Journal of Pharmacology and Experimental Therapeutics: 324 (3)

March 01, 2008; Volume 324,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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NAD⁺ and Vitamin B₃: From Metabolism to Therapies
Anthony A. Sauve

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 883-893; DOI: https://doi.org/10.1124/jpet.107.120758

CARDIOVASCULAR

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Functional Antagonism between Endogenous Neuropeptide Y and Calcitonin Gene-Related Peptide in Mesenteric Resistance Arteries
Jo G. R. De Mey, Remco Megens and Gregorio E. Fazzi

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 930-937; DOI: https://doi.org/10.1124/jpet.107.133660
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Characterization of Epoxyeicosatrienoic Acid Binding Site in U937 Membranes Using a Novel Radiolabeled Agonist, 20-¹²⁵I-14,15-Epoxyeicosa-8(Z)-Enoic Acid
Wenqi Yang, Venugopal Raju Tuniki, Siddam Anjaiah, J. R. Falck, Cecilia J. Hillard and William B. Campbell

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1019-1027; DOI: https://doi.org/10.1124/jpet.107.129577
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Inhibiting Protease-Activated Receptor 4 Limits Myocardial Ischemia/Reperfusion Injury in Rat Hearts by Unmasking Adenosine Signaling
Jennifer L. Strande, Anna Hsu, Jidong Su, Xiangping Fu, Garrett J. Gross and John E. Baker

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1045-1054; DOI: https://doi.org/10.1124/jpet.107.133595
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Characterization of the Molecular Fragment That Is Responsible for Agonism of Pergolide at Serotonin 5-Hydroxytryptamine_2B and 5-Hydroxytryptamine_2A Receptors
Tilo Görnemann, Harald Hübner, Peter Gmeiner, Reinhard Horowski, Klaus Peter Latté, Miroslav Flieger and Heinz H. Pertz

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1136-1145; DOI: https://doi.org/10.1124/jpet.107.133165
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Doxycycline Attenuates Isoproterenol- and Transverse Aortic Banding-Induced Cardiac Hypertrophy in Mice
Mounir Errami, Cristi L. Galindo, Amina T. Tassa, John M. DiMaio, Joseph A. Hill and Harold R. Garner

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1196-1203; DOI: https://doi.org/10.1124/jpet.107.133975
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Mechanism-Based Pharmacodynamic Modeling of S(–)-Atenolol: Estimation of in Vivo Affinity for the β₁-Adrenoceptor with an Agonist-Antagonist Interaction Model
Tamara J. van Steeg, Jan Freijer, Meindert Danhof and Elizabeth C. M. de Lange

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1234-1242; DOI: https://doi.org/10.1124/jpet.107.131680

CELLULAR AND MOLECULAR

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7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423), a Benzodiazepine, Suppresses Keratinocyte Proliferation and Has Antipsoriatic Activity in the Human Skin-Severe, Combined Immunodeficient Mouse Transplant Model
Narasimharao Bhagavathula, Kamalakar C. Nerusu, Andrew Hanosh, Muhammad N. Aslam, Thomas B. Sundberg, Anthony W. Opipari, Kent Johnson, Sewon Kang, Gary D. Glick and James Varani

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 938-947; DOI: https://doi.org/10.1124/jpet.107.130955
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Inhibition of the Cardiac L-Type Calcium Channel Current by Antidepressant Drugs
Ivan Zahradník, Igor Minarovič and Alexandra Zahradníková

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 977-984; DOI: https://doi.org/10.1124/jpet.107.132456
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Inhibition of Geranylgeranyl Diphosphate Synthase Induces Apoptosis through Multiple Mechanisms and Displays Synergy with Inhibition of Other Isoprenoid Biosynthetic Enzymes
Amel Dudakovic, Andrew J. Wiemer, Kimberly M. Lamb, Laura A. Vonnahme, Sara E. Dietz and Raymond J. Hohl

