Journal of Pharmacology and Experimental Therapeutics: 323 (2)

November 01, 2007; Volume 323,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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Serotonin (5-HT) in Veins: Not All in Vain
A. Elizabeth Linder, Wei Ni, Jessica L. Diaz, Theodora Szasz, Robert Burnett and Stephanie W. Watts

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 415-421; DOI: https://doi.org/10.1124/jpet.107.122630

BEHAVIORAL PHARMACOLOGY

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κ Agonist-Induced Reinstatement of Cocaine Seeking in Squirrel Monkeys: A Role for Opioid and Stress-Related Mechanisms
Glenn R. Valdez, Donna M. Platt, James K. Rowlett, Daniela Rüedi-Bettschen and Roger D. Spealman

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 525-533; DOI: https://doi.org/10.1124/jpet.107.125484
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Drug and Reinforcement History as Determinants of the Response-Maintaining Effects of Quinpirole in the Rat
Gregory T. Collins and James H. Woods

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 599-605; DOI: https://doi.org/10.1124/jpet.107.123042

CARDIOVASCULAR

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Platelet-Endothelial Cell Adhesion Molecule-1-Directed Endothelial Targeting of Superoxide Dismutase Alleviates Oxidative Stress Caused by Either Extracellular or Intracellular Superoxide
Vladimir V. Shuvaev, Samira Tliba, Marian Nakada, Steven M. Albelda and Vladimir R. Muzykantov

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 450-457; DOI: https://doi.org/10.1124/jpet.107.127126
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B-9972 (D-Arg-[Hyp³,Igl⁵,Oic⁷,Igl⁸]-bradykinin) Is an Inactivation-Resistant Agonist of the Bradykinin B₂ Receptor Derived from the Peptide Antagonist B-9430 (D-Arg-[Hyp³,Igl⁵,D-Igl⁷,Oic⁸]-bradykinin): Pharmacologic Profile and Effective Induction of Receptor Degradation
Marie-Thérèse Bawolak, Lajos Gera, Guillaume Morissette, John M. Stewart and François Marceau

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 534-546; DOI: https://doi.org/10.1124/jpet.107.123422
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The Cytochrome P450 Inhibitor Ketoconazole Potentiates 5-Hydroxytryptamine-Induced Contraction in Rat Aorta
Kevin K. Ogden, John R. Falck and Stephanie W. Watts

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 606-613; DOI: https://doi.org/10.1124/jpet.107.128454
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N-Benzyladriamycin-14-valerate (AD 198): A Non-Cardiotoxic Anthracycline That Is Cardioprotective through PKC-ϵ Activation
Polly A. Hofmann, Mervyn Israel, Yoshihiro Koseki, Jeffrey Laskin, Joshua Gray, Aleksandra Janik, Trevor W. Sweatman and Leonard Lothstein

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 658-664; DOI: https://doi.org/10.1124/jpet.107.126110

CELLULAR AND MOLECULAR

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The Endogenous Cannabinoid Anandamide Inhibits Cromakalim-Activated K⁺ Currents in Follicle-Enclosed Xenopus Oocytes
Murat Oz, Keun-Hang Yang, Meral Dinc and Toni S. Shippenberg

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 547-554; DOI: https://doi.org/10.1124/jpet.107.125336
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Conversion of Phosphodiesterase-5 (PDE5) Catalytic Site to Higher Affinity by PDE5 Inhibitors
Mitsi A. Blount, Roya Zoraghi, Emmanuel P. Bessay, Alfreda Beasley, Sharron H. Francis and Jackie D. Corbin

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 730-737; DOI: https://doi.org/10.1124/jpet.107.126540

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Activation of Nonsteroidal Anti-Inflammatory Drug-Activated Gene-1 via Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase Revealed a Isochaihulactone-Triggered Apoptotic Pathway in Human Lung Cancer A549 Cells
Yi-Lin Chen, Po-Cheng Lin, Shee-Ping Chen, Chai-Ching Lin, Nu-Man Tsai, Yeung-Leung Cheng, Wen-Liang Chang, Shinn-Zong Lin and Horng-Jyh Harn

