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Research ArticleMETABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Characterization of the pH of Folate Receptor-Containing Endosomes and the Rate of Hydrolysis of Internalized Acid-Labile Folate-Drug Conjugates

Jun Yang, Hongtao Chen, Iontcho R. Vlahov, Ji-Xin Cheng and Philip S. Low
Journal of Pharmacology and Experimental Therapeutics May 2007, 321 (2) 462-468; DOI: https://doi.org/10.1124/jpet.106.117648
Jun Yang
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Hongtao Chen
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Iontcho R. Vlahov
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Ji-Xin Cheng
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Philip S. Low
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Article Information

vol. 321 no. 2 462-468
DOI 
https://doi.org/10.1124/jpet.106.117648
PubMed 
17289839

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received November 26, 2006
  • Accepted February 6, 2007
  • Published online April 16, 2007.

Article Versions

  • Earlier version (February 8, 2007 - 11:47).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jun Yang1,
  2. Hongtao Chen,
  3. Iontcho R. Vlahov,
  4. Ji-Xin Cheng and
  5. Philip S. Low
  1. Department of Chemistry (J.Y., H.C., J.-X.C., P.S.L.), Weldon School of Biomedical Engineering (H.C., J.-X.C.), Purdue University, West Lafayette, Indiana; and Endocyte, Inc., West Lafayette, Indiana (I.R.V.)
  1. Address correspondence to:
    Dr. Philip S. Low, Department of Chemistry, Purdue University, West Lafayette, IN 47907. E-mail: plow{at}purdue.edu
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Journal of Pharmacology and Experimental Therapeutics: 385 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 385, Issue 1
1 Apr 2023
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Research ArticleMETABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Characterization of the pH of Folate Receptor-Containing Endosomes and the Rate of Hydrolysis of Internalized Acid-Labile Folate-Drug Conjugates

Jun Yang, Hongtao Chen, Iontcho R. Vlahov, Ji-Xin Cheng and Philip S. Low
Journal of Pharmacology and Experimental Therapeutics May 1, 2007, 321 (2) 462-468; DOI: https://doi.org/10.1124/jpet.106.117648

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Research ArticleMETABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Characterization of the pH of Folate Receptor-Containing Endosomes and the Rate of Hydrolysis of Internalized Acid-Labile Folate-Drug Conjugates

Jun Yang, Hongtao Chen, Iontcho R. Vlahov, Ji-Xin Cheng and Philip S. Low
Journal of Pharmacology and Experimental Therapeutics May 1, 2007, 321 (2) 462-468; DOI: https://doi.org/10.1124/jpet.106.117648
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