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1028-1036; DOI: https://doi.org/10.1124/jpet.107.132217
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Involvement of P2Y₁ and P2Y₁₁ Purinoceptors in Parasympathetic Inhibition of Colonic Smooth Muscle
Brian F. King and Andrea Townsend-Nicholson

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1055-1063; DOI: https://doi.org/10.1124/jpet.107.131169
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A Conservative, Single-Amino Acid Substitution in the Second Cytoplasmic Domain of the Human Serotonin_2C Receptor Alters Both Ligand-Dependent and -Independent Receptor Signaling
Kelly A. Berg, John Dunlop, Teresa Sanchez, Michelle Silva and William P. Clarke

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1084-1092; DOI: https://doi.org/10.1124/jpet.107.131524
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Plitidepsin Has a Dual Effect Inhibiting Cell Cycle and Inducing Apoptosis via Rac1/c-Jun NH₂-Terminal Kinase Activation in Human Melanoma Cells
María J. Muñoz-Alonso, Laura González-Santiago, Natasha Zarich, Teresa Martínez, Enrique Alvarez, José María Rojas and Alberto Muñoz

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1093-1101; DOI: https://doi.org/10.1124/jpet.107.132662
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Statins Decrease Expression of the Proinflammatory Neuropeptides Calcitonin Gene-Related Peptide and Substance P in Sensory Neurons
Robert C. Bucelli, Eugene A. Gonsiorek, Woo-Yang Kim, Donald Bruun, Richard A. Rabin, Dennis Higgins and Pamela J. Lein

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1172-1180; DOI: https://doi.org/10.1124/jpet.107.132795
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Estrogen Receptor-Independent Neuroprotection via Protein Phosphatase Preservation and Attenuation of Persistent Extracellular Signal-Regulated Kinase 1/2 Activation
Kun Don Yi, Zu Yun Cai, Douglas F. Covey and James W. Simpkins

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1188-1195; DOI: https://doi.org/10.1124/jpet.107.132308
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Erythropoietin Stimulates Cancer Cell Migration and Activates RhoA Protein through a Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase-Dependent Mechanism
Sumaya N. Hamadmad and Raymond J. Hohl

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1227-1233; DOI: https://doi.org/10.1124/jpet.107.129643

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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The Effects of Cyclooxygenase-2 Expression in Prostate Cancer Cells: Modulation of Response to Cytotoxic Agents
Ayaz Mehar, Patricia Macanas-Pirard, Atsushi Mizokami, Yutaka Takahashi, Georges E. N. Kass and Helen M. Coley

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1181-1187; DOI: https://doi.org/10.1124/jpet.107.131383

ENDOCRINE AND DIABETES

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Studies with an Orally Bioavailable α_V Integrin Antagonist in Animal Models of Ocular Vasculopathy: Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats
Rosemary J. Santulli, William A. Kinney, Shyamali Ghosh, Bart L. DeCorte, Li Liu, Robert W. A. Tuman, Zhao Zhou, Norman Huebert, Sven E. Bursell, Alan C. Clermont, Maria B. Grant, Lynn C. Shaw, Shaker A. Mousa, Robert A. Galemmo, Dana L. Johnson, Bruce E. Maryanoff and Bruce P. Damiano

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 894-901; DOI: https://doi.org/10.1124/jpet.107.131656

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Cellular Targeting of the Apoptosis-Inducing Compound Gliotoxin to Fibrotic Rat Livers
W. I. Hagens, L. Beljaars, D.A. Mann, M. C. Wright, B. Julien, S. Lotersztajn, C. Reker-Smit and K. Poelstra

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 902-910; DOI: https://doi.org/10.1124/jpet.107.132290

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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Reduction of Peroxisome Proliferation-Activated Receptor γ Expression by γ-Irradiation as a Mechanism Contributing to Inflammatory Response in Rat Colon: Modulation by the 5-Aminosalicylic Acid Agonist
Christine Linard, Olivier Grémy and Marc Benderitter

