Table of Contents

NEUROPHARMACOLOGY

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  l-3-n-Butylphthalide Improves Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats

  Ying Peng, Shaofeng Xu, Guiquan Chen, Ling Wang, Yipu Feng and Xiaoliang Wang

  Journal of Pharmacology and Experimental Therapeutics June 2007, 321 (3) 902-910; DOI: https://doi.org/10.1124/jpet.106.118760
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  Pharmacological Characterization of the Nociceptin/Orphanin FQ Receptor Antagonist SB-612111 [(–)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: In Vitro Studies

  Barbara Spagnolo, Giacomo Carrà, Martina Fantin, Carmela Fischetti, Chris Hebbes, John McDonald, Timothy A. Barnes, Anna Rizzi, Claudio Trapella, Giulia Fanton, Michele Morari, Dave G. Lambert, Domenico Regoli and Girolamo Calò

  Journal of Pharmacology and Experimental Therapeutics June 2007, 321 (3) 961-967; DOI: https://doi.org/10.1124/jpet.106.116764
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  Pharmacological Characterization of the Nociceptin/Orphanin FQ Receptor Antagonist SB-612111 [(–)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: In Vivo Studies

  Anna Rizzi, Elaine C. Gavioli, Giuliano Marzola, Barbara Spagnolo, Silvia Zucchini, Roberto Ciccocioppo, Claudio Trapella, Domenico Regoli and Girolamo Calò

  Journal of Pharmacology and Experimental Therapeutics June 2007, 321 (3) 968-974; DOI: https://doi.org/10.1124/jpet.106.116780
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  Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents

  Tung M. Fong, Xiao-Ming Guan, Donald J. Marsh, Chun-Pyn Shen, D. Sloan Stribling, Kim M. Rosko, Julie Lao, Hong Yu, Yue Feng, Jing C. Xiao, Lex H. T. Van der Ploeg, Mark T. Goulet, Williams K. Hagmann, Linus S. Lin, Thomas J. Lanza, James P. Jewell, Ping Liu, Shrenik K. Shah, Hongbo Qi, Xinchun Tong, Junying Wang, Suoyu S. Xu, Barbara Francis, Alison M. Strack, D. Euan MacIntyre and Lauren P. Shearman

  Journal of Pharmacology and Experimental Therapeutics June 2007, 321 (3) 1013-1022; DOI: https://doi.org/10.1124/jpet.106.118737
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  GSK189254, a Novel H₃ Receptor Antagonist That Binds to Histamine H₃ Receptors in Alzheimer's Disease Brain and Improves Cognitive Performance in Preclinical Models

  Andrew D. Medhurst, Alan R. Atkins, Isabel J. Beresford, Kim Brackenborough, Michael A. Briggs, Andrew R. Calver, Jackie Cilia, Jane E. Cluderay, Barry Crook, John B. Davis, Rebecca K. Davis, Robert P. Davis, Lee A. Dawson, Andrew G. Foley, Jane Gartlon, M. Isabel Gonzalez, Teresa Heslop, Warren D. Hirst, Carol Jennings, Declan N. C. Jones, Laurent P. Lacroix, Abbe Martyn, Sandrine Ociepka, Alison Ray, Ciaran M. Regan, Jennifer C. Roberts, Joanne Schogger, Eric Southam, Tania O. Stean, Brenda K. Trail, Neil Upton, Graham Wadsworth, Jeffrey A. Wald, Trevor White, Jason Witherington, Marie L. Woolley, Angela Worby and David M. Wilson

  Journal of Pharmacology and Experimental Therapeutics June 2007, 321 (3) 1032-1045; DOI: https://doi.org/10.1124/jpet.107.120311
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  Roles of 5-Hydroxytryptamine (5-HT) Receptor Subtypes in the Inhibitory Effects of 5-HT on C-Fiber Responses of Spinal Wide Dynamic Range Neurons in Rats

  Feng-Yu Liu, Guo-Gang Xing, Xiao-Xiu Qu, Isabella S. Xu, Ji-Sheng Han and You Wan

