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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

March 01, 2008; Volume 324,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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    NAD+ and Vitamin B3: From Metabolism to Therapies
    Anthony A. Sauve
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 883-893; DOI: https://doi.org/10.1124/jpet.107.120758

CARDIOVASCULAR

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    Functional Antagonism between Endogenous Neuropeptide Y and Calcitonin Gene-Related Peptide in Mesenteric Resistance Arteries
    Jo G. R. De Mey, Remco Megens and Gregorio E. Fazzi
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 930-937; DOI: https://doi.org/10.1124/jpet.107.133660
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    Characterization of Epoxyeicosatrienoic Acid Binding Site in U937 Membranes Using a Novel Radiolabeled Agonist, 20-125I-14,15-Epoxyeicosa-8(Z)-Enoic Acid
    Wenqi Yang, Venugopal Raju Tuniki, Siddam Anjaiah, J. R. Falck, Cecilia J. Hillard and William B. Campbell
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1019-1027; DOI: https://doi.org/10.1124/jpet.107.129577
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    Inhibiting Protease-Activated Receptor 4 Limits Myocardial Ischemia/Reperfusion Injury in Rat Hearts by Unmasking Adenosine Signaling
    Jennifer L. Strande, Anna Hsu, Jidong Su, Xiangping Fu, Garrett J. Gross and John E. Baker
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1045-1054; DOI: https://doi.org/10.1124/jpet.107.133595
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    Characterization of the Molecular Fragment That Is Responsible for Agonism of Pergolide at Serotonin 5-Hydroxytryptamine2B and 5-Hydroxytryptamine2A Receptors
    Tilo Görnemann, Harald Hübner, Peter Gmeiner, Reinhard Horowski, Klaus Peter Latté, Miroslav Flieger and Heinz H. Pertz
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1136-1145; DOI: https://doi.org/10.1124/jpet.107.133165
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    Doxycycline Attenuates Isoproterenol- and Transverse Aortic Banding-Induced Cardiac Hypertrophy in Mice
    Mounir Errami, Cristi L. Galindo, Amina T. Tassa, John M. DiMaio, Joseph A. Hill and Harold R. Garner
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1196-1203; DOI: https://doi.org/10.1124/jpet.107.133975
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    Mechanism-Based Pharmacodynamic Modeling of S(–)-Atenolol: Estimation of in Vivo Affinity for the β1-Adrenoceptor with an Agonist-Antagonist Interaction Model
    Tamara J. van Steeg, Jan Freijer, Meindert Danhof and Elizabeth C. M. de Lange
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1234-1242; DOI: https://doi.org/10.1124/jpet.107.131680

