Journal of Pharmacology and Experimental Therapeutics: 325 (3)

June 01, 2008; Volume 325,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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The Ambiguities of Opioid Tolerance Mechanisms: Barriers to Pain Therapeutics or New Pain Therapeutic Possibilities
Alan R. Gintzler and Sumita Chakrabarti

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 709-713; DOI: https://doi.org/10.1124/jpet.107.135533

BEHAVIORAL PHARMACOLOGY

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Effects of Spinal α₂-Adrenoceptor and I₁-Imidazoline Receptor Activation on Hindlimb Movement Induction in Spinal Cord-Injured Mice
Nicolas P. Lapointe, Roth-Visal Ung, Pascal Rouleau and Pierre A. Guertin

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 994-1006; DOI: https://doi.org/10.1124/jpet.107.134874

CARDIOVASCULAR

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A Serotonergic System in Veins: Serotonin Transporter-Independent Uptake
A. Elizabeth Linder, Wei Ni, Theodora Szasz, Robert Burnett, Jessica Diaz, Timothy J. Geddes, Donald M. Kuhn and Stephanie W. Watts

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 714-722; DOI: https://doi.org/10.1124/jpet.107.135699
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The T- and L-Type Calcium Channel Blocker (CCB) Mibefradil Attenuates Leg Edema Induced by the L-Type CCB Nifedipine in the Spontaneously Hypertensive Rat: A Novel Differentiating Assay
Terry C. Major, Shantanu Dhamija, Nicole Black, Serguei Liachenko, Brandy Morenko, Gregg Sobocinski, Carlin Okerberg, Paula Tinholt, Steven Madore and Mark C. Kowala

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 723-731; DOI: https://doi.org/10.1124/jpet.107.133892
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Long-Term but Not Short-Term p38 Mitogen-Activated Protein Kinase Inhibition Improves Cardiac Function and Reduces Cardiac Remodeling Post-Myocardial Infarction
A. R. Kompa, F. See, D. A. Lewis, A. Adrahtas, D. M. Cantwell, B. H. Wang and H. Krum

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 741-750; DOI: https://doi.org/10.1124/jpet.107.133546
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Interdependent Regulation of Afferent Renal Nerve Activity and Renal Function: Role of Transient Receptor Potential Vanilloid Type 1, Neurokinin 1, and Calcitonin Gene-Related Peptide Receptors
Chaoqin Xie, Jeffrey R. Sachs and Donna H. Wang

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 751-757; DOI: https://doi.org/10.1124/jpet.108.136374
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Combination of the Angiotensin-Converting Enzyme Inhibitor Perindopril and the Diuretic Indapamide Activate Postnatal Vasculogenesis in Spontaneously Hypertensive Rats
Dong You, Clément Cochain, Céline Loinard, José Vilar, Barend Mees, Micheline Duriez, Bernard I. Lévy and Jean-Sébastien Silvestre

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 766-773; DOI: https://doi.org/10.1124/jpet.107.131532
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Mitochondrial Effects of Estrogen Are Mediated by Estrogen Receptor α in Brain Endothelial Cells
Ali Razmara, Lorraine Sunday, Chris Stirone, Xiao Bo Wang, Diana N. Krause, Sue P. Duckles and Vincent Procaccio

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 782-790; DOI: https://doi.org/10.1124/jpet.107.134072
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Nebivolol, but Not Metoprolol, Improves Endothelial Function of the Corpus Cavernosum in Apolipoprotein E-Knockout Mice
Magnus Baumhäkel, Nils Schlimmer, Kansu Büyükafşar, Onur Arikan and Michael Böhm

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 818-823; DOI: https://doi.org/10.1124/jpet.107.135681
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Differential Effect of the Protein Synthesis Inhibitors Puromycin and Cycloheximide on Vascular Smooth Muscle Cell Viability
Valerie Croons, Wim Martinet, Arnold G. Herman and Guido R. Y. De Meyer

