Journal of Pharmacology and Experimental Therapeutics: 327 (2)

November 01, 2008; Volume 327,Issue 2

HIGHLIGHTED PAPERS

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Dissecting Oxidative Stress following Ischemic Reperfusion
Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 287;
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An Unexpected Role for Peripheral Serotonin 5-HT_2A Receptors
Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 287;
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T-Cell Migrations during Inflammatory Bowel Disease
Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 287;

CENTENNIAL PERSPECTIVE

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Humanized Mouse Lines and Their Application for Prediction of Human Drug Metabolism and Toxicological Risk Assessment
Connie Cheung and Frank J. Gonzalez

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 288-299; DOI: https://doi.org/10.1124/jpet.108.141242

PERSPECTIVES IN PHARMACOLOGY

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Regulation and Pathological Role of p53 in Cisplatin Nephrotoxicity
Man Jiang and Zheng Dong

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 300-307; DOI: https://doi.org/10.1124/jpet.108.139162

BEHAVIORAL PHARMACOLOGY

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Inhibition of Anandamide Hydrolysis by Cyclohexyl Carbamic Acid 3′-Carbamoyl-3-yl Ester (URB597) Reverses Abuse-Related Behavioral and Neurochemical Effects of Nicotine in Rats
Maria Scherma, Leigh V. Panlilio, Paola Fadda, Liana Fattore, Islam Gamaleddin, Bernard Le Foll, Zuzana Justinová, Eva Mikics, Jozsef Haller, Julie Medalie, Jessica Stroik, Chanel Barnes, Sevil Yasar, Gianluigi Tanda, Daniele Piomelli, Walter Fratta and Steven R. Goldberg

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 482-490; DOI: https://doi.org/10.1124/jpet.108.142224
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Selective Activation of Cannabinoid CB₂ Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats
Elizabeth J. Rahn, Alexander M. Zvonok, Ganesh A. Thakur, Atmaram D. Khanolkar, Alexandros Makriyannis and Andrea G. Hohmann

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 584-591; DOI: https://doi.org/10.1124/jpet.108.141994

CARDIOVASCULAR

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Bivalirudin Decreases NO Bioavailability by Vascular Immobilization of Myeloperoxidase
Volker Rudolph, Tanja K. Rudolph, Francisco J. Schopfer, Gustavo Bonacci, Denise Lau, Katalin Szöcs, Anna Klinke, Thomas Meinertz, Bruce A. Freeman and Stephan Baldus

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 324-331; DOI: https://doi.org/10.1124/jpet.108.142414
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Antiatherosclerotic Effects of a Novel Synthetic Tissue-Selective Steroidal Liver X Receptor Agonist in Low-Density Lipoprotein Receptor-Deficient Mice
Dacheng Peng, Richard A. Hiipakka, Qing Dai, Jian Guo, Catherine A. Reardon, Godfrey S. Getz and Shutsung Liao

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 332-342; DOI: https://doi.org/10.1124/jpet.108.142687
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Formation of Hydrogen Peroxide and Reduction of Peroxynitrite via Dismutation of Superoxide at Reperfusion Enhances Myocardial Blood Flow and Oxygen Consumption in Postischemic Mouse Heart
Yi Xu, Bin Liu, Jay L. Zweier and Guanglong He

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 402-410; DOI: https://doi.org/10.1124/jpet.108.142372
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Effect of cGMP on Pharmacomechanical Coupling in the Uterine Artery of Near-Term Pregnant Sheep
Lubo Zhang, DaLiao Xiao and Xiangqun Hu

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 425-431; DOI: https://doi.org/10.1124/jpet.108.141283

CELLULAR AND MOLECULAR

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Evidence for an Asialoglycoprotein Receptor on Nonparenchymal Cells for O-Linked Glycoproteins
Eric G. Stefanich, Song Ren, Dimitry M. Danilenko, Amy Lim, An Song, Suhasini Iyer and Paul J. Fielder

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 308-315; DOI: https://doi.org/10.1124/jpet.108.142232
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G Protein Coupling and Signaling Pathway Activation by M₁ Muscarinic Acetylcholine Receptor Orthosteric and Allosteric Agonists
Rachel L. Thomas, Rajendra Mistry, Christopher J. Langmead, Martyn D. Wood and R. A. John Challiss

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 365-374; DOI: https://doi.org/10.1124/jpet.108.141788
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Use of Acetylcholine Mustard to Study Allosteric Interactions at the M₂ Muscarinic Receptor
Hinako Suga, Katherine W. Figueroa and Frederick J. Ehlert

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 518-528; DOI: https://doi.org/10.1124/jpet.108.141234