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 911-920; DOI: https://doi.org/10.1124/jpet.107.129122
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p38α-Selective Mitogen-Activated Protein Kinase Inhibitor SD-282 Reduces Inflammation in a Subchronic Model of Tobacco Smoke-Induced Airway Inflammation
Satyanarayana Medicherla, Mary F. Fitzgerald, Dianne Spicer, Paul Woodman, Jing Y. Ma, Ann M. Kapoun, Sarvajit Chakravarty, Sundeep Dugar, Andrew A. Protter and Linda S. Higgins

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 921-929; DOI: https://doi.org/10.1124/jpet.107.127092
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Thionamides Inhibit the Transcription Factor Nuclear Factor-κB by Suppression of Rac1 and Inhibitor of κB Kinase α
Matjaz Humar, Hannah Dohrmann, Philipp Stein, Nikolaos Andriopoulos, Ulrich Goebel, Martin Roesslein, Rene Schmidt, Christian I. Schwer, Torsten Loop, Klaus K. Geiger, Heike L. Pahl and Benedikt H.J. Pannen

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1037-1044; DOI: https://doi.org/10.1124/jpet.107.132407

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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Inhibitor Binding in the Human Renal Low- and High-Affinity Na⁺/Glucose Cotransporters
Ana M. Pajor, Kathleen M. Randolph, Sandy A. Kerner and Chari D. Smith

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 985-991; DOI: https://doi.org/10.1124/jpet.107.129825
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Selegiline Is a Mechanism-Based Inactivator of CYP2A6 Inhibiting Nicotine Metabolism in Humans and Mice
Eric C.K. Siu and Rachel F. Tyndale

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 992-999; DOI: https://doi.org/10.1124/jpet.107.133900
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Identification and Design of Peptides as a New Drug Delivery System for the Brain
Michel Demeule, Anthony Régina, Christian Ché, Julie Poirier, Tran Nguyen, Reinhard Gabathuler, Jean-Paul Castaigne and Richard Béliveau

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1064-1072; DOI: https://doi.org/10.1124/jpet.107.131318
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Age-Dependent Kinetics and Metabolism of Dichloroacetate: Possible Relevance to Toxicity
Albert L. Shroads, Xu Guo, Vaishali Dixit, Hui-Ping Liu, Margaret O. James and Peter W. Stacpoole

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1163-1171; DOI: https://doi.org/10.1124/jpet.107.134593
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Extracting Global System Dynamics of Corticosteroid Genomic Effects in Rat Liver
E. Yang, R. R. Almon, D. C. DuBois, W. J. Jusko and I. P. Androulakis

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1243-1254; DOI: https://doi.org/10.1124/jpet.107.133074

NEUROPHARMACOLOGY

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Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity
Lothar Lindemann, Claas Aiko Meyer, Karine Jeanneau, Amyaouch Bradaia, Laurence Ozmen, Horst Bluethmann, Bernhard Bettler, Joseph G. Wettstein, Edilio Borroni, Jean-Luc Moreau and Marius C. Hoener

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 948-956; DOI: https://doi.org/10.1124/jpet.107.132647
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In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1
Sethu Sankaranarayanan, Eric A. Price, Guoxin Wu, Ming-Chih Crouthamel, Xiao-Ping Shi, Katherine Tugusheva, Keala X. Tyler, Jason Kahana, Joan Ellis, Lixia Jin, Thomas Steele, Shawn Stachel, Craig Coburn and Adam J. Simon

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 957-969; DOI: https://doi.org/10.1124/jpet.107.130039
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Increased C-Fiber Nociceptive Input Potentiates Inhibitory Glycinergic Transmission in the Spinal Dorsal Horn
Hong-Yi Zhou, Hong-Mei Zhang, Shao-Rui Chen and Hui-Lin Pan

