Discovery and Characterization of Novel Tryptophan Hydroxylase Inhibitors That Selectively Inhibit Serotonin Synthesis in the Gastrointestinal Tract

Lexicon Pharmaceuticals, Inc., The Woodlands, Texas (Q.L., Q.Y., W.S., P.V., W.H., X.-Q.Y., Z.H., W.Y., B.J., R.P., V.C.-G., M.G., E.O., R.B., E.C., K.P., A.W., D.P., A.S., B.Z.); and Lexicon Pharmaceuticals, Inc., Princeton, New Jersey (Z.-c.S.)

Address correspondence to:
Dr. Qingyun Liu, Lexicon Pharmaceuticals, Inc., 8800 Technology Forest Place, The Woodlands, TX 77382. E-mail: jliu{at}lexpharma.com

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: January 2008 to June 2022

	Abstract	Full	Pdf
Jan 2008	77	0	217
Feb 2008	44	0	134
Mar 2008	92	23	142
Apr 2008	73	35	87
May 2008	41	22	36
Jun 2008	66	22	41
Jul 2008	36	12	23
Aug 2008	47	15	20
Sep 2008	66	26	32
Oct 2008	67	32	29
Nov 2008	76	23	29
Dec 2008	47	14	29
Jan 2009	51	19	30
Feb 2009	43	20	33
Mar 2009	59	15	21
Apr 2009	27	33	37
May 2009	35	51	45
Jun 2009	28	45	40
Jul 2009	23	31	34
Aug 2009	49	40	39
Sep 2009	17	41	32
Oct 2009	29	47	51
Nov 2009	23	13	26
Dec 2009	42	14	31
Jan 2010	60	115	48
Feb 2010	140	465	199
Mar 2010	142	157	111
Apr 2010	142	129	85
May 2010	87	106	55
Jun 2010	41	110	64
Jul 2010	54	71	46
Aug 2010	64	81	54
Sep 2010	58	77	57
Oct 2010	69	57	54
Nov 2010	45	54	39
Dec 2010	34	59	34
Jan 2011	46	47	37
Feb 2011	33	62	39
Mar 2011	42	54	39
Apr 2011	38	56	36
May 2011	56	77	45
Jun 2011	48	44	51
Jul 2011	25	37	30
Aug 2011	33	36	29
Sep 2011	39	48	31
Oct 2011	49	65	53
Nov 2011	48	75	58
Dec 2011	39	46	28
Jan 2012	31	53	34
Feb 2012	32	50	40
Mar 2012	51	57	45
Apr 2012	65	56	47
May 2012	32	57	32
Jun 2012	35	37	32
Jul 2012	45	48	46
Aug 2012	33	44	36
Sep 2012	31	31	32
Oct 2012	51	68	66
Nov 2012	50	74	46
Dec 2012	29	42	32
Jan 2013	32	52	26
Feb 2013	27	59	44
Mar 2013	47	62	34
Apr 2013	45	65	48
May 2013	61	50	48
Jun 2013	33	43	32
Jul 2013	29	60	39
Aug 2013	19	42	31
Sep 2013	28	34	21
Oct 2013	25	53	32
Nov 2013	23	60	30
Dec 2013	23	81	33
Jan 2014	27	47	28
Feb 2014	18	46	29
Mar 2014	27	74	54
Apr 2014	36	68	57
May 2014	31	70	43
Jun 2014	42	87	56
Jul 2014	60	68	37
Aug 2014	20	47	36
Sep 2014	21	42	30
Oct 2014	24	30	21
Nov 2014	28	25	31
Dec 2014	33	66	33
Jan 2015	28	53	23
Feb 2015	43	33	32
Mar 2015	39	58	46
Apr 2015	24	67	41
May 2015	33	88	84
Jun 2015	36	109	55
Jul 2015	22	60	25
Aug 2015	26	75	57
Sep 2015	29	64	44
Oct 2015	32	80	39
Nov 2015	34	66	39
Dec 2015	26	49	24
Jan 2016	36	67	43
Feb 2016	25	78	28
Mar 2016	23	70	48
Apr 2016	29	74	31
May 2016	22	57	30
Jun 2016	26	144	44
Jul 2016	52	65	51
Aug 2016	34	53	48
Sep 2016	24	38	45
Oct 2016	24	92	44
Nov 2016	10	77	45
Dec 2016	4	72	37
Jan 2017	3	82	40
Feb 2017	1	92	45
Mar 2017	0	92	42
Apr 2017	0	56	25
May 2017	2	64	48
Jun 2017	0	64	37
Jul 2017	3	75	40
Aug 2017	4	57	36
Sep 2017	1	59	20
Oct 2017	0	58	26
Nov 2017	1	88	35
Dec 2017	2	70	24
Jan 2018	3	60	25
Feb 2018	2	65	25
Mar 2018	1	95	33
Apr 2018	4	104	30
May 2018	1	92	32
Jun 2018	3	90	37
Jul 2018	0	62	20
Aug 2018	0	71	24
Sep 2018	8	58	22
Oct 2018	9	86	40
Nov 2018	2	972	39
Dec 2018	103	26	14
Jan 2019	57	9	9
Feb 2019	81	4	10
Mar 2019	84	14	11
Apr 2019	99	9	18
May 2019	42	13	20
Jun 2019	45	6	14
Jul 2019	52	5	10
Aug 2019	52	5	25
Sep 2019	55	3	8
Oct 2019	47	7	16
Nov 2019	65	15	10
Dec 2019	73	6	10
Jan 2020	29	2	1
Feb 2020	45	2	8
Mar 2020	38	4	11
Apr 2020	47	9	9
May 2020	30	2	1
Jun 2020	32	12	3
Jul 2020	40	0	2
Aug 2020	34	6	11
Sep 2020	59	7	6
Oct 2020	66	4	7
Nov 2020	51	2	4
Dec 2020	49	2	3
Jan 2021	52	7	6
Feb 2021	67	6	9
Mar 2021	49	4	9
Apr 2021	49	3	5
May 2021	58	5	12
Jun 2021	23	6	3
Jul 2021	67	7	11
Aug 2021	33	10	10
Sep 2021	59	8	10
Oct 2021	62	5	9
Nov 2021	64	5	12
Dec 2021	38	5	9
Jan 2022	49	2	17
Feb 2022	51	6	8
Mar 2022	74	8	6
Apr 2022	60	7	13
May 2022	35	5	1
Jun 2022	44	3	3