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Enhancement of Cisplatin [cis-Diammine Dichloroplatinum (II)] Cytotoxicity by O⁶-Benzylguanine Involves Endoplasmic Reticulum Stress
Cara A. Rabik, Melissa L. Fishel, Julianne L. Holleran, Kristen Kasza, Mark R. Kelley, Merrill J. Egorin and M. Eileen Dolan

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 442-452; DOI: https://doi.org/10.1124/jpet.108.141291

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Clotrimazole Ameliorates Intestinal Inflammation and Abnormal Angiogenesis by Inhibiting Interleukin-8 Expression through a Nuclear Factor-κB-Dependent Manner
Dinesh Thapa, Jong Suk Lee, Su-Young Park, Yun-Hee Bae, Soo-Kyung Bae, Jun Bum Kwon, Kyoung-Jin Kim, Mi-Kyoung Kwak, Young-Joon Park, Han Gon Choi and Jung-Ae Kim

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 353-364; DOI: https://doi.org/10.1124/jpet.108.141887
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Blockade of CXCL12/CXCR4 Axis Ameliorates Murine Experimental Colitis
Sakae Mikami, Hiroshi Nakase, Shuji Yamamoto, Yasuhiro Takeda, Takuya Yoshino, Katushiro Kasahara, Satoru Ueno, Norimitsu Uza, Shinya Oishi, Nobutaka Fujii, Takashi Nagasawa and Tsutomu Chiba

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 383-392; DOI: https://doi.org/10.1124/jpet.108.141085
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Involvement of the Neurokinin-2 Receptor in Airway Smooth Muscle Stretch-Activated Contractions Assessed in Perfused Intact Bovine Bronchial Segments
Jeremy Mark Hernandez, Gerard Cox and Luke Jeffrey Janssen

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 503-510; DOI: https://doi.org/10.1124/jpet.108.141176
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Morphine Tolerance in the Mouse Ileum and Colon
Gracious R. Ross, Bichoy H. Gabra, William L. Dewey and Hamid I. Akbarali

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 561-572; DOI: https://doi.org/10.1124/jpet.108.143438

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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Serotonin 5-Hydroxytryptamine_2A Receptor Activation Suppresses Tumor Necrosis Factor-α-Induced Inflammation with Extraordinary Potency
Bangning Yu, Jaime Becnel, Mourad Zerfaoui, Rasika Rohatgi, A. Hamid Boulares and Charles D. Nichols

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 316-323; DOI: https://doi.org/10.1124/jpet.108.143461
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Diarctigenin, a Lignan Constituent from Arctium lappa, Down-Regulated Zymosan-Induced Transcription of Inflammatory Genes through Suppression of DNA Binding Ability of Nuclear Factor-κB in Macrophages
Byung Hak Kim, Seong Su Hong, Soon Woo Kwon, Hwa Young Lee, Hyeran Sung, In-Jeong Lee, Bang Yeon Hwang, Sukgil Song, Chong-Kil Lee, Daehyun Chung, Byeongwoo Ahn, Sang-Yoon Nam, Sang-Bae Han and Youngsoo Kim

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 393-401; DOI: https://doi.org/10.1124/jpet.108.140145

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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Transport of Angiotensin-Converting Enzyme Inhibitors by H⁺/Peptide Transporters Revisited
Ilka Knütter, Claudia Wollesky, Gabor Kottra, Martin G. Hahn, Wiebke Fischer, Katja Zebisch, Reinhard H. H. Neubert, Hannelore Daniel and Matthias Brandsch

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 432-441; DOI: https://doi.org/10.1124/jpet.108.143339
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Increasing Systemic Exposure of Methotrexate by Active Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3)
Yoshiaki Kitamura, Masakazu Hirouchi, Hiroyuki Kusuhara, John D. Schuetz and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 465-473; DOI: https://doi.org/10.1124/jpet.108.140475
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A Novel Human Multidrug Resistance Gene MDR1 Variant G571A (G191R) Modulates Cancer Drug Resistance and Efflux Transport
Ziping Yang, Daniel Wu, Tot Bui and Rodney J. Y. Ho

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 474-481; DOI: https://doi.org/10.1124/jpet.108.138313
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The Inhibitory Effect of 2-Halo Derivatives of d-Glucose on Glycolysis and on the Proliferation of the Human Malaria Parasite Plasmodium falciparum
Donelly A. van Schalkwyk, Waldemar Priebe and Kevin J. Saliba

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 511-517; DOI: https://doi.org/10.1124/jpet.108.141929
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The Endocannabinoid Anandamide Is a Substrate for the Human Polymorphic Cytochrome P450 2D6
Natasha T. Snider, Matthew J. Sikora, Chitra Sridar, Thomas J. Feuerstein, James M. Rae and Paul F. Hollenberg