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 746-756; DOI: https://doi.org/10.1124/jpet.107.126193

ENDOCRINE AND DIABETES

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Identification of Novel Orally Available Small Molecule Insulin Mimetics
Bo Lin, Zhitao Li, Kaapjoo Park, Liu Deng, Ashok Pai, Ling Zhong, Michael C. Pirrung and Nicholas J. G. Webster

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 579-585; DOI: https://doi.org/10.1124/jpet.107.126102
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A Novel Long-Acting Selective Neuropeptide Y2 Receptor Polyethylene Glycol-Conjugated Peptide Agonist Reduces Food Intake and Body Weight and Improves Glucose Metabolism in Rodents
Astrid A. Ortiz, Lucinda F. Milardo, Lynn B. DeCarr, Thomas M. Buckholz, Michelle R. Mays, Thomas H. Claus, James N. Livingston, Cathy D. Mahle and Kevin J. Lumb

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 692-700; DOI: https://doi.org/10.1124/jpet.107.125211

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Inhibition of Renal Dipeptidyl Peptidase IV Enhances Peptide YY_1–36-Induced Potentiation of Angiotensin II-Mediated Renal Vasoconstriction in Spontaneously Hypertensive Rats
Edwin K. Jackson, Mingdi Zhang, Weili Liu and Zaichuan Mi

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 431-437; DOI: https://doi.org/10.1124/jpet.107.126847
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Differential Down-Regulation of Aquaporin-2 in Rat Kidney Zones by Peripheral Nociceptin/Orphanin FQ Receptor Agonism and Vasopressin Type-2 Receptor Antagonism
Niels Hadrup, Jørgen S. Petersen, Søren Windfeld, Lotte Risom, Claus B. Andersen, Søren Nielsen, Sten Christensen and Thomas E. N. Jonassen

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 516-524; DOI: https://doi.org/10.1124/jpet.107.123588
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Influence of Estrogen and Xenoestrogens on Basolateral Uptake of Tetraethylammonium by Opossum Kidney Cells in Culture
Ryan M. Pelis, Randall C. Hartman, Stephen H. Wright, Theresa M. Wunz and Carlotta E. Groves

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 555-561; DOI: https://doi.org/10.1124/jpet.107.126748
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3-[5-(3,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionate (JNJ-17156516), a Novel, Potent, and Selective Cholecystokinin 1 Receptor Antagonist: In Vitro and in Vivo Pharmacological Comparison with Dexloxiglumide
Magda F. Morton, Terrance D. Barrett, Wen Yan, Jamie M. Freedman, Guy Lagaud, Clodagh E. Prendergast, Veronica Moreno, Jayashree Pyati, Katherine Figueroa, Lina Li, Xiaodong Wu, Michele Rizzolio, James G. Breitenbucher, Kelly McClure and Nigel P. Shankley

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 562-569; DOI: https://doi.org/10.1124/jpet.107.124578

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis
Carolyn A. Foster, Laurence M. Howard, Alain Schweitzer, Elke Persohn, Peter C. Hiestand, Balázs Balatoni, Roland Reuschel, Christian Beerli, Manuela Schwartz and Andreas Billich

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 469-475; DOI: https://doi.org/10.1124/jpet.107.127183
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Pharmacology and Antitussive Efficacy of 4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic Acid (5-Trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a Transient Receptor Potential Vanilloid 1 Antagonist in Guinea Pigs
Anindya Bhattacharya, Brian P. Scott, Nadia Nasser, Hong Ao, Michael P. Maher, Adrienne E. Dubin, Devin M. Swanson, Nigel P. Shankley, Alan D. Wickenden and Sandra R. Chaplan

