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Research ArticleCELLULAR AND MOLECULAR

Targeting AML1/ETO-Histone Deacetylase Repressor Complex: A Novel Mechanism for Valproic Acid-Mediated Gene Expression and Cellular Differentiation in AML1/ETO-Positive Acute Myeloid Leukemia Cells

Shujun Liu, Rebecca B. Klisovic, Tamara Vukosavljevic, Jianhua Yu, Peter Paschka, Lenguyen Huynh, Jiuxia Pang, Paolo Neviani, Zhongfa Liu, William Blum, Kenneth K. Chan, Danilo Perrotti and Guido Marcucci
Journal of Pharmacology and Experimental Therapeutics June 2007, 321 (3) 953-960; DOI: https://doi.org/10.1124/jpet.106.118406

Article Information

vol. 321 no. 3 953-960
DOI 
https://doi.org/10.1124/jpet.106.118406
PubMed 
17389244
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received December 21, 2006
  • Accepted March 22, 2007
  • Published online May 14, 2007.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Shujun Liu,
  2. Rebecca B. Klisovic,
  3. Tamara Vukosavljevic,
  4. Jianhua Yu,
  5. Peter Paschka,
  6. Lenguyen Huynh,
  7. Jiuxia Pang,
  8. Paolo Neviani,
  9. Zhongfa Liu,
  10. William Blum,
  11. Kenneth K. Chan,
  12. Danilo Perrotti and
  13. Guido Marcucci
  1. Divisions of Hematology-Oncology (S.L., R.B.K., T.V., P.P., L.H., J.P., W.B., G.M.), Human Cancer Genetics (J.Y., P.N., D.P., G.M.), College of Pharmacy (Z.L., K.K.C.), and Comprehensive Cancer Center (D.P., G.M.), The Ohio State University, Columbus, Ohio
  1. Address correspondence to:
    Dr. Guido, Marcucci, 458A Starling-Loving Hall, The Ohio State University, 320 West 10th Avenue, Columbus, OH 43210. E mail: guido.marcucci{at}osumc.edu
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Research ArticleCELLULAR AND MOLECULAR

Targeting AML1/ETO-Histone Deacetylase Repressor Complex: A Novel Mechanism for Valproic Acid-Mediated Gene Expression and Cellular Differentiation in AML1/ETO-Positive Acute Myeloid Leukemia Cells

Shujun Liu, Rebecca B. Klisovic, Tamara Vukosavljevic, Jianhua Yu, Peter Paschka, Lenguyen Huynh, Jiuxia Pang, Paolo Neviani, Zhongfa Liu, William Blum, Kenneth K. Chan, Danilo Perrotti and Guido Marcucci
Journal of Pharmacology and Experimental Therapeutics June 1, 2007, 321 (3) 953-960; DOI: https://doi.org/10.1124/jpet.106.118406
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