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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

October 01, 2008; Volume 327,Issue 1

BEHAVIORAL PHARMACOLOGY

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    The Extensive Nitration of Neurofilament Light Chain in the Hippocampus Is Associated with the Cognitive Impairment Induced by Amyloid β in Mice
    Tursun Alkam, Atsumi Nitta, Hiroyuki Mizoguchi, Akio Itoh, Rina Murai, Taku Nagai, Kiyofumi Yamada and Toshitaka Nabeshima
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 137-147; DOI: https://doi.org/10.1124/jpet.108.141309
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    Continuous and Intermittent Nicotine Treatment Reduces l-3,4-Dihydroxyphenylalanine (l-DOPA)-Induced Dyskinesias in a Rat Model of Parkinson's Disease
    Tanuja Bordia, Carla Campos, Luping Huang and Maryka Quik
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 239-247; DOI: https://doi.org/10.1124/jpet.108.140897
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    K+ Channel TASK-1 Knockout Mice Show Enhanced Sensitivities to Ataxic and Hypnotic Effects of GABAA Receptor Ligands
    Anni-Maija Linden, M. Isabel Aller, Elli Leppä, Per H. Rosenberg, William Wisden and Esa R. Korpi
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 277-286; DOI: https://doi.org/10.1124/jpet.108.142083

CARDIOVASCULAR

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    Anti-Inflammatory and Anti-Apoptotic Effects of Fumonisin B1, an Inhibitor of Ceramide Synthase, in a Rodent Model of Splanchnic Ischemia and Reperfusion Injury
    Salvatore Cuzzocrea, Rosanna Di Paola, Tiziana Genovese, Emanuela Mazzon, Emanuela Esposito, Concetta Crisafulli, Placido Bramanti and Daniela Salvemini
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 45-57; DOI: https://doi.org/10.1124/jpet.108.139808
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    Dissociation between Superoxide Accumulation and Nitroglycerin-Induced Tolerance
    Pei-Suen Tsou, Vamsi Addanki and Ho-Leung Fung
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 97-104; DOI: https://doi.org/10.1124/jpet.108.138784
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    Sodium Hydrogen Exchange 1 (NHE-1) Regulates Connexin 43 Expression in Cardiomyocytes via Reverse Mode Sodium Calcium Exchange and c-Jun NH2-Terminal Kinase-Dependent Pathways
    Seta Stanbouly, Lorrie A. Kirshenbaum, Douglas L. Jones and Morris Karmazyn
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 105-113; DOI: https://doi.org/10.1124/jpet.108.140228
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    Simvastatin Inhibits Catecholamine Secretion and Synthesis Induced by Acetylcholine via Blocking Na+ and Ca2+ Influx in Bovine Adrenal Medullary Cells
    Taeko Matsuda, Yumiko Toyohira, Susumu Ueno, Masato Tsutsui and Nobuyuki Yanagihara
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 130-136; DOI: https://doi.org/10.1124/jpet.108.139659
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    Gap Junction Inhibitors Reduce Endothelium-Dependent Contractions in the Aorta of Spontaneously Hypertensive Rats
    Eva H. C. Tang and Paul M. Vanhoutte
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 148-153; DOI: https://doi.org/10.1124/jpet.108.140046

CELLULAR AND MOLECULAR

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    Expression of CYP4A1 in U251 Human Glioma Cell Induces Hyperproliferative Phenotype in Vitro and Rapidly Growing Tumors in Vivo
    Austin M. Guo, Ju Sheng, Gloria M. Scicli, Ali S. Arbab, Norman L. Lehman, Paul A. Edwards, John R. Falck, Richard J. Roman and A. Guillermo Scicli
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 10-19; DOI: https://doi.org/10.1124/jpet.108.140889
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    The Pore Region of N-Methyl-d-aspartate Receptors Differentially Influences Stimulation and Block by Spermine
    Lihua Jin, Maki Miyazaki, Satomi Mizuno, Miki Takigawa, Tadao Hirose, Kazuhiro Nishimura, Toshihiko Toida, Keith Williams, Keiko Kashiwagi and Kazuei Igarashi
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 68-77; DOI: https://doi.org/10.1124/jpet.108.140459
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    Phenylalanine 169 in the Second Extracellular Loop of the Human Histamine H4 Receptor Is Responsible for the Difference in Agonist Binding between Human and Mouse H4 Receptors
    Herman D. Lim, Aldo Jongejan, Remko A. Bakker, Eric Haaksma, Iwan J. P. de Esch and Rob Leurs
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 88-96; DOI: https://doi.org/10.1124/jpet.108.140343
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    1-[1-Hexyl-6-(methyloxy)-1H-indazol-3-yl]-2-methyl-1-propanone, a Potent and Highly Selective Small Molecule Blocker of the Large-Conductance Voltage-Gated and Calcium-Dependent K+ Channel
    Haoyu Zeng, Earl Gordon, Zuojun Lin, Irina M. Lozinskaya, Robert N. Willette and Xiaoping Xu
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 168-177; DOI: https://doi.org/10.1124/jpet.108.139733
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    Vasoactive Intestinal Peptide Increases Cystic Fibrosis Transmembrane Conductance Regulator Levels in the Apical Membrane of Calu-3 Cells through a Protein Kinase C-Dependent Mechanism
    Frédéric Chappe, Matthew E. Loewen, John W. Hanrahan and Valérie Chappe
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 226-238; DOI: https://doi.org/10.1124/jpet.108.141143

