Preclinical Pharmacokinetic and Pharmacodynamic Evaluation of Metronomic and Conventional Temozolomide Dosing Regimens

Address correspondence to:
Dr. James M. Gallo, Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, 3307 N. Broad St., Philadelphia, PA 19140. E-mail: jmgallo{at}temple.edu

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	Abstract	Full	Pdf
Jan 2007	20	0	26
Feb 2007	30	0	167
Mar 2007	76	18	133
Apr 2007	65	37	64
May 2007	22	28	48
Jun 2007	19	22	49
Jul 2007	33	28	40
Aug 2007	18	28	38
Sep 2007	34	15	42
Oct 2007	24	23	32
Nov 2007	28	13	21
Dec 2007	24	13	21
Jan 2008	34	29	39
Feb 2008	35	25	34
Mar 2008	40	21	35
Apr 2008	25	69	66
May 2008	28	50	52
Jun 2008	42	53	60
Jul 2008	25	64	58
Aug 2008	25	54	31
Sep 2008	35	78	48
Oct 2008	24	48	42
Nov 2008	39	51	41
Dec 2008	25	38	27
Jan 2009	31	40	35
Feb 2009	24	36	40
Mar 2009	40	45	49
Apr 2009	35	43	50
May 2009	18	53	52
Jun 2009	21	34	39
Jul 2009	24	34	23
Aug 2009	21	24	26
Sep 2009	17	27	31
Oct 2009	25	30	23
Nov 2009	24	21	19
Dec 2009	28	14	22
Jan 2010	37	25	33
Feb 2010	13	16	24
Mar 2010	27	34	29
Apr 2010	19	25	20
May 2010	33	26	21
Jun 2010	40	56	45
Jul 2010	20	41	25
Aug 2010	17	37	18
Sep 2010	19	36	21
Oct 2010	20	34	22
Nov 2010	16	32	16
Dec 2010	11	22	13
Jan 2011	22	24	15
Feb 2011	13	32	22
Mar 2011	13	39	28
Apr 2011	13	26	22
May 2011	16	15	22
Jun 2011	28	16	23
Jul 2011	18	22	30
Aug 2011	19	36	17
Sep 2011	17	39	18
Oct 2011	23	34	25
Nov 2011	23	30	25
Dec 2011	16	24	30
Jan 2012	19	36	41
Feb 2012	28	29	40
Mar 2012	32	48	26
Apr 2012	17	19	28
May 2012	23	28	32
Jun 2012	9	29	30
Jul 2012	20	41	28
Aug 2012	19	21	33
Sep 2012	22	29	33
Oct 2012	17	42	47
Nov 2012	23	25	27
Dec 2012	29	26	48
Jan 2013	13	32	61
Feb 2013	15	17	38
Mar 2013	19	22	39
Apr 2013	24	27	31
May 2013	13	17	30
Jun 2013	17	16	25
Jul 2013	3	19	20
Aug 2013	16	18	22
Sep 2013	19	23	30
Oct 2013	19	13	13
Nov 2013	15	18	11
Dec 2013	6	10	7
Jan 2014	9	12	23
Feb 2014	7	20	14
Mar 2014	9	17	14
Apr 2014	13	16	19
May 2014	6	33	33
Jun 2014	9	44	26
Jul 2014	21	28	21
Aug 2014	6	151	7
Sep 2014	9	41	25
Oct 2014	15	11	13
Nov 2014	11	9	2
Dec 2014	12	16	11
Jan 2015	11	23	8
Feb 2015	11	8	7
Mar 2015	7	35	14
Apr 2015	15	32	16
May 2015	6	35	14
Jun 2015	7	31	19
Jul 2015	4	40	30
Aug 2015	12	18	22
Sep 2015	8	29	23
Oct 2015	6	26	10
Nov 2015	10	37	16
Dec 2015	12	26	7
Jan 2016	13	20	10
Feb 2016	11	30	20
Mar 2016	16	35	28
Apr 2016	8	31	35
May 2016	4	23	21
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Jul 2016	8	39	22
Aug 2016	5	23	19
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Oct 2016	2	25	41
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Dec 2016	0	27	16
Jan 2017	4	46	13
Feb 2017	1	35	18
Mar 2017	1	34	9
Apr 2017	5	20	18
May 2017	1	33	12
Jun 2017	3	24	15
Jul 2017	4	14	15
Aug 2017	3	26	16
Sep 2017	3	26	14
Oct 2017	0	33	14
Nov 2017	2	42	21
Dec 2017	1	31	15
Jan 2018	0	36	17
Feb 2018	1	41	18
Mar 2018	4	62	24
Apr 2018	1	54	13
May 2018	0	57	31
Jun 2018	1	38	15
Jul 2018	4	69	22
Aug 2018	4	74	7
Sep 2018	0	34	12
Oct 2018	2	48	21
Nov 2018	1	82	20
Dec 2018	38	16	6
Jan 2019	42	1	7
Feb 2019	22	4	5
Mar 2019	26	10	5
Apr 2019	15	2	3
May 2019	18	6	3
Jun 2019	27	4	9
Jul 2019	13	2	4
Aug 2019	52	2	7
Sep 2019	47	2	4
Oct 2019	37	5	10
Nov 2019	51	9	15
Dec 2019	28	4	4
Jan 2020	33	2	3
Feb 2020	41	17	12
Mar 2020	16	4	5
Apr 2020	22	3	5
May 2020	26	0	2
Jun 2020	60	1	4
Jul 2020	27	0	2
Aug 2020	15	0	5
Sep 2020	68	3	9
Oct 2020	53	6	5
Nov 2020	55	3	6
Dec 2020	36	2	5
Jan 2021	22	4	4
Feb 2021	31	6	6
Mar 2021	74	6	10
Apr 2021	53	4	4
May 2021	31	8	8
Jun 2021	23	3	9