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 665-674; DOI: https://doi.org/10.1124/jpet.107.127258
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Modulation of Airway Responses to Influenza A/PR/8/34 by Δ⁹-Tetrahydrocannabinol in C57BL/6 Mice
John P. Buchweitz, Peer W. F. Karmaus, Jack R. Harkema, Kurt J. Williams and Norbert E. Kaminski

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 675-683; DOI: https://doi.org/10.1124/jpet.107.124719

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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Human Renal Cortical and Medullary UDP-Glucuronosyltransferases (UGTs): Immunohistochemical Localization of UGT2B7 and UGT1A Enzymes and Kinetic Characterization of S-Naproxen Glucuronidation
Paraskevi Gaganis, John O. Miners, James S. Brennan, Anthony Thomas and Kathleen M. Knights

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 422-430; DOI: https://doi.org/10.1124/jpet.107.128603
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CYP2A13: Variable Expression and Role in Human Lung Microsomal Metabolic Activation of the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
Xiuling Zhang, Jaime D'Agostino, Hong Wu, Qing-Yu Zhang, Linda von Weymarn, Sharon E. Murphy and Xinxin Ding

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 570-578; DOI: https://doi.org/10.1124/jpet.107.127068
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Positive and Negative Regulation of Human Hepatic Hydroxysteroid Sulfotransferase (SULT2A1) Gene Transcription by Rifampicin: Roles of Hepatocyte Nuclear Factor 4α and Pregnane X Receptor
Hai-Lin Fang, Stephen C. Strom, Ewa Ellis, Zhengbo Duanmu, Jiaqi Fu, Zofia Duniec-Dmuchowski, Charles N. Falany, Josie L. Falany, Thomas A. Kocarek and Melissa Runge-Morris

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 586-598; DOI: https://doi.org/10.1124/jpet.107.124610

NEUROPHARMACOLOGY

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Activity-Dependent Neuroprotective Protein Snippet NAP Reduces Tau Hyperphosphorylation and Enhances Learning in a Novel Transgenic Mouse Model
Inna Vulih-Shultzman, Albert Pinhasov, Shmuel Mandel, Nikolaos Grigoriadis, Olga Touloumi, Zipora Pittel and Illana Gozes

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 438-449; DOI: https://doi.org/10.1124/jpet.107.129551
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Prolonged Attenuation of Amygdala-Kindled Seizure Measures in Rats by Convection-Enhanced Delivery of the N-Type Calcium Channel Antagonists ω-Conotoxin GVIA and ω-Conotoxin MVIIA
Maciej Gasior, Natalie A. White and Michael A. Rogawski

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 458-468; DOI: https://doi.org/10.1124/jpet.107.125047
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3,4-Methylenedioxymethamphetamine- and 8-Hydroxy-2-di-n-propylamino-tetralin-Induced Hypothermia: Role and Location of 5-Hydroxytryptamine 1A Receptors
Daniel E. Rusyniak, Maria V. Zaretskaia, Dmitry V. Zaretsky and Joseph A. DiMicco

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 477-487; DOI: https://doi.org/10.1124/jpet.107.126169
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Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-α in the Rat
Eduardo Candelario-Jalil, Saeid Taheri, Yi Yang, Rohit Sood, Mark Grossetete, Eduardo Y. Estrada, Bernd L. Fiebich and Gary A. Rosenberg

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 488-498; DOI: https://doi.org/10.1124/jpet.107.127035
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Expression of Cannabinoid CB₁ Receptors in Models of Diabetic Neuropathy
Fan Zhang, Shuangsong Hong, Vicki Stone and Paula J. W. Smith

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 508-515; DOI: https://doi.org/10.1124/jpet.107.128272
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A Select Set of Opioid Ligands Induce Up-Regulation by Promoting the Maturation and Stability of the Rat κ-Opioid Receptor in Human Embryonic Kidney 293 Cells
Kenneth M. Wannemacher, Prem N. Yadav and Richard D. Howells

