A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery

Keiichi Kuwano; Asami Hashino; Kumiko Noda; Keiji Kosugi; Kenji Kuwabara

doi:10.1124/jpet.108.138305

Research ArticleCARDIOVASCULAR

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery

Keiichi Kuwano, Asami Hashino, Kumiko Noda, Keiji Kosugi and Kenji Kuwabara

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 691-699; DOI: https://doi.org/10.1124/jpet.108.138305

Keiichi Kuwano

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Asami Hashino

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Kumiko Noda

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Keiji Kosugi

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Kenji Kuwabara

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Research ArticleCARDIOVASCULAR