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Research ArticleNEUROPHARMACOLOGY

N,N′-Alkane-diyl-bis-3-picoliniums as Nicotinic Receptor Antagonists: Inhibition of Nicotine-Evoked Dopamine Release and Hyperactivity

Linda P. Dwoskin, Thomas E. Wooters, Sangeetha P. Sumithran, Kiran B. Siripurapu, B. Matthew Joyce, Paul R. Lockman, Vamshi K. Manda, Joshua T. Ayers, Zhenfa Zhang, Agripina G. Deaciuc, J. Michael McIntosh, Peter A. Crooks and Michael T. Bardo
Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 563-576; DOI: https://doi.org/10.1124/jpet.108.136630

Article Information

vol. 326 no. 2 563-576
DOI 
https://doi.org/10.1124/jpet.108.136630
PubMed 
18460644
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received January 16, 2008
  • Accepted May 5, 2008
  • Published online July 18, 2008.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Linda P. Dwoskin,
  2. Thomas E. Wooters,
  3. Sangeetha P. Sumithran,
  4. Kiran B. Siripurapu,
  5. B. Matthew Joyce,
  6. Paul R. Lockman,
  7. Vamshi K. Manda,
  8. Joshua T. Ayers,
  9. Zhenfa Zhang,
  10. Agripina G. Deaciuc,
  11. J. Michael McIntosh,
  12. Peter A. Crooks and
  13. Michael T. Bardo
  1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (L.P.D., S.P.S., K.B.S., B.M.J., J.T.A., Z.Z., A.G.D., P.A.C.); Department of Psychology, College of Arts and Sciences, University of Kentucky, Lexington, Kentucky (T.E.W., M.T.B.); School of Pharmacy, Texas Tech University of Health Sciences, Amarillo, Texas (P.R.L., V.K.M.); and Departments of Pharmaceutical Sciences, Psychiatry, and Biology, University of Utah, Salt Lake City, Utah (J.M.M.)
  1. Address correspondence to:
    Dr. Linda P. Dwoskin, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082. E-mail: ldwoskin{at}email.uky.edu
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Research ArticleNEUROPHARMACOLOGY

N,N′-Alkane-diyl-bis-3-picoliniums as Nicotinic Receptor Antagonists: Inhibition of Nicotine-Evoked Dopamine Release and Hyperactivity

Linda P. Dwoskin, Thomas E. Wooters, Sangeetha P. Sumithran, Kiran B. Siripurapu, B. Matthew Joyce, Paul R. Lockman, Vamshi K. Manda, Joshua T. Ayers, Zhenfa Zhang, Agripina G. Deaciuc, J. Michael McIntosh, Peter A. Crooks and Michael T. Bardo
Journal of Pharmacology and Experimental Therapeutics August 1, 2008, 326 (2) 563-576; DOI: https://doi.org/10.1124/jpet.108.136630
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