Journal of Pharmacology and Experimental Therapeutics: 326 (3)

September 01, 2008; Volume 326,Issue 3

CENTENNIAL PERSPECTIVE

You have access
Peter B. Dews and Pharmacological Studies on Behavior
James E. Barrett and Jack Bergman

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 683-690; DOI: https://doi.org/10.1124/jpet.108.139261

BEHAVIORAL PHARMACOLOGY

You have access
Olanzapine (LY170053, 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] Benzodiazepine), but Not the Novel Atypical Antipsychotic ST2472 (9-Piperazin-1-ylpyrrolo[2,1-b][1,3]benzothiazepine), Chronic Administration Induces Weight Gain, Hyperphagia, and Metabolic Dysregulation in Mice
Roberto Coccurello, Antonio Caprioli, Roberto Conti, Orlando Ghirardi, Franco Borsini, Paolo Carminati and Anna Moles

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 905-911; DOI: https://doi.org/10.1124/jpet.108.137240
You have access
Morphine Deprivation Increases Self-Administration of the Fast- and Short-Acting μ-Opioid Receptor Agonist Remifentanil in the Rat
Ziva D. Cooper, Yen Nhu-Thi Truong, Yong-Gong Shi and James H. Woods

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 920-929; DOI: https://doi.org/10.1124/jpet.108.139196
You have access
Behavioral Pharmacology of the μ/δ Opioid Glycopeptide MMP2200 in Rhesus Monkeys
Gail Pereira Do Carmo, Robin Polt, Edward J. Bilsky, Kenner C. Rice and S. Stevens Negus

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 939-948; DOI: https://doi.org/10.1124/jpet.108.138180

CARDIOVASCULAR

You have access
A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery
Keiichi Kuwano, Asami Hashino, Kumiko Noda, Keiji Kosugi and Kenji Kuwabara

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 691-699; DOI: https://doi.org/10.1124/jpet.108.138305
You have access
meta-Iodobenzylguanidine, an Inhibitor of Arginine-Dependent Mono(ADP-ribosyl)ation, Prevents Neointimal Hyperplasia
Lorraine Yau, Peter Molnar, Michael C. Moon, Shelly Buhay, Jeffrey P. Werner, Katerina Molnar, Laura Saward, Dario Del Rizzo and Peter Zahradka

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 717-724; DOI: https://doi.org/10.1124/jpet.108.137513
You have access
Endothelin-1 Regulates Cardiac L-Type Calcium Channels via NAD(P)H Oxidase-Derived Superoxide
Qinghua Zeng, Qingwei Zhou, Fanrong Yao, Stephen T. O'Rourke and Chengwen Sun

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 732-738; DOI: https://doi.org/10.1124/jpet.108.140301
You have access
Cyclooxygenase 2-Selective and Nonselective Nonsteroidal Anti-Inflammatory Drugs Induce Oxidative Stress by Up-Regulating Vascular NADPH Oxidases
Huige Li, Marcus Hortmann, Andreas Daiber, Matthias Oelze, Mir Abolfazl Ostad, Petra M. Schwarz, Hui Xu, Ning Xia, Andrei L. Kleschyov, Christian Mang, Ascan Warnholtz, Thomas Münzel and Ulrich Förstermann

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 745-753; DOI: https://doi.org/10.1124/jpet.108.139030
You have access
Vascular Protection with Candesartan after Experimental Acute Stroke in Hypertensive Rats: A Dose-Response Study
Wieslaw Kozak, Anna Kozak, Maribeth H. Johnson, Hazem F. Elewa and Susan C. Fagan

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 773-782; DOI: https://doi.org/10.1124/jpet.108.139618
You have access
Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells and Experimental Animals
Julie L. Hawkins, Michael D. Robbins, Laurie C. Warren, Donghui Xia, Stephen F. Petras, James J. Valentine, Alison H. Varghese, Ing-Kae Wang, Timothy A. Subashi, Lorraine D. Shelly, Bruce A. Hay, Katherine T. Landschulz, Kieran F. Geoghegan and H. James Harwood

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 801-808; DOI: https://doi.org/10.1124/jpet.108.139626
You have access
P2X₇ Receptor Activation Amplifies Lipopolysaccharide-Induced Vascular Hyporeactivity via Interleukin-1β Release
Chin-Wei Chiao, Rita C. Tostes and R. Clinton Webb

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 864-870; DOI: https://doi.org/10.1124/jpet.107.135350
You have access
Cardioprotective Effect of Histamine H₃-Receptor Activation: Pivotal Role of Gβγ-Dependent Inhibition of Voltage-Operated Ca²⁺ Channels
Christopher Morrey, Rima Estephan, Geoffrey W. Abbott and Roberto Levi

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 871-878; DOI: https://doi.org/10.1124/jpet.108.137919
You have access
Modulation of Sarcoplasmic Reticulum Function by PST2744 [Istaroxime; (E,Z)-3-((2-Aminoethoxy)imino) Androstane-6,17-dione Hydrochloride)] in a Pressure-Overload Heart Failure Model
Marcella Rocchetti, Matteo Alemanni, Gaspare Mostacciuolo, Paolo Barassi, Claudia Altomare, Riccardo Chisci, Rosella Micheletti, Patrizia Ferrari and Antonio Zaza

