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Research ArticleCARDIOVASCULAR

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery

Keiichi Kuwano, Asami Hashino, Kumiko Noda, Keiji Kosugi and Kenji Kuwabara
Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 691-699; DOI: https://doi.org/10.1124/jpet.108.138305

Article Information

vol. 326 no. 3 691-699
DOI 
https://doi.org/10.1124/jpet.108.138305
PubMed 
18552131
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received February 21, 2008
  • Accepted June 12, 2008
  • Published online August 18, 2008.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Keiichi Kuwano,
  2. Asami Hashino,
  3. Kumiko Noda,
  4. Keiji Kosugi and
  5. Kenji Kuwabara
  1. Discovery Research Laboratories, Nippon Shinyaku Co., Ltd., Kisshoin, Minami-Ku, Kyoto, Japan
  1. Address correspondence to:
    Dr. Keiichi Kuwano, Discovery Research Laboratories, Nippon Shinyaku Co., Ltd., 14 Nishinosho-Monguchi-Cho, Kisshoin, Minami-Ku, Kyoto 601-8550, Japan. E-mail: k.kuwano{at}po.nippon-shinyaku.co.jp
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Research ArticleCARDIOVASCULAR

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery

Keiichi Kuwano, Asami Hashino, Kumiko Noda, Keiji Kosugi and Kenji Kuwabara
Journal of Pharmacology and Experimental Therapeutics September 1, 2008, 326 (3) 691-699; DOI: https://doi.org/10.1124/jpet.108.138305
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