Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn

Table of Contents

September 01, 2008; Volume 326,Issue 3

CENTENNIAL PERSPECTIVE

  • You have access
    Peter B. Dews and Pharmacological Studies on Behavior
    James E. Barrett and Jack Bergman
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 683-690; DOI: https://doi.org/10.1124/jpet.108.139261

BEHAVIORAL PHARMACOLOGY

  • You have access
    Olanzapine (LY170053, 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] Benzodiazepine), but Not the Novel Atypical Antipsychotic ST2472 (9-Piperazin-1-ylpyrrolo[2,1-b][1,3]benzothiazepine), Chronic Administration Induces Weight Gain, Hyperphagia, and Metabolic Dysregulation in Mice
    Roberto Coccurello, Antonio Caprioli, Roberto Conti, Orlando Ghirardi, Franco Borsini, Paolo Carminati and Anna Moles
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 905-911; DOI: https://doi.org/10.1124/jpet.108.137240
  • You have access
    Morphine Deprivation Increases Self-Administration of the Fast- and Short-Acting μ-Opioid Receptor Agonist Remifentanil in the Rat
    Ziva D. Cooper, Yen Nhu-Thi Truong, Yong-Gong Shi and James H. Woods
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 920-929; DOI: https://doi.org/10.1124/jpet.108.139196
  • You have access
    Behavioral Pharmacology of the μ/δ Opioid Glycopeptide MMP2200 in Rhesus Monkeys
    Gail Pereira Do Carmo, Robin Polt, Edward J. Bilsky, Kenner C. Rice and S. Stevens Negus
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 939-948; DOI: https://doi.org/10.1124/jpet.108.138180

CARDIOVASCULAR

  • You have access
    A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery
    Keiichi Kuwano, Asami Hashino, Kumiko Noda, Keiji Kosugi and Kenji Kuwabara
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 691-699; DOI: https://doi.org/10.1124/jpet.108.138305
  • You have access
    meta-Iodobenzylguanidine, an Inhibitor of Arginine-Dependent Mono(ADP-ribosyl)ation, Prevents Neointimal Hyperplasia
    Lorraine Yau, Peter Molnar, Michael C. Moon, Shelly Buhay, Jeffrey P. Werner, Katerina Molnar, Laura Saward, Dario Del Rizzo and Peter Zahradka
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 717-724; DOI: https://doi.org/10.1124/jpet.108.137513
  • You have access
    Endothelin-1 Regulates Cardiac L-Type Calcium Channels via NAD(P)H Oxidase-Derived Superoxide
    Qinghua Zeng, Qingwei Zhou, Fanrong Yao, Stephen T. O'Rourke and Chengwen Sun
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 732-738; DOI: https://doi.org/10.1124/jpet.108.140301
  • You have access
    Cyclooxygenase 2-Selective and Nonselective Nonsteroidal Anti-Inflammatory Drugs Induce Oxidative Stress by Up-Regulating Vascular NADPH Oxidases
    Huige Li, Marcus Hortmann, Andreas Daiber, Matthias Oelze, Mir Abolfazl Ostad, Petra M. Schwarz, Hui Xu, Ning Xia, Andrei L. Kleschyov, Christian Mang, Ascan Warnholtz, Thomas Münzel and Ulrich Förstermann
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 745-753; DOI: https://doi.org/10.1124/jpet.108.139030
  • You have access
    Vascular Protection with Candesartan after Experimental Acute Stroke in Hypertensive Rats: A Dose-Response Study
    Wieslaw Kozak, Anna Kozak, Maribeth H. Johnson, Hazem F. Elewa and Susan C. Fagan
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 773-782; DOI: https://doi.org/10.1124/jpet.108.139618
  • You have access
    Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells and Experimental Animals
    Julie L. Hawkins, Michael D. Robbins, Laurie C. Warren, Donghui Xia, Stephen F. Petras, James J. Valentine, Alison H. Varghese, Ing-Kae Wang, Timothy A. Subashi, Lorraine D. Shelly, Bruce A. Hay, Katherine T. Landschulz, Kieran F. Geoghegan and H. James Harwood
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 801-808; DOI: https://doi.org/10.1124/jpet.108.139626
  • You have access
    P2X7 Receptor Activation Amplifies Lipopolysaccharide-Induced Vascular Hyporeactivity via Interleukin-1β Release
    Chin-Wei Chiao, Rita C. Tostes and R. Clinton Webb
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 864-870; DOI: https://doi.org/10.1124/jpet.107.135350
  • You have access
    Cardioprotective Effect of Histamine H3-Receptor Activation: Pivotal Role of Gβγ-Dependent Inhibition of Voltage-Operated Ca2+ Channels
    Christopher Morrey, Rima Estephan, Geoffrey W. Abbott and Roberto Levi
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 871-878; DOI: https://doi.org/10.1124/jpet.108.137919
  • You have access
    Modulation of Sarcoplasmic Reticulum Function by PST2744 [Istaroxime; (E,Z)-3-((2-Aminoethoxy)imino) Androstane-6,17-dione Hydrochloride)] in a Pressure-Overload Heart Failure Model
    Marcella Rocchetti, Matteo Alemanni, Gaspare Mostacciuolo, Paolo Barassi, Claudia Altomare, Riccardo Chisci, Rosella Micheletti, Patrizia Ferrari and Antonio Zaza
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 957-965; DOI: https://doi.org/10.1124/jpet.108.138701
  • You have access
    Isoflavone Attenuates Vascular Contraction through Inhibition of the RhoA/Rho-Kinase Signaling Pathway
    Young Mi Seok, Inji Baek, Yong-Hoon Kim, Yeon-Shin Jeong, In-Jung Lee, Dong Hyun Shin, Young Hyun Hwang and In Kyeom Kim
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 991-998; DOI: https://doi.org/10.1124/jpet.108.138529

