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Research ArticleCELLULAR AND MOLECULAR

Phenylalanine 169 in the Second Extracellular Loop of the Human Histamine H4 Receptor Is Responsible for the Difference in Agonist Binding between Human and Mouse H4 Receptors

Herman D. Lim, Aldo Jongejan, Remko A. Bakker, Eric Haaksma, Iwan J. P. de Esch and Rob Leurs
Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 88-96; DOI: https://doi.org/10.1124/jpet.108.140343
Herman D. Lim
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Aldo Jongejan
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Remko A. Bakker
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Eric Haaksma
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Iwan J. P. de Esch
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Rob Leurs
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Article Information

vol. 327 no. 1 88-96
DOI 
https://doi.org/10.1124/jpet.108.140343
PubMed 
18635748

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 24, 2008
  • Accepted July 16, 2008
  • Published online September 19, 2008.

Article Versions

  • Earlier version (July 17, 2008 - 10:50).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Herman D. Lim,
  2. Aldo Jongejan,
  3. Remko A. Bakker,
  4. Eric Haaksma,
  5. Iwan J. P. de Esch and
  6. Rob Leurs
  1. Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (H.D.L., A.J., R.A.B., E.H., I.J.P.d.E., R.L.); and Boehringer Ingelheim Austria GmbH, Vienna, Austria (E.H.)
  1. Address correspondence to:
    Prof. Dr. Rob Leurs, Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands. E-mail: r.leurs{at}few.vu.nl
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Journal of Pharmacology and Experimental Therapeutics: 381 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 381, Issue 2
1 May 2022
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Research ArticleCELLULAR AND MOLECULAR

Phenylalanine 169 in the Second Extracellular Loop of the Human Histamine H4 Receptor Is Responsible for the Difference in Agonist Binding between Human and Mouse H4 Receptors

Herman D. Lim, Aldo Jongejan, Remko A. Bakker, Eric Haaksma, Iwan J. P. de Esch and Rob Leurs
Journal of Pharmacology and Experimental Therapeutics October 1, 2008, 327 (1) 88-96; DOI: https://doi.org/10.1124/jpet.108.140343

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Research ArticleCELLULAR AND MOLECULAR

Phenylalanine 169 in the Second Extracellular Loop of the Human Histamine H4 Receptor Is Responsible for the Difference in Agonist Binding between Human and Mouse H4 Receptors

Herman D. Lim, Aldo Jongejan, Remko A. Bakker, Eric Haaksma, Iwan J. P. de Esch and Rob Leurs
Journal of Pharmacology and Experimental Therapeutics October 1, 2008, 327 (1) 88-96; DOI: https://doi.org/10.1124/jpet.108.140343
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