Journal of Pharmacology and Experimental Therapeutics: 326 (2)

August 01, 2008; Volume 326,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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Mineral Arsenicals in Traditional Medicines: Orpiment, Realgar, and Arsenolite
Jie Liu, Yuanfu Lu, Qin Wu, Robert A. Goyer and Michael P. Waalkes

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 363-368; DOI: https://doi.org/10.1124/jpet.108.139543

BEHAVIORAL PHARMACOLOGY

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Specific Antinociceptive Activity of Cholest-4-en-3-one, Oxime (TRO19622) in Experimental Models of Painful Diabetic and Chemotherapy-Induced Neuropathy
Thierry Bordet, Bruno Buisson, Magali Michaud, Jean-Louis Abitbol, Fabien Marchand, John Grist, Emile Andriambeloson, Marzia Malcangio and Rebecca M. Pruss

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 623-632; DOI: https://doi.org/10.1124/jpet.108.139410
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Spinal Antiallodynia Action of Glycine Transporter Inhibitors in Neuropathic Pain Models in Mice
Katsuya Morita, Naoyo Motoyama, Tomoya Kitayama, Norimitsu Morioka, Koki Kifune and Toshihiro Dohi

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 633-645; DOI: https://doi.org/10.1124/jpet.108.136267
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The Anxiolytic-Like Effects of the Novel, Orally Active Nociceptin Opioid Receptor Agonist 8-[bis(2-Methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510)
Geoffrey B. Varty, Sherry X. Lu, Cynthia A. Morgan, Mary E. Cohen-Williams, Robert A. Hodgson, April Smith-Torhan, Hongtao Zhang, Ahmad B. Fawzi, Michael P. Graziano, Ginny D. Ho, Julius Matasi, Deen Tulshian, Vicki L. Coffin and Galen J. Carey

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 672-682; DOI: https://doi.org/10.1124/jpet.108.136937

CARDIOVASCULAR

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Sustained Soluble Guanylate Cyclase Stimulation Offsets Nitric-Oxide Synthase Inhibition to Restore Acute Cardiac Modulation by Sildenafil
Takahiro Nagayama, Manling Zhang, Steven Hsu, Eiki Takimoto and David A. Kass

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 380-387; DOI: https://doi.org/10.1124/jpet.108.137422
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2-Aminopurine Inhibits Lipid Accumulation Induced by Apolipoprotein E-Deficient Lipoprotein in Macrophages: Potential Role of Eukaryotic Initiation Factor-2α Phosphorylation in Foam Cell Formation
DongFang Wu, Hong Yang, YanFeng Zhao, Chakradhari Sharan, J. Shawn Goodwin, Lichun Zhou, Yang Guo and ZhongMao Guo

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 395-405; DOI: https://doi.org/10.1124/jpet.107.134833
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Effects of Novel Vasopressin Receptor Antagonists on Renal Function and Cardiac Hypertrophy in Rats with Experimental Congestive Heart Failure
Bishara Bishara, Hiba Shiekh, Tony Karram, Irit Rubinstein, Zaher S. Azzam, Niroz Abu-Saleh, Samy Nitecki, Joseph Winaver, Aaron Hoffman and Zaid A. Abassi

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 414-422; DOI: https://doi.org/10.1124/jpet.108.137745

CELLULAR AND MOLECULAR

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Arsenic Trioxide, Arsenic Pentoxide, and Arsenic Iodide Inhibit Human Keratinocyte Proliferation through the Induction of Apoptosis
Wai-Pui Tse, Christopher H. K. Cheng, Chun-Tao Che and Zhi-Xiu Lin

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 388-394; DOI: https://doi.org/10.1124/jpet.107.134080
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Autoregulation of McA-RH7777 Hepatoma Cell Proliferation by Histamine H₃ Receptors
E. Davenas, A. Rouleau, S. Morisset and J. M. Arrang

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 406-413; DOI: https://doi.org/10.1124/jpet.107.135368
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Derivatized 2-Furoyl-LIGRLO-amide, a Versatile and Selective Probe for Proteinase-Activated Receptor 2: Binding and Visualization
Morley D. Hollenberg, Bernard Renaux, Eric Hyun, Steeve Houle, Nathalie Vergnolle, Mahmoud Saifeddine and Rithwik Ramachandran

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 453-462; DOI: https://doi.org/10.1124/jpet.108.136432

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Point Mutation of the Proteasome β5 Subunit Gene Is an Important Mechanism of Bortezomib Resistance in Bortezomib-Selected Variants of Jurkat T Cell Lymphoblastic Lymphoma/Leukemia Line
Shuqing Lü, Jianmin Yang, Xianmin Song, Shenglan Gong, Hong Zhou, Lieping Guo, Ningxia Song, Xiaochen Bao, Pingping Chen and Jianmin Wang

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 423-431; DOI: https://doi.org/10.1124/jpet.108.138131