ENDOCRINE AND DIABETES

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    The Translational Pharmacology of a Novel, Potent, and Selective Nonsteroidal Progesterone Receptor Antagonist, 2-[4-(4-Cyano-phenoxy)-3,5-dicyclopropyl-1H-pyrazol-1-yl]-N-methylacetamide (PF-02367982)
    Alexander de Giorgio-Miller, Peter Bungay, Michelle Tutt, Julie Owen, David Goodwin and Nick Pullen
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 78-87; DOI: https://doi.org/10.1124/jpet.108.140467
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    Remogliflozin Etabonate, in a Novel Category of Selective Low-Affinity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models
    Yoshikazu Fujimori, Kenji Katsuno, Ikumi Nakashima, Yukiko Ishikawa-Takemura, Hideki Fujikura and Masayuki Isaji
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 268-276; DOI: https://doi.org/10.1124/jpet.108.140210

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Levcromakalim and MgGDP Activate Small Conductance ATP-Sensitive K+ Channels of K+ Channel Pore 6.1/Sulfonylurea Receptor 2A in Pig Detrusor Smooth Muscle Cells: Uncoupling of cAMP Signal Pathways
    Shunichi Kajioka, Shinsuke Nakayama, Haruhiko Asano, Narihito Seki, Seiji Naito and Alison F. Brading
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 114-123; DOI: https://doi.org/10.1124/jpet.108.140269
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    Calcium Sensitization in Human Esophageal Muscle: Role for RhoA Kinase in Maintenance of Lower Esophageal Sphincter Tone
    Stephen M. Sims, Tom Chrones and Harold G. Preiksaitis
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 178-186; DOI: https://doi.org/10.1124/jpet.108.140806
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    E Series of Prostaglandin Receptor 2-Mediated Activation of Extracellular Signal-Regulated Kinase/Activator Protein-1 Signaling Is Required for the Mitogenic Action of Prostaglandin E2 in Esophageal Squamous-Cell Carcinoma
    Le Yu, William Ka Kei Wu, Zhi Jie Li, Helen Pui Shan Wong, Emily Kin Ki Tai, Hai Tao Li, Ya Chun Wu and Chi Hin Cho
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 258-267; DOI: https://doi.org/10.1124/jpet.108.141275

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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    Pharmacological Profile of JNJ-27141491 [(S)-3-[3,4-Difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl Acid Methyl Ester], as a Noncompetitive and Orally Active Antagonist of the Human Chemokine Receptor CCR2
    Mieke Buntinx, Bart Hermans, Jan Goossens, Dieder Moechars, Ron A. H. J. Gilissen, Julien Doyon, Staf Boeckx, Erwin Coesemans, Guy Van Lommen and Jean P. Van Wauwe
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 1-9; DOI: https://doi.org/10.1124/jpet.108.140723
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    Fispemifene [Z-2-{2-[4-(4-Chloro-1,2-diphenylbut-1-enyl)-phenoxy]ethoxy}-ethanol], a Novel Selective Estrogen Receptor Modulator, Attenuates Glandular Inflammation in an Animal Model of Chronic Nonbacterial Prostatitis
    Emrah Yatkin, Jenni Bernoulli, Risto Lammintausta and Risto Santti
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 58-67; DOI: https://doi.org/10.1124/jpet.108.139501
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    7-Epiclusianone, a Tetraprenylated Benzophenone, Relaxes Airway Smooth Muscle through Activation of the Nitric Oxide-cGMP Pathway
    Luciana Pontes Coelho, Magda Fráguas Serra, Ana Lúcia de Aguiar Pires, Renato Sérgio Balão Cordeiro, Patrícia Machado Rodrigues e Silva, Marcelo Henrique dos Santos and Marco Aurélio Martins
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 206-214; DOI: https://doi.org/10.1124/jpet.108.138032
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    Thiorphan-Induced Survival and Proliferation of Rat Thymocytes by Activation of Akt/Survivin Pathway and Inhibition of Caspase-3 Activity
    Consuelo Amantini, Michela Mosca, Roberta Lucciarini, Marina Cecilia Perfumi and Giorgio Santoni
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 215-225; DOI: https://doi.org/10.1124/jpet.108.138719