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 824-832; DOI: https://doi.org/10.1124/jpet.107.132944
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Heme Oxygenase-Mediated Increases in Adiponectin Decrease Fat Content and Inflammatory Cytokines Tumor Necrosis Factor-α and Interleukin-6 in Zucker Rats and Reduce Adipogenesis in Human Mesenchymal Stem Cells
Dong Hyun Kim, Angela P. Burgess, Ming Li, Peter L. Tsenovoy, Francesco Addabbo, John A. McClung, Nitin Puri and Nader G. Abraham

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 833-840; DOI: https://doi.org/10.1124/jpet.107.135285
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Antitorsadogenic Effects of (±)-N-(2,6-Dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (Ranolazine) in Anesthetized Rabbits
Wei-Qun Wang, Chelsea Robertson, Arvinder K. Dhalla and Luiz Belardinelli

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 875-881; DOI: https://doi.org/10.1124/jpet.108.137729
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Female Rats Fed a High-Fat Diet Were Associated with Vascular Dysfunction and Cardiac Fibrosis in the Absence of Overt Obesity and Hyperlipidemia: Therapeutic Potential of Resveratrol
Marie-Claude Aubin, Claude Lajoie, Robert Clément, Hugues Gosselin, Angelino Calderone and Louis P. Perrault

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 961-968; DOI: https://doi.org/10.1124/jpet.107.135061
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5-Hydroxytryptamine Lowers Blood Pressure in Normotensive and Hypertensive Rats
Jessica Diaz, Wei Ni, Janice Thompson, Andrew King, Gregory D. Fink and Stephanie W. Watts

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1031-1038; DOI: https://doi.org/10.1124/jpet.108.136226

CELLULAR AND MOLECULAR

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Extracellular Signal-Regulated Kinase Activation Mediates Mitochondrial Dysfunction and Necrosis Induced by Hydrogen Peroxide in Renal Proximal Tubular Cells
Shougang Zhuang, Gilbert R. Kinsey, Yan Yan, Jiahuai Han and Rick G. Schnellmann

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 732-740; DOI: https://doi.org/10.1124/jpet.108.136358
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MSFTZ, a Flavanone Derivative, Induces Human Hepatoma Cell Apoptosis via a Reactive Oxygen Species- and Caspase-Dependent Mitochondrial Pathway
Meidan Ying, Chongxing Tu, Huazhou Ying, Yongzhou Hu, Qiaojun He and Bo Yang

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 758-765; DOI: https://doi.org/10.1124/jpet.107.135657
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Lysophosphatidic Acid Induces Rapid and Sustained Decreases in Epidermal Growth Factor Receptor Binding via Different Signaling Pathways in BEAS-2B Airway Epithelial Cells
Karen M. Kassel, Puttappa R. Dodmane, Nancy A. Schulte and Myron L. Toews

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 809-817; DOI: https://doi.org/10.1124/jpet.107.133736
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Synthesis and Characterization of ¹²⁵I-α-Conotoxin ArIB[V11L;V16A], a Selective α7 Nicotinic Acetylcholine Receptor Antagonist
Paul Whiteaker, Michael J. Marks, Sean Christensen, Cheryl Dowell, Allan C. Collins and J. Michael McIntosh

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 910-919; DOI: https://doi.org/10.1124/jpet.108.136895
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The Impact of Orthosteric Radioligand Depletion on the Quantification of Allosteric Modulator Interactions
Vimesh A. Avlani, David J. McLoughlin, Patrick M. Sexton and Arthur Christopoulos

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 927-934; DOI: https://doi.org/10.1124/jpet.108.136978
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Muscarinic M4 Receptor Recycling Requires a Motif in the Third Intracellular Loop
Yuichi Hashimoto, Kanoko Morisawa, Hiroyuki Saito, Eri Jojima, Norihiro Yoshida and Tatsuya Haga

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 947-953; DOI: https://doi.org/10.1124/jpet.107.135095
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Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8
Luciano De Petrocellis, Vittorio Vellani, Aniello Schiano-Moriello, Pietro Marini, Pier Cosimo Magherini, Pierangelo Orlando and Vincenzo Di Marzo