Cardiovascular

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Systemic Activation of the Transient Receptor Potential Vanilloid Subtype 4 Channel Causes Endothelial Failure and Circulatory Collapse: Part 2
Robert N. Willette, Weike Bao, Sandhya Nerurkar, Tian-li Yue, Chris P. Doe, Gerald Stankus, Gregory H. Turner, Haisong Ju, Heath Thomas, Cindy E. Fishman, Anthony Sulpizio, David J. Behm, Sandra Hoffman, Zuojun Lin, Irina Lozinskaya, Linda N. Casillas, Min Lin, Robert E. Lee Trout, Bartholomew J. Votta, Kevin Thorneloe, Erin S. R. Lashinger, David J. Figueroa, Robert Marquis and Xiaoping Xu

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 443-452; DOI: https://doi.org/10.1124/jpet.107.134551

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Topical Implantation of Mesenchymal Stem Cells Has Beneficial Effects on Healing of Experimental Colitis in Rats
Yujiro Hayashi, Shingo Tsuji, Masahiko Tsujii, Tsutomu Nishida, Shuji Ishii, Hideki Iijima, Toru Nakamura, Hiroshi Eguchi, Eiji Miyoshi, Norio Hayashi and Sunao Kawano

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 523-531; DOI: https://doi.org/10.1124/jpet.108.137083

Gastrointestinal, Hepatic, Pulmonary, and Renal

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N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I
Kevin S. Thorneloe, Anthony C. Sulpizio, Zuojun Lin, David J. Figueroa, Angela K. Clouse, Gerald P. McCafferty, Tim P. Chendrimada, Erin S. R. Lashinger, Earl Gordon, Louise Evans, Blake A. Misajet, Douglas J. DeMarini, Josephine H. Nation, Linda N. Casillas, Robert W. Marquis, Bartholomew J. Votta, Steven A. Sheardown, Xiaoping Xu, David P. Brooks, Nicholas J. Laping and Timothy D. Westfall

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 432-442; DOI: https://doi.org/10.1124/jpet.108.139295

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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Lipopolysaccharide Induces Macrophage Migration via Prostaglandin D₂ and Prostaglandin E₂
Tsuyoshi Tajima, Takahisa Murata, Kosuke Aritake, Yoshihiro Urade, Hiroyuki Hirai, Masataka Nakamura, Hiroshi Ozaki and Masatoshi Hori

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 493-501; DOI: https://doi.org/10.1124/jpet.108.137992
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Compounds That Increase or Mimic Cyclic Adenosine Monophosphate Enhance Tristetraprolin Degradation in Lipopolysaccharide-Treated Murine J774 Macrophages
Ulla Jalonen, Erja-Leena Paukkeri and Eeva Moilanen

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 514-522; DOI: https://doi.org/10.1124/jpet.107.133702
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Modeling Corticosteroid Effects in a Rat Model of Rheumatoid Arthritis I: Mechanistic Disease Progression Model for the Time Course of Collagen-Induced Arthritis in Lewis Rats
Justin C. Earp, Debra C. DuBois, Diana S. Molano, Nancy A. Pyszczynski, Craig E. Keller, Richard R. Almon and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 532-545; DOI: https://doi.org/10.1124/jpet.108.137372
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Modeling Corticosteroid Effects in a Rat Model of Rheumatoid Arthritis II: Mechanistic Pharmacodynamic Model for Dexamethasone Effects in Lewis Rats with Collagen-Induced Arthritis
Justin C. Earp, Debra C. DuBois, Diana S. Molano, Nancy A. Pyszczynski, Richard R. Almon and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 546-554; DOI: https://doi.org/10.1124/jpet.108.137414
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Integrated Cellular Bone Homeostasis Model for Denosumab Pharmacodynamics in Multiple Myeloma Patients
Anshu Marathe, Mark C. Peterson and Donald E. Mager

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 555-562; DOI: https://doi.org/10.1124/jpet.108.137703

NEUROPHARMACOLOGY

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Reversal of Oxidative Stress-Induced Anxiety by Inhibition of Phosphodiesterase-2 in Mice
Anbrin Masood, Ahmed Nadeem, S. Jamal Mustafa and James M. O'Donnell

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 369-379; DOI: https://doi.org/10.1124/jpet.108.137208
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Ethanol Modulates Synaptic and Extrasynaptic GABA_A Receptors in the Thalamus
Fan Jia, Dev Chandra, Gregg E. Homanics and Neil L. Harrison

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 475-482; DOI: https://doi.org/10.1124/jpet.108.139303
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The Endogenous Cannabinoid System Modulates Nicotine Reward and Dependence
Lisa L. Merritt, B. R. Martin, C. Walters, A. H. Lichtman and M. Imad Damaj