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 957-965; DOI: https://doi.org/10.1124/jpet.108.138701
You have access
Isoflavone Attenuates Vascular Contraction through Inhibition of the RhoA/Rho-Kinase Signaling Pathway
Young Mi Seok, Inji Baek, Yong-Hoon Kim, Yeon-Shin Jeong, In-Jung Lee, Dong Hyun Shin, Young Hyun Hwang and In Kyeom Kim

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 991-998; DOI: https://doi.org/10.1124/jpet.108.138529

CELLULAR AND MOLECULAR

You have access
Circadian Variations in Rat Liver Gene Expression: Relationships to Drug Actions
Richard R. Almon, Eric Yang, William Lai, Ioannis P. Androulakis, Debra C. DuBois and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 700-716; DOI: https://doi.org/10.1124/jpet.108.140186
You have access
Ligand-Specific Contribution of the N Terminus and E2-Loop to Pharmacological Properties of the Histamine H₁-Receptor
Andrea Straßer, Hans-Joachim Wittmann and Roland Seifert

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 783-791; DOI: https://doi.org/10.1124/jpet.108.140913
You have access
The Glucosylceramide Synthase Inhibitor N-(5-Adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin Induces Sterol Regulatory Element-Binding Protein-Regulated Gene Expression and Cholesterol Synthesis in HepG2 Cells
Nora Bijl, Saskia Scheij, Sander Houten, Rolf G. Boot, Albert K. Groen and Johannes M. F. G. Aerts

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 849-855; DOI: https://doi.org/10.1124/jpet.108.139394
You have access
Proinflammatory Effect of Sodium 4-Phenylbutyrate in ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator Lung Epithelial Cells: Involvement of Extracellular Signal-Regulated Protein Kinase 1/2 and c-Jun-NH₂-Terminal Kinase Signaling
Telma Roque, Emilie Boncoeur, Vinciane Saint-Criq, Elise Bonvin, Annick Clement, Olivier Tabary and Jacky Jacquot

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 949-956; DOI: https://doi.org/10.1124/jpet.107.135186
You have access
Licofelone Suppresses Prostaglandin E₂ Formation by Interference with the Inducible Microsomal Prostaglandin E₂ Synthase-1
Andreas Koeberle, Ulf Siemoneit, Ulrike Bühring, Hinnak Northoff, Stefan Laufer, Wolfgang Albrecht and Oliver Werz

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 975-982; DOI: https://doi.org/10.1124/jpet.108.139444

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

You have access
Phosphodiesterase Isozymes Involved in Regulation of $\text{[math]}$ Secretion in Isolated Mouse Stomach in Vitro
Kazutomo Kita, Kento Takahashi, Yumi Ohashi, Hironori Takasuka, Eitaro Aihara and Koji Takeuchi

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 889-896; DOI: https://doi.org/10.1124/jpet.108.138941
You have access
Nociceptin/Orphanin FQ (N/OFQ)-Evoked Bradycardia, Hypotension, and Diuresis Are Absent in N/OFQ Peptide (NOP) Receptor Knockout Mice
Melissa A. Burmeister, Michael A. Ansonoff, John E. Pintar and Daniel R. Kapusta

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 897-904; DOI: https://doi.org/10.1124/jpet.107.135905

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

You have access
MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation
Daigen Xu, Steven E. Rowland, Patsy Clark, André Giroux, Bernard Côté, Sébastien Guiral, Myriam Salem, Yves Ducharme, Richard W. Friesen, Nathalie Méthot, Joseph Mancini, Laurent Audoly and Denis Riendeau

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 754-763; DOI: https://doi.org/10.1124/jpet.108.138776

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

You have access
The Protein Kinase A Pathway Contributes to Hg²⁺-Induced Alterations in Phosphorylation and Subcellular Distribution of Occludin Associated with Increased Tight Junction Permeability of Salivary Epithelial Cell Monolayers
Jitesh D. Kawedia, Mengmeng Jiang, Amit Kulkarni, Holly E. Waechter, Karl S. Matlin, Giovanni M. Pauletti and Anil G. Menon

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 829-837; DOI: https://doi.org/10.1124/jpet.107.135798
You have access
The Role of Systemic Handling in the Pathophysiologic Actions of Botulinum Toxin
Fetweh H. Al-Saleem, Denise M. Ancharski, Easwaran Ravichandran, Suresh G. Joshi, Ajay K. Singh, Yujing Gong and Lance L. Simpson

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 856-863; DOI: https://doi.org/10.1124/jpet.108.136242
You have access
In Vitro Biliary Clearance of Angiotensin II Receptor Blockers and 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitors in Sandwich-Cultured Rat Hepatocytes: Comparison with in Vivo Biliary Clearance
Koji Abe, Arlene S. Bridges, Wei Yue and Kim L. R. Brouwer

