura
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Masakazu Hirouchi
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Hiroyuki Kusuhara
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John D. Schuetz
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Yuichi Sugiyama
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Article Information

vol. 327 no. 2 465-473
DOI 
https://doi.org/10.1124/jpet.108.140475
PubMed 
18719291

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 28, 2008
  • Accepted July 14, 2008
  • Published online October 17, 2008.

Article Versions

  • Earlier version (August 21, 2008 - 11:58).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yoshiaki Kitamura,
  2. Masakazu Hirouchi,
  3. Hiroyuki Kusuhara,
  4. John D. Schuetz and
  5. Yuichi Sugiyama
  1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (Y.K., M.H., H.K., Y.S.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (J.D.S.)
  1. Address correspondence to:
    Dr. Hiroyuki Kusuhara, Associate Professor, Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. E-mail: kusuhara{at}mol.f.u-tokyo.ac.jp
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Journal of Pharmacology and Experimental Therapeutics: 377 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 377, Issue 2
1 May 2021
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Research ArticleMETABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Increasing Systemic Exposure of Methotrexate by Active Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3)

Yoshiaki Kitamura, Masakazu Hirouchi, Hiroyuki Kusuhara, John D. Schuetz and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics November 1, 2008, 327 (2) 465-473; DOI: https://doi.org/10.1124/jpet.108.140475

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Research ArticleMETABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Increasing Systemic Exposure of Methotrexate by Active Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3)

Yoshiaki Kitamura, Masakazu Hirouchi, Hiroyuki Kusuhara, John D. Schuetz and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics November 1, 2008, 327 (2) 465-473; DOI: https://doi.org/10.1124/jpet.108.140475
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