  Journal of Pharmacology and Experimental Therapeutics June 2007, 321 (3) 1046-1053; DOI: https://doi.org/10.1124/jpet.106.115204
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  α1A-Adrenergic Receptors Are Functionally Expressed by a Subpopulation of Cornu Ammonis 1 Interneurons in Rat Hippocampus

  Kristin L. Hillman, Van A. Doze and James E. Porter

  Journal of Pharmacology and Experimental Therapeutics June 2007, 321 (3) 1062-1068; DOI: https://doi.org/10.1124/jpet.106.119297
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  Subunit-Dependent Modulation of the 5-Hydroxytryptamine Type 3 Receptor Open-Close Equilibrium by n-Alcohols

  Dirk Rüsch, Boris Musset, Hinnerk Wulf, Anika Schuster and Douglas E. Raines

  Journal of Pharmacology and Experimental Therapeutics June 2007, 321 (3) 1069-1074; DOI: https://doi.org/10.1124/jpet.106.118752
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  Pharmacological Characterization of a New, Orally Active and Potent Allosteric Metabotropic Glutamate Receptor 1 Antagonist, 4-[1-(2-Fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC)

  Gentaroh Suzuki, Toshifumi Kimura, Akio Satow, Naoki Kaneko, Junko Fukuda, Hirohiko Hikichi, Naoko Sakai, Shunsuke Maehara, Hiroko Kawagoe-Takaki, Mikiko Hata, Tomoko Azuma, Satoru Ito, Hiroshi Kawamoto and Hisashi Ohta

  Journal of Pharmacology and Experimental Therapeutics June 2007, 321 (3) 1144-1153; DOI: https://doi.org/10.1124/jpet.106.116574
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  Genetic Approaches Identify Differential Roles for α₄β₂^* Nicotinic Receptors in Acute Models of Antinociception in Mice

  M. I. Damaj, C. Fonck, M. J. Marks, P. Deshpande, C. Labarca, H. A. Lester, A. C. Collins and B. R. Martin

  Journal of Pharmacology and Experimental Therapeutics June 2007, 321 (3) 1161-1169; DOI: https://doi.org/10.1124/jpet.106.112649
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  The Acetylcholinesterase Inhibitor Galantamine Inhibits d-Amphetamine-Induced Psychotic-Like Behavior in Cebus Monkeys

  Maibritt B. Andersen, Thomas Werge and Anders Fink-Jensen

  Journal of Pharmacology and Experimental Therapeutics June 2007, 321 (3) 1179-1182; DOI: https://doi.org/10.1124/jpet.107.119677
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  Characterization of SB-705498, a Potent and Selective Vanilloid Receptor-1 (VR1/TRPV1) Antagonist That Inhibits the Capsaicin-, Acid-, and Heat-Mediated Activation of the Receptor

  Martin J. Gunthorpe, Sara Luis Hannan, Darren Smart, Jeffrey C. Jerman, Sandra Arpino, Graham D. Smith, Stephen Brough, Jim Wright, Julie Egerton, Sarah C. Lappin, Vicky A. Holland, Kim Winborn, Mervyn Thompson, Harshad K. Rami, Andrew Randall and John B. Davis

  Journal of Pharmacology and Experimental Therapeutics June 2007, 321 (3) 1183-1192; DOI: https://doi.org/10.1124/jpet.106.116657
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  Characterization of the Antinociceptive Actions of Bicifadine in Models of Acute, Persistent, and Chronic Pain

  Anthony S. Basile, Aaron Janowsky, Krystyna Golembiowska, Magdalena Kowalska, Eyal Tam, Morris Benveniste, Piotr Popik, Agnieszka Nikiforuk, Martyna Krawczyk, Gabriel Nowak, Philip A. Krieter, Arnold S. Lippa, Phil Skolnick and Elena Koustova

  Journal of Pharmacology and Experimental Therapeutics June 2007, 321 (3) 1208-1225; DOI: https://doi.org/10.1124/jpet.106.116483