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1007-1015; DOI: https://doi.org/10.1124/jpet.107.134809
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Parallel Improvement of Sodium and Chloride Transport Defects by Miglustat (n-Butyldeoxynojyrimicin) in Cystic Fibrosis Epithelial Cells
Sabrina Noël, Martina Wilke, Alice G. M. Bot, Hugo R. De Jonge and Frédéric Becq

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1016-1023; DOI: https://doi.org/10.1124/jpet.107.135582
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Cysteinyl Leukotriene-1 Receptor Activation in a Human Bronchial Epithelial Cell Line Leads to Signal Transducer and Activator of Transcription 1-Mediated Eosinophil Adhesion
Mirella Profita, Angelo Sala, Anna Bonanno, Liboria Siena, Maria Ferraro, Rossana Di Giorgi, Angela M. Montalbano, Giusy D. Albano, Rosalia Gagliardo and Mark Gjomarkaj

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1024-1030; DOI: https://doi.org/10.1124/jpet.107.131649
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Two-State Models and the Analysis of the Allosteric Effect of Gallamine at the M₂ Muscarinic Receptor
Frederick J. Ehlert and Michael T. Griffin

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1039-1060; DOI: https://doi.org/10.1124/jpet.108.136960

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Protoapigenone, a Novel Flavonoid, Induces Apoptosis in Human Prostate Cancer Cells through Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH₂-Terminal Kinase 1/2
Hsueh-Ling Chang, Yang-Chang Wu, Jinu-Huang Su, Yao-Tsung Yeh and Shyng-Shiou F. Yuan

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 841-849; DOI: https://doi.org/10.1124/jpet.107.135442

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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New Role of Resistin in Lipopolysaccharide-Induced Liver Damage in Mice
Juliane I. Beier, Luping Guo, Claudia von Montfort, J. Phillip Kaiser, Swati Joshi-Barve and Gavin E. Arteel

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 801-808; DOI: https://doi.org/10.1124/jpet.108.136721
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Assessment of Nerve Stimulation-Induced Release of Purines from Mouse Kidneys by Tandem Mass Spectrometry
Jin Ren, Zaichuan Mi and Edwin K. Jackson

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 920-926; DOI: https://doi.org/10.1124/jpet.108.137752
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The Use of Occupation Isoboles for Analysis of a Response Mediated by Two Receptors: M₂ and M₃ Muscarinic Receptor Subtype-Induced Mouse Stomach Contractions
Alan S. Braverman, Ronald J. Tallarida and Michael R. Ruggieri

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 954-960; DOI: https://doi.org/10.1124/jpet.108.137018
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Induction of Apoptosis in Renal Tubular Cells by Histone Deacetylase Inhibitors, a Family of Anticancer Agents
Guie Dong, Lysa Wang, Cong-Yi Wang, Tianxin Yang, M. Vijay Kumar and Zheng Dong

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 978-984; DOI: https://doi.org/10.1124/jpet.108.137398

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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Interleukin-13 Neutralization by Two Distinct Receptor Blocking Mechanisms Reduces Immunoglobulin E Responses and Lung Inflammation in Cynomolgus Monkeys
Marion T. Kasaian, Xiang-Yang Tan, Macy Jin, Lori Fitz, Kimberly Marquette, Nancy Wood, Timothy A. Cook, Julie Lee, Angela Widom, Rita Agostinelli, Andrea Bree, Franklin J. Schlerman, Stephane Olland, Michael Wadanoli, Joseph Sypek, Davinder Gill, Samuel J. Goldman and Lioudmila Tchistiakova

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 882-892; DOI: https://doi.org/10.1124/jpet.108.136515

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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The Human Multidrug Resistance Protein 4 (MRP4, ABCC4): Functional Analysis of a Highly Polymorphic Gene
Nada Abla, Leslie W. Chinn, Tsutomu Nakamura, Li Liu, Conrad C. Huang, Susan J. Johns, Michiko Kawamoto, Doug Stryke, Travis R. Taylor, Thomas E. Ferrin, Kathleen M. Giacomini and Deanna L. Kroetz

