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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

May 01, 2008; Volume 325,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    Progress in Brain Penetration Evaluation in Drug Discovery and Development
    Xingrong Liu, Cuiping Chen and Bill J. Smith
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 349-356; DOI: https://doi.org/10.1124/jpet.107.130294

BEHAVIORAL PHARMACOLOGY

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    Effects of a Cannabinoid1 Receptor Antagonist and Serotonin2C Receptor Agonist Alone and in Combination on Motivation for Palatable Food: A Dose-Addition Analysis Study in Mice
    Sara Jane Ward, Timothy W. Lefever, Cavario Jackson, Ronald J. Tallarida and Ellen A. Walker
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 567-576; DOI: https://doi.org/10.1124/jpet.107.131771
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    Food Restriction Alters N′-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (Pramipexole)-Induced Yawning, Hypothermia, and Locomotor Activity in Rats: Evidence for Sensitization of Dopamine D2 Receptor-Mediated Effects
    Gregory T. Collins, Diane M. Calinski, Amy Hauck Newman, Peter Grundt and James H. Woods
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 691-697; DOI: https://doi.org/10.1124/jpet.107.133181

CARDIOVASCULAR

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    Endothelial Dysfunction in Rat Mesenteric Resistance Artery after Transient Middle Cerebral Artery Occlusion
    Sonia Martinez-Revelles, Francesc Jiménez-Altayó, Laura Caracuel, Fernando J. Pérez-Asensio, Anna M. Planas and Elisabet Vila
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 363-369; DOI: https://doi.org/10.1124/jpet.107.134619
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    Antiatherosclerotic Effects of Small-Molecular-Weight Compounds Enhancing Endothelial Nitric-Oxide Synthase (eNOS) Expression and Preventing eNOS Uncoupling
    Paulus Wohlfart, Hui Xu, Alexandra Endlich, Alice Habermeier, Ellen I. Closs, Thomas Hübschle, Christian Mang, Hartmut Strobel, Teri Suzuki, Hartmut Kleinert, Ulrich Förstermann, Hartmut Ruetten and Huige Li
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 370-379; DOI: https://doi.org/10.1124/jpet.107.128009
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    Delivery of Acid Sphingomyelinase in Normal and Niemann-Pick Disease Mice Using Intercellular Adhesion Molecule-1-Targeted Polymer Nanocarriers
    Carmen Garnacho, Rajwinder Dhami, Eric Simone, Thomas Dziubla, John Leferovich, Edward H. Schuchman, Vladimir Muzykantov and Silvia Muro
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 400-408; DOI: https://doi.org/10.1124/jpet.107.133298
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    Oxygenated Perfluorochemicals Improve Cell Survival during Reoxygenation by Pacifying Mitochondrial Activity
    Amina Arab, Klaus Kuemmerer, Jin Wang, Christoph Bode and Christoph Hehrlein
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 417-424; DOI: https://doi.org/10.1124/jpet.107.133710
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    In Vivo Activation of Peroxisome Proliferator-Activated Receptor-δ Protects the Heart from Ischemia/Reperfusion Injury in Zucker Fatty Rats
    Tian-Li Yue, Sandhya S. Nerurkar, Weike Bao, Beat M. Jucker, Lea Sarov-Blat, Klaudia Steplewski, Eliot H. Ohlstein and Robert N. Willette
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 466-474; DOI: https://doi.org/10.1124/jpet.107.135327
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    Vascular KCNQ Potassium Channels as Novel Targets for the Control of Mesenteric Artery Constriction by Vasopressin, Based on Studies in Single Cells, Pressurized Arteries, and in Vivo Measurements of Mesenteric Vascular Resistance
    Alexander R. Mackie, Lioubov I. Brueggemann, Kyle K. Henderson, Aaron J. Shiels, Leanne L. Cribbs, Karie E. Scrogin and Kenneth L. Byron
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 475-483; DOI: https://doi.org/10.1124/jpet.107.135764
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    Cardioprotective and Survival Benefits of Long-Term Combined Therapy with β2 Adrenoreceptor (AR) Agonist and β1 AR Blocker in Dilated Cardiomyopathy Postmyocardial Infarction
    Ismayil Ahmet, Melissa Krawczyk, Weizhong Zhu, Anthony Yiu-Ho Woo, Christopher Morrell, Suresh Poosala, Riu-ping Xiao, Edward G. Lakatta and Mark I. Talan
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 491-499; DOI: https://doi.org/10.1124/jpet.107.135335
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    An Estrogen Metabolite, 2-Methoxyestradiol, Disrupts Cardiac Microtubules and Unmasks Muscarinic Inhibition of Calcium Current
    Jian-Bing Shen and Achilles J. Pappano
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 507-512; DOI: https://doi.org/10.1124/jpet.107.134932

CELLULAR AND MOLECULAR

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    Regulation of Dedifferentiation and Redifferentiation in Renal Proximal Tubular Cells by the Epidermal Growth Factor Receptor
    Mark A. Hallman, Shougang Zhuang and Rick G. Schnellmann
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 520-528; DOI: https://doi.org/10.1124/jpet.107.134031
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    α-Aminoazaheterocyclic-Methylglyoxal Adducts Do Not Inhibit Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Activity
    N. D. Sonawane, Olga Zegarra-Moran, Wan Namkung, Luis J. V. Galietta and A. S. Verkman
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 529-535; DOI: https://doi.org/10.1124/jpet.107.132357
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    Noncompetitive Antagonism and Inverse Agonism as Mechanism of Action of Nonpeptidergic Antagonists at Primate and Rodent CXCR3 Chemokine Receptors
    Dennis Verzijl, Stefania Storelli, Danny J. Scholten, Leontien Bosch, Todd A. Reinhart, Daniel N. Streblow, Cornelis P. Tensen, Carlos P. Fitzsimons, Guido J. R. Zaman, James E. Pease, Iwan J. P. de Esch, Martine J. Smit and Rob Leurs
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 544-555; DOI: https://doi.org/10.1124/jpet.107.134783
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    UDP Is a Competitive Antagonist at the Human P2Y14 Receptor
    Ingrid P. Fricks, Savitri Maddileti, Rhonda L. Carter, Eduardo R. Lazarowski, Robert A. Nicholas, Kenneth A. Jacobson and T. Kendall Harden
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 588-594; DOI: https://doi.org/10.1124/jpet.108.136309

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Statin-Induced Inhibition of 3-Hydroxy-3-Methyl Glutaryl Coenzyme A Reductase Sensitizes Human Osteosarcoma Cells to Anticancer Drugs
    Olivia Fromigué, Zahia Hamidouche and Pierre J. Marie
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 595-600; DOI: https://doi.org/10.1124/jpet.108.136127
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    Cytokeratin-RNA Cross-Linking Mediated by the Antitumor Aminoflavone, 5-Amino-2,3-fluorophenyl-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one
    Ling-hua Meng, Zhaojing Meng, Ze-hong Miao, Timothy D. Veenstra and Yves Pommier
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 674-680; DOI: https://doi.org/10.1124/jpet.108.137802

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Thioredoxin-1 Ameliorates Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice
    Atsuyasu Sato, Yuma Hoshino, Tomijiro Hara, Shigeo Muro, Hajime Nakamura, Michiaki Mishima and Junji Yodoi
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 380-388; DOI: https://doi.org/10.1124/jpet.107.134007
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    Drug-Induced Alterations to Gene and Protein Expression in Intestinal Epithelial Cell 6 Cells Suggest a Role for Calpains in the Gastrointestinal Toxicity of Nonsteroidal Anti-Inflammatory Agents
    N. N. Raveendran, K. Silver, L. C. Freeman, D. Narvaez, K. Weng, S. Ganta and J. D. Lillich
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 389-399; DOI: https://doi.org/10.1124/jpet.107.127720
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    Tetrathiomolybdate Protects against Bile Duct Ligation-Induced Cholestatic Liver Injury and Fibrosis
    Ming Song, Zhenyuan Song, Shirish Barve, Jingwen Zhang, Theresa Chen, Marcia Liu, Gavin E. Arteel, George J. Brewer and Craig J. McClain
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 409-416; DOI: https://doi.org/10.1124/jpet.107.131227
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    Isoflavones Promote Mitochondrial Biogenesis
    Kyle A. Rasbach and Rick G. Schnellmann
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 536-543; DOI: https://doi.org/10.1124/jpet.107.134882

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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    MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis
    Patsy Clark, Steven E. Rowland, Danielle Denis, Marie-Claude Mathieu, Rino Stocco, Hugo Poirier, Jason Burch, Yongxin Han, Laurent Audoly, Alex G. Therien and Daigen Xu
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 425-434; DOI: https://doi.org/10.1124/jpet.107.134510
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    Prostaglandin I2 Plays a Key Role in Zymosan-Induced Mouse Pleurisy
    Koh-ichi Yuhki, Fumitaka Ushikubi, Hiroaki Naraba, Akinori Ueno, Hirotsugu Kato, Fumiaki Kojima, Shuh Narumiya, Yukihiko Sugimoto, Misao Matsushita and Sachiko Oh-ishi
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 601-609; DOI: https://doi.org/10.1124/jpet.107.134494
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    Relation between mRNA Expression Level of Multidrug Resistance 1/ABCB1 in Blood Cells and Required Level of Tacrolimus in Pediatric Living-Donor Liver Transplantation
    Maki Goto, Satohiro Masuda, Tetsuya Kiuchi, Yasuhiro Ogura, Fumitaka Oike, Koichi Tanaka, Shinji Uemoto and Ken-ichi Inui
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 610-616; DOI: https://doi.org/10.1124/jpet.107.135665
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    Structural Requirements for Activation of the 5-Oxo-6E,8Z, 11Z,14Z-eicosatetraenoic Acid (5-Oxo-ETE) Receptor: Identification of a Mead Acid Metabolite with Potent Agonist Activity
    Pranav Patel, Chantal Cossette, Jaganmohan R. Anumolu, Sylvie Gravel, Alain Lesimple, Orval A. Mamer, Joshua Rokach and William S. Powell
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 698-707; DOI: https://doi.org/10.1124/jpet.107.134908

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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    Substrate-Dependent Effects of Human ABCB1 Coding Polymorphisms
    Jason M. Gow, Laura M. Hodges, Leslie W. Chinn and Deanna L. Kroetz
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 435-442; DOI: https://doi.org/10.1124/jpet.107.135194
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    NF-E2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet
    Yuji Tanaka, Lauren M. Aleksunes, Ronnie L. Yeager, Maxwell A. Gyamfi, Noriko Esterly, Grace L. Guo and Curtis D. Klaassen
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 655-664; DOI: https://doi.org/10.1124/jpet.107.135822

NEUROPHARMACOLOGY

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    Activities of 7-Nitroindazole and 1-(2-(Trifluoromethylphenyl)-imidazole Independent of Neuronal Nitric-Oxide Synthase Inhibition
    Nobuko Matsumura, Kazue Kikuchi-Utsumi and Toshio Nakaki
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 357-362; DOI: https://doi.org/10.1124/jpet.107.135160
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    Modeling the Binding and Function of Metabotropic Glutamate Receptors
    Xavier Rovira, David Roche, Juan Serra, Julie Kniazeff, Jean-Philippe Pin and Jesús Giraldo
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 443-456; DOI: https://doi.org/10.1124/jpet.107.133967
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    Activation of Muscarinic Cholinergic Receptors on Human SH-SY5Y Neuroblastoma Cells Enhances Both the Influx and Efflux of K+ under Conditions of Hypo-Osmolarity
    Daniel J. Foster, Anne M. Heacock, Richard F. Keep and Stephen K. Fisher
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 457-465; DOI: https://doi.org/10.1124/jpet.107.135475
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    Unexceptional Seizure Potential of Tramadol or Its Enantiomers or Metabolites in Mice
    Robert B. Raffa and Dennis J. Stone
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 500-506; DOI: https://doi.org/10.1124/jpet.108.137273
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    Delivery of Galanin-Like Peptide to the Brain: Targeting with Intranasal Delivery and Cyclodextrins
    Naoko Nonaka, Susan A. Farr, Haruaki Kageyama, Seiji Shioda and William A. Banks
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 513-519; DOI: https://doi.org/10.1124/jpet.107.132381
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    Neurotensin in the Ventral Pallidum Increases Extracellular γ-Aminobutyric Acid and Differentially Affects Cue- and Cocaine-Primed Reinstatement
    Mary M. Torregrossa and Peter W. Kalivas
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 556-566; DOI: https://doi.org/10.1124/jpet.107.130310
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    Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine2C Agonist: in Vitro and in Vivo Pharmacological Characterization
    William J. Thomsen, Andrew J. Grottick, Frederique Menzaghi, Hazel Reyes-Saldana, Stephen Espitia, Diane Yuskin, Kevin Whelan, Michael Martin, Michael Morgan, Weichao Chen, Hussien Al-Shamma, Brian Smith, Derek Chalmers and Dominic Behan
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 577-587; DOI: https://doi.org/10.1124/jpet.107.133348
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    β-Phenylethylamine Alters Monoamine Transporter Function via Trace Amine-Associated Receptor 1: Implication for Modulatory Roles of Trace Amines in Brain
    Zhihua Xie and Gregory M. Miller
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 617-628; DOI: https://doi.org/10.1124/jpet.107.134247
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    Modulation of Monoamine Transporters by Common Biogenic Amines via Trace Amine-Associated Receptor 1 and Monoamine Autoreceptors in Human Embryonic Kidney 293 Cells and Brain Synaptosomes
    Zhihua Xie, Susan V. Westmoreland and Gregory M. Miller
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 629-640; DOI: https://doi.org/10.1124/jpet.107.135079
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    First in Vivo Evidence for a Functional Interaction between Chemokine and Cannabinoid Systems in the Brain
    Khalid Benamar, Ellen B. Geller and Martin W. Adler
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 641-645; DOI: https://doi.org/10.1124/jpet.107.135053
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    Cotinine Selectively Activates a Subpopulation of α3/α6β2 Nicotinic Receptors in Monkey Striatum
    Kathryn O'Leary, Neeraja Parameswaran, J. Michael McIntosh and Maryka Quik
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 646-654; DOI: https://doi.org/10.1124/jpet.108.136838
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    Diclofenac Attenuates the Regional Effect of λ-Carrageenan on Blood-Brain Barrier Function and Cytoarchitecture
    Tracy A. Brooks, Nicole Nametz, Rachael Charles and Thomas P. Davis
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 665-673; DOI: https://doi.org/10.1124/jpet.107.135632
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    Preclinical Characterization of Selective Phosphodiesterase 10A Inhibitors: A New Therapeutic Approach to the Treatment of Schizophrenia
    C. J. Schmidt, D. S. Chapin, J. Cianfrogna, M. L. Corman, M. Hajos, J. F. Harms, W. E. Hoffman, L. A. Lebel, S. A. McCarthy, F. R. Nelson, C. Proulx-LaFrance, M. J. Majchrzak, A. D. Ramirez, K. Schmidt, P. A. Seymour, J. A. Siuciak, F. D. Tingley, R. D. Williams, P. R. Verhoest and F. S. Menniti
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 681-690; DOI: https://doi.org/10.1124/jpet.107.132910

TOXICOLOGY

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    Preclinical Toxicology (Subacute and Acute) and Efficacy of a New Squalenoyl Gemcitabine Anticancer Nanomedicine
    L. Harivardhan Reddy, Pierre-Emmanuel Marque, Catherine Dubernet, Sinda-Lepêtre Mouelhi, Didier Desmaële and Patrick Couvreur
    Journal of Pharmacology and Experimental Therapeutics May 2008, 325 (2) 484-490; DOI: https://doi.org/10.1124/jpet.107.133751
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Journal of Pharmacology and Experimental Therapeutics: 325 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 325, Issue 2
1 May 2008
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  • INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA
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