Journal of Pharmacology and Experimental Therapeutics: 325 (2)

May 01, 2008; Volume 325,Issue 2

PERSPECTIVES IN PHARMACOLOGY

You have access
Progress in Brain Penetration Evaluation in Drug Discovery and Development
Xingrong Liu, Cuiping Chen and Bill J. Smith

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 349-356; DOI: https://doi.org/10.1124/jpet.107.130294

BEHAVIORAL PHARMACOLOGY

You have access
Effects of a Cannabinoid₁ Receptor Antagonist and Serotonin_2C Receptor Agonist Alone and in Combination on Motivation for Palatable Food: A Dose-Addition Analysis Study in Mice
Sara Jane Ward, Timothy W. Lefever, Cavario Jackson, Ronald J. Tallarida and Ellen A. Walker

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 567-576; DOI: https://doi.org/10.1124/jpet.107.131771
You have access
Food Restriction Alters N′-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (Pramipexole)-Induced Yawning, Hypothermia, and Locomotor Activity in Rats: Evidence for Sensitization of Dopamine D2 Receptor-Mediated Effects
Gregory T. Collins, Diane M. Calinski, Amy Hauck Newman, Peter Grundt and James H. Woods

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 691-697; DOI: https://doi.org/10.1124/jpet.107.133181

CARDIOVASCULAR

You have access
Endothelial Dysfunction in Rat Mesenteric Resistance Artery after Transient Middle Cerebral Artery Occlusion
Sonia Martinez-Revelles, Francesc Jiménez-Altayó, Laura Caracuel, Fernando J. Pérez-Asensio, Anna M. Planas and Elisabet Vila

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 363-369; DOI: https://doi.org/10.1124/jpet.107.134619
You have access
Antiatherosclerotic Effects of Small-Molecular-Weight Compounds Enhancing Endothelial Nitric-Oxide Synthase (eNOS) Expression and Preventing eNOS Uncoupling
Paulus Wohlfart, Hui Xu, Alexandra Endlich, Alice Habermeier, Ellen I. Closs, Thomas Hübschle, Christian Mang, Hartmut Strobel, Teri Suzuki, Hartmut Kleinert, Ulrich Förstermann, Hartmut Ruetten and Huige Li

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 370-379; DOI: https://doi.org/10.1124/jpet.107.128009
You have access
Delivery of Acid Sphingomyelinase in Normal and Niemann-Pick Disease Mice Using Intercellular Adhesion Molecule-1-Targeted Polymer Nanocarriers
Carmen Garnacho, Rajwinder Dhami, Eric Simone, Thomas Dziubla, John Leferovich, Edward H. Schuchman, Vladimir Muzykantov and Silvia Muro

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 400-408; DOI: https://doi.org/10.1124/jpet.107.133298
You have access
Oxygenated Perfluorochemicals Improve Cell Survival during Reoxygenation by Pacifying Mitochondrial Activity
Amina Arab, Klaus Kuemmerer, Jin Wang, Christoph Bode and Christoph Hehrlein

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 417-424; DOI: https://doi.org/10.1124/jpet.107.133710
You have access
In Vivo Activation of Peroxisome Proliferator-Activated Receptor-δ Protects the Heart from Ischemia/Reperfusion Injury in Zucker Fatty Rats
Tian-Li Yue, Sandhya S. Nerurkar, Weike Bao, Beat M. Jucker, Lea Sarov-Blat, Klaudia Steplewski, Eliot H. Ohlstein and Robert N. Willette

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 466-474; DOI: https://doi.org/10.1124/jpet.107.135327
You have access
Vascular KCNQ Potassium Channels as Novel Targets for the Control of Mesenteric Artery Constriction by Vasopressin, Based on Studies in Single Cells, Pressurized Arteries, and in Vivo Measurements of Mesenteric Vascular Resistance
Alexander R. Mackie, Lioubov I. Brueggemann, Kyle K. Henderson, Aaron J. Shiels, Leanne L. Cribbs, Karie E. Scrogin and Kenneth L. Byron