CELLULAR AND MOLECULAR

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    7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423), a Benzodiazepine, Suppresses Keratinocyte Proliferation and Has Antipsoriatic Activity in the Human Skin-Severe, Combined Immunodeficient Mouse Transplant Model
    Narasimharao Bhagavathula, Kamalakar C. Nerusu, Andrew Hanosh, Muhammad N. Aslam, Thomas B. Sundberg, Anthony W. Opipari, Kent Johnson, Sewon Kang, Gary D. Glick and James Varani
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 938-947; DOI: https://doi.org/10.1124/jpet.107.130955
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    Inhibition of the Cardiac L-Type Calcium Channel Current by Antidepressant Drugs
    Ivan Zahradník, Igor Minarovič and Alexandra Zahradníková
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 977-984; DOI: https://doi.org/10.1124/jpet.107.132456
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    Inhibition of Geranylgeranyl Diphosphate Synthase Induces Apoptosis through Multiple Mechanisms and Displays Synergy with Inhibition of Other Isoprenoid Biosynthetic Enzymes
    Amel Dudakovic, Andrew J. Wiemer, Kimberly M. Lamb, Laura A. Vonnahme, Sara E. Dietz and Raymond J. Hohl
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1028-1036; DOI: https://doi.org/10.1124/jpet.107.132217
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    Involvement of P2Y1 and P2Y11 Purinoceptors in Parasympathetic Inhibition of Colonic Smooth Muscle
    Brian F. King and Andrea Townsend-Nicholson
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1055-1063; DOI: https://doi.org/10.1124/jpet.107.131169
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    A Conservative, Single-Amino Acid Substitution in the Second Cytoplasmic Domain of the Human Serotonin2C Receptor Alters Both Ligand-Dependent and -Independent Receptor Signaling
    Kelly A. Berg, John Dunlop, Teresa Sanchez, Michelle Silva and William P. Clarke
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1084-1092; DOI: https://doi.org/10.1124/jpet.107.131524
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    Plitidepsin Has a Dual Effect Inhibiting Cell Cycle and Inducing Apoptosis via Rac1/c-Jun NH2-Terminal Kinase Activation in Human Melanoma Cells
    María J. Muñoz-Alonso, Laura González-Santiago, Natasha Zarich, Teresa Martínez, Enrique Alvarez, José María Rojas and Alberto Muñoz
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1093-1101; DOI: https://doi.org/10.1124/jpet.107.132662
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    Statins Decrease Expression of the Proinflammatory Neuropeptides Calcitonin Gene-Related Peptide and Substance P in Sensory Neurons
    Robert C. Bucelli, Eugene A. Gonsiorek, Woo-Yang Kim, Donald Bruun, Richard A. Rabin, Dennis Higgins and Pamela J. Lein
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1172-1180; DOI: https://doi.org/10.1124/jpet.107.132795
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    Estrogen Receptor-Independent Neuroprotection via Protein Phosphatase Preservation and Attenuation of Persistent Extracellular Signal-Regulated Kinase 1/2 Activation
    Kun Don Yi, Zu Yun Cai, Douglas F. Covey and James W. Simpkins
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1188-1195; DOI: https://doi.org/10.1124/jpet.107.132308
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    Erythropoietin Stimulates Cancer Cell Migration and Activates RhoA Protein through a Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase-Dependent Mechanism
    Sumaya N. Hamadmad and Raymond J. Hohl
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1227-1233; DOI: https://doi.org/10.1124/jpet.107.129643

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    The Effects of Cyclooxygenase-2 Expression in Prostate Cancer Cells: Modulation of Response to Cytotoxic Agents
    Ayaz Mehar, Patricia Macanas-Pirard, Atsushi Mizokami, Yutaka Takahashi, Georges E. N. Kass and Helen M. Coley
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1181-1187; DOI: https://doi.org/10.1124/jpet.107.131383

ENDOCRINE AND DIABETES

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    Studies with an Orally Bioavailable αV Integrin Antagonist in Animal Models of Ocular Vasculopathy: Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats
    Rosemary J. Santulli, William A. Kinney, Shyamali Ghosh, Bart L. DeCorte, Li Liu, Robert W. A. Tuman, Zhao Zhou, Norman Huebert, Sven E. Bursell, Alan C. Clermont, Maria B. Grant, Lynn C. Shaw, Shaker A. Mousa, Robert A. Galemmo, Dana L. Johnson, Bruce E. Maryanoff and Bruce P. Damiano
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 894-901; DOI: https://doi.org/10.1124/jpet.107.131656

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Cellular Targeting of the Apoptosis-Inducing Compound Gliotoxin to Fibrotic Rat Livers
    W. I. Hagens, L. Beljaars, D.A. Mann, M. C. Wright, B. Julien, S. Lotersztajn, C. Reker-Smit and K. Poelstra
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 902-910; DOI: https://doi.org/10.1124/jpet.107.132290

