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Research ArticleNEUROPHARMACOLOGY

P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid β Reduction by β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice

Jere E. Meredith Jr., Lorin A. Thompson, Jeremy H. Toyn, Lawrence Marcin, Donna M. Barten, Jovita Marcinkeviciene, Lisa Kopcho, Young Kim, Alan Lin, Valerie Guss, Catherine Burton, Lawrence Iben, Craig Polson, Joe Cantone, Michael Ford, Dieter Drexler, Tracey Fiedler, Kimberley A. Lentz, James E. Grace Jr., Janet Kolb, Jason Corsa, Maria Pierdomenico, Kelli Jones, Richard E. Olson, John E. Macor and Charles F. Albright
Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 502-513; DOI: https://doi.org/10.1124/jpet.108.138974

Article Information

vol. 326 no. 2 502-513
DOI 
https://doi.org/10.1124/jpet.108.138974
PubMed 
18499745
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received March 10, 2008
  • Accepted May 21, 2008
  • Published online July 18, 2008.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jere E. Meredith, Jr.,
  2. Lorin A. Thompson,
  3. Jeremy H. Toyn,
  4. Lawrence Marcin,
  5. Donna M. Barten,
  6. Jovita Marcinkeviciene,
  7. Lisa Kopcho,
  8. Young Kim,
  9. Alan Lin,
  10. Valerie Guss,
  11. Catherine Burton,
  12. Lawrence Iben,
  13. Craig Polson,
  14. Joe Cantone,
  15. Michael Ford,
  16. Dieter Drexler,
  17. Tracey Fiedler,
  18. Kimberley A. Lentz,
  19. James E. Grace, Jr.,
  20. Janet Kolb,
  21. Jason Corsa,
  22. Maria Pierdomenico,
  23. Kelli Jones,
  24. Richard E. Olson,
  25. John E. Macor and
  26. Charles F. Albright
  1. Research and Development, Bristol-Myers Squibb Co., Wallingford, Connecticut (J.E.Me., L.A.T., J.H.T., L.M., D.M.B., A.L., V.G., C.B., L.I., C.P., J.Ca., M.F., D.D., T.F., K.A.L., J.E.G., J.K., J.Co., M.P., K.J., R.E.O., J.E.Ma., C.F.A.); and Research and Development, Bristol-Myers Squibb Co., Hopewell, New Jersey (J.M., L.K., Y.K.)
  1. Address correspondence to:
    Dr. Jere E. Meredith Jr., Bristol Myers Squibb, 5 Research Parkway, Wallingford, CT. E-mail: jere.meredith{at}bms.com
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Research ArticleNEUROPHARMACOLOGY

P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid β Reduction by β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice

Jere E. Meredith, Lorin A. Thompson, Jeremy H. Toyn, Lawrence Marcin, Donna M. Barten, Jovita Marcinkeviciene, Lisa Kopcho, Young Kim, Alan Lin, Valerie Guss, Catherine Burton, Lawrence Iben, Craig Polson, Joe Cantone, Michael Ford, Dieter Drexler, Tracey Fiedler, Kimberley A. Lentz, James E. Grace, Janet Kolb, Jason Corsa, Maria Pierdomenico, Kelli Jones, Richard E. Olson, John E. Macor and Charles F. Albright
Journal of Pharmacology and Experimental Therapeutics August 1, 2008, 326 (2) 502-513; DOI: https://doi.org/10.1124/jpet.108.138974
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