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 614-625; DOI: https://doi.org/10.1124/jpet.107.125500
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The Immunomodulator FTY720 Has a Direct Cytoprotective Effect in Oligodendrocyte Progenitors
Rochelle P. Coelho, Shawn G. Payne, Robert Bittman, Sarah Spiegel and Carmen Sato-Bigbee

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 626-635; DOI: https://doi.org/10.1124/jpet.107.123927
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Regulator of G-Protein Signaling 4 Interacts with Metabotropic Glutamate Receptor Subtype 5 in Rat Striatum: Relevance to Amphetamine Behavioral Sensitization
Marek Schwendt and Jacqueline F. McGinty

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 650-657; DOI: https://doi.org/10.1124/jpet.107.128561
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Ethanol Sensitivity of GABAergic Currents in Cerebellar Granule Neurons Is Not Increased by a Single Amino Acid Change (R100Q) in the α₆ GABA_A Receptor Subunit
Paolo Botta, Manuel Mameli, Kirsten L. Floyd, Richard A. Radcliffe and C. Fernando Valenzuela

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 684-691; DOI: https://doi.org/10.1124/jpet.107.127894
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μ-Opioid Receptor Up-Regulation and Functional Supersensitivity Are Independent of Antagonist Efficacy
Sunil Sirohi, Priyank Kumar and Byron C. Yoburn

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 701-707; DOI: https://doi.org/10.1124/jpet.107.127019
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Pharmacological Characterization of a Novel, Potent Adenosine A₁ and A_2A Receptor Dual Antagonist, 5-[5-Amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in Models of Parkinson's Disease and Cognition
Takuma Mihara, Kayoko Mihara, Junko Yarimizu, Yasuyuki Mitani, Ritsuko Matsuda, Hiroko Yamamoto, Satoshi Aoki, Atsushi Akahane, Akinori Iwashita and Nobuya Matsuoka

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 708-719; DOI: https://doi.org/10.1124/jpet.107.121962
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Desvenlafaxine Succinate Identifies Novel Antagonist Binding Determinants in the Human Norepinephrine Transporter
John N. Mason, Darlene C. Deecher, Rhonda L. Richmond, Gary Stack, Paige E. Mahaney, Eugene Trybulski, Richard C. Winneker and Randy D. Blakely

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 720-729; DOI: https://doi.org/10.1124/jpet.107.125716
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Methylphenidate Administration Alters Vesicular Monoamine Transporter-2 Function in Cytoplasmic and Membrane-Associated Vesicles
Trent J. Volz, Sarah J. Farnsworth, Jill L. King, Evan L. Riddle, Glen R. Hanson and Annette E. Fleckenstein

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 738-745; DOI: https://doi.org/10.1124/jpet.107.126888

TOXICOLOGY

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Mitochondrial Complex I Inhibitor Rotenone-Elicited Dopamine Redistribution from Vesicles to Cytosol in Human Dopaminergic SH-SY5Y Cells
Masahiko Watabe and Toshio Nakaki

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 499-507; DOI: https://doi.org/10.1124/jpet.107.127597
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Mitochondrially Targeted Effects of Berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 Mouse Melanoma Cells: Comparison with Direct Effects on Isolated Mitochondrial Fractions
Gonçalo C. Pereira, Ana F. Branco, Júlio A. C. Matos, Sandro L. Pereira, Donna Parke, Edward L. Perkins, Teresa L. Serafim, Vilma A. Sardão, Maria S. Santos, Antonio J. M. Moreno, Jon Holy and Paulo J. Oliveira

Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 636-649; DOI: https://doi.org/10.1124/jpet.107.128017

Erratum

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Correction to “Lysophosphatidic Acid Decreases Epidermal Growth Factor Receptor Binding in Airway Epithelial Cells”
Journal of Pharmacology and Experimental Therapeutics November 2007, 323 (2) 757;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND DIABETES

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

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