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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    Reduction of Peroxisome Proliferation-Activated Receptor γ Expression by γ-Irradiation as a Mechanism Contributing to Inflammatory Response in Rat Colon: Modulation by the 5-Aminosalicylic Acid Agonist
    Christine Linard, Olivier Grémy and Marc Benderitter
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 911-920; DOI: https://doi.org/10.1124/jpet.107.129122
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    p38α-Selective Mitogen-Activated Protein Kinase Inhibitor SD-282 Reduces Inflammation in a Subchronic Model of Tobacco Smoke-Induced Airway Inflammation
    Satyanarayana Medicherla, Mary F. Fitzgerald, Dianne Spicer, Paul Woodman, Jing Y. Ma, Ann M. Kapoun, Sarvajit Chakravarty, Sundeep Dugar, Andrew A. Protter and Linda S. Higgins
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 921-929; DOI: https://doi.org/10.1124/jpet.107.127092
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    Thionamides Inhibit the Transcription Factor Nuclear Factor-κB by Suppression of Rac1 and Inhibitor of κB Kinase α
    Matjaz Humar, Hannah Dohrmann, Philipp Stein, Nikolaos Andriopoulos, Ulrich Goebel, Martin Roesslein, Rene Schmidt, Christian I. Schwer, Torsten Loop, Klaus K. Geiger, Heike L. Pahl and Benedikt H.J. Pannen
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1037-1044; DOI: https://doi.org/10.1124/jpet.107.132407

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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    Inhibitor Binding in the Human Renal Low- and High-Affinity Na+/Glucose Cotransporters
    Ana M. Pajor, Kathleen M. Randolph, Sandy A. Kerner and Chari D. Smith
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 985-991; DOI: https://doi.org/10.1124/jpet.107.129825
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    Selegiline Is a Mechanism-Based Inactivator of CYP2A6 Inhibiting Nicotine Metabolism in Humans and Mice
    Eric C.K. Siu and Rachel F. Tyndale
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 992-999; DOI: https://doi.org/10.1124/jpet.107.133900
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    Identification and Design of Peptides as a New Drug Delivery System for the Brain
    Michel Demeule, Anthony Régina, Christian Ché, Julie Poirier, Tran Nguyen, Reinhard Gabathuler, Jean-Paul Castaigne and Richard Béliveau
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1064-1072; DOI: https://doi.org/10.1124/jpet.107.131318
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    Age-Dependent Kinetics and Metabolism of Dichloroacetate: Possible Relevance to Toxicity
    Albert L. Shroads, Xu Guo, Vaishali Dixit, Hui-Ping Liu, Margaret O. James and Peter W. Stacpoole
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1163-1171; DOI: https://doi.org/10.1124/jpet.107.134593
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    Extracting Global System Dynamics of Corticosteroid Genomic Effects in Rat Liver
    E. Yang, R. R. Almon, D. C. DuBois, W. J. Jusko and I. P. Androulakis
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1243-1254; DOI: https://doi.org/10.1124/jpet.107.133074