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1000-1010; DOI: https://doi.org/10.1124/jpet.107.133470
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Arginine 246 of the Pretransmembrane Domain 1 Region Alters 2,2,2-Trichloroethanol Action in the 5-Hydroxytryptamine_3A Receptor
Xiang-Qun Hu and Robert W. Peoples

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1011-1018; DOI: https://doi.org/10.1124/jpet.107.131011
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2-Methoxymethyl-Salvinorin B Is a Potent κ Opioid Receptor Agonist with Longer Lasting Action in Vivo Than Salvinorin A
Yulin Wang, Yong Chen, Wei Xu, David Y.W. Lee, Zhongze Ma, Scott M. Rawls, Alan Cowan and Lee-Yuan Liu-Chen

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1073-1083; DOI: https://doi.org/10.1124/jpet.107.132142
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The Triple Uptake Inhibitor (1R,5S)-(+)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0] Hexane Hydrochloride (DOV 21947) Reduces Body Weight and Plasma Triglycerides in Rodent Models of Diet-Induced Obesity
Joseph P. Tizzano, D. Sloan Stribling, Diego Perez-Tilve, Alison Strack, Andrea Frassetto, Richard Z. Chen, Tung M. Fong, Lauren Shearman, Philip A. Krieter, Matthias H. Tschöp, Phil Skolnick and Anthony S. Basile

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1111-1126; DOI: https://doi.org/10.1124/jpet.107.133132
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Isoflurane Is a Potent Modulator of Extrasynaptic GABA_A Receptors in the Thalamus
Fan Jia, Minerva Yue, Dev Chandra, Gregg E. Homanics, Peter A. Goldstein and Neil L. Harrison

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1127-1135; DOI: https://doi.org/10.1124/jpet.107.134569
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A Selective Na_v1.8 Sodium Channel Blocker, A-803467 [5-(4-Chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], Attenuates Spinal Neuronal Activity in Neuropathic Rats
Steve McGaraughty, Katharine L. Chu, Marc J. C. Scanio, Michael E. Kort, Connie R. Faltynek and Michael F. Jarvis

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1204-1211; DOI: https://doi.org/10.1124/jpet.107.134148
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S33138 (N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1] benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenyl-acetamide), a Preferential Dopamine D₃ versus D₂ Receptor Antagonist and Potential Antipsychotic Agent: III. Actions in Models of Therapeutic Activity and Induction of Side Effects
Mark J. Millan, Florence Loiseau, Anne Dekeyne, Alain Gobert, Gunnar Flik, Thomas I. Cremers, Jean-Michel Rivet, Dorothée Sicard, Rodolphe Billiras and Mauricette Brocco

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1212-1226; DOI: https://doi.org/10.1124/jpet.107.134536

TOXICOLOGY

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Inhibition of Mitochondrial Hydrogen Peroxide Production by Lipophilic Metalloporphyrins
Pablo R. Castello, Derek A. Drechsel, Brian J. Day and Manisha Patel

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 970-976; DOI: https://doi.org/10.1124/jpet.107.132134
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Omeprazole Stimulates the Induction of Human Insulin-Like Growth Factor Binding Protein-1 through Aryl Hydrocarbon Receptor Activation
Iain A. Murray and Gary H. Perdew

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1102-1110; DOI: https://doi.org/10.1124/jpet.107.132241
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The Butyrylcholinesterase Knockout Mouse as a Model for Human Butyrylcholinesterase Deficiency
Bin Li, Ellen G. Duysen, Michaela Carlson and Oksana Lockridge

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1146-1154; DOI: https://doi.org/10.1124/jpet.107.133330
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Succinate Ameliorates Energy Deficits and Prevents Dysfunction of Complex I in Injured Renal Proximal Tubular Cells
Grażyna Nowak, Ginger L. Clifton and Diana Bakajsova

Journal of Pharmacology and Experimental Therapeutics March 2008, 324 (3) 1155-1162; DOI: https://doi.org/10.1124/jpet.107.130872

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND DIABETES

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

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