Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleCARDIOVASCULAR

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery

Keiichi Kuwano, Asami Hashino, Kumiko Noda, Keiji Kosugi and Kenji Kuwabara
Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 691-699; DOI: https://doi.org/10.1124/jpet.108.138305
Keiichi Kuwano
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Asami Hashino
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kumiko Noda
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Keiji Kosugi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kenji Kuwabara
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

vol. 326 no. 3 691-699
DOI 
https://doi.org/10.1124/jpet.108.138305
PubMed 
18552131

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received February 21, 2008
  • Accepted June 12, 2008
  • Published online August 18, 2008.

Article Versions

  • Earlier version (June 13, 2008 - 10:45).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Keiichi Kuwano,
  2. Asami Hashino,
  3. Kumiko Noda,
  4. Keiji Kosugi and
  5. Kenji Kuwabara
  1. Discovery Research Laboratories, Nippon Shinyaku Co., Ltd., Kisshoin, Minami-Ku, Kyoto, Japan
  1. Address correspondence to:
    Dr. Keiichi Kuwano, Discovery Research Laboratories, Nippon Shinyaku Co., Ltd., 14 Nishinosho-Monguchi-Cho, Kisshoin, Minami-Ku, Kyoto 601-8550, Japan. E-mail: k.kuwano{at}po.nippon-shinyaku.co.jp
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: June 2008 to January 2023

AbstractFullPdf
Jun 2008290110
Jul 200821062
Aug 2008572171
Sep 2008593459
Oct 2008571833
Nov 2008422715
Dec 2008261726
Jan 2009261015
Feb 20092557
Mar 200937710
Apr 2009341520
May 200922823
Jun 200922611
Jul 2009261622
Aug 2009271327
Sep 2009233229
Oct 2009172326
Nov 200992025
Dec 2009241725
Jan 2010322021
Feb 2010301423
Mar 2010333030
Apr 2010272829
May 2010363627
Jun 2010351430
Jul 2010363230
Aug 2010161517
Sep 2010102233
Oct 2010203329
Nov 2010221924
Dec 2010112320
Jan 2011243827
Feb 2011222022
Mar 2011243837
Apr 2011232429
May 2011233841
Jun 2011182832
Jul 2011121826
Aug 2011152530
Sep 2011292130
Oct 2011252529
Nov 201192219
Dec 2011312126
Jan 2012241722
Feb 2012302224
Mar 2012291725
Apr 2012111219
May 2012252428
Jun 2012292223
Jul 2012303125
Aug 2012221824
Sep 2012182723
Oct 2012302827
Nov 2012162223
Dec 2012191413
Jan 2013271420
Feb 2013191319
Mar 20139126
Apr 2013221921
May 2013271820
Jun 2013171320
Jul 2013102217
Aug 201314269
Sep 2013231113
Oct 2013142017
Nov 20131529
Dec 201341312
Jan 2014142013
Feb 2014121312
Mar 20147149
Apr 2014191317
May 2014121417
Jun 2014122220
Jul 2014172224
Aug 2014191414
Sep 2014111116
Oct 2014251821
Nov 201481514
Dec 201471116
Jan 2015271323
Feb 2015121319
Mar 201512138
Apr 2015222514
May 2015232527
Jun 201572111
Jul 201582238
Aug 2015141910
Sep 2015282316
Oct 2015201917
Nov 201514148
Dec 2015231918
Jan 2016322929
Feb 2016131823
Mar 2016393750
Apr 2016294936
May 2016142722
Jun 2016302643
Jul 2016241645
Aug 2016193438
Sep 2016123728
Oct 201635826
Nov 2016225035
Dec 201663320
Jan 201713715
Feb 201744420
Mar 201725910
Apr 2017102520
May 201734723
Jun 201703413
Jul 201754013
Aug 201712914
Sep 2017224616
Oct 2017317112
Nov 201743736
Dec 20174199
Jan 201805222
Feb 201842614
Mar 201842814
Apr 201864320
May 20181238
Jun 201843312
Jul 201814222
Aug 201802010
Sep 201803619
Oct 201813614
Nov 201822810
Dec 20182878
Jan 20191296
Feb 2019973
Mar 2019362011
Apr 2019284013
May 201937168
Jun 201910179
Jul 201922105
Aug 2019141212
Sep 20195033
Oct 20192759
Nov 20194247
Dec 20192822
Jan 202022610
Feb 202013911
Mar 20201976
Apr 202020109
May 202028124
Jun 20204774
Jul 20203294
Aug 2020881
Sep 20202054
Oct 20203785
Nov 20203357
Dec 20201795
Jan 202139125
Feb 202127156
Mar 20213278
Apr 202134119
May 202141238
Jun 20212295
Jul 202125106
Aug 202116112
Sep 20213295
Oct 202153166
Nov 202145911
Dec 20212784
Jan 2022442019
Feb 20222575
Mar 20221786
Apr 202232811
May 202238125
Jun 202222104
Jul 20223431
Aug 20223873
Sep 202240165
Oct 202228103
Nov 20222465
Dec 202211713
Jan 20232031

Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics: 384 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 384, Issue 2
1 Feb 2023
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active F…
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleCARDIOVASCULAR

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery

Keiichi Kuwano, Asami Hashino, Kumiko Noda, Keiji Kosugi and Kenji Kuwabara
Journal of Pharmacology and Experimental Therapeutics September 1, 2008, 326 (3) 691-699; DOI: https://doi.org/10.1124/jpet.108.138305

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleCARDIOVASCULAR

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery

Keiichi Kuwano, Asami Hashino, Kumiko Noda, Keiji Kosugi and Kenji Kuwabara
Journal of Pharmacology and Experimental Therapeutics September 1, 2008, 326 (3) 691-699; DOI: https://doi.org/10.1124/jpet.108.138305
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • 4-Chloro ring-substituted synthetic cathinones
  • 14-3-3 Influences Nav1.5 Response to Anti-Arrhythmic Drugs
  • Inhaled Treprostinil Palmitil in the Sugen/Hypoxia Rat Model
Show more Cardiovascular

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics