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Research ArticleTOXICOLOGY

Tamoxifen Inhibits Topoisomerases, Depletes Mitochondrial DNA, and Triggers Steatosis in Mouse Liver

Isabelle Larosche, Philippe Lettéron, Bernard Fromenty, Nathalie Vadrot, Adjé Abbey-Toby, Gérard Feldmann, Dominique Pessayre and Abdellah Mansouri
Journal of Pharmacology and Experimental Therapeutics May 2007, 321 (2) 526-535; DOI: https://doi.org/10.1124/jpet.106.114546

Article Information

vol. 321 no. 2 526-535
DOI 
https://doi.org/10.1124/jpet.106.114546
PubMed 
17277197
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received September 26, 2006
  • Accepted February 1, 2007
  • Published online April 16, 2007.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Isabelle Larosche,
  2. Philippe Lettéron,
  3. Bernard Fromenty,
  4. Nathalie Vadrot,
  5. Adjé Abbey-Toby,
  6. Gérard Feldmann,
  7. Dominique Pessayre and
  8. Abdellah Mansouri
  1. Institut National de la Santé et de la Recherche Médicale, U773, Centre de Recherche Biomédicale Bichat Beaujon CRB3, Equipe Mitochondries, Paris, France (I.L., P.L., B.F., N.V., G.F., D.P., A.M.); and Université Paris 7 Denis Diderot, Site Bichat, Paris, France (P.L., B.F., N.V., G.F., A.A.-T., D.P., A.M.)
  1. Address correspondence to:
    Dr. Abdellah Mansouri, Institut National de la Santé et de la Recherche Médicale U773, Equipe Mitochondries, Facultéde Médecine Xavier Bichat, 16 rue Henri Huchard, BP 416, F-75018 Paris, France. E-mail: mansouri{at}bichat.inserm.fr
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Research ArticleTOXICOLOGY

Tamoxifen Inhibits Topoisomerases, Depletes Mitochondrial DNA, and Triggers Steatosis in Mouse Liver

Isabelle Larosche, Philippe Lettéron, Bernard Fromenty, Nathalie Vadrot, Adjé Abbey-Toby, Gérard Feldmann, Dominique Pessayre and Abdellah Mansouri
Journal of Pharmacology and Experimental Therapeutics May 1, 2007, 321 (2) 526-535; DOI: https://doi.org/10.1124/jpet.106.114546
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