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 983-990; DOI: https://doi.org/10.1124/jpet.108.138073

NEUROPHARMACOLOGY

You have access
Relationship of Spinal Dynorphin Neurons to δ-Opioid Receptors and Estrogen Receptor α: Anatomical Basis for Ovarian Sex Steroid Opioid Antinociception
Alan R. Gintzler, Stephen A. Schnell, Daya S. Gupta, Nai-Jiang Liu and Martin W. Wessendorf

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 725-731; DOI: https://doi.org/10.1124/jpet.108.139816
You have access
Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and Aβ Pathology in a Transgenic Mouse Model of Alzheimer's Disease
Hiroshi Onozuka, Akira Nakajima, Kentaro Matsuzaki, Ryong-Woon Shin, Koichi Ogino, Daisuke Saigusa, Naomi Tetsu, Akihito Yokosuka, Yutaka Sashida, Yoshihiro Mimaki, Tohru Yamakuni and Yasushi Ohizumi

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 739-744; DOI: https://doi.org/10.1124/jpet.108.140293
You have access
Genomic Insights into Acute Alcohol Tolerance
Wei Hu, Laura Saba, Katherina Kechris, Sanjiv V. Bhave, Paula L. Hoffman and Boris Tabakoff

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 792-800; DOI: https://doi.org/10.1124/jpet.108.137521
You have access
In Vivo Profile of ICA-27243 [N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a Potent and Selective KCNQ2/Q3 (Kv7.2/Kv7.3) Activator in Rodent Anticonvulsant Models
Rosemarie Roeloffs, Alan D. Wickenden, Christopher Crean, Stephen Werness, Grant McNaughton-Smith, James Stables, James O. McNamara, Neil Ghodadra and Greg C. Rigdon

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 818-828; DOI: https://doi.org/10.1124/jpet.108.137794
You have access
Lithium Protection of Phencyclidine-Induced Neurotoxicity in Developing Brain: The Role of Phosphatidylinositol-3 Kinase/Akt and Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways
Yan Xia, Cheng Z. Wang, Jie Liu, Noelle C. Anastasio and Kenneth M. Johnson

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 838-848; DOI: https://doi.org/10.1124/jpet.107.133272
You have access
(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo
Carol S. Surowy, Torben R. Neelands, Bruce R. Bianchi, Steve McGaraughty, Rachid El Kouhen, Ping Han, Katharine L. Chu, Heath A. McDonald, Melissa Vos, Wende Niforatos, Erol K. Bayburt, Arthur Gomtsyan, Chih-Hung Lee, Prisca Honore, James P. Sullivan, Michael F. Jarvis and Connie R. Faltynek

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 879-888; DOI: https://doi.org/10.1124/jpet.108.138511
You have access
Methanandamide Allosterically Inhibits in Vivo the Function of Peripheral Nicotinic Acetylcholine Receptors Containing the α7-Subunit
Urszula Baranowska, Manfred Göthert, Radosław Rudź and Barbara Malinowska

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 912-919; DOI: https://doi.org/10.1124/jpet.108.140863
You have access
The Dopamine D₃/D₂ Agonist (+)-PD-128,907 [(R-(+)-trans-3,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol)] Protects against Acute and Cocaine-Kindled Seizures in Mice: Further Evidence for the Involvement of D₃ Receptors
J. M. Witkin, B. Levant, A. Zapata, R. Kaminski and M. Gasior

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 930-938; DOI: https://doi.org/10.1124/jpet.108.139212
You have access
Combination Therapy with Fenofibrate, a Peroxisome Proliferator-Activated Receptor α Agonist, and Simvastatin, a 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitor, on Experimental Traumatic Brain Injury
Xiao Ru Chen, Valerie C. Besson, Tiphaine Beziaud, Michel Plotkine and Catherine Marchand-Leroux

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 966-974; DOI: https://doi.org/10.1124/jpet.108.140368

TOXICOLOGY

You have access
p38 and c-Jun N-Terminal Kinase Mitogen-Activated Protein Kinase Signaling Pathways Play Distinct Roles in the Response of Organogenesis-Stage Embryos to a Teratogen
Jin Yan and Barbara F. Hales

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 764-772; DOI: https://doi.org/10.1124/jpet.108.139907
You have access
l-Methionine Toxicity in Freshly Isolated Mouse Hepatocytes Is Gender-Dependent and Mediated in Part by Transamination
Joseph T. Dever and Adnan A. Elfarra

Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 809-817; DOI: https://doi.org/10.1124/jpet.108.141044

Erratum

You have access
Correction to “Antihyperalgesic Effects of (R,E)-N-(2-Hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a Novel Transient Receptor Potential Vanilloid Type 1 Modulator That Does Not Cause Hyperthermia in Rats”
Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 999;

Main menu

User menu

Search

Table of Contents

CENTENNIAL PERSPECTIVE

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

Erratum

In this issue

Jump to

Navigate

More Information

ASPET's Other Journals