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 475-483; DOI: https://doi.org/10.1124/jpet.107.135764
You have access
Cardioprotective and Survival Benefits of Long-Term Combined Therapy with β₂ Adrenoreceptor (AR) Agonist and β₁ AR Blocker in Dilated Cardiomyopathy Postmyocardial Infarction
Ismayil Ahmet, Melissa Krawczyk, Weizhong Zhu, Anthony Yiu-Ho Woo, Christopher Morrell, Suresh Poosala, Riu-ping Xiao, Edward G. Lakatta and Mark I. Talan

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 491-499; DOI: https://doi.org/10.1124/jpet.107.135335
You have access
An Estrogen Metabolite, 2-Methoxyestradiol, Disrupts Cardiac Microtubules and Unmasks Muscarinic Inhibition of Calcium Current
Jian-Bing Shen and Achilles J. Pappano

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 507-512; DOI: https://doi.org/10.1124/jpet.107.134932

CELLULAR AND MOLECULAR

You have access
Regulation of Dedifferentiation and Redifferentiation in Renal Proximal Tubular Cells by the Epidermal Growth Factor Receptor
Mark A. Hallman, Shougang Zhuang and Rick G. Schnellmann

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 520-528; DOI: https://doi.org/10.1124/jpet.107.134031
You have access
α-Aminoazaheterocyclic-Methylglyoxal Adducts Do Not Inhibit Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Activity
N. D. Sonawane, Olga Zegarra-Moran, Wan Namkung, Luis J. V. Galietta and A. S. Verkman

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 529-535; DOI: https://doi.org/10.1124/jpet.107.132357
You have access
Noncompetitive Antagonism and Inverse Agonism as Mechanism of Action of Nonpeptidergic Antagonists at Primate and Rodent CXCR3 Chemokine Receptors
Dennis Verzijl, Stefania Storelli, Danny J. Scholten, Leontien Bosch, Todd A. Reinhart, Daniel N. Streblow, Cornelis P. Tensen, Carlos P. Fitzsimons, Guido J. R. Zaman, James E. Pease, Iwan J. P. de Esch, Martine J. Smit and Rob Leurs

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 544-555; DOI: https://doi.org/10.1124/jpet.107.134783
You have access
UDP Is a Competitive Antagonist at the Human P2Y₁₄ Receptor
Ingrid P. Fricks, Savitri Maddileti, Rhonda L. Carter, Eduardo R. Lazarowski, Robert A. Nicholas, Kenneth A. Jacobson and T. Kendall Harden

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 588-594; DOI: https://doi.org/10.1124/jpet.108.136309

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

You have access
Statin-Induced Inhibition of 3-Hydroxy-3-Methyl Glutaryl Coenzyme A Reductase Sensitizes Human Osteosarcoma Cells to Anticancer Drugs
Olivia Fromigué, Zahia Hamidouche and Pierre J. Marie

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 595-600; DOI: https://doi.org/10.1124/jpet.108.136127
You have access
Cytokeratin-RNA Cross-Linking Mediated by the Antitumor Aminoflavone, 5-Amino-2,3-fluorophenyl-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one
Ling-hua Meng, Zhaojing Meng, Ze-hong Miao, Timothy D. Veenstra and Yves Pommier

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 674-680; DOI: https://doi.org/10.1124/jpet.108.137802

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

You have access
Thioredoxin-1 Ameliorates Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice
Atsuyasu Sato, Yuma Hoshino, Tomijiro Hara, Shigeo Muro, Hajime Nakamura, Michiaki Mishima and Junji Yodoi

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 380-388; DOI: https://doi.org/10.1124/jpet.107.134007
You have access
Drug-Induced Alterations to Gene and Protein Expression in Intestinal Epithelial Cell 6 Cells Suggest a Role for Calpains in the Gastrointestinal Toxicity of Nonsteroidal Anti-Inflammatory Agents
N. N. Raveendran, K. Silver, L. C. Freeman, D. Narvaez, K. Weng, S. Ganta and J. D. Lillich

