Pharmacokinetics and Pharmacodynamics of Seven Opioids in P-Glycoprotein-Competent Mice: Assessment of Unbound Brain EC50,u and Correlation of in Vitro, Preclinical, and Clinical Data

School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.C.K., E.R.O., G.M.P.); and Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond Virginia (M.P.C., D.E.S.)

Address correspondence to:
Dr. J. Cory Kalvass, Department of Drug Disposition, Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285. E-mail: kalvassjo{at}lilly.com

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