Table of Contents

NEUROPHARMACOLOGY

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  Activation of a Novel Injury-Induced Calcium-Permeable Channel That Plays a Key Role in Causing Extended Neuronal Depolarization and Initiating Neuronal Death in Excitotoxic Neuronal Injury

  Laxmikant S. Deshpande, David D. Limbrick, Sompong Sombati and Robert J. DeLorenzo

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 443-452; DOI: https://doi.org/10.1124/jpet.107.123182
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  Effects of Lamotrigine Alone and in Combination with MK-801, Phenobarbital, or Phenytoin on Cell Death in the Neonatal Rat Brain

  Irina Katz, Jinsook Kim, Karen Gale and Alexei Kondratyev

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 494-500; DOI: https://doi.org/10.1124/jpet.107.123133
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  The Effect of Recombinant Human Erythropoietin on Neurovasculature Repair after Focal Ischemic Stroke in Neonatal Rats

  Christine L. Keogh, Shan Ping Yu and Ling Wei

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 521-528; DOI: https://doi.org/10.1124/jpet.107.121392
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  Pharmacokinetics and Amyloid Plaque Targeting Ability of a Novel Peptide-Based Magnetic Resonance Contrast Agent in Wild-Type and Alzheimer's Disease Transgenic Mice

  Karunya K. Kandimalla, Thomas M. Wengenack, Geoffry L. Curran, Emily J. Gilles and Joseph F. Poduslo

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 541-549; DOI: https://doi.org/10.1124/jpet.107.119883
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  Antiepileptic Drugs Affect Neuronal Androgen Signaling via a Cytochrome P450-Dependent Pathway

  Marcel Gehlhaus, Nina Schmitt, Benedikt Volk and Ralf P. Meyer

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 550-559; DOI: https://doi.org/10.1124/jpet.107.120303
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  Benzodiazepine Withdrawal-Induced Glutamatergic Plasticity Involves Up-Regulation of GluR1-Containing α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptors in Hippocampal CA1 Neurons

  Jun Song, Guofu Shen, L. John Greenfield and Elizabeth I. Tietz

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 569-581; DOI: https://doi.org/10.1124/jpet.107.121798
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  Atrial Natriuretic Peptide Reduces Ischemia/Reperfusion-Induced Spinal Cord Injury in Rats by Enhancing Sensory Neuron Activation

  Takuya Nakayama, Naoaki Harada, Miki Asano, Norikazu Nomura, Takayuki Saito, Akira Mishima and Kenji Okajima

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 582-590; DOI: https://doi.org/10.1124/jpet.107.120725
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  Galantamine Postischemia Provides Neuroprotection and Memory Recovery against Transient Global Cerebral Ischemia in Gerbils

  Silvia Lorrio, Mónica Sobrado, Esperanza Arias, José M. Roda, Antonio G. García and Manuela G. López

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 591-599; DOI: https://doi.org/10.1124/jpet.107.122747
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  Pharmacological, Pharmacokinetic, and Primate Analgesic Efficacy Profile of the Novel Bradykinin B₁ Receptor Antagonist ELN441958

  Jon E. Hawkinson, Balazs G. Szoke, Albert W. Garofalo, Dennis S. Hom, Hongbing Zhang, Mark Dreyer, Juri Y. Fukuda, Linda Chen, Bhushan Samant, Stellanie Simmonds, Karla P. Zeitz, Angie Wadsworth, Anna Liao, Raymond A. Chavez, Wes Zmolek, Lany Ruslim, Michael P. Bova, Ryan Holcomb, Eduardo R. Butelman, Mei-Chuan Ko and Annika B. Malmberg

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 619-630; DOI: https://doi.org/10.1124/jpet.107.120352
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  Sexually Dimorphic Recruitment of Spinal Opioid Analgesic Pathways by the Spinal Application of Morphine

  Nai-Jiang Liu, Hans von Gizycki and Alan R. Gintzler

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 654-660; DOI: https://doi.org/10.1124/jpet.107.123620
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  Low Sensitivity of the Positron Emission Tomography Ligand [¹¹C]Diprenorphine to Agonist Opiates

  Susan P. Hume, Anne R. Lingford-Hughes, Valerie Nataf, Ella Hirani, Rabia Ahmad, Andrew N. Davies and David J. Nutt

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 661-667; DOI: https://doi.org/10.1124/jpet.107.121749
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  CJ-023,423, a Novel, Potent and Selective Prostaglandin EP₄ Receptor Antagonist with Antihyperalgesic Properties

  Kazunari Nakao, Akio Murase, Hiroyuki Ohshiro, Takako Okumura, Kana Taniguchi, Yoko Murata, Masatoshi Masuda, Tomoki Kato, Yoshiyuki Okumura and Junji Takada

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 686-694; DOI: https://doi.org/10.1124/jpet.107.122010
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  Identification and Characterization of Cholest-4-en-3-one, Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis

  Thierry Bordet, Bruno Buisson, Magali Michaud, Cyrille Drouot, Pascale Galéa, Pierre Delaage, Natalia P. Akentieva, Alex S. Evers, Douglas F. Covey, Mariano A. Ostuni, Jean-Jacques Lacapère, Charbel Massaad, Michael Schumacher, Esther-Marie Steidl, Delphine Maux, Michel Delaage, Christopher E. Henderson and Rebecca M. Pruss

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 709-720; DOI: https://doi.org/10.1124/jpet.107.123000
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  Memantine Inhibits ATP-Dependent K⁺ Conductances in Dopamine Neurons of the Rat Substantia Nigra Pars Compacta

  Michela Giustizieri, Maria Letizia Cucchiaroni, Ezia Guatteo, Giorgio Bernardi, Nicola B. Mercuri and Nicola Berretta

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 721-729; DOI: https://doi.org/10.1124/jpet.107.122036
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  Applicability of the Dopamine and Rate Hypotheses in Explaining the Differences in Behavioral Pharmacology of the Chloro-Benztropine Analogs: Studies Conducted Using Intracerebral Microdialysis and Population Pharmacodynamic Modeling

  Ahmed A. Othman, Amy Hauck Newman and Natalie D. Eddington

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 760-769; DOI: https://doi.org/10.1124/jpet.107.123315
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  Impaired Microsomal Oxidation of the Atypical Antipsychotic Agent Clozapine in Hepatic Steatosis

  Wei V. Zhang, Iqbal Ramzan and Michael Murray

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 770-777; DOI: https://doi.org/10.1124/jpet.107.124024
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  Tumor Necrosis Factor (TNF)-Soluble High-Affinity Receptor Complex as a TNF Antagonist

  Sean D. McKenna, Georg Feger, Christie Kelton, Meijia Yang, Vittoria Ardissone, Rocco Cirillo, Pierre-Alain Vitte, Xuliang Jiang and Robert K. Campbell

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 822-828; DOI: https://doi.org/10.1124/jpet.107.119875
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  ACP-103, a 5-Hydroxytryptamine 2A Receptor Inverse Agonist, Improves the Antipsychotic Efficacy and Side-Effect Profile of Haloperidol and Risperidone in Experimental Models

  Luis R. Gardell, Kimberly E. Vanover, Linda Pounds, Robert W. Johnson, Richard Barido, Gary T. Anderson, Isaac Veinbergs, Agnete Dyssegaard, Per Brunmark, Ali Tabatabaei, Robert E. Davis, Mark R. Brann, Uli Hacksell and Douglas W. Bonhaus

  Journal of Pharmacology and Experimental Therapeutics August 2007, 322 (2) 862-870; DOI: https://doi.org/10.1124/jpet.107.121715