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 389-399; DOI: https://doi.org/10.1124/jpet.107.127720
You have access
Tetrathiomolybdate Protects against Bile Duct Ligation-Induced Cholestatic Liver Injury and Fibrosis
Ming Song, Zhenyuan Song, Shirish Barve, Jingwen Zhang, Theresa Chen, Marcia Liu, Gavin E. Arteel, George J. Brewer and Craig J. McClain

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 409-416; DOI: https://doi.org/10.1124/jpet.107.131227
You have access
Isoflavones Promote Mitochondrial Biogenesis
Kyle A. Rasbach and Rick G. Schnellmann

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 536-543; DOI: https://doi.org/10.1124/jpet.107.134882

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

You have access
MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis
Patsy Clark, Steven E. Rowland, Danielle Denis, Marie-Claude Mathieu, Rino Stocco, Hugo Poirier, Jason Burch, Yongxin Han, Laurent Audoly, Alex G. Therien and Daigen Xu

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 425-434; DOI: https://doi.org/10.1124/jpet.107.134510
You have access
Prostaglandin I₂ Plays a Key Role in Zymosan-Induced Mouse Pleurisy
Koh-ichi Yuhki, Fumitaka Ushikubi, Hiroaki Naraba, Akinori Ueno, Hirotsugu Kato, Fumiaki Kojima, Shuh Narumiya, Yukihiko Sugimoto, Misao Matsushita and Sachiko Oh-ishi

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 601-609; DOI: https://doi.org/10.1124/jpet.107.134494
You have access
Relation between mRNA Expression Level of Multidrug Resistance 1/ABCB1 in Blood Cells and Required Level of Tacrolimus in Pediatric Living-Donor Liver Transplantation
Maki Goto, Satohiro Masuda, Tetsuya Kiuchi, Yasuhiro Ogura, Fumitaka Oike, Koichi Tanaka, Shinji Uemoto and Ken-ichi Inui

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 610-616; DOI: https://doi.org/10.1124/jpet.107.135665
You have access
Structural Requirements for Activation of the 5-Oxo-6E,8Z, 11Z,14Z-eicosatetraenoic Acid (5-Oxo-ETE) Receptor: Identification of a Mead Acid Metabolite with Potent Agonist Activity
Pranav Patel, Chantal Cossette, Jaganmohan R. Anumolu, Sylvie Gravel, Alain Lesimple, Orval A. Mamer, Joshua Rokach and William S. Powell

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 698-707; DOI: https://doi.org/10.1124/jpet.107.134908

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

You have access
Substrate-Dependent Effects of Human ABCB1 Coding Polymorphisms
Jason M. Gow, Laura M. Hodges, Leslie W. Chinn and Deanna L. Kroetz

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 435-442; DOI: https://doi.org/10.1124/jpet.107.135194
You have access
NF-E2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet
Yuji Tanaka, Lauren M. Aleksunes, Ronnie L. Yeager, Maxwell A. Gyamfi, Noriko Esterly, Grace L. Guo and Curtis D. Klaassen

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 655-664; DOI: https://doi.org/10.1124/jpet.107.135822

NEUROPHARMACOLOGY

You have access
Activities of 7-Nitroindazole and 1-(2-(Trifluoromethylphenyl)-imidazole Independent of Neuronal Nitric-Oxide Synthase Inhibition
Nobuko Matsumura, Kazue Kikuchi-Utsumi and Toshio Nakaki

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 357-362; DOI: https://doi.org/10.1124/jpet.107.135160
You have access
Modeling the Binding and Function of Metabotropic Glutamate Receptors
Xavier Rovira, David Roche, Juan Serra, Julie Kniazeff, Jean-Philippe Pin and Jesús Giraldo

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 443-456; DOI: https://doi.org/10.1124/jpet.107.133967
You have access
Activation of Muscarinic Cholinergic Receptors on Human SH-SY5Y Neuroblastoma Cells Enhances Both the Influx and Efflux of K⁺ under Conditions of Hypo-Osmolarity
Daniel J. Foster, Anne M. Heacock, Richard F. Keep and Stephen K. Fisher

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 457-465; DOI: https://doi.org/10.1124/jpet.107.135475
You have access
Unexceptional Seizure Potential of Tramadol or Its Enantiomers or Metabolites in Mice
Robert B. Raffa and Dennis J. Stone

