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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

June 01, 2008; Volume 325,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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    The Ambiguities of Opioid Tolerance Mechanisms: Barriers to Pain Therapeutics or New Pain Therapeutic Possibilities
    Alan R. Gintzler and Sumita Chakrabarti
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 709-713; DOI: https://doi.org/10.1124/jpet.107.135533

BEHAVIORAL PHARMACOLOGY

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    Effects of Spinal α2-Adrenoceptor and I1-Imidazoline Receptor Activation on Hindlimb Movement Induction in Spinal Cord-Injured Mice
    Nicolas P. Lapointe, Roth-Visal Ung, Pascal Rouleau and Pierre A. Guertin
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 994-1006; DOI: https://doi.org/10.1124/jpet.107.134874

CARDIOVASCULAR

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    A Serotonergic System in Veins: Serotonin Transporter-Independent Uptake
    A. Elizabeth Linder, Wei Ni, Theodora Szasz, Robert Burnett, Jessica Diaz, Timothy J. Geddes, Donald M. Kuhn and Stephanie W. Watts
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 714-722; DOI: https://doi.org/10.1124/jpet.107.135699
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    The T- and L-Type Calcium Channel Blocker (CCB) Mibefradil Attenuates Leg Edema Induced by the L-Type CCB Nifedipine in the Spontaneously Hypertensive Rat: A Novel Differentiating Assay
    Terry C. Major, Shantanu Dhamija, Nicole Black, Serguei Liachenko, Brandy Morenko, Gregg Sobocinski, Carlin Okerberg, Paula Tinholt, Steven Madore and Mark C. Kowala
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 723-731; DOI: https://doi.org/10.1124/jpet.107.133892
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    Long-Term but Not Short-Term p38 Mitogen-Activated Protein Kinase Inhibition Improves Cardiac Function and Reduces Cardiac Remodeling Post-Myocardial Infarction
    A. R. Kompa, F. See, D. A. Lewis, A. Adrahtas, D. M. Cantwell, B. H. Wang and H. Krum
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 741-750; DOI: https://doi.org/10.1124/jpet.107.133546
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    Interdependent Regulation of Afferent Renal Nerve Activity and Renal Function: Role of Transient Receptor Potential Vanilloid Type 1, Neurokinin 1, and Calcitonin Gene-Related Peptide Receptors
    Chaoqin Xie, Jeffrey R. Sachs and Donna H. Wang
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 751-757; DOI: https://doi.org/10.1124/jpet.108.136374
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    Combination of the Angiotensin-Converting Enzyme Inhibitor Perindopril and the Diuretic Indapamide Activate Postnatal Vasculogenesis in Spontaneously Hypertensive Rats
    Dong You, Clément Cochain, Céline Loinard, José Vilar, Barend Mees, Micheline Duriez, Bernard I. Lévy and Jean-Sébastien Silvestre
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 766-773; DOI: https://doi.org/10.1124/jpet.107.131532
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    Mitochondrial Effects of Estrogen Are Mediated by Estrogen Receptor α in Brain Endothelial Cells
    Ali Razmara, Lorraine Sunday, Chris Stirone, Xiao Bo Wang, Diana N. Krause, Sue P. Duckles and Vincent Procaccio
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 782-790; DOI: https://doi.org/10.1124/jpet.107.134072
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    Nebivolol, but Not Metoprolol, Improves Endothelial Function of the Corpus Cavernosum in Apolipoprotein E-Knockout Mice
    Magnus Baumhäkel, Nils Schlimmer, Kansu Büyükafşar, Onur Arikan and Michael Böhm
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 818-823; DOI: https://doi.org/10.1124/jpet.107.135681
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    Differential Effect of the Protein Synthesis Inhibitors Puromycin and Cycloheximide on Vascular Smooth Muscle Cell Viability
    Valerie Croons, Wim Martinet, Arnold G. Herman and Guido R. Y. De Meyer
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 824-832; DOI: https://doi.org/10.1124/jpet.107.132944
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    Heme Oxygenase-Mediated Increases in Adiponectin Decrease Fat Content and Inflammatory Cytokines Tumor Necrosis Factor-α and Interleukin-6 in Zucker Rats and Reduce Adipogenesis in Human Mesenchymal Stem Cells
    Dong Hyun Kim, Angela P. Burgess, Ming Li, Peter L. Tsenovoy, Francesco Addabbo, John A. McClung, Nitin Puri and Nader G. Abraham
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 833-840; DOI: https://doi.org/10.1124/jpet.107.135285
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    Antitorsadogenic Effects of (±)-N-(2,6-Dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (Ranolazine) in Anesthetized Rabbits
    Wei-Qun Wang, Chelsea Robertson, Arvinder K. Dhalla and Luiz Belardinelli
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 875-881; DOI: https://doi.org/10.1124/jpet.108.137729
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    Female Rats Fed a High-Fat Diet Were Associated with Vascular Dysfunction and Cardiac Fibrosis in the Absence of Overt Obesity and Hyperlipidemia: Therapeutic Potential of Resveratrol
    Marie-Claude Aubin, Claude Lajoie, Robert Clément, Hugues Gosselin, Angelino Calderone and Louis P. Perrault
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 961-968; DOI: https://doi.org/10.1124/jpet.107.135061
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    5-Hydroxytryptamine Lowers Blood Pressure in Normotensive and Hypertensive Rats
    Jessica Diaz, Wei Ni, Janice Thompson, Andrew King, Gregory D. Fink and Stephanie W. Watts
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1031-1038; DOI: https://doi.org/10.1124/jpet.108.136226