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 538-545; DOI: https://doi.org/10.1124/jpet.108.141796
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Contribution of Down-Regulation of Intestinal and Hepatic Cytochrome P450 3A to Increased Absorption of Cyclosporine A in a Rat Nephrosis Model
Tomoe Fujita, Shuichi Yasuda, Yuji Kamata, Kazumi Fujita, Yoshio Ohtani, Yuji Kumagai and Masataka Majima

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 592-599; DOI: https://doi.org/10.1124/jpet.108.142091

NEUROPHARMACOLOGY

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Inhibition of Calpain Prevents N-Methyl-d-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction
Volker Nimmrich, Robert Szabo, Csaba Nyakas, Ivica Granic, Klaus G. Reymann, Ulrich H. Schröder, Gerhard Gross, Hans Schoemaker, Karsten Wicke, Achim Möller and Paul Luiten

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 343-352; DOI: https://doi.org/10.1124/jpet.108.142679
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Sustained Inhibition of Neurotransmitter Release from Nontransient Receptor Potential Vanilloid Type 1-Expressing Primary Afferents by μ-Opioid Receptor Activation-Enkephalin in the Spinal Cord
Hong-Yi Zhou, Shao-Rui Chen, Hong Chen and Hui-Lin Pan

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 375-382; DOI: https://doi.org/10.1124/jpet.108.141226
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Dynamics of Aβ Turnover and Deposition in Different β-Amyloid Precursor Protein Transgenic Mouse Models Following γ-Secretase Inhibition
Dorothee Abramowski, Karl-Heinz Wiederhold, Ulrich Furrer, Anne-Lise Jaton, Anton Neuenschwander, Marie-Josephine Runser, Simone Danner, Julia Reichwald, Domenico Ammaturo, Dieter Staab, Markus Stoeckli, Heinrich Rueeger, Ulf Neumann and Matthias Staufenbiel

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 411-424; DOI: https://doi.org/10.1124/jpet.108.140327
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σ-1 Receptor Modulation of Acid-Sensing Ion Channel a (ASIC1a) and ASIC1a-Induced Ca²⁺ Influx in Rat Cortical Neurons
Yelenis Herrera, Christopher Katnik, Jael D. Rodriguez, Aaron A. Hall, Alison Willing, Keith R. Pennypacker and Javier Cuevas

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 491-502; DOI: https://doi.org/10.1124/jpet.108.143974
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αConotoxin Arenatus IB[V11L,V16D] Is a Potent and Selective Antagonist at Rat and Human Native α7 Nicotinic Acetylcholine Receptors
Neal Innocent, Phil D. Livingstone, Arik Hone, Atsuko Kimura, Tracey Young, Paul Whiteaker, J. Michael McIntosh and Susan Wonnacott

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 529-537; DOI: https://doi.org/10.1124/jpet.108.142943
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N-Arachidonyl Maleimide Potentiates the Pharmacological and Biochemical Effects of the Endocannabinoid 2-Arachidonylglycerol through Inhibition of Monoacylglycerol Lipase
James J. Burston, Laura J. Sim-Selley, John P. Harloe, Anu Mahadevan, Raj K. Razdan, Dana E. Selley and Jenny L. Wiley

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 546-553; DOI: https://doi.org/10.1124/jpet.108.141382
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The Effects of Methylphenidate on Knockin Mice with a Methylphenidate-Resistant Dopamine Transporter
Michael R. Tilley and Howard H. Gu

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 554-560; DOI: https://doi.org/10.1124/jpet.108.141713
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Antidepressant-Like Pharmacological Profile of a Novel Triple Reuptake Inhibitor, (1S,2S)-3-(Methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)
Yanqi Liang, Amanda M. Shaw, Mona Boules, Siobhan Briody, Jessica Robinson, Alfredo Oliveros, Eric Blazar, Katrina Williams, Yiqun Zhang, Paul R. Carlier and Elliott Richelson

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 573-583; DOI: https://doi.org/10.1124/jpet.108.143610

TOXICOLOGY

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Dual Pathway Activated by tert-Butyl Hydroperoxide in Human Airway Anion Secretion
Tadakatsu Matsuno, Yasushi Ito, Takamasa Ohashi, Masahiro Morise, Naoya Takeda, Kaoru Shimokata, Kazuyoshi Imaizumi, Hiroaki Kume and Yoshinori Hasegawa

Journal of Pharmacology and Experimental Therapeutics November 2008, 327 (2) 453-464; DOI: https://doi.org/10.1124/jpet.108.141580

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Table of Contents

HIGHLIGHTED PAPERS

CENTENNIAL PERSPECTIVE

PERSPECTIVES IN PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

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