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Research ArticleINFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation

Daigen Xu, Steven E. Rowland, Patsy Clark, André Giroux, Bernard Côté, Sébastien Guiral, Myriam Salem, Yves Ducharme, Richard W. Friesen, Nathalie Méthot, Joseph Mancini, Laurent Audoly and Denis Riendeau
Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 754-763; DOI: https://doi.org/10.1124/jpet.108.138776

Article Information

vol. 326 no. 3 754-763
DOI 
https://doi.org/10.1124/jpet.108.138776
PubMed 
18524979
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received March 11, 2008
  • Accepted May 12, 2008
  • Published online August 18, 2008.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Daigen Xu,
  2. Steven E. Rowland,
  3. Patsy Clark,
  4. André Giroux,
  5. Bernard Côté,
  6. Sébastien Guiral,
  7. Myriam Salem,
  8. Yves Ducharme,
  9. Richard W. Friesen,
  10. Nathalie Méthot,
  11. Joseph Mancini,
  12. Laurent Audoly and
  13. Denis Riendeau
  1. Departments of Pharmacology (D.X., S.E.R., P.C., M.S., L.A., D.R.), Biochemistry and Molecular Biology (S.G., N.M., J.M.), and Medicinal Chemistry (A.G., B.C., Y.D., R.W.F.), Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
  1. Address correspondence to:
    Daigen Xu, Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Hwy, Kirkland, QC, Canada H9H 3L1. E-mail: daigen_xu{at}merck.com
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Research ArticleINFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation

Daigen Xu, Steven E. Rowland, Patsy Clark, André Giroux, Bernard Côté, Sébastien Guiral, Myriam Salem, Yves Ducharme, Richard W. Friesen, Nathalie Méthot, Joseph Mancini, Laurent Audoly and Denis Riendeau
Journal of Pharmacology and Experimental Therapeutics September 1, 2008, 326 (3) 754-763; DOI: https://doi.org/10.1124/jpet.108.138776
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