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 500-506; DOI: https://doi.org/10.1124/jpet.108.137273
You have access
Delivery of Galanin-Like Peptide to the Brain: Targeting with Intranasal Delivery and Cyclodextrins
Naoko Nonaka, Susan A. Farr, Haruaki Kageyama, Seiji Shioda and William A. Banks

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 513-519; DOI: https://doi.org/10.1124/jpet.107.132381
You have access
Neurotensin in the Ventral Pallidum Increases Extracellular γ-Aminobutyric Acid and Differentially Affects Cue- and Cocaine-Primed Reinstatement
Mary M. Torregrossa and Peter W. Kalivas

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 556-566; DOI: https://doi.org/10.1124/jpet.107.130310
You have access
Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine_2C Agonist: in Vitro and in Vivo Pharmacological Characterization
William J. Thomsen, Andrew J. Grottick, Frederique Menzaghi, Hazel Reyes-Saldana, Stephen Espitia, Diane Yuskin, Kevin Whelan, Michael Martin, Michael Morgan, Weichao Chen, Hussien Al-Shamma, Brian Smith, Derek Chalmers and Dominic Behan

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 577-587; DOI: https://doi.org/10.1124/jpet.107.133348
You have access
β-Phenylethylamine Alters Monoamine Transporter Function via Trace Amine-Associated Receptor 1: Implication for Modulatory Roles of Trace Amines in Brain
Zhihua Xie and Gregory M. Miller

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 617-628; DOI: https://doi.org/10.1124/jpet.107.134247
You have access
Modulation of Monoamine Transporters by Common Biogenic Amines via Trace Amine-Associated Receptor 1 and Monoamine Autoreceptors in Human Embryonic Kidney 293 Cells and Brain Synaptosomes
Zhihua Xie, Susan V. Westmoreland and Gregory M. Miller

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 629-640; DOI: https://doi.org/10.1124/jpet.107.135079
You have access
First in Vivo Evidence for a Functional Interaction between Chemokine and Cannabinoid Systems in the Brain
Khalid Benamar, Ellen B. Geller and Martin W. Adler

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 641-645; DOI: https://doi.org/10.1124/jpet.107.135053
You have access
Cotinine Selectively Activates a Subpopulation of α3/α6β2 Nicotinic Receptors in Monkey Striatum
Kathryn O'Leary, Neeraja Parameswaran, J. Michael McIntosh and Maryka Quik

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 646-654; DOI: https://doi.org/10.1124/jpet.108.136838
You have access
Diclofenac Attenuates the Regional Effect of λ-Carrageenan on Blood-Brain Barrier Function and Cytoarchitecture
Tracy A. Brooks, Nicole Nametz, Rachael Charles and Thomas P. Davis

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 665-673; DOI: https://doi.org/10.1124/jpet.107.135632
You have access
Preclinical Characterization of Selective Phosphodiesterase 10A Inhibitors: A New Therapeutic Approach to the Treatment of Schizophrenia
C. J. Schmidt, D. S. Chapin, J. Cianfrogna, M. L. Corman, M. Hajos, J. F. Harms, W. E. Hoffman, L. A. Lebel, S. A. McCarthy, F. R. Nelson, C. Proulx-LaFrance, M. J. Majchrzak, A. D. Ramirez, K. Schmidt, P. A. Seymour, J. A. Siuciak, F. D. Tingley, R. D. Williams, P. R. Verhoest and F. S. Menniti

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 681-690; DOI: https://doi.org/10.1124/jpet.107.132910

TOXICOLOGY

You have access
Preclinical Toxicology (Subacute and Acute) and Efficacy of a New Squalenoyl Gemcitabine Anticancer Nanomedicine
L. Harivardhan Reddy, Pierre-Emmanuel Marque, Catherine Dubernet, Sinda-Lepêtre Mouelhi, Didier Desmaële and Patrick Couvreur

Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 484-490; DOI: https://doi.org/10.1124/jpet.107.133751

Main menu

User menu

Search

Table of Contents

PERSPECTIVES IN PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

In this issue

Jump to

Navigate

More Information

ASPET's Other Journals