NEUROPHARMACOLOGY

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    Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity
    Lothar Lindemann, Claas Aiko Meyer, Karine Jeanneau, Amyaouch Bradaia, Laurence Ozmen, Horst Bluethmann, Bernhard Bettler, Joseph G. Wettstein, Edilio Borroni, Jean-Luc Moreau and Marius C. Hoener
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 948-956; DOI: https://doi.org/10.1124/jpet.107.132647
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    In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1
    Sethu Sankaranarayanan, Eric A. Price, Guoxin Wu, Ming-Chih Crouthamel, Xiao-Ping Shi, Katherine Tugusheva, Keala X. Tyler, Jason Kahana, Joan Ellis, Lixia Jin, Thomas Steele, Shawn Stachel, Craig Coburn and Adam J. Simon
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 957-969; DOI: https://doi.org/10.1124/jpet.107.130039
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    Increased C-Fiber Nociceptive Input Potentiates Inhibitory Glycinergic Transmission in the Spinal Dorsal Horn
    Hong-Yi Zhou, Hong-Mei Zhang, Shao-Rui Chen and Hui-Lin Pan
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1000-1010; DOI: https://doi.org/10.1124/jpet.107.133470
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    Arginine 246 of the Pretransmembrane Domain 1 Region Alters 2,2,2-Trichloroethanol Action in the 5-Hydroxytryptamine3A Receptor
    Xiang-Qun Hu and Robert W. Peoples
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1011-1018; DOI: https://doi.org/10.1124/jpet.107.131011
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    2-Methoxymethyl-Salvinorin B Is a Potent κ Opioid Receptor Agonist with Longer Lasting Action in Vivo Than Salvinorin A
    Yulin Wang, Yong Chen, Wei Xu, David Y.W. Lee, Zhongze Ma, Scott M. Rawls, Alan Cowan and Lee-Yuan Liu-Chen
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1073-1083; DOI: https://doi.org/10.1124/jpet.107.132142
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    The Triple Uptake Inhibitor (1R,5S)-(+)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0] Hexane Hydrochloride (DOV 21947) Reduces Body Weight and Plasma Triglycerides in Rodent Models of Diet-Induced Obesity
    Joseph P. Tizzano, D. Sloan Stribling, Diego Perez-Tilve, Alison Strack, Andrea Frassetto, Richard Z. Chen, Tung M. Fong, Lauren Shearman, Philip A. Krieter, Matthias H. Tschöp, Phil Skolnick and Anthony S. Basile
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1111-1126; DOI: https://doi.org/10.1124/jpet.107.133132
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    Isoflurane Is a Potent Modulator of Extrasynaptic GABAA Receptors in the Thalamus
    Fan Jia, Minerva Yue, Dev Chandra, Gregg E. Homanics, Peter A. Goldstein and Neil L. Harrison
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1127-1135; DOI: https://doi.org/10.1124/jpet.107.134569
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    A Selective Nav1.8 Sodium Channel Blocker, A-803467 [5-(4-Chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], Attenuates Spinal Neuronal Activity in Neuropathic Rats
    Steve McGaraughty, Katharine L. Chu, Marc J. C. Scanio, Michael E. Kort, Connie R. Faltynek and Michael F. Jarvis
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1204-1211; DOI: https://doi.org/10.1124/jpet.107.134148
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    S33138 (N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1] benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenyl-acetamide), a Preferential Dopamine D3 versus D2 Receptor Antagonist and Potential Antipsychotic Agent: III. Actions in Models of Therapeutic Activity and Induction of Side Effects
    Mark J. Millan, Florence Loiseau, Anne Dekeyne, Alain Gobert, Gunnar Flik, Thomas I. Cremers, Jean-Michel Rivet, Dorothée Sicard, Rodolphe Billiras and Mauricette Brocco
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1212-1226; DOI: https://doi.org/10.1124/jpet.107.134536

TOXICOLOGY

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    Inhibition of Mitochondrial Hydrogen Peroxide Production by Lipophilic Metalloporphyrins
    Pablo R. Castello, Derek A. Drechsel, Brian J. Day and Manisha Patel
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 970-976; DOI: https://doi.org/10.1124/jpet.107.132134
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    Omeprazole Stimulates the Induction of Human Insulin-Like Growth Factor Binding Protein-1 through Aryl Hydrocarbon Receptor Activation
    Iain A. Murray and Gary H. Perdew
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1102-1110; DOI: https://doi.org/10.1124/jpet.107.132241
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    The Butyrylcholinesterase Knockout Mouse as a Model for Human Butyrylcholinesterase Deficiency
    Bin Li, Ellen G. Duysen, Michaela Carlson and Oksana Lockridge
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1146-1154; DOI: https://doi.org/10.1124/jpet.107.133330
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    Succinate Ameliorates Energy Deficits and Prevents Dysfunction of Complex I in Injured Renal Proximal Tubular Cells
    Grażyna Nowak, Ginger L. Clifton and Diana Bakajsova
    Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1155-1162; DOI: https://doi.org/10.1124/jpet.107.130872
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Journal of Pharmacology and Experimental Therapeutics: 324 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 324, Issue 3
1 Mar 2008
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