CELLULAR AND MOLECULAR

  • You have access
    Circadian Variations in Rat Liver Gene Expression: Relationships to Drug Actions
    Richard R. Almon, Eric Yang, William Lai, Ioannis P. Androulakis, Debra C. DuBois and William J. Jusko
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 700-716; DOI: https://doi.org/10.1124/jpet.108.140186
  • You have access
    Ligand-Specific Contribution of the N Terminus and E2-Loop to Pharmacological Properties of the Histamine H1-Receptor
    Andrea Straßer, Hans-Joachim Wittmann and Roland Seifert
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 783-791; DOI: https://doi.org/10.1124/jpet.108.140913
  • You have access
    The Glucosylceramide Synthase Inhibitor N-(5-Adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin Induces Sterol Regulatory Element-Binding Protein-Regulated Gene Expression and Cholesterol Synthesis in HepG2 Cells
    Nora Bijl, Saskia Scheij, Sander Houten, Rolf G. Boot, Albert K. Groen and Johannes M. F. G. Aerts
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 849-855; DOI: https://doi.org/10.1124/jpet.108.139394
  • You have access
    Proinflammatory Effect of Sodium 4-Phenylbutyrate in ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator Lung Epithelial Cells: Involvement of Extracellular Signal-Regulated Protein Kinase 1/2 and c-Jun-NH2-Terminal Kinase Signaling
    Telma Roque, Emilie Boncoeur, Vinciane Saint-Criq, Elise Bonvin, Annick Clement, Olivier Tabary and Jacky Jacquot
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 949-956; DOI: https://doi.org/10.1124/jpet.107.135186
  • You have access
    Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1
    Andreas Koeberle, Ulf Siemoneit, Ulrike Bühring, Hinnak Northoff, Stefan Laufer, Wolfgang Albrecht and Oliver Werz
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 975-982; DOI: https://doi.org/10.1124/jpet.108.139444

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

  • You have access
    Phosphodiesterase Isozymes Involved in Regulation of Formula Secretion in Isolated Mouse Stomach in Vitro
    Kazutomo Kita, Kento Takahashi, Yumi Ohashi, Hironori Takasuka, Eitaro Aihara and Koji Takeuchi
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 889-896; DOI: https://doi.org/10.1124/jpet.108.138941
  • You have access
    Nociceptin/Orphanin FQ (N/OFQ)-Evoked Bradycardia, Hypotension, and Diuresis Are Absent in N/OFQ Peptide (NOP) Receptor Knockout Mice
    Melissa A. Burmeister, Michael A. Ansonoff, John E. Pintar and Daniel R. Kapusta
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 897-904; DOI: https://doi.org/10.1124/jpet.107.135905

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

  • You have access
    MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation
    Daigen Xu, Steven E. Rowland, Patsy Clark, André Giroux, Bernard Côté, Sébastien Guiral, Myriam Salem, Yves Ducharme, Richard W. Friesen, Nathalie Méthot, Joseph Mancini, Laurent Audoly and Denis Riendeau
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 754-763; DOI: https://doi.org/10.1124/jpet.108.138776

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

  • You have access
    The Protein Kinase A Pathway Contributes to Hg2+-Induced Alterations in Phosphorylation and Subcellular Distribution of Occludin Associated with Increased Tight Junction Permeability of Salivary Epithelial Cell Monolayers
    Jitesh D. Kawedia, Mengmeng Jiang, Amit Kulkarni, Holly E. Waechter, Karl S. Matlin, Giovanni M. Pauletti and Anil G. Menon
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 829-837; DOI: https://doi.org/10.1124/jpet.107.135798
  • You have access
    The Role of Systemic Handling in the Pathophysiologic Actions of Botulinum Toxin
    Fetweh H. Al-Saleem, Denise M. Ancharski, Easwaran Ravichandran, Suresh G. Joshi, Ajay K. Singh, Yujing Gong and Lance L. Simpson
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 856-863; DOI: https://doi.org/10.1124/jpet.108.136242
  • You have access
    In Vitro Biliary Clearance of Angiotensin II Receptor Blockers and 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitors in Sandwich-Cultured Rat Hepatocytes: Comparison with in Vivo Biliary Clearance
    Koji Abe, Arlene S. Bridges, Wei Yue and Kim L. R. Brouwer
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 983-990; DOI: https://doi.org/10.1124/jpet.108.138073