CELLULAR AND MOLECULAR

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    Extracellular Signal-Regulated Kinase Activation Mediates Mitochondrial Dysfunction and Necrosis Induced by Hydrogen Peroxide in Renal Proximal Tubular Cells
    Shougang Zhuang, Gilbert R. Kinsey, Yan Yan, Jiahuai Han and Rick G. Schnellmann
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 732-740; DOI: https://doi.org/10.1124/jpet.108.136358
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    MSFTZ, a Flavanone Derivative, Induces Human Hepatoma Cell Apoptosis via a Reactive Oxygen Species- and Caspase-Dependent Mitochondrial Pathway
    Meidan Ying, Chongxing Tu, Huazhou Ying, Yongzhou Hu, Qiaojun He and Bo Yang
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 758-765; DOI: https://doi.org/10.1124/jpet.107.135657
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    Lysophosphatidic Acid Induces Rapid and Sustained Decreases in Epidermal Growth Factor Receptor Binding via Different Signaling Pathways in BEAS-2B Airway Epithelial Cells
    Karen M. Kassel, Puttappa R. Dodmane, Nancy A. Schulte and Myron L. Toews
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 809-817; DOI: https://doi.org/10.1124/jpet.107.133736
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    Synthesis and Characterization of 125I-α-Conotoxin ArIB[V11L;V16A], a Selective α7 Nicotinic Acetylcholine Receptor Antagonist
    Paul Whiteaker, Michael J. Marks, Sean Christensen, Cheryl Dowell, Allan C. Collins and J. Michael McIntosh
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 910-919; DOI: https://doi.org/10.1124/jpet.108.136895
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    The Impact of Orthosteric Radioligand Depletion on the Quantification of Allosteric Modulator Interactions
    Vimesh A. Avlani, David J. McLoughlin, Patrick M. Sexton and Arthur Christopoulos
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 927-934; DOI: https://doi.org/10.1124/jpet.108.136978
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    Muscarinic M4 Receptor Recycling Requires a Motif in the Third Intracellular Loop
    Yuichi Hashimoto, Kanoko Morisawa, Hiroyuki Saito, Eri Jojima, Norihiro Yoshida and Tatsuya Haga
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 947-953; DOI: https://doi.org/10.1124/jpet.107.135095
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    Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8
    Luciano De Petrocellis, Vittorio Vellani, Aniello Schiano-Moriello, Pietro Marini, Pier Cosimo Magherini, Pierangelo Orlando and Vincenzo Di Marzo
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1007-1015; DOI: https://doi.org/10.1124/jpet.107.134809
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    Parallel Improvement of Sodium and Chloride Transport Defects by Miglustat (n-Butyldeoxynojyrimicin) in Cystic Fibrosis Epithelial Cells
    Sabrina Noël, Martina Wilke, Alice G. M. Bot, Hugo R. De Jonge and Frédéric Becq
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1016-1023; DOI: https://doi.org/10.1124/jpet.107.135582
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    Cysteinyl Leukotriene-1 Receptor Activation in a Human Bronchial Epithelial Cell Line Leads to Signal Transducer and Activator of Transcription 1-Mediated Eosinophil Adhesion
    Mirella Profita, Angelo Sala, Anna Bonanno, Liboria Siena, Maria Ferraro, Rossana Di Giorgi, Angela M. Montalbano, Giusy D. Albano, Rosalia Gagliardo and Mark Gjomarkaj
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1024-1030; DOI: https://doi.org/10.1124/jpet.107.131649
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    Two-State Models and the Analysis of the Allosteric Effect of Gallamine at the M2 Muscarinic Receptor
    Frederick J. Ehlert and Michael T. Griffin
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1039-1060; DOI: https://doi.org/10.1124/jpet.108.136960

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Protoapigenone, a Novel Flavonoid, Induces Apoptosis in Human Prostate Cancer Cells through Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH2-Terminal Kinase 1/2
    Hsueh-Ling Chang, Yang-Chang Wu, Jinu-Huang Su, Yao-Tsung Yeh and Shyng-Shiou F. Yuan
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 841-849; DOI: https://doi.org/10.1124/jpet.107.135442

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    New Role of Resistin in Lipopolysaccharide-Induced Liver Damage in Mice
    Juliane I. Beier, Luping Guo, Claudia von Montfort, J. Phillip Kaiser, Swati Joshi-Barve and Gavin E. Arteel
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 801-808; DOI: https://doi.org/10.1124/jpet.108.136721
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    Assessment of Nerve Stimulation-Induced Release of Purines from Mouse Kidneys by Tandem Mass Spectrometry
    Jin Ren, Zaichuan Mi and Edwin K. Jackson
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 920-926; DOI: https://doi.org/10.1124/jpet.108.137752
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    The Use of Occupation Isoboles for Analysis of a Response Mediated by Two Receptors: M2 and M3 Muscarinic Receptor Subtype-Induced Mouse Stomach Contractions
    Alan S. Braverman, Ronald J. Tallarida and Michael R. Ruggieri
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 954-960; DOI: https://doi.org/10.1124/jpet.108.137018
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    Induction of Apoptosis in Renal Tubular Cells by Histone Deacetylase Inhibitors, a Family of Anticancer Agents
    Guie Dong, Lysa Wang, Cong-Yi Wang, Tianxin Yang, M. Vijay Kumar and Zheng Dong
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 978-984; DOI: https://doi.org/10.1124/jpet.108.137398

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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    Interleukin-13 Neutralization by Two Distinct Receptor Blocking Mechanisms Reduces Immunoglobulin E Responses and Lung Inflammation in Cynomolgus Monkeys
    Marion T. Kasaian, Xiang-Yang Tan, Macy Jin, Lori Fitz, Kimberly Marquette, Nancy Wood, Timothy A. Cook, Julie Lee, Angela Widom, Rita Agostinelli, Andrea Bree, Franklin J. Schlerman, Stephane Olland, Michael Wadanoli, Joseph Sypek, Davinder Gill, Samuel J. Goldman and Lioudmila Tchistiakova
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 882-892; DOI: https://doi.org/10.1124/jpet.108.136515

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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    The Human Multidrug Resistance Protein 4 (MRP4, ABCC4): Functional Analysis of a Highly Polymorphic Gene
    Nada Abla, Leslie W. Chinn, Tsutomu Nakamura, Li Liu, Conrad C. Huang, Susan J. Johns, Michiko Kawamoto, Doug Stryke, Travis R. Taylor, Thomas E. Ferrin, Kathleen M. Giacomini and Deanna L. Kroetz
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 859-868; DOI: https://doi.org/10.1124/jpet.108.136523
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    CYP2C75-Involved Autoinduction of Metabolism in Rhesus Monkeys of Methyl 3-Chloro-3′-fluoro-4′-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1′-biphenyl-2-carboxylate (MK-0686), a Bradykinin B1 Receptor Antagonist
    Cuyue Tang, Brian A. Carr, Frédéric Poignant, Bennett Ma, Stacey L. Polsky-Fisher, Yuhsin Kuo, Kristie Strong-Basalyga, Alisha Norcross, Karen Richards, Roy Eisenhandler, Edward J. Carlini, Christina Ng Di Marco, Scott D. Kuduk, Nathan X. Yu, Conrad E. Raab, Tom Rushmore, Clay B. Frederick, Mark G. Bock and Thomayant Prueksaritanont
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 935-946; DOI: https://doi.org/10.1124/jpet.107.136044