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 859-868; DOI: https://doi.org/10.1124/jpet.108.136523
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CYP2C75-Involved Autoinduction of Metabolism in Rhesus Monkeys of Methyl 3-Chloro-3′-fluoro-4′-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1′-biphenyl-2-carboxylate (MK-0686), a Bradykinin B₁ Receptor Antagonist
Cuyue Tang, Brian A. Carr, Frédéric Poignant, Bennett Ma, Stacey L. Polsky-Fisher, Yuhsin Kuo, Kristie Strong-Basalyga, Alisha Norcross, Karen Richards, Roy Eisenhandler, Edward J. Carlini, Christina Ng Di Marco, Scott D. Kuduk, Nathan X. Yu, Conrad E. Raab, Tom Rushmore, Clay B. Frederick, Mark G. Bock and Thomayant Prueksaritanont

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 935-946; DOI: https://doi.org/10.1124/jpet.107.136044

NEUROPHARMACOLOGY

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In Vivo Quantitative Autoradiographic Analysis of Brain Muscarinic Receptor Occupancy by Antimuscarinic Agents for Overactive Bladder Treatment
Shuji Maruyama, Hideo Tsukada, Shingo Nishiyama, Takeharu Kakiuchi, Dai Fukumoto, Naoto Oku and Shizuo Yamada

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 774-781; DOI: https://doi.org/10.1124/jpet.108.136390
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Comparative Molecular Field Analysis Using Selectivity Fields Reveals Residues in the Third Transmembrane Helix of the Serotonin Transporter Associated with Substrate and Antagonist Recognition
Crystal C. Walline, David E. Nichols, F. Ivy Carroll and Eric L. Barker

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 791-800; DOI: https://doi.org/10.1124/jpet.108.136200
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Cannabinoids Inhibit Network-Driven Synapse Loss between Hippocampal Neurons in Culture
Hee Jung Kim, Jonathan J. Waataja and Stanley A. Thayer

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 850-858; DOI: https://doi.org/10.1124/jpet.107.131607
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Pharmacological Assessment of M₁ Muscarinic Acetylcholine Receptor-G_q/11 Protein Coupling in Membranes Prepared from Postmortem Human Brain Tissue
Hasib Salah-Uddin, David R. Thomas, Ceri H. Davies, Jim J. Hagan, Martyn D. Wood, Jeannette M. Watson and R. A. John Challiss

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 869-874; DOI: https://doi.org/10.1124/jpet.108.137968
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Synthesis and Pharmacological in Vitro and in Vivo Profile of 3-Oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic Acid 4-Fluoro-benzylamide (SHA 68), a Selective Antagonist of the Neuropeptide S Receptor
Naoe Okamura, Stephen A. Habay, Joanne Zeng, A. Richard Chamberlin and Rainer K. Reinscheid

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 893-901; DOI: https://doi.org/10.1124/jpet.107.135103
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Correlation between ex Vivo Receptor Occupancy and Wake-Promoting Activity of Selective H₃ Receptor Antagonists
Siyuan Le, John A. Gruner, Joanne R. Mathiasen, Michael J. Marino and Hervé Schaffhauser

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 902-909; DOI: https://doi.org/10.1124/jpet.107.135343
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Combined Active and Passive Immunization Enhances the Efficacy of Immunotherapy against Nicotine in Rats
Samuel A. Roiko, Andrew C. Harris, Daniel E. Keyler, Mark G. LeSage, Yan Zhang and Paul R. Pentel

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 985-993; DOI: https://doi.org/10.1124/jpet.107.135111

TOXICOLOGY

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Dependence of Reactive Oxygen Species and FLICE Inhibitory Protein on Lipofectamine-Induced Apoptosis in Human Lung Epithelial Cells
Lalana Kongkaneramit, Narong Sarisuta, Neelam Azad, Yongju Lu, Anand Krishnan V. Iyer, Liying Wang and Yon Rojanasakul

Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 969-977; DOI: https://doi.org/10.1124/jpet.107.136077

Errata

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Correction to “First in Vivo Evidence for a Functional Interaction between Chemokine and Cannabinoid Systems in the Brain”
Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1061;
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Correction to “Tetrathiomolybdate Protects against Bile Duct Ligation-Induced Cholestatic Liver Injury and Fibrosis”
Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1062;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

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