NEUROPHARMACOLOGY

  • You have access
    Relationship of Spinal Dynorphin Neurons to δ-Opioid Receptors and Estrogen Receptor α: Anatomical Basis for Ovarian Sex Steroid Opioid Antinociception
    Alan R. Gintzler, Stephen A. Schnell, Daya S. Gupta, Nai-Jiang Liu and Martin W. Wessendorf
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 725-731; DOI: https://doi.org/10.1124/jpet.108.139816
  • You have access
    Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and Aβ Pathology in a Transgenic Mouse Model of Alzheimer's Disease
    Hiroshi Onozuka, Akira Nakajima, Kentaro Matsuzaki, Ryong-Woon Shin, Koichi Ogino, Daisuke Saigusa, Naomi Tetsu, Akihito Yokosuka, Yutaka Sashida, Yoshihiro Mimaki, Tohru Yamakuni and Yasushi Ohizumi
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 739-744; DOI: https://doi.org/10.1124/jpet.108.140293
  • You have access
    Genomic Insights into Acute Alcohol Tolerance
    Wei Hu, Laura Saba, Katherina Kechris, Sanjiv V. Bhave, Paula L. Hoffman and Boris Tabakoff
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 792-800; DOI: https://doi.org/10.1124/jpet.108.137521
  • You have access
    In Vivo Profile of ICA-27243 [N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a Potent and Selective KCNQ2/Q3 (Kv7.2/Kv7.3) Activator in Rodent Anticonvulsant Models
    Rosemarie Roeloffs, Alan D. Wickenden, Christopher Crean, Stephen Werness, Grant McNaughton-Smith, James Stables, James O. McNamara, Neil Ghodadra and Greg C. Rigdon
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 818-828; DOI: https://doi.org/10.1124/jpet.108.137794
  • You have access
    Lithium Protection of Phencyclidine-Induced Neurotoxicity in Developing Brain: The Role of Phosphatidylinositol-3 Kinase/Akt and Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways
    Yan Xia, Cheng Z. Wang, Jie Liu, Noelle C. Anastasio and Kenneth M. Johnson
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 838-848; DOI: https://doi.org/10.1124/jpet.107.133272
  • You have access
    (R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo
    Carol S. Surowy, Torben R. Neelands, Bruce R. Bianchi, Steve McGaraughty, Rachid El Kouhen, Ping Han, Katharine L. Chu, Heath A. McDonald, Melissa Vos, Wende Niforatos, Erol K. Bayburt, Arthur Gomtsyan, Chih-Hung Lee, Prisca Honore, James P. Sullivan, Michael F. Jarvis and Connie R. Faltynek
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 879-888; DOI: https://doi.org/10.1124/jpet.108.138511
  • You have access
    Methanandamide Allosterically Inhibits in Vivo the Function of Peripheral Nicotinic Acetylcholine Receptors Containing the α7-Subunit
    Urszula Baranowska, Manfred Göthert, Radosław Rudź and Barbara Malinowska
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 912-919; DOI: https://doi.org/10.1124/jpet.108.140863
  • You have access
    The Dopamine D3/D2 Agonist (+)-PD-128,907 [(R-(+)-trans-3,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol)] Protects against Acute and Cocaine-Kindled Seizures in Mice: Further Evidence for the Involvement of D3 Receptors
    J. M. Witkin, B. Levant, A. Zapata, R. Kaminski and M. Gasior
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 930-938; DOI: https://doi.org/10.1124/jpet.108.139212
  • You have access
    Combination Therapy with Fenofibrate, a Peroxisome Proliferator-Activated Receptor α Agonist, and Simvastatin, a 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitor, on Experimental Traumatic Brain Injury
    Xiao Ru Chen, Valerie C. Besson, Tiphaine Beziaud, Michel Plotkine and Catherine Marchand-Leroux
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 966-974; DOI: https://doi.org/10.1124/jpet.108.140368

TOXICOLOGY

  • You have access
    p38 and c-Jun N-Terminal Kinase Mitogen-Activated Protein Kinase Signaling Pathways Play Distinct Roles in the Response of Organogenesis-Stage Embryos to a Teratogen
    Jin Yan and Barbara F. Hales
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 764-772; DOI: https://doi.org/10.1124/jpet.108.139907
  • You have access
    l-Methionine Toxicity in Freshly Isolated Mouse Hepatocytes Is Gender-Dependent and Mediated in Part by Transamination
    Joseph T. Dever and Adnan A. Elfarra
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 809-817; DOI: https://doi.org/10.1124/jpet.108.141044

Erratum

  • You have access
    Correction to “Antihyperalgesic Effects of (R,E)-N-(2-Hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a Novel Transient Receptor Potential Vanilloid Type 1 Modulator That Does Not Cause Hyperthermia in Rats”
    Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 999;
Back to top
PreviousNext

In this issue

Journal of Pharmacology and Experimental Therapeutics: 326 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 326, Issue 3
1 Sep 2008
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Sign up for alerts

Jump to

  • CENTENNIAL PERSPECTIVE
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA
  • METABOLISM, TRANSPORT, AND PHARMACOGENOMICS
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • Erratum
  • Most Cited
  • Most Read
Loading
  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
More...
Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics