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Research ArticleGASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Discovery and Characterization of Novel Tryptophan Hydroxylase Inhibitors That Selectively Inhibit Serotonin Synthesis in the Gastrointestinal Tract

Qingyun Liu, Qi Yang, Weimei Sun, Pete Vogel, William Heydorn, Xiang-Qing Yu, Zhixiang Hu, Wangsheng Yu, Brandie Jonas, Randy Pineda, Valerie Calderon-Gay, Michael Germann, Emily O'Neill, Robert Brommage, Emily Cullinan, Ken Platt, Alan Wilson, Dave Powell, Arthur Sands, Brian Zambrowicz and Zhi-cai Shi
Journal of Pharmacology and Experimental Therapeutics April 2008, 325 (1) 47-55; DOI: https://doi.org/10.1124/jpet.107.132670
Qingyun Liu
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Qi Yang
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Weimei Sun
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Pete Vogel
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William Heydorn
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Xiang-Qing Yu
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Zhixiang Hu
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Wangsheng Yu
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Brandie Jonas
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Randy Pineda
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Valerie Calderon-Gay
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Michael Germann
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Emily O'Neill
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Robert Brommage
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Emily Cullinan
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Ken Platt
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Alan Wilson
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Dave Powell
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Arthur Sands
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Brian Zambrowicz
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Zhi-cai Shi
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Article Information

vol. 325 no. 1 47-55
DOI 
https://doi.org/10.1124/jpet.107.132670
PubMed 
18192499

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received October 8, 2007
  • Accepted January 9, 2008
  • Published online March 17, 2008.

Article Versions

  • Earlier version (January 11, 2008 - 11:14).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Qingyun Liu,
  2. Qi Yang,
  3. Weimei Sun,
  4. Pete Vogel,
  5. William Heydorn,
  6. Xiang-Qing Yu,
  7. Zhixiang Hu,
  8. Wangsheng Yu,
  9. Brandie Jonas,
  10. Randy Pineda,
  11. Valerie Calderon-Gay,
  12. Michael Germann,
  13. Emily O'Neill,
  14. Robert Brommage,
  15. Emily Cullinan,
  16. Ken Platt,
  17. Alan Wilson,
  18. Dave Powell,
  19. Arthur Sands,
  20. Brian Zambrowicz and
  21. Zhi-cai Shi
  1. Lexicon Pharmaceuticals, Inc., The Woodlands, Texas (Q.L., Q.Y., W.S., P.V., W.H., X.-Q.Y., Z.H., W.Y., B.J., R.P., V.C.-G., M.G., E.O., R.B., E.C., K.P., A.W., D.P., A.S., B.Z.); and Lexicon Pharmaceuticals, Inc., Princeton, New Jersey (Z.-c.S.)
  1. Address correspondence to:
    Dr. Qingyun Liu, Lexicon Pharmaceuticals, Inc., 8800 Technology Forest Place, The Woodlands, TX 77382. E-mail: jliu{at}lexpharma.com
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Journal of Pharmacology and Experimental Therapeutics: 381 (3)
Journal of Pharmacology and Experimental Therapeutics
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Research ArticleGASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Discovery and Characterization of Novel Tryptophan Hydroxylase Inhibitors That Selectively Inhibit Serotonin Synthesis in the Gastrointestinal Tract

Qingyun Liu, Qi Yang, Weimei Sun, Pete Vogel, William Heydorn, Xiang-Qing Yu, Zhixiang Hu, Wangsheng Yu, Brandie Jonas, Randy Pineda, Valerie Calderon-Gay, Michael Germann, Emily O'Neill, Robert Brommage, Emily Cullinan, Ken Platt, Alan Wilson, Dave Powell, Arthur Sands, Brian Zambrowicz and Zhi-cai Shi
Journal of Pharmacology and Experimental Therapeutics April 1, 2008, 325 (1) 47-55; DOI: https://doi.org/10.1124/jpet.107.132670

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Research ArticleGASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Discovery and Characterization of Novel Tryptophan Hydroxylase Inhibitors That Selectively Inhibit Serotonin Synthesis in the Gastrointestinal Tract

Qingyun Liu, Qi Yang, Weimei Sun, Pete Vogel, William Heydorn, Xiang-Qing Yu, Zhixiang Hu, Wangsheng Yu, Brandie Jonas, Randy Pineda, Valerie Calderon-Gay, Michael Germann, Emily O'Neill, Robert Brommage, Emily Cullinan, Ken Platt, Alan Wilson, Dave Powell, Arthur Sands, Brian Zambrowicz and Zhi-cai Shi
Journal of Pharmacology and Experimental Therapeutics April 1, 2008, 325 (1) 47-55; DOI: https://doi.org/10.1124/jpet.107.132670
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