Table of Contents

NEUROPHARMACOLOGY

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  Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity

  Lothar Lindemann, Claas Aiko Meyer, Karine Jeanneau, Amyaouch Bradaia, Laurence Ozmen, Horst Bluethmann, Bernhard Bettler, Joseph G. Wettstein, Edilio Borroni, Jean-Luc Moreau and Marius C. Hoener

  Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 948-956; DOI: https://doi.org/10.1124/jpet.107.132647
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  In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1

  Sethu Sankaranarayanan, Eric A. Price, Guoxin Wu, Ming-Chih Crouthamel, Xiao-Ping Shi, Katherine Tugusheva, Keala X. Tyler, Jason Kahana, Joan Ellis, Lixia Jin, Thomas Steele, Shawn Stachel, Craig Coburn and Adam J. Simon

  Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 957-969; DOI: https://doi.org/10.1124/jpet.107.130039
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  Increased C-Fiber Nociceptive Input Potentiates Inhibitory Glycinergic Transmission in the Spinal Dorsal Horn

  Hong-Yi Zhou, Hong-Mei Zhang, Shao-Rui Chen and Hui-Lin Pan

  Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1000-1010; DOI: https://doi.org/10.1124/jpet.107.133470
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  Arginine 246 of the Pretransmembrane Domain 1 Region Alters 2,2,2-Trichloroethanol Action in the 5-Hydroxytryptamine_3A Receptor

  Xiang-Qun Hu and Robert W. Peoples

  Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1011-1018; DOI: https://doi.org/10.1124/jpet.107.131011
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  2-Methoxymethyl-Salvinorin B Is a Potent κ Opioid Receptor Agonist with Longer Lasting Action in Vivo Than Salvinorin A

  Yulin Wang, Yong Chen, Wei Xu, David Y.W. Lee, Zhongze Ma, Scott M. Rawls, Alan Cowan and Lee-Yuan Liu-Chen

  Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1073-1083; DOI: https://doi.org/10.1124/jpet.107.132142
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  The Triple Uptake Inhibitor (1R,5S)-(+)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0] Hexane Hydrochloride (DOV 21947) Reduces Body Weight and Plasma Triglycerides in Rodent Models of Diet-Induced Obesity

  Joseph P. Tizzano, D. Sloan Stribling, Diego Perez-Tilve, Alison Strack, Andrea Frassetto, Richard Z. Chen, Tung M. Fong, Lauren Shearman, Philip A. Krieter, Matthias H. Tschöp, Phil Skolnick and Anthony S. Basile

  Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1111-1126; DOI: https://doi.org/10.1124/jpet.107.133132
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  Isoflurane Is a Potent Modulator of Extrasynaptic GABA_A Receptors in the Thalamus

  Fan Jia, Minerva Yue, Dev Chandra, Gregg E. Homanics, Peter A. Goldstein and Neil L. Harrison

  Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1127-1135; DOI: https://doi.org/10.1124/jpet.107.134569
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  A Selective Na_v1.8 Sodium Channel Blocker, A-803467 [5-(4-Chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], Attenuates Spinal Neuronal Activity in Neuropathic Rats

  Steve McGaraughty, Katharine L. Chu, Marc J. C. Scanio, Michael E. Kort, Connie R. Faltynek and Michael F. Jarvis

  Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1204-1211; DOI: https://doi.org/10.1124/jpet.107.134148
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  S33138 (N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1] benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenyl-acetamide), a Preferential Dopamine D₃ versus D₂ Receptor Antagonist and Potential Antipsychotic Agent: III. Actions in Models of Therapeutic Activity and Induction of Side Effects

  Mark J. Millan, Florence Loiseau, Anne Dekeyne, Alain Gobert, Gunnar Flik, Thomas I. Cremers, Jean-Michel Rivet, Dorothée Sicard, Rodolphe Billiras and Mauricette Brocco

  Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1212-1226; DOI: https://doi.org/10.1124/jpet.107.134536