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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    Targeting of VX2 Rabbit Liver Tumor by Selective Delivery of 3-Bromopyruvate: A Biodistribution and Survival Study
    Mustafa Vali, Josephina A. Vossen, Manon Buijs, James M. Engles, Eleni Liapi, Veronica Prieto Ventura, Afsheen Khwaja, Obele Acha-Ngwodo, Ganapathy Shanmugasundaram, Labiq Syed, Richard L. Wahl and Jean-Francois H. Geschwind
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 32-37; DOI: https://doi.org/10.1124/jpet.108.141093
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    Nonlinear Pharmacokinetics of (±)3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) and Its Major Metabolites in Squirrel Monkeys at Plasma Concentrations of MDMA That Develop After Typical Psychoactive Doses
    Melanie Mueller, Frank T. Peters, Hans H. Maurer, Una D. McCann and George A. Ricaurte
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 38-44; DOI: https://doi.org/10.1124/jpet.108.141366
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    Apparent High CYP3A5 Expression Is Required for Significant Metabolism of Vincristine by Human Cryopreserved Hepatocytes
    Jennifer B. Dennison, Michael A. Mohutsky, Robert J. Barbuch, Steven A. Wrighton and Stephen D. Hall
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 248-257; DOI: https://doi.org/10.1124/jpet.108.139998

NEUROPHARMACOLOGY

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    MDMA (3,4-Methylenedioxymethamphetamine)-Mediated Distortion of Somatosensory Signal Transmission and Neurotransmitter Efflux in the Ventral Posterior Medial Thalamus
    M. A. Starr, M. E. Page and B. D. Waterhouse
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 20-31; DOI: https://doi.org/10.1124/jpet.108.139337
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    Paraquat Exposure Reduces Nicotinic Receptor-Evoked Dopamine Release in Monkey Striatum
    Kathryn T. O'Leary, Neeraja Parameswaran, Louisa C. Johnston, J. Michael McIntosh, Donato A. Di Monte and Maryka Quik
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 124-129; DOI: https://doi.org/10.1124/jpet.108.141861
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    The Effects of Herkinorin, the First μ-Selective Ligand from a Salvinorin A-Derived Scaffold, in a Neuroendocrine Biomarker Assay in Nonhuman Primates
    Eduardo R. Butelman, Szymon Rus, Denise S. Simpson, Angela Wolf, Thomas E. Prisinzano and Mary Jeanne Kreek
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 154-160; DOI: https://doi.org/10.1124/jpet.108.140079
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    Methylphenidate-Induced Increases in Vesicular Dopamine Sequestration and Dopamine Release in the Striatum: The Role of Muscarinic and Dopamine D2 Receptors
    Trent J. Volz, Sarah J. Farnsworth, Shane D. Rowley, Glen R. Hanson and Annette E. Fleckenstein
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 161-167; DOI: https://doi.org/10.1124/jpet.108.139386
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    Alterations in Fos-Related Antigen 2 and σ1 Receptor Gene and Protein Expression Are Associated with the Development of Cocaine-Induced Behavioral Sensitization: Time Course and Regional Distribution Studies
    Yun Liu and Rae R. Matsumoto
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 187-195; DOI: https://doi.org/10.1124/jpet.108.141051
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    Purinergic Type 2 Receptors at GABAergic Synapses on Ventral Tegmental Area Dopamine Neurons Are Targets for Ethanol Action
    Cheng Xiao, Chunyi Zhou, Kaixun Li, Daryl L. Davies and Jiang H. Ye
    Journal of Pharmacology and Experimental Therapeutics October 2008, 327 (1) 196-205; DOI: https://doi.org/10.1124/jpet.108.139766
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Journal of Pharmacology and Experimental Therapeutics: 327 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 327, Issue 1
1 Oct 2008
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  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • ENDOCRINE AND DIABETES
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA
  • METABOLISM, TRANSPORT, AND PHARMACOGENOMICS
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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