NEUROPHARMACOLOGY

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    In Vivo Quantitative Autoradiographic Analysis of Brain Muscarinic Receptor Occupancy by Antimuscarinic Agents for Overactive Bladder Treatment
    Shuji Maruyama, Hideo Tsukada, Shingo Nishiyama, Takeharu Kakiuchi, Dai Fukumoto, Naoto Oku and Shizuo Yamada
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 774-781; DOI: https://doi.org/10.1124/jpet.108.136390
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    Comparative Molecular Field Analysis Using Selectivity Fields Reveals Residues in the Third Transmembrane Helix of the Serotonin Transporter Associated with Substrate and Antagonist Recognition
    Crystal C. Walline, David E. Nichols, F. Ivy Carroll and Eric L. Barker
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 791-800; DOI: https://doi.org/10.1124/jpet.108.136200
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    Cannabinoids Inhibit Network-Driven Synapse Loss between Hippocampal Neurons in Culture
    Hee Jung Kim, Jonathan J. Waataja and Stanley A. Thayer
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 850-858; DOI: https://doi.org/10.1124/jpet.107.131607
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    Pharmacological Assessment of M1 Muscarinic Acetylcholine Receptor-Gq/11 Protein Coupling in Membranes Prepared from Postmortem Human Brain Tissue
    Hasib Salah-Uddin, David R. Thomas, Ceri H. Davies, Jim J. Hagan, Martyn D. Wood, Jeannette M. Watson and R. A. John Challiss
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 869-874; DOI: https://doi.org/10.1124/jpet.108.137968
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    Synthesis and Pharmacological in Vitro and in Vivo Profile of 3-Oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic Acid 4-Fluoro-benzylamide (SHA 68), a Selective Antagonist of the Neuropeptide S Receptor
    Naoe Okamura, Stephen A. Habay, Joanne Zeng, A. Richard Chamberlin and Rainer K. Reinscheid
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 893-901; DOI: https://doi.org/10.1124/jpet.107.135103
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    Correlation between ex Vivo Receptor Occupancy and Wake-Promoting Activity of Selective H3 Receptor Antagonists
    Siyuan Le, John A. Gruner, Joanne R. Mathiasen, Michael J. Marino and Hervé Schaffhauser
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 902-909; DOI: https://doi.org/10.1124/jpet.107.135343
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    Combined Active and Passive Immunization Enhances the Efficacy of Immunotherapy against Nicotine in Rats
    Samuel A. Roiko, Andrew C. Harris, Daniel E. Keyler, Mark G. LeSage, Yan Zhang and Paul R. Pentel
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 985-993; DOI: https://doi.org/10.1124/jpet.107.135111

TOXICOLOGY

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    Dependence of Reactive Oxygen Species and FLICE Inhibitory Protein on Lipofectamine-Induced Apoptosis in Human Lung Epithelial Cells
    Lalana Kongkaneramit, Narong Sarisuta, Neelam Azad, Yongju Lu, Anand Krishnan V. Iyer, Liying Wang and Yon Rojanasakul
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 969-977; DOI: https://doi.org/10.1124/jpet.107.136077

Errata

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    Correction to “First in Vivo Evidence for a Functional Interaction between Chemokine and Cannabinoid Systems in the Brain”
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1061;
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    Correction to “Tetrathiomolybdate Protects against Bile Duct Ligation-Induced Cholestatic Liver Injury and Fibrosis”
    Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1062;
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Journal of Pharmacology and Experimental Therapeutics: 325 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 325, Issue 3
1 Jun 2008
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  • INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA
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