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 483-492; DOI: https://doi.org/10.1124/jpet.108.138321
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P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid β Reduction by β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice
Jere E. Meredith, Lorin A. Thompson, Jeremy H. Toyn, Lawrence Marcin, Donna M. Barten, Jovita Marcinkeviciene, Lisa Kopcho, Young Kim, Alan Lin, Valerie Guss, Catherine Burton, Lawrence Iben, Craig Polson, Joe Cantone, Michael Ford, Dieter Drexler, Tracey Fiedler, Kimberley A. Lentz, James E. Grace, Janet Kolb, Jason Corsa, Maria Pierdomenico, Kelli Jones, Richard E. Olson, John E. Macor and Charles F. Albright

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 502-513; DOI: https://doi.org/10.1124/jpet.108.138974
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N,N′-Alkane-diyl-bis-3-picoliniums as Nicotinic Receptor Antagonists: Inhibition of Nicotine-Evoked Dopamine Release and Hyperactivity
Linda P. Dwoskin, Thomas E. Wooters, Sangeetha P. Sumithran, Kiran B. Siripurapu, B. Matthew Joyce, Paul R. Lockman, Vamshi K. Manda, Joshua T. Ayers, Zhenfa Zhang, Agripina G. Deaciuc, J. Michael McIntosh, Peter A. Crooks and Michael T. Bardo

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 563-576; DOI: https://doi.org/10.1124/jpet.108.136630
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Pharmacological Effects of the Metabotropic Glutamate Receptor 1 Antagonist Compared with Those of the Metabotropic Glutamate Receptor 5 Antagonist and Metabotropic Glutamate Receptor 2/3 Agonist in Rodents: Detailed Investigations with a Selective Allosteric Metabotropic Glutamate Receptor 1 Antagonist, FTIDC [4-[1-(2-Fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide]
Akio Satow, Shunsuke Maehara, Satoko Ise, Hirohiko Hikichi, Miyuki Fukushima, Gentaroh Suzuki, Toshifumi Kimura, Takeshi Tanaka, Satoru Ito, Hiroshi Kawamoto and Hisashi Ohta

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 577-586; DOI: https://doi.org/10.1124/jpet.108.138107
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In Vivo Characterization of a Novel Phenylisothiocyanate Tropane Analog at Monoamine Transporters in Rat Brain
Vishakantha Murthy, Thomas J. Martin, Susy Kim, Huw M. L. Davies and Steven R. Childers

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 587-595; DOI: https://doi.org/10.1124/jpet.108.138842
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Brain Regional Differences in the Effect of Ethanol on GABA Release from Presynaptic Terminals
Hugh E. Criswell, Zhen Ming, M. Katherine Kelm and George R. Breese

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 596-603; DOI: https://doi.org/10.1124/jpet.107.135418
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Antinociception Produced by 14,15-Epoxyeicosatrienoic Acid Is Mediated by the Activation of β-Endorphin and Met-Enkephalin in the Rat Ventrolateral Periaqueductal Gray
Maia Terashvili, Leon F. Tseng, Hsiang-en Wu, Jayashree Narayanan, Lucas M. Hart, John R. Falck, Phillip F. Pratt and David R. Harder

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 614-622; DOI: https://doi.org/10.1124/jpet.108.136739
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Neuroprotective Effects of the Novel Glutamate Transporter Inhibitor (–)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic Acid, Which Preferentially Inhibits Reverse Transport (Glutamate Release) Compared with Glutamate Reuptake
Simona Colleoni, Anders A. Jensen, Elisa Landucci, Elena Fumagalli, Paola Conti, Andrea Pinto, Marco De Amici, Domenico E. Pellegrini-Giampietro, Carlo De Micheli, Tiziana Mennini and Marco Gobbi

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 646-656; DOI: https://doi.org/10.1124/jpet.107.135251

TOXICOLOGY

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2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Impairment of B Cell Differentiation Involves Dysregulation of Paired Box 5 (Pax5) Isoform, Pax5a
Dina Schneider, Maria A. Manzan, Robert B. Crawford, Weimin Chen and Norbert E. Kaminski

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 463-474; DOI: https://doi.org/10.1124/jpet.108.139857
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Influence of Lipid-Soluble Gating Modifier Toxins on Sodium Influx in Neocortical Neurons
Zhengyu Cao, Joju George, William H. Gerwick, Daniel G. Baden, Jon D. Rainier and Thomas F. Murray

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 604-613; DOI: https://doi.org/10.1124/jpet.108.138230
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Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore
Emma E. Graham, Rachel J. Walsh, Charlotte M. Hirst, James L. Maggs, Scott Martin, Martin J. Wild, Ian D. Wilson, John R. Harding, J. Gerald Kenna, Raimund M. Peter, Dominic P. Williams and B. Kevin Park

Journal of Pharmacology and Experimental Therapeutics August 2008, 326 (2) 657-671; DOI: https://doi.org/10.1124/jpet.107.135483

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

Cardiovascular

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Gastrointestinal, Hepatic, Pulmonary, and Renal

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

NEUROPHARMACOLOGY

TOXICOLOGY

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