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Research ArticleNEUROPHARMACOLOGY

In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1

Sethu Sankaranarayanan, Eric A. Price, Guoxin Wu, Ming-Chih Crouthamel, Xiao-Ping Shi, Katherine Tugusheva, Keala X. Tyler, Jason Kahana, Joan Ellis, Lixia Jin, Thomas Steele, Shawn Stachel, Craig Coburn and Adam J. Simon
Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 957-969; DOI: https://doi.org/10.1124/jpet.107.130039
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Research ArticleNEUROPHARMACOLOGY

In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1

Sethu Sankaranarayanan, Eric A. Price, Guoxin Wu, Ming-Chih Crouthamel, Xiao-Ping Shi, Katherine Tugusheva, Keala X. Tyler, Jason Kahana, Joan Ellis, Lixia Jin, Thomas Steele, Shawn Stachel, Craig Coburn and Adam J. Simon
Journal of Pharmacology and Experimental Therapeutics March 1, 2008, 324 (3) 957-969; DOI: https://doi.